Biomedical Engineering and Bioengineering Commons^™

Differentiation Of Kidney Progenitors Using Induced Pluripotent Stem Cells And Conditioned Media Of Renal Cortical Tubular Epithelial Cells, Matthew Nielsen 3644978, Steven Passey, Maxwell Beers, Alonzo Cook

Biomedical Engineering Western Regional Conference

No abstract provided.

Dual Mechanism For Toughening And Sustained Aminoglycoside Elution From A Polyphosphate Hydrogel, Dwight D. Lane, Russell J. Stewart Phd

Biomedical Engineering Western Regional Conference

No abstract provided.

Redesign Of Computer Keyboards For Hospital And Consumer Use, Kent Williams, Brian Jensen, Anton Bowden

Biomedical Engineering Western Regional Conference

Application of carbon nanotube coatings to computer keyboards in order to reduce the spread of bacteria in hospitals and homes.

Keywords: carbon nanotube, bacteria, antimicrobial, keyboard, design, MRSA, biofilm

Soft-Tissue Artifact Compensation For Electromagnetic Motion Capture, George T. Dickinson, Steven K. Charles

Biomedical Engineering Western Regional Conference

This purpose of this study is to develop a soft-tissue artifact compensation algorithm for the upper arm using electromagnetic motion capture systems that can be implemented in a wide range of applications. This study focuses on compensation of humeral axial rotation and forearm axial rotation.

The Sub-Chronic Vascular Response To Water-Borne Embolic Coacervates., Joshua P. Jones, Monika Sima, Russell J. Stewart

Biomedical Engineering Western Regional Conference

Water-borne coacervates that solidify in response to decreasing ionic strength have been developed as an agent for small vessel transcatheter embolization. Here, the sub-chronic vascular response to these agents will be presented. Embolic coacervates demonstrated a benign foreign body response, which supported tissue ingrowth and stabilized vessel occlusion out to 28 days. As with other liquid embolics, occlusion is dependent upon mechanical obstruction of the vessel and native thrombus. Over time, the thrombus becomes more organized by fibroblasts. Continuation of the processes seen at 28 days will likely result in fibrous encapsulation of the embolic coacervate, further stabilizing the occlusion.

Serum Comp And The Inflammatory Environment Of The Knee Before And After Exercise-Induced Load, Alyssa Evans, Robert D. Hyldahl, Sarah T. Ridge, Sunku Kwon, Ty J. Hopkins, Eric R. Robinson, Matthew K. Seeley

Biomedical Engineering Western Regional Conference

The purpose of this study was to determine how accurately serum COMP represents inflammatory cytokine levels, within the knee, before and after exercise.

Cytokines included: GM-CSF, IFNa2, IL-10, IL-12p40, IL-13, IL-15, IL-1ra, IL1b, IL1a, IL-4, IL-6, IL-8, IP-10, MCP-1, MIP-1a, MIP-1b and IL-17.

Differentiation And Containment Of Derived Pancreatic Beta Cells, Caden Duffy, Alonzo Cook Ph.D.

Biomedical Engineering Western Regional Conference

Currently, the only permanent cure for Type 1 Diabetes is a pancreatic or islet transplant. With the shortage of donors, we are progressing research towards alternative therapies by differentiating induced pluripotent stem cells into derived pancreatic β-cells that can be transplanted and used as treatment for Type 1 Diabetes. We are investigating methods to increase the yield of fully derived, insulin producing pancreatic β-cells and are additionally researching the use of hydrophilized expanded polytetrafluoroethylene for use in cell containment devices. These devices could offer a future alternative for islet transplantation in human patients.

Beating Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes On Porcine Extracellular Matrix, Kaitlyn J. Mcentire, Alonzo Cook, Toph Knutson, Gevan Eldredge, Hunter Behrmann, Clayton Holding, Matthew Hodgson, Dillon Despain, Jacob Preslar, Joseph Rich, Matthew Stephens, Matthew Trone, Michael Neff, Sam Worrall, Joshua Mcclellan, Abbie Kondel, Donnie Pfeifer

Biomedical Engineering Western Regional Conference

Despite modern technology and developments in heart disease treatment and prevention, heart disease remains the number one cause of death in America. With an inability to meet an ever-increasing demand for heart transplants and the dangers of immunosuppressant drugs, any potential alternative to cardiac transplantation must be pursued. The end goal of this research is to engineer biocompatible tissues that are fully functional to repair or replace damaged portions of the heart following the loss of cardiac function. This research investigates the effect of porcine extracellular matrix as the scaffold for beating IPS-differentiated cardiomyocytes.

Nerve Growth Factor And Lysophosphatidylcholine In Peripheral Nerve Repair, Keaton Karlinsey 8741888

Biomedical Engineering Western Regional Conference

NGF, Nerve Growth Factor, Lysophosphatidylcholine, Peripheral nerve regeneration, Sciatic nerve, Sciatic crush injury

Ocular Lens Engineering: A Regenerative Approach To Correcting Visual Impairments, Dallin Busby, Joshua Hansen, Cameron Crook, Diane Donaldson, Alonzo Cook

Biomedical Engineering Western Regional Conference

No abstract provided.

Super-Hydrophobic And Anti-Microbial Surfaces Via Carbon Infiltrated-Carbon Nanotubes, Christian Dalon Esplin, Anton Bowden, Brian Jensen

Biomedical Engineering Western Regional Conference

No abstract provided.

A Nanocomposite Sensor Neck Sleeve For Tracking In Vivo Spine Kinematics In The Alpaca, Colton Porter Graham, Anton Bowden

Biomedical Engineering Western Regional Conference

Chronic low back pain in the US is often attributed to intervertebral disc degeneration. Camelids, particularly alpacas, pose a potential model for spinal treatment due to similarity of the spinal structure and vertical loading. Alpacas also exhibit a high rate of natural disc degeneration. To gain more understanding about how disc degeneration is caused in alpacas it is necessary to understand the loading and motion of the alpaca cervical spine. The goal of the present work was to incorporate nanocomposite sensors into a custom-designed neck sleeve to track the daily in-vivo neck motion of an alpaca in its natural environment.

Structural Mrsa Resistance Through Carbon-Infiltrated Carbon Nanotube Coating Of External Fixator Pins, Jaclyn Larsen, Stephanie Morco, Brian Jensen, Anton Bowden

Biomedical Engineering Western Regional Conference

No abstract provided.

Design Of A Device For Measuring Bulk Fluid Flow In Spine Segments Under Tensile Loads, Tysum Ruchti, Anton Bowden

Biomedical Engineering Western Regional Conference

No abstract provided.

Separation Of Bacteria From Blood For Rapid Sepsis Diagnosis, Mahsa Alizadeh, Daniel Scott Mc Clellan, Colin Grant Bledsoe, Rae Blanco, Madison Melville, William G. Pitt

Biomedical Engineering Western Regional Conference

No abstract provided.

Resorption Rate Of Bioresorbable Materials For Possible Use In Self-Expanding Stents, Jared R. Park, Jason Porter, Anton Bowden

Biomedical Engineering Western Regional Conference

This study investigates the mechanical behavior of various polymers after a period of degradation from exposure to a Saline Solution. The study found that PLA and PDLLA do not have significant degradation over a period of 2 months, while PLA has a sharp decrease in strength after 7 days.

Cancer Therapeutic Onconase And Lyophilized Cell-Free Protein Expression Systems, Porter Hunt, Bradley C. Bundy, Amin Salehi, Mark Thomas Smith, Jacob Williams, William G. Pitt, Anthony Bennett

Biomedical Engineering Western Regional Conference

Recently reported high-yield synthesis of cytotoxic protein Onconase from lyophilized E. coli extract preparations demonstrates the utility of lyophilized cell-free protein expression and its potential for creating on-demand biotherapeutics, vaccines, biosensors, biocatalysts, and high throughput protein synthesis.

Analysis Of Magnetic Resonance Imaging Of Peripheral Nerve Regeneration, Jaron J. Lundwall, Alonzo Cook

Biomedical Engineering Western Regional Conference

Due to accident related neural damage, many people’s lives are impaired or limited in what they can do. Current medical practices are limited at helping distal and proximal nerve stubs regenerate. Many recent research studies have focused on trying to improve this problem by understanding how cut or crushed nerves heal. Our study hopes to help these efforts by improving non-invasive analysis techniques of nerve growth. Magnetic Resonance Imaging (MRI) is one possible solution to creating a reliable analysis technique that in the future could be used on humans. However, current methods of taking MRI scans involve toxic resolving fluid …

Developing A Renal Cell Carcinoma Kidney-Tumor-On-A-Chip To Mimic Tumor-Induced Angiogenesis, Connor Tsuchida, Chris Miller, Ying Zheng

Biomedical Engineering Western Regional Conference

Currently, models for testing developing cancer therapeutics are inaccurate. To address this issue, the Zheng Lab is developing a kidney-tumor-on-a-chip to mimic tumor-induced angiogenesis. Initial steps were taken toward this ultimate goal by creating an in vitro study between human kidney microvascular endothelial cells and renal cell carcinoma spheroids. The experiments showed an increase in endothelial sprouts in the presence of renal cell carcinoma spheroids vs. normal kidney cortex spheroids.

Effect Of Multiple Confined Compression/Stress Relaxation Cycles On Cross-Linked Alginate Pore Size., Sindhu Kolar Venkat, Erik L. Risa, Bergren Antell, Maryam Mobed-Miremadi

Biomedical Engineering Western Regional Conference

No abstract provided.