20 Institutions 52 Full-Text Articles 73 Authors 12,636 Downloads
Recent Articles in Other Analytical, Diagnostic and Therapeutic Techniques and Equipment
Biomedical Photoacoustic Imaging Using Gas-Coupled Laser Acoustic Detection, Jami Johnson Boise State University
Biomedical Photoacoustic Imaging Using Gas-Coupled Laser Acoustic Detection, Jami Johnson
Student Research Initiatives
Several detection methods have been explored for photoacoustic and ultrasound imaging of biological tissues. Piezoelectric transducers are commonly used, which require contact with the sample to be imaged and have limiting bandwidth characteristics. Interferometry detection exhibits improved bandwidth characteristics and resolution, yet generally require complicated optics and the incorporation of a contacting reflective medium. In this paper, we report the use of a noncontact photoacoustic imaging system that does not require the use of a reflective layer. A simple, robust technique known as gas-coupled laser acoustic detection is used, which has previously been applied to evaluation of composite materials. This ...
Automated Home Apnea System, Collin G. Howser, Trevor Grieco University of Tennessee, Knoxville
Automated Home Apnea System, Collin G. Howser, Trevor Grieco
University of Tennessee Honors Thesis Projects
No abstract provided.
Tumour Heterogeneity And Treatment: One Step Forward Or Two Steps Back?, Branavan Manoranjan, Mohsin Ali McMaster University
Tumour Heterogeneity And Treatment: One Step Forward Or Two Steps Back?, Branavan Manoranjan, Mohsin Ali
No abstract provided.
The Effects Of Nursing Care On The Patient Experiencing A Stillborn Birth, Katherine Totten Liberty University
The Effects Of Nursing Care On The Patient Experiencing A Stillborn Birth, Katherine Totten
Senior Honors Papers
Childbirth has the potential of being one of the most joyous and fulfilling experiences a woman goes through in her entire life. Being a mom, driving the kids to soccer practice, and sitting around the Christmas tree with the family can easily be seen as an ideal life. Conversely, the negative experiences with childbirth are rarely discussed. There is an overlooked category: moms who conceive but lose the baby in the womb. Not only are these women overlooked, but also the hospital care they receive proves inconsistent with the latest research. Nurses and doctors should be aware of the latest ...
Using Optimal Control Theory To Optimize The Use Of Oxygen Therapy In Chronic Wound Healing, Donna Lynn Daulton Western Kentucky University
Using Optimal Control Theory To Optimize The Use Of Oxygen Therapy In Chronic Wound Healing, Donna Lynn Daulton
Masters Theses & Specialist Projects
Approximately 2 to 3 million people in the United States suffer from chronic wounds, which are defined as wounds that do not heal in 30 days time; an estimated $25 billion per year is spent on their treatment in the United States. In our work, we focused on treating chronic wounds with bacterial infections using hyperbaric and topical oxygen therapies.
We used a mathematical model describing the interaction between bacteria, neutrophils and oxygen. Optimal control theory was then employed to study oxygen treatment strategies with the mathematical model. Existence of a solution was shown for both therapies. Uniqueness was also ...
Flash4 Dark Reference Images, George McNamara University of Miami
Flash4 Dark Reference Images, George Mcnamara
Hamamatsu FLASH4.0 dark reference images, acquired with 10 second exposure times, no light to camera. Camera offset (set by Hamamatsu( is ~100 (the average intensity of the first image is always ~1 intensity level higher - an odd feature, but trivial in practice for a 16-bit camera).
George McNamara, Ph.D.
Single Cells Analyst at L.J.N. Cooper Lab
University of Texas M.D. Anderson Cancer Center
Just Beautiful Portrays Of The Mind? The Relevance Of Aesthetic Strategies On Knowledge Creation In Neuroscience, Valerie Kummer Claremont Colleges
Just Beautiful Portrays Of The Mind? The Relevance Of Aesthetic Strategies On Knowledge Creation In Neuroscience, Valerie Kummer
The STEAM Journal
We live in the age of big data. All types of data are being generated at an increasing rate but theories about the strategies and methods to visualize them is lagging. One of the main challenges we face today in research is to keep up with the massive amounts of data we produce (Allen, Elena A. et.al, 2012). Especially in the field of neuroscience and its use of imaging technologies, the vast array of data has risen to such a high number that it is impossible to grasp the inherent information without additional software tools and intelligent interfaces. Only ...
Video Codec Performance (Excel Spreadsheet), George McNamara University of Miami
Video Codec Performance (Excel Spreadsheet), George Mcnamara
Video codec performance (Excel spreadsheet). Movie was made in 2005-2006 when I worked at City of Hope National Medical Center. VTLF refers to Video Timelapse Light Facility. Videos were outputted from MetaMorph as AVI files. Personally, I always recommend uncompressed video files fro scientific uses. I also encourage posting the original scientific data format (ex. .lsm, .zvi, .lif, .stk).
Pubspectra Tattletales, George McNamara University of Miami
Pubspectra Tattletales, George Mcnamara
Tattletales for Multiplex Fluorescent Reporters in Single Cells for Metabolomics
Analytical Imaging Core Facility, University of Miami, Miller School of Medicine, Miami, FL
As of April 2013: L.J.N. Cooper & D.A. Lee Cellular Immunotherapy Lab, University of Texas M.D. Anderson Cancer Center, Houston, TX
Email: firstname.lastname@example.org, email@example.com
Tattletales is my concept for spatial multiplexing many fluorescent protein (FP) biosensors in the same live cell. For example, there are excellent FP biosensors to Ca++ ions, pH, glucose, ribose, glutamine, glutamate, ATP, redox, ROS, pyruvate, cAMP, cGMP, IP3, PI(3,4,5)P3, cell cycle indicators (Fucci2), PKA, PKC, photsphatases, caspase(s) [1, 2]. However, these are typically used one biosensor per experiment, due in part to flooding the cell with soluble biosensor. That is, conventionally, either a metabolite (glucose) reporter or a signal transduction (Ca++) reporter can be imaged. By flooding the cell with the reporter, signal to noise ratio is compromized by autofluorescence.
Tattletales takes advantage of spatial multiplexing to both increase the number of different reporters, and improve signal to noise ratio by localizing each biosensor to a small volume. I started with the observation by Robinett et al  who localized 512 GFP-nls-LacI to a 256 LacO array as a 200 nm diameter diffraction limited spot (nuclear background due to overexpression). Many thousands of DNA binding proteins, of known sequence specifities, exist (LacI, TetR, GalR, etc for cell line studies; ZF-FPs, TALE-FPs to STRs, telomere repeat binding factors-FPs, etc for primary cells) and can be fused (as cDNAs) to different fluorescent proteins and FP biosensors.
Many biosensors are available as affinity series [1, 4], now enabling extended dynamic range. I realized that spatial multiplexing of many DNA binding protein-reporters by localizing to different spots in the cell nucleus and distinguished by combinatorial addressing, where N address colors ...
Anti-Cancer Drug Screening Of Dual Tubulin And Hsp27 Inhibitors With 2d And 3d Lung Cancer Cell Assays, Janine Maria Naim, Rati Lama Cleveland State University
Anti-Cancer Drug Screening Of Dual Tubulin And Hsp27 Inhibitors With 2d And 3d Lung Cancer Cell Assays, Janine Maria Naim, Rati Lama
Undergraduate Research Posters 2012
Cancer is the leading cause of death worldwide. The current treatment options available for lung cancer are limited and have drawbacks such as poor bioavailability, numerous side effects, poor efficacy and drug resistance. 3D model serve as a novel approach for drug screening purposes and the evaluation of compounds in the platform can help identify potent compounds for further in vivo xenograft studies.
Normalizing For Noise Removal From Electrocardiogram Signals, Dominique Diamond Brooks, Daniel J. Simon Cleveland State University
Normalizing For Noise Removal From Electrocardiogram Signals, Dominique Diamond Brooks, Daniel J. Simon
Undergraduate Research Posters 2012
Electrocardiography (ECG) measures the electrical impulse of the heart over time using electrodes that attached to the body. Designing a computational program using a synthetic ECG to test Normalized Least Mean Square (NLMS) filter serves as a basis to remove noise from the signal.
Halloween 2012 Jack O'Lanterns Trick Or Treat, George McNamara University of Miami
Halloween 2012 Jack O'Lanterns Trick Or Treat, George Mcnamara
Halloween 2012 makes trick or treating more visual and interactive than in past years.
the download is a ZIP file containing three files.
Print out the (unnumbered) image on as large and nice printer paper as possible - I used glossy 44" wide here in Miami (University of Miami, MillerSchool of Medicine, Calder Library, Biomedical Communications dept - I also made another print on "fabric", also 44" wide to take with me to an HHMI Janelia Farm conference on 'turning images into knowledge' that ends on Oct 31 - might stay up for a second conference, "GFP..." that start Nov 4).
The other ...
Magnetic Resonance And Radiography In Rheumatoid Arthritis: Intermodality Comparisons Of Erosion Detection, Ruben V. Tavares McMaster University
Magnetic Resonance And Radiography In Rheumatoid Arthritis: Intermodality Comparisons Of Erosion Detection, Ruben V. Tavares
Open Access Dissertations and Theses
BACKGROUND. Classically, radiography (x-ray) has been used to visualize the destructive effects of uncontrolled rheumatoid arthritis (RA) on articular bones. Both x-ray and magnetic resonance imaging (MRI) may be used to visualize erosive disease. The multi-slice and multi-planar characteristics of MRI provide greater detail per anatomy imaged than x-ray.
OBJECTIVE. The objective of this dissertation was to compare the relative merits of x-ray and MRI erosion detection.
METHODS. In Chapters 1 through 3, RA, its clinical management, and the role of diagnostic imaging were introduced. In Chapter 4, the overall objective was first investigated by evaluating the current state of ...
Mcnamara 20120831fri-20120904tue Cosmic Ray Particles By Ccd Imaging, George McNamara University of Miami
Mcnamara 20120831fri-20120904tue Cosmic Ray Particles By Ccd Imaging, George Mcnamara
McNamara 20120831Fri-20120904Tue Cosmic Ray Particles by CCD imaging.zip contains image files in support of a Microscopy Today article - please see
Accounting For Centre In The Early External Cephalic Version Trials: An Empirical Comparison Of Statistical Methods To Account For Centre In Multicentre Randomised Controlled Trials With Binary Outcomes, Angela H. Reitsma McMaster University
Accounting For Centre In The Early External Cephalic Version Trials: An Empirical Comparison Of Statistical Methods To Account For Centre In Multicentre Randomised Controlled Trials With Binary Outcomes, Angela H. Reitsma
Open Access Dissertations and Theses
Background External cephalic version (ECV) is an effective intervention to reduce breech presentation and the corresponding Caesarean section (CS) rate. The Early ECV (EECV) trials were international multicentre randomized controlled trials that compared the timing of ECV (early or delayed) on obstetric and neonatal outcomes. In consideration of current recommendations that multicentre trials should account for centre effects in their analysis, a secondary analysis of the EECV trials was undertaken.
Purpose To analyse the EECV Trial data using statistical methods that account for centre effect and compare the results to standard analysis.
Methods Fisher’s exact test was used to ...
Cosmic Ray Particles Images With Orca-Ii Erg, George McNamara University of Miami
Cosmic Ray Particles Images With Orca-Ii Erg, George Mcnamara
Cosmic ray particles image series acquired using a Hamamatsu ORCA-II ERG scientific grade CCD camera, cooled to -60 C. Each image is a consecutive 600 second (10 minute) exposure time with no light to the camera.
While processing the data, I discoverd that the background changed around planes 25 and 227 (see Excel file and jpeg screenshots), so I also processed only planes 025-227 (203 planes total, 2030 minutes, 33.83 hours). the CCD industry "rule of thumb" for a "typical" CCD sensor (i.e. 1/3" CCD) is that one cosmic ray particle strikes a sensor approximately every 30 ...
Based on downloads this month
Rapid Multi-Class Multi-Residue Method For The Confirmation Of Chloramphenicol And Eleven Nitroimidazoles In Milk And Honey By Liquid Chromatography Tandem Mass Spectrometry, Barry Foley, Sheila Martin, Michael Doyle, Mark Cronly, Patrice Behan, Liam Regan, Edward Malone
Development And Validation Of A Rapid Multi-Class Method For The Confirmation Of Fourteen Prohibited Medicinal Additives In Pig And Poultry Compound Feed By Liquid Chromatography Tandem Mass Spectrometry, Barry Foley, Mark Cronly, Patrice Behan, Liam Regan, Edward Malone, Paula Shearan, Marella Gallagher, Sean Earley
Enhancing Student Usability Of The Osmette, Mitchell Foutz
Based on downloads this month