A Simple Mathematical Model For The Nonlinear Compliance Of Arteries,
2018
Purdue University
A Simple Mathematical Model For The Nonlinear Compliance Of Arteries, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Working Papers
No abstract provided.
Identification Of Unique Features And Exploration Of Leap Motion Controller For Detecting Hand Hygiene Stages,
2018
Technological University Dublin
Identification Of Unique Features And Exploration Of Leap Motion Controller For Detecting Hand Hygiene Stages, Rashmi Bakshi, Jane Courtney, Damon Berry, Graham Gavin
Conference Papers
Hospital acquired infections (HAIs) are contracted by the patients during the hospital stay. Antibiotic resistant microbes are the major cause and spread due to the contaminated medical equipment, crowded hospitals, frequent transfer of patients from one unit to another and poor hand hygiene. [1] In high income countries, approximately 30% of patients in intensive care units are affected by at least one HAI. [2] Hand hygiene is identified as a measure to prevent cross-transmission and to reduce the rate of HAI. [3] Technology is now used as a means of assessing hand hygiene compliance. Current approaches involve the use of …
Optimal Wavelength Selection For Optical Spectroscopy Of Hemoglobin And Water Within A Simulated Light-Scattering Tissue,
2018
Dartmouth College
Optimal Wavelength Selection For Optical Spectroscopy Of Hemoglobin And Water Within A Simulated Light-Scattering Tissue, Mikael Marois, Stephen L. Jacques, Keith D. Paulsen
Dartmouth Scholarship
An algorithm that selects optimal wavelengths for spectral fitting of diffuse light reflectance spectra using a nonnegative least squares method is presented. Oxyhemoglobin, deoxyhemoglobin, and water are considered representative absorbers, but the approach is not constrained or limited by absorber selection provided native basis spectra are available. The method removes wavelengths iteratively from a scattering-modulated absorption matrix by maximizing the product of its singular values and offers considerable improvements over previously published wavelength selection schemes. Resulting wavelength selections are valid for a broad range of optical properties and yield lower RMS errors than other wavelength combinations. The method is easily …
Optimizing Within-Subject Experimental Designs For Jica Of Multi-Channel Erp And Fmri,
2018
Marquette University
Optimizing Within-Subject Experimental Designs For Jica Of Multi-Channel Erp And Fmri, Jain Mangalathu-Arumana, Einat Liebenthal, Scott A. Beardsley
Biomedical Engineering Faculty Research and Publications
No abstract provided.
Assessing The Validity Of Pressure-Measuring Insoles In Quantifying Gait Variables,
2018
University of Nevada, Las Vegas
Assessing The Validity Of Pressure-Measuring Insoles In Quantifying Gait Variables, Jessica Deberardinis, Janet S. Dufek, Mohamed B. Trabia, Daniel E. Lidstone
Integrated Health Sciences Faculty Research
Introduction Pressure-measuring insoles can provide a portable alternative to existing gait analysis tools. However, there is disagreement among researchers on their accuracy and the appropriate calibration methods. The purposes of this study were to (1) determine the validity of pressure-measuring insoles for calculating stance time and support-phase impulse during walking using two calibration procedures, and (2) examine the effect of insole size on the results. Methods Data were collected from 39 participants (23.5 ± 3.24 yrs, 66.7 ± 17.5 kg, 1.64 ± 0.09 m), each wearing appropriately sized insoles as they walked over two consecutive force platforms. Two calibration methods …
Collective Adhesion And Displacement Of Retinal Progenitor Cells Upon Extracellular Matrix Substrates Of Transplantable Biomaterials,
2018
CUNY City College
Collective Adhesion And Displacement Of Retinal Progenitor Cells Upon Extracellular Matrix Substrates Of Transplantable Biomaterials, Ankush Thakur, Shawn Mishra, Juan Pena, Jing Zhou, Stephen Redenti, Robert Majeska, Maribel Vazquez
Publications and Research
Strategies to replace retinal photoreceptors lost to damage or disease rely upon the migration of replacement cells transplanted into sub-retinal spaces. A significant obstacle to the advancement of cell transplantation for retinal repair is the limited migration of transplanted cells into host retina. In this work, we examine the adhesion and displacement responses of retinal progenitor cells on extracellular matrix substrates found in retina as well as widely used in the design and preparation of transplantable scaffolds. The data illustrate that retinal progenitor cells exhibit unique adhesive and displacement dynamics in response to poly-l-lysine, fibronectin, laminin, hyaluronic acid, and Matrigel. …
Noncontact Three-Dimensional Diffuse Optical Imaging Of Deep Tissue Blood Flow Distribution,
2018
University of Kentucky
Noncontact Three-Dimensional Diffuse Optical Imaging Of Deep Tissue Blood Flow Distribution, Guoqiang Yu, Yu Lin, Chong Huang
Biomedical Engineering Faculty Patents
The present invention provides for three-dimensional reflectance diffuse optical imaging of deep tissue blood flow distribution that removes the need for probe-tissue contact, thereby allowing for such technology to be applied to sensitive, vulnerable, damaged, or reconstructive tissue. The systems utilize noncontact application and detection of near-infrared light through optical lens and detection through a linear array or two-dimensional array of avalanche photodiodes or a two-dimensional array of detectors provided by charge-coupled-device (CCD). Both further feature a finite-element-method (FEM) based facilitation to provide for three-dimensional flow image reconstruction in deep tissues with arbitrary geometries.
Production Of Genetically Engineered Golden Syrian Hamsters By Pronuclear Injection Of The Crispr/Cas9 Complex,
2018
Utah State University
Production Of Genetically Engineered Golden Syrian Hamsters By Pronuclear Injection Of The Crispr/Cas9 Complex, Rong Li, Jinxin Miao, Seokhwan Song, Il-Keun Kong, Yaohe Wang, Zhongde Wang
Animal, Dairy, and Veterinary Science Faculty Publications
The pronuclear (PN) injection technique was first established in mice to introduce foreign genetic materials into the pronuclei of one-cell stage embryos. The introduced genetic material may integrate into the embryonic genome and generate transgenic animals with foreign genetic information following transfer of the injected embryos to foster mothers. Following the success in mice, PN injection has been applied successfully in many other animal species. Recently, PN injection has been successfully employed to introduce reagents with gene-modifying activities, such as the CRISPR/Cas9 system, to achieve site-specific genetic modifications in several laboratory and farm animal species. In addition to mastering the …
Specific Nanoporous Geometries On Anodized Alumina Surfaces Influence Astrocyte Adhesion And Glial Fibrillary Acidic Protein Immunoreactivity Levels,
2018
Missouri University of Science and Technology
Specific Nanoporous Geometries On Anodized Alumina Surfaces Influence Astrocyte Adhesion And Glial Fibrillary Acidic Protein Immunoreactivity Levels, D. Ganguly, C. D.L. Johnson, M. K. Gottipati, D. Rende, D. A. Borca-Tasciuc, R. J. Gilbert
Chemical and Biochemical Engineering Faculty Research & Creative Works
Electrodes implanted in the brain or spinal cord trigger the activation of resident astrocytes. In their reactive state, astrocytes surrounding the electrode form a glial scar, compromising the ability of the electrode to interface with the surrounding neural tissue. One approach to reduce the inhibiting scar tissue is to incorporate nanoarchitecture on the surface of the implanted materials to modify the astrocytic response. The incorporated nanoarchitecture changes both the surface characteristics and the material properties of the implant interface. We investigated the response of rat cortical astrocytes to nanoporous anodic aluminum oxide (AAO) surfaces. Astrocytes were seeded onto nonporous aluminum …
Comparison Of Eosin And Fluorescein Conjugates For The Photoinitiation Of Cell-Compatible Polymer Coatings,
2018
Battelle
Comparison Of Eosin And Fluorescein Conjugates For The Photoinitiation Of Cell-Compatible Polymer Coatings, Jacob L. Lilly, Anuhya Gottipati, Calvin F. Cahall, Mohamed Agoub, Brad J. Berron
Chemical and Materials Engineering Faculty Publications
Targeted photopolymerization is the basis for multiple diagnostic and cell encapsulation technologies. While eosin is used in conjunction with tertiary amines as a water-soluble photoinitiation system, eosin is not widely sold as a conjugate with antibodies and other targeting biomolecules. Here we evaluate the utility of fluorescein-labeled bioconjugates to photopolymerize targeted coatings on live cells. We show that although fluorescein conjugates absorb approximately 50% less light energy than eosin in matched photopolymerization experiments using a 530 nm LED lamp, appreciable polymer thicknesses can still be formed in cell compatible environments with fluorescein photosensitization. At low photoinitiator density, eosin allows more …
Biomedical Optics Scientific Community,
2018
Dartmouth College
Biomedical Optics Scientific Community, Brian W. Pogue
Dartmouth Scholarship
The new Editor-in-Chief, Brian Pogue, gives an overview of the biomedical optics community.
Low Cost Waist Line Circumference Health Management Belt,
2018
Wayne State University
Low Cost Waist Line Circumference Health Management Belt, Raghav Talreja
Research Opportunities for Engineering Undergraduates (ROEU) Program 2017-18
One third of the American population is obese or near obese, and $150 billion is spent in weight management. Current devices to monitor weight are expensive, and niche products are designed for health enthusiasts. This project investigates user needs, development and commercialization steps for a low cost health management belt.
Preparation For The Study Of Gene Expression Aboard The International Space Station,
2018
STAR Program
Preparation For The Study Of Gene Expression Aboard The International Space Station, Amber Paturzo
STAR Program Research Presentations
WetLab-2 performs quantitative polymerase chain reaction (qPCR) aboard the micro-gravity environment of the International Space Station in order to research how the stress of micro-gravity affects an organism’s RNA production and gene expression. This on-station qPCR allows researchers to gather information earlier and thereby allow them to modify experiments in a matter of hours rather than wait until the next flight opportunity. After a successful validation flight on SpaceX-8 and follow-up investigation on SpaceX-9, system components must now be adjusted for a new type of biological sample. Specifically, the WetLab-2 facility includes a commercial qPCR instrument (RNA SmartCycler), a sample …
Machine Learning Provides Predictive Analysis Into Silver Nanoparticle Protein Corona Formation From Physicochemical Properties,
2018
Santa Clara University
Machine Learning Provides Predictive Analysis Into Silver Nanoparticle Protein Corona Formation From Physicochemical Properties, Matthew R. Findlay, Daniel N. Freitas, Maryam Mobed-Miremadi, Korin E. Wheeler
Bioengineering
Proteins encountered in biological and environmental systems bind to engineered nanomaterials (ENMs) to form a protein corona (PC) that alters the surface chemistry, reactivity, and fate of the ENMs. Complexities such as the diversity of the PC and variation with ENM properties and reaction conditions make the PC population difficult to predict. Here, we support the development of predictive models for PC populations by relating biophysicochemical characteristics of proteins, ENMs, and solution conditions to PC formation using random forest classification. The resulting model offers a predictive analysis into the population of PC proteins in Ag ENM systems of various ENM …
Modeling Liver Diseases Using Hepatic Cell Microarrays,
2018
Cleveland State University
Modeling Liver Diseases Using Hepatic Cell Microarrays, Alexander David Roth
ETD Archive
Hepatocellular carcinoma (HCC) is an invasive and aggressive cancer of the liver that arises due to chronic cirrhosis. Research into understanding HCC has focused on two-dimensional (2D) and three-dimensional (3D) technologies to simulate the liver microenvironment and use animal models to model how HCC affects the rest of the body. 3D hydrogel models are desired because they can mimic the transport behavior observed in vivo by structurally mimicking the extracellular matrix (ECM) without the ethical concerns of animal models. However, hydrogels can be toxic to cells and require optimal procedures for appropriate handling. In this study, we created 3D models …
Advanced Manufacturing Of Titanium Alloys For Biomedical Applications,
2018
Cleveland State University
Advanced Manufacturing Of Titanium Alloys For Biomedical Applications, Nicholas C. Mavros
ETD Archive
In metallurgy, Titanium has been a staple for biomedical purposes. Its low toxicity and alloying versatility make it an attractive choice for medical applications. However, studies have shown the difference in elastic modulus between Titanium alloys (116 GPa) and human bone (40-60 GPa) contribute to long term issues with loose hardware fixation. Additionally, long term studies have shown elements such as Vanadium and Aluminum, which are commonly used in Ti-6Al-4V biomedical alloys, have been linked to neurodegenerative diseases like Alzheimers and Parkinsons. Alternative metals known to be less toxic are being explored as replacements for alloying elements in Titanium alloys. …
Implementation Of A Reverse Staggered-Herringbone Microfluidic Mixer For High-Throughput Polymeric Nanoparticles Synthesis,
2018
Cleveland State University
Implementation Of A Reverse Staggered-Herringbone Microfluidic Mixer For High-Throughput Polymeric Nanoparticles Synthesis, Alexa Roberts
Undergraduate Research Posters 2018
The goal of this research is to implement and optimize the operating conditions of a microfluidic mixer to synthesize polymeric nanoparticles (NPs) in a high-throughput fashion. Using a reverse staggered-herringbone microfluidic mixer that we recently designed, the effects of experimental conditions such as flowrate and reactant composition on NP characteristics were investigated and optimized. The device design allowed for physical contact between two streams of fluids – one containing poly(lactic-co-glycolic acid; PLGA) in acetonitrile and the other deionized water, to allow for efficient mixing and NP precipitation to occur. The resulting NPs were characterized using dynamic light scattering (DLS) and …
Prediction Of Metabolism-Induced Neurotoxicity On A 384pillarplate,
2018
Cleveland State University
Prediction Of Metabolism-Induced Neurotoxicity On A 384pillarplate, Rushabh Patel, Pranav Joshi, Soo-Yeon Kang, Stephen Hong, Parnian Bigdelou
Undergraduate Research Posters 2018
Metabolism of compounds including neurotoxins primarily occurs in the liver by a variety of drug-metabolizing enzymes (DMEs) followed by a series of downstream responses. Unmodified (or parent) neurotoxins are transported into human hepatocytes through several influx transporters or via passive diffusion and undergo Phase I and Phase II biotransformation by DMEs before they are cleared. Neurotoxins and their metabolites generated from human hepatocytes could potentially lead to the toxic effects on neural stem cells (NSCs) as the reactive metabolites have potential for producing reactive oxygen species (ROS), which can lead to irreversible oxidative damage to NSCs via lipid peroxidation, DNA, …
Dendrite Morphology Of Pb-5.8 Sb Alloy: Gradient Freeze Ds With Cross-Section Area Change,
2018
Cleveland State University
Dendrite Morphology Of Pb-5.8 Sb Alloy: Gradient Freeze Ds With Cross-Section Area Change, Michael Shannon
Undergraduate Research Posters 2018
Directional solidification (DS) is the process of solidifying a metal alloy from one end to another resulting in aligned primary dendrites which are branched tree like features. Alignment of primary dendrites along [100] direction and their uniformity and distribution along the DS length determines the mechanical properties. These properties are especially important for single crystal turbine blade applications in modern gas turbine engines. Convection during solidification plays an important role in formation of detrimental defects, such as, misaligned grains, non-uniformity of dendrites and composition inhomogeneity. In this study the microstructural evolution during “Gradient Freeze DS process”, involving an abrupt cross-section …
Optimization Of Wavelength Selection For Multispectral Image Acquisition: A Case Study Of Atrial Ablation Lesions,
2018
George Washington University
Optimization Of Wavelength Selection For Multispectral Image Acquisition: A Case Study Of Atrial Ablation Lesions, Huda Asfour, S. Guan, Narine Muselimyan, Luther M. Swift, Murray Loew, Narine Sarvazyan
Pharmacology and Physiology Faculty Publications
In vivo autofluorescence hyperspectral imaging of moving objects can be challenging due to motion artifacts and to the limited amount of acquired photons. To address both limitations, we selectively reduced the number of spectral bands while maintaining accurate target identification. Several downsampling approaches were applied to data obtained from the atrial tissue of adult pigs with sites of radiofrequency ablation lesions. Standard image qualifiers such as the mean square error, the peak signal-to-noise ratio, the structural similarity index map, and an accuracy index of lesion component images were used to quantify the effects of spectral binning, an increased spectral distance …
