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Prescription Analgesia And Adjuvant Use By Pain Severity At Admission Among Nursing Home Residents With Non-Malignant Pain, Kate L. Lapane, Anne L. Hume, Reynolds A. Morrison, William M. Jesdale 2020 University of Massachusetts Medical School

Prescription Analgesia And Adjuvant Use By Pain Severity At Admission Among Nursing Home Residents With Non-Malignant Pain, Kate L. Lapane, Anne L. Hume, Reynolds A. Morrison, William M. Jesdale

Population and Quantitative Health Sciences Publications

OBJECTIVE: We estimated the use of prescribed analgesics and adjuvants among nursing home residents without cancer who reported pain at their admission assessment, in relation to resident-reported pain severity.

METHODS: Medicare Part D claims were used to define 3 classes of analgesics and 7 classes of potential adjuvants on the 21st day after nursing home admission (or the day of discharge for residents discharged before that date) among 180,780 residents with complete information admitted between January 1, 2011 and December 9, 2016, with no cancer diagnosis.

RESULTS: Of these residents, 27.9% reported mild pain, 46.6% moderate pain ...


Lhrh-Conjugated Drugs As Targeted Therapeutic Agents For The Specific Targeting And Localized Treatment Of Triple Negative Breast Cancer, J. D. Obayemi, A. A. Salifu, S. C. Eluu, V. O. Uzonwanne, S. M. Jusu, C. C. Nwazojie, C. E. Onyekanne, Ogooluwa Ojelabi, L. Payne, Constance M. Moore, Jean A. King, W. O. Soboyejo 2020 Worcester Polytechnic Institute

Lhrh-Conjugated Drugs As Targeted Therapeutic Agents For The Specific Targeting And Localized Treatment Of Triple Negative Breast Cancer, J. D. Obayemi, A. A. Salifu, S. C. Eluu, V. O. Uzonwanne, S. M. Jusu, C. C. Nwazojie, C. E. Onyekanne, Ogooluwa Ojelabi, L. Payne, Constance M. Moore, Jean A. King, W. O. Soboyejo

Open Access Articles

Bulk chemotherapy and drug release strategies for cancer treatment have been associated with lack of specificity and high drug concentrations that often result in toxic side effects. This work presents the results of an experimental study of cancer drugs (prodigiosin or paclitaxel) conjugated to Luteinizing Hormone-Releasing Hormone (LHRH) for the specific targeting and treatment of triple negative breast cancer (TNBC). Injections of LHRH-conjugated drugs (LHRH-prodigiosin or LHRH-paclitaxel) into groups of 4-week-old athymic female nude mice (induced with subcutaneous triple negative xenograft breast tumors) were found to specifically target, eliminate or shrink tumors at early, mid and late stages without any ...


Effectiveness Of Aerobic Exercise For Adults With Leukemia, Jalin Davis, Summer Hood, Alex Miller, Sam Stein, Kaylee Stem 2020 University of Tennessee Health Science Center

Effectiveness Of Aerobic Exercise For Adults With Leukemia, Jalin Davis, Summer Hood, Alex Miller, Sam Stein, Kaylee Stem

Master of Occupational Therapy Student Critically Appraised Topics

We wanted to look at the most effective interventions for increasing strength and endurance in clients with Leukemia experiencing functional decline.


The Partial Immersion Aquatic Approach Using Adjustable Weight Bearing To Improve Posture And Sitting Balance Adaptation For Children With Severe Cerebral Palsy, Niv Shelef 2020 Jerusalem Board of Education

The Partial Immersion Aquatic Approach Using Adjustable Weight Bearing To Improve Posture And Sitting Balance Adaptation For Children With Severe Cerebral Palsy, Niv Shelef

International Journal of Aquatic Research and Education

The innovative ‟Partial Immersion” Aquatic Therapy Approach was developed to enhance balance and posture during sitting adaptation for children with severe cerebral palsy who exhibit deficiency in those skills on land. Stable balance during sitting posture is one of the preconditions for hands function in activities of daily living. Aquatic skills learned during aquatic therapy were then transferred to a land environment. Therapy included the use of a treatment chair that enabled adjustable weight bearing in a series of 30 mm steps. A mixed-methods design employing a multiple case study approach (n=5) including quantitative and qualitative methods investigated the ...


A Review Of Major Role Of Vitamin D3 In Human Immune System And Its Possible Use For Novel Corona Virus Treatment, Florentin Smarandache, Victor Christianto 2020 University of New Mexico

A Review Of Major Role Of Vitamin D3 In Human Immune System And Its Possible Use For Novel Corona Virus Treatment, Florentin Smarandache, Victor Christianto

Mathematics and Statistics Faculty and Staff Publications

the evidences showing major role of Vitamin D3 in human immune system and its potential use for novel corona virus treatment. Our argument is based on research finding that corona virus has viral envelope glycoproteins. In this regard, Vitamin D3 proves to offer various beneficial effects, including immunomodulatory effect, in order to break the glycoproteins envelope of the virus. One of the greatest benefit of vitamin D3 is the fact that it is easy to get 10,000 - 20,000 IU of daily intake requirement, by sunbathing for more or less twenty minutes. Such a method is likely applicable in ...


Gardner's "Friends Like Henry: Everything Your Family Needs To Know About Finding, Training And Learning From An Autism Companion Dog" (Book Review), Xin "Lucy" Bai 2020 Southwestern Baptist Theological Seminary

Gardner's "Friends Like Henry: Everything Your Family Needs To Know About Finding, Training And Learning From An Autism Companion Dog" (Book Review), Xin "Lucy" Bai

The Christian Librarian

No abstract provided.


The Development And Evaluation Of Alginate Nanofibers As A Neuroprotective Nano-Scaffold For Amyotrophic Lateral Sclerosis (Als), Julia Bielanin 2020 University of Arkansas, Fayetteville

The Development And Evaluation Of Alginate Nanofibers As A Neuroprotective Nano-Scaffold For Amyotrophic Lateral Sclerosis (Als), Julia Bielanin

Chemistry & Biochemistry Undergraduate Honors Theses

Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disorder characterized in pathology by a significant loss of upper and lower motor neurons, leading to muscle wasting and loss of voluntary movement. There are about 6,000-8,000 new cases of ALS diagnosed per year in the U.S., with a fatal outcome within 2 to 4 years (on average) after diagnosis. There are only two FDA approved drugs for treating ALS. Both are very expensive and only have modest benefits for patients. The population is in dire need of more affordable and effective medicine for the treatment of ALS ...


Oh, The Places You’Ll Go: A Journey Through Ohiohealth Home Care, Holly Williams 2020 Otterbein University

Oh, The Places You’Ll Go: A Journey Through Ohiohealth Home Care, Holly Williams

Masters Theses/Capstone Projects

This project focuses on the OhioHealth Home Care Practicum with Heather McDavid the Director of Finance and Interim Director of HME (Home Medical Equipment). OhioHealth Home Care has five business lines. These include Home Health, HME, Palliative Care, Hospice, and IV infusion.

There are multiple Home Care locations that enable access to these resources. These locations include, The David P Blom Administrative Complex (The BAC), The Preserve, The HME Warehouse, Riverside Hospital, The Westerville Medical Campus, The Marion HME Offices, The Mansfield HME Offices, and The Dublin Methodist Hospital.

The purpose of this project is to understand processes and decision ...


Effects Of Shift Length On Nursing Staff’S Productivity, Safety, And Well-Being, Victoria Sivesind 2020 Dominican University of California

Effects Of Shift Length On Nursing Staff’S Productivity, Safety, And Well-Being, Victoria Sivesind

Nursing | Senior Theses

In this thesis the relationship between normal shift length for nurses and fatigue, burnout, intention to leave job, and patient outcomes and satisfaction. A review of literature has been done and conclusions have been made about the previous research reviewed in the thesis. A proposal for further research has been included and details how the author plans to provide further clarification to the questions at hand in order to better clinical nursing practice for the future. The proposed study includes sending out a survey to members of the Sigma Theta Tau Honors Nursing Society. It will inquire about shift length ...


Pain Care In The Department Of Veterans Affairs: Understanding How A Cultural Shift In Pain Care Impacts Provider Decisions And Collaboration, Kristin M. Mattocks, Marc I. Rosen, John Sellinger, Tu Ngo, Brad Brummett, Diana M. Higgins, Thomas E. Reznik, Paul Holtzheimer, Alicia M. Semiatin, Todd Stapley, Steve Martino 2020 University of Massachusetts Medical School

Pain Care In The Department Of Veterans Affairs: Understanding How A Cultural Shift In Pain Care Impacts Provider Decisions And Collaboration, Kristin M. Mattocks, Marc I. Rosen, John Sellinger, Tu Ngo, Brad Brummett, Diana M. Higgins, Thomas E. Reznik, Paul Holtzheimer, Alicia M. Semiatin, Todd Stapley, Steve Martino

Open Access Articles

OBJECTIVE: Over the past decade, the Department of Veterans Affairs (VA) has experienced a sizeable shift in its approach to pain. The VA's 2009 Pain Management Directive introduced the Stepped Care Model, which emphasizes an interdisciplinary approach to pain management involving pain referrals and management from primary to specialty care providers. Additionally, the Opioid Safety Initiative and 2017 VA/Department of Defense (DoD) clinical guidelines on opioid prescribing set a new standard for reducing opioid use in the VA. These shifts in pain care have led to new pain management strategies that rely on multidisciplinary teams and nonpharmacologic pain ...


Effect Of An Electronic Order Set On Newborn Hepatitis B Immunization Rates, Daniel Pedersen, Angelina Rodriguez, Michael King, Heather Schramm 2020 HCA Healthcare

Effect Of An Electronic Order Set On Newborn Hepatitis B Immunization Rates, Daniel Pedersen, Angelina Rodriguez, Michael King, Heather Schramm

West Florida Division Virtual Research Day

No abstract provided.


The Difficult Airway: Developing A Consistent Approach, Catherine Divingian MD, Tammy Ferro DO, Dudith Pierre-Victor PhD 2020 HCA Healthcare

The Difficult Airway: Developing A Consistent Approach, Catherine Divingian Md, Tammy Ferro Do, Dudith Pierre-Victor Phd

West Florida Division Virtual Research Day

The primary objectives were to determine the best practices in managing difficult airways (DAs) and to generate a simplified algorithm for a consistent approach. Additional objectives included organizing a DA cart, and integrating the information into the electronic medical record (EMR).


Safety And Feasibility Of Bilateral Lower Extremity Cold-Compression Therapy For Older Adults, Savannah Trussell 2020 Bellarmine University

Safety And Feasibility Of Bilateral Lower Extremity Cold-Compression Therapy For Older Adults, Savannah Trussell

Undergraduate Theses

Older adults often suffer from diseases that cause chronic pain and swelling that have been treated using a variety of modalities, including cold therapy, compression garments, and analgesics. Cold-compression has been shown to reduce pain and inflammation after exercise in young, healthy adults (Dupont et al., 2017). This therapy also may relieve pain and inflammation from older adults, especially those suffering from chronic conditions.

To determine if cold-compression is a safe modality for older adults, both older (65 +) and young (18-30) adults were recruited for a 15-minute bilateral lower extremity therapy session. Outcome measures include blood pressure, ankle brachial index ...


Individual Vs. Group Delivery Of Acupuncture Therapy For Chronic Musculoskeletal Pain In Urban Primary Care-A Randomized Trial, M. Diane McKee, Arya Nielsen, Belinda Anderson, Elizabeth Chuang, Mariel Connolly, Qi Gao, Eric N. Gil, Claudia Lechuga, Mimi Kim, Huma Naqvi, Benjamin Kligler 2020 University of Massachusetts Medical School

Individual Vs. Group Delivery Of Acupuncture Therapy For Chronic Musculoskeletal Pain In Urban Primary Care-A Randomized Trial, M. Diane Mckee, Arya Nielsen, Belinda Anderson, Elizabeth Chuang, Mariel Connolly, Qi Gao, Eric N. Gil, Claudia Lechuga, Mimi Kim, Huma Naqvi, Benjamin Kligler

Open Access Articles

BACKGROUND: Acupuncture has been shown to be effective for the treatment of chronic musculoskeletal back, neck, and osteoarthritis pain. However, access to acupuncture treatment has been limited in medically underserved and low-income populations.

OBJECTIVE: Acupuncture therapy delivered in groups could reduce cost and expand access. We compared the effectiveness of group versus individual acupuncture for pain and function among ethnically diverse, low-income primary care patients with chronic musculoskeletal pain.

DESIGN: This was a randomized comparative effectiveness non-inferiority trial in 6 Bronx primary care community health centers. Participants with chronic ( > 3 months) back, neck, or osteoarthritis pain were randomly assigned to ...


Are Dietary Fish Oil Supplements Appropriate For Dyslipidemia Management? A Review Of The Evidence, Samuel C. R. Sherratt, Michael Lero, R. Preston Mason 2020 Elucida Research LLC

Are Dietary Fish Oil Supplements Appropriate For Dyslipidemia Management? A Review Of The Evidence, Samuel C. R. Sherratt, Michael Lero, R. Preston Mason

Open Access Articles

PURPOSE OF REVIEW: The purpose of this review is to assess whether dietary fish oil supplements can be appropriate for patients with elevated triglycerides and cardiovascular risk based on a comprehensive analysis of their composition, and level of regulatory oversight.

RECENT FINDINGS: Approximately 19 million people in the United States take fish oil supplements, many for the purpose of treating or preventing heart disease. Unlike prescription products, fish oil supplements are classified as food by the Food and Drug Administration (FDA) and are not required to undergo manufacturing oversight or clinical testing. Analysis of widely used dietary fish oil supplements ...


Decreased Initiation Time Of Therapeutic Hypothermia, Amber Dublo 2020 Murray State University

Decreased Initiation Time Of Therapeutic Hypothermia, Amber Dublo

Scholars Week

No abstract provided.


Functional Blockade Of E-Selectin In Tumor-Associated Vessels Enhances Anti-Tumor Effect Of Doxorubicin In Breast Cancer, Yoshihiro Morita, Macall Leslie, Hiroyasu Kameyama, Ganesh L R Lokesh, Norihisa Ichimura, Rachel Davis, Natalie Hills, Nafis Hasan, Roy Zhang, Yuji Kondo, David G Gorenstein, David E Volk, Inna Chervoneva, Hallgeir Rui, Takemi Tanaka 2020 University of Oklahoma Health Sciences Center

Functional Blockade Of E-Selectin In Tumor-Associated Vessels Enhances Anti-Tumor Effect Of Doxorubicin In Breast Cancer, Yoshihiro Morita, Macall Leslie, Hiroyasu Kameyama, Ganesh L R Lokesh, Norihisa Ichimura, Rachel Davis, Natalie Hills, Nafis Hasan, Roy Zhang, Yuji Kondo, David G Gorenstein, David E Volk, Inna Chervoneva, Hallgeir Rui, Takemi Tanaka

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Chemotherapy is a mainstay of treatment for solid tumors. However, little is known about how therapy-induced immune cell infiltration may affect therapy response. We found substantial CD45+ immune cell density adjacent to E-selectin expressing inflamed vessels in doxorubicin (DOX)-treated residual human breast tumors. While CD45 level was significantly elevated in DOX-treated wildtype mice, it remained unchanged in DOX-treated tumors from E-selectin null mice. Similarly, intravenous administration of anti-E-selectin aptamer (ESTA) resulted in a significant reduction in CD45+ immune cell density in DOX-treated residual tumors, which coincided with a delay in tumor growth and lung metastasis in MMTV-pyMT mice. Additionally ...


Management Of Childhood Migraine By Headache Specialist Versus Non-Headache Specialists, Kelly Valentini, Radhika Gutta, Gunjanpreet Kaur, Ahmad Farooqi, Lalitha Sivaswamy 2020 Wayne State University

Management Of Childhood Migraine By Headache Specialist Versus Non-Headache Specialists, Kelly Valentini, Radhika Gutta, Gunjanpreet Kaur, Ahmad Farooqi, Lalitha Sivaswamy

Medical Student Research Symposium

This study aims to compare the management practices of a headache specialist with non-headache specialists in the treatment of pediatric migraine. The use of appropriate rescue medications and prophylactic agents, application of neuro-imaging, and short-term outcomes are compared in children treated by the two groups of physicians. A retrospective cohort study was conducted utilizing the electronic medical records of children 3-18 years of age with migraine, who were evaluated at a tertiary care children’s hospital from 2016-2018. Of the 849 patients that met the study criteria, 469 were classified as having chronic migraine or high-frequency episodic migraine and were ...


Impact Of Treatment Modality On Overall Survival In Localized Ductal Prostate Adenocarcinoma: A National Cancer Database Analysis, Chandler Bronkema, Sohrab Arora, Nikola Rakic, Akshay Sood, Deepansh Dalela, Jacob Keeley, Marcus Jamil, James O. Peabody, Craig G. Rogers, Mani Menon, Firas Abdollah 2020 Wayne State University

Impact Of Treatment Modality On Overall Survival In Localized Ductal Prostate Adenocarcinoma: A National Cancer Database Analysis, Chandler Bronkema, Sohrab Arora, Nikola Rakic, Akshay Sood, Deepansh Dalela, Jacob Keeley, Marcus Jamil, James O. Peabody, Craig G. Rogers, Mani Menon, Firas Abdollah

Medical Student Research Symposium

INTRODUCTION AND OBJECTIVE: Ductal adenocarcinoma is considered a rare histological variant of prostate adenocarcinoma (PCa). Given the rarity of this subtype, optimal treatment strategies for men with nonmetastatic ductal PCa is largely unknown. We aimed to describe the impact of surgery, radiotherapy, and systemic therapy on overall survival (OS) in men with nonmetastatic ductal PCa.

METHODS: We retrospectively selected 2209 cases of ductal PCa, diagnosed between 2004 and 2015, within the National Cancer Database (NCDB). Exclusion of metastatic patients yielded a total sample of 1993 individuals. Cox regression analysis tested the impact of treatment (surgery, radiotherapy, systemic therapy and no ...


Liver-Directed But Not Muscle-Directed Aav-Antibody Gene Transfer Limits Humoral Immune Responses In Rhesus Monkeys, Sebastian P. Fuchs, Jose M. Martinez-Navio, Eva G. Rakasz, Guangping Gao, Ronald C. Desrosiers 2020 University of Miami

Liver-Directed But Not Muscle-Directed Aav-Antibody Gene Transfer Limits Humoral Immune Responses In Rhesus Monkeys, Sebastian P. Fuchs, Jose M. Martinez-Navio, Eva G. Rakasz, Guangping Gao, Ronald C. Desrosiers

Open Access Articles

A number of publications have described the use of adeno-associated virus (AAV) for the delivery of anti-HIV and anti-simian immunodeficiency virus (SIV) monoclonal antibodies (mAbs) to rhesus monkeys. Anti-drug antibodies (ADAs) have been frequently observed, and long-term AAV-mediated delivery has been inconsistent. Here, we investigated different AAV vector strategies and delivery schemes to rhesus monkeys using the rhesus monkey mAb 4L6. We compared 4L6 immunoglobulin G1 (IgG1) delivery using the AAV1 versus the AAV8 serotype with a cytomegalovirus (CMV) promoter and the use of a muscle-specific versus a liver-specific promoter. Long-term expression levels of 4L6 IgG1 following AAV8-mediated gene transfer ...


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