Biomedical Engineering and Bioengineering Commons^™

Novel Nanomaterials For Developing Bone Scaffolds And Tissue Regeneration, Nazim Uddin Emon, Lu Zhang, Shelby Dawn Osborne, Mark Allen Lanoue, Yan Huang, Z. Ryan Tian

Cell and Molecular Biology Faculty Publications and Presentations

Nanotechnologies bring a rapid paradigm shift in hard and soft bone tissue regeneration (BTR) through unprecedented control over the nanoscale structures and chemistry of biocompatible materials to regenerate the intricate architecture and functional adaptability of bone. This review focuses on the transformative analyses and prospects of current and next-generation nanomaterials in designing bioactive bone scaffolds, emphasizing hierarchical architecture, mechanical resilience, and regenerative precision. Mainly, this review elucidated the innovative findings, new capabilities, unmet challenges, and possible future opportunities associated with biocompatible inorganic ceramics (e.g., phosphates, metallic oxides) and the United States Food and Drug Administration (USFDA) approved synthetic polymers, including …

Utilizing Wearable Technology To Improve Pots Diagnostic Testing, Monique Watson, Damen Wilson, Matthew Ward

Discovery Undergraduate Interdisciplinary Research Internship

Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia characterized by a heart rate (HR) increase ≥30 beats/minute (bpm) within 10 minutes of standing from a supine position, without a significant blood pressure drop. POTS can diminish quality of life with symptoms including tachycardia, headaches, and fatigue. Despite established diagnostic criteria, POTS is often underrecognized or misdiagnosed due to its episodic nature. Symptoms may not consistently be present during diagnostic testing, leading to false negatives during in-office testing. Wearables offer a promising solution through continuous physiological monitoring. Individuals with hypermobile Ehler-Danlos Syndrome (hEDS), a population in which POTS is …

Volumetric Imaging Of Cellular Dynamics Using Light-Sheet Microscopy: From Subcellular Structures To Whole Organisms, Md Nasful Huda Prince

Optical Science and Engineering ETDs

Advancing biomedical imaging requires platforms that combine high-resolution, speed, and stability across biological scales. This dissertation presents three innovations designed to address limitations of conventional light-sheet and oblique plane imaging. First, we introduce Reflected Inline Detection in Epi-Oblique Plane Microscopy (RIDE-OPM), a compact and drift-resistant system that eliminates a tertiary detection path while maintaining alignment flexibility, enabling robust long-term live imaging. Second, we present a high-speed Axially Swept Light-Sheet Microscopy (ASLM) platform for cleared tissues, using dual foci and synchronized sweeping to achieve isotropic sub-micron resolution at up to 40 frames-per-second, a fourfold improvement over standard ASLM. Integrated with a …

Measurements Of Spinal Posture During Common Strawberry Picking Positions Using Inertial Measurement Units, Madeline E. Everson

Master's Theses

Physically demanding professions, such as agriculture, put people at an increased

risk for experiencing back pain. This is due to the awkward and harmful postures sustained

throughout their workday. While studies have been done demonstrating that back pain is

prevalent amongst this community, most do not collect motion capture (MoCap) data,

leaving the specifics of the kinematics, such as the amount of time spent in harmful

postures, unknown. Unfortunately, MoCap data is typically limited to that of a lab or

facility where the cameras are housed. Therefore, this study aimed to mitigate the

inaccessibility of traditional MoCap by validating that …

Polyphenols For The Mitigation Of Vascular Calcification; In Vitro And In Vivo Studies, Abdullah Altuhami

All Theses

Globally, cardiovascular diseases, in most cases associated with calcification, are the main cause of death. However, currently, the only effective cure is to undergo surgery to augment or receive a healthy donor heart, which could be very difficult due to the long waiting list and the associated risks. The possibility of body rejection of the foreign organs is attributed to immunoreaction or the risk of infection, since the donor must be on immunosuppressant drugs that lower the body's immunity and facilitate the body's acceptance of the new organ as one of its own. Taking that into consideration, using tissue-engineered vascular …

Challenges And Artificial Intelligence Solutions For Clinically Optimal Hepatic Venous Vessel Segmentation, Håvard Bjørke Jenssen, Varatharajan Nainamalai, Egidijus Pelanis, Rahul P. Kumar, Andreas Abildgaard, Finn Kristian Kolrud, Bjørn Edwin, Jingfeng Jiang, Joseph Vettukattil, Ole Jakob Elle, Smund Avdem Fretland

Michigan Tech Publications

Background:: Liver vessel identification is crucial for clinical disease assessment and treatment planning, especially concerning local treatment of liver tumors. As artificial intelligence (AI) develops in radiology, opportunities arise to craft models adept at hepatic venous vessel segmentation, opening possibilities for creating patient-specific models of the liver anatomy quickly, despite the diverse features of CT images encountered in clinical settings. Objective: This research evaluates the performance of AI models combined with various pre-processing filters for liver vessel segmentation, emphasizing clinically relevant results. A novel evaluation method was introduced to offer more anatomically accurate assessments, moving beyond traditional metrics like the …

Crevice Corrosion Mechanisms Of Cocrmo Alloys In Orthopedic Implants: Retrieval Analysis, Nano-Tribocorrosion And Cellular Responses, Hwaran Lee

All Dissertations

Mechanically assisted corrosion and non-mechanically (chemically) driven corrosion in modular junctions of orthopedic implants using cobalt-chromium-molybdenum (CoCrMo) alloys remain clinical concerns and may contribute to implant failure. The underlying corrosion mechanisms are not yet fully understood, leaving a critical research gap. We hypothesized that corrosion in modular junctions may be driven by aggressive local environments, including fretting, metal ion release (cobalt ion, Co²⁺), low pH and reactive oxygen species (ROS). This dissertation aims to (1) analyze corrosion modes and potential causes in modular junctions; (2) identify chemically driven corrosion modes on CoCrMo alloys using simulated inflammatory modular taper …

Mechanoregulation Of Osteogenesis And Adipogenesis Of Human Mesenchymal Stem Cells, Justin Caron

Master's Theses

Bone-related diseases (e.g., osteoporosis) are primarily treated with pharmacologic therapies that often exhibit limited efficacy and substantial side effects. Currently, bone marrow derived mesenchymal stem cells (MSCs) have become one of most important cell options in bone regeneration due to readily available sources, strong proliferation abilities, weak immune rejection responses, and strong osteogenic differentiation potential. While identifying the most effective approach to enhance osteogenic differentiation of MSCs for bone regeneration is challenging, understanding the regulatory mechanisms is crucial for improving therapeutic efficacy. Recent research has focused on developing strategies to enhance osteogenesis, which involve biophysical and biochemical stimulation. Mechanical and …

Mathematical Modeling Of Effects Of Tumor Location On Lung Function., Lamargaret Temukisa Johnson

Master of Engineering Theses

Lung cancer has the highest rates of incidence and mortality of all cancers. Most lung cancer tumors are Non-Small Cell Lung Cancer (NSCLC). NSCLC patients with lesions in the upper lobes are found to have better prognosis compared to those with lesions in the middle and lower lobes. Previous studies have suggested various causes for this discrepancy at both the organ-scale and tissue-scale. To model NSCLC growth in different locations within the lung, an organ scale lung model and tissue scale tumor model were coupled through the tissue pressure, and oxygen and carbon dioxide partial pressures. The coupling was used …

Development Of A Wearable Biosensor For Cortisol Detection In Human Sweat Utilizing Pani/Peo Polymer Blend And Nitrogen-Doped Graphene Quantum Dots, Cesar Sanchez

Theses and Dissertations

Since the development of the first biosensor in 1962, the evolution of commercially available wearable biosensors has been driven by an increasing consumer interest in real-time health tracking. However, challenges related to sensor sensitivity and cost have hindered progress. Deploying a novel approach, the biosensor integrates a blend of Polyaniline (PANi) and Polyethylene Oxide (PEO) along with Nitrogen-doped Graphene Quantum Dots (N-GQDs) to enhance sensitivity and electroactivity, crucial for cortisol detection. To optimize performance, three distinct synthesis methods for N-GQDs; hydrothermal, microwave, and hot plate synthesis were compared employing a bottom-up approach utilizing citric acid (CA) as the primary reactant …

Computational And Experimental Analysis Of Knee Kinematics And Gait Variability: The Effects Of Load, Speed, And Fatigue On Human Motion, Alfirio Trejo Jr.

Theses and Dissertations

This thesis investigates the biomechanical behavior of the human knee under varying conditions of motion, load, and fatigue, with a focus on clinical angle analysis and gait stability. Four studies were conducted using motion capture data and a modified Grood and Suntay Joint Coordinate System (JCS) to evaluate knee joint kinematics—specifically flexion-extension, abduction-adduction, and internal-external rotation. The first study examined the effects of incremental weight loads during isolated knee extension exercises, revealing dose-dependent increases in abduction and internal rotation that may contribute to joint stress. The second study assessed the impact of walking speed and asymmetric loading on gait, showing …

Interdigitated Gear-Shaped Screen-Printed Electrode Using G-Pani Ink For Sensitive Electrochemical Detection Of Stress Related Hormones Dopamine And Cortisol, Pritu Parna Sarkar

Theses and Dissertations

This research introduces a novel interdigitated gear-shaped graphene-based electrochemical biosensor for the simultaneous detection of dopamine (DA) and cortisol. Modified with graphene–polyaniline (G–PANI) conductive ink, the sensor increased active surface area—94.52% and 57% higher than Metrohm DropSens 110 and circular printed sensors, respectively. Scanning Electron Microscopy (SEM), Fourier Transform Infrared (FTIR) Spectroscopy and X-ray diffraction (XRD) were employed for physicochemical characterization. The sensor detects dopamine and cortisol over a linear range of 0.1–100 µM, with limits of detection of 0.043 µM (R² = 0.98) and 0.0577 µg/mL (R² = 0.976), respectively, in phosphate-buffered saline (PBS) using redox probe. Electrochemical performance …

Impact Of Cysteine And Tyrosine Dipeptides On Cho Cell Performance In A Perfusion Mimic, Corrin L. Pruitt

All Theses

Perfusion cell cultures typically achieve higher cell densities and generate higher volumetric productivities than fed-batch cultures due to continuous nutrient supply and spent media removal. Despite these advantages, perfusion cell cultures remain underutilized for licensed product manufacturing, primarily due to the lack of small-scale perfusion models for high-throughput process development and the complexities involved in media formulation capable of supporting high cell densities during long-term continuous operation. To avoid nutrient limitation at high cell densities, current perfusion processes rely on using higher perfusion rates, which results in significant media wastage and downstream product dilution. Therefore, there has been an effort …

Effect Of Cigarette Smoke Extract And Nutrient Deficiency On Energy Metabolism And Biosynthesis: An In Vitro Intervertebral Disc Explant Culture Study, Avery E. Madden

All Theses

Low back pain consistently ranks among the leading causes of disability worldwide, with degenerative changes in spinal intervertebral discs (IVDs) recognized as a key contributor. Degeneration arises from the disruption of mechanical and biological cues within the disc’s cartilaginous tissue, often exacerbated by aging or injury. In recent decades, cigarette smoking has also been identified as a significant risk factor, as IVD degeneration is more prevalent among individuals with a history of smoking. Smoke inhalation is thought to promote degeneration both directly, by exposing cells to water-soluble toxic chemicals in smoke; and indirectly, through nutrient deficiency resulting from vasoconstriction and …

A Deep Learning Approach For Semantic Segmentation And Its Application On Ctc., Samir Farag Harb

Electronic Theses and Dissertations

This dissertation explores the modeling and analysis of medical images, focusing on the intricate task of colon segmentation and subsequent 3D reconstruction, which are critical steps in Computed Tomography Colonography (CTC) systems. The primary objective of this research is to develop precise segmentation approaches to enhance the accuracy of colon identification and reconstruction from abdominal CT scans. Three distinct segmentation approaches are proposed and evaluated: a Markov Random Field (MRF)-based approach, a convolutional neural network (CNN)-based deep learning (DL) approach, and a sequential episodic training with dual contrastive learning Approach (G-SET-DCL) that has a flavor of few-shot learning (FSL). To …

Aging Effect On Effective Connectivity Within The Prefrontal-Motor Network And Postural-Related Muscle Responses During Dual-Task Paradigms, Jiahao Pan

Boise State University Theses and Dissertations

Falls are a significant global public issue for older adults, leading to severe health and social impacts. To understand the underlying mechanism of increased fall risk with aging, loss of postural automaticity has been suggested as increased prefrontal cortex and motor cortices activation, as well as worse balance performance in response to the secondary cognitive task. However, the interaction within these cortical regions and its effects on postural-related muscle responses are poorly understood. This dissertation investigated age-related changes in effective connectivity within the prefrontal-motor network, postural related lower limb muscle response, and biomechanical characteristics in response to the secondary cognitive …

Synthesis And Characterization Of Magnetic Nanoparticles To Study Effective Magnetic Anisotropy For Biomedical And Catalytic Applications, Alexander Malaj

All Dissertations

This dissertation focuses on understanding how to tune the magnetic properties of nanoparticles through controlling the effective magnetic anisotropy (Keff), which is a key variable in determining a nanoparticle’s Néel relaxation time, which will dictate its magnetic behavior in various applications. In this work, magnetocrystalline anisotropy is tuned by synthesizing tri-metallic substituted ferrite (Fe3-x-yMnxCoyO4) nanoparticles with specific metallic compositions that were informed by computer simulations using density functional theory (DFT) to target magnetocrystalline anisotropy values. A drip synthesis was used to control the size and composition of the tri-metallic ferrites, which were revealed to be monodisperse and compositionally mixed by …

Optimization And Utilization Of Microbial Electrolysis Cells In Waste To Product Applications, Hayden Harrison

All Graduate Theses and Dissertations, Fall 2023 to Present

As the world searches for cleaner and more sustainable energy solutions, turning waste into fuel is an increasingly attractive strategy. This research focuses on microbial electrolysis cells, a new technology that uses bacteria and a small amount of electricity to convert organic waste—like food scraps or wastewater—into useful gases such as hydrogen and methane. These gases can be used as energy sources to reduce dependency on more traditional fuels.

This thesis tackles two key challenges that limit the real-world use of microbial electrolysis systems. First, it introduces a simpler and more effective method to stop hydrogen losses in single-chamber cells. …

Population Analysis Of Cyanobacteria In Rotating Algal Biofilm Reactors, Eric H. Matthews

All Graduate Theses and Dissertations, Fall 2023 to Present

Algal biofilms have numerous applications in wastewater treatment and bioproduct production. The Sustainable Waste-to-Bioproducts Engineering Center at Utah State University is working to develop rotating algal biofilm reactors (RABRs) to remove excess nitrogen and phosphorus from wastewater effluent while producing biomass for downstream production.

Genetic analysis of algal biofilms on various RABRs was performed to gain improved understanding of the biofilm populations. This analysis focuses on a pilot-scale RABR and how it compares to several other RABRs. Additionally, old methods of genetic analysis filtered out important cyanobacterial populations. A new method was developed to identify the cyanobacteria within the biofilms. …

Predictors Of Permanent And Temporary Motor Deficits In Patients Undergoing Glioma Resection: A Systematic Review And Meta-Analysis, Brian J. Conway, Stephanie A. Armstrong, Nada Botros, Sergey Tarima, Max O. Krucoff

Biomedical Engineering Faculty Research and Publications

Objective

To identify predictors of permanent and temporary motor deficits in patients undergoing glioma resection.

Methods

A literature search accessed the databases Ovid Medline, Scopus, Web of Science, Cumulative Index to Nursing and Allied Health Literature/EBSCO, PsychInfo, Cochrane, and Wiley for studies reporting motor outcomes following surgical resection of glioma. Outcomes were stratified by patient/tumor characteristics, preoperative condition, and intraoperative factors for both permanent and temporary motor deficits. Generalized estimating equations were used to generate odds ratios.

Results

A total of 1332 titles and abstracts were reviewed resulting in the evaluation of 261 full-text articles. Data were extracted from 67 …