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Neural Networks: Using Biomarkers To Inform Diagnosis, Classification Of Disease And Approach To Therapy, Paula Grajdeanu 2016 Shenandoah University

Neural Networks: Using Biomarkers To Inform Diagnosis, Classification Of Disease And Approach To Therapy, Paula Grajdeanu

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


Book Reviews, John M. Gleason 2016 University of New Hampshire

Book Reviews, John M. Gleason

RISK: Health, Safety & Environment

Reviews of the books: Mark A. Rothstein, Medical Screening and the Employee Health Cost Crisis (BNA Books 1989). Foreword Edward L. Baker, MD, MPH. 296 pp. Notes, figures, tables, glossary of legal terms, glossary of medical and health care terms, table of cases and index. LC 89-977; ISBN 0-87179-628-7.

Robert Decresce, Mark Lifshitz, Adrianne Mazura, & Joseph Tilson, Drug Testing In The Workplace (ASCP Press and BNA Books 1989). Forewords by Edward Miller, JD and George Lundberg, MD. 278 pp. Notes, figures, tables, table of cases and index. LC 88-39191; ISBN 0-89189-260-5 (ASCP), 0-87179-588-4 (BNA). Both of these books deal with the topic of medical screening of employees. As indicated by the titles, Rothstein's book deals with various types of screening, with a focus on health costs, while DeCresce et al. focus on one ...


The Postfinasteride Syndrome; An Overview, David L. Rowland, Ion G. Motofei, Florian Popa, Vlad D. Constantin, Adriana Vasilache, Ioana Păunică, Cristian Bălălău, Georgeta P. Păunică, Petrisor Banu, Stana Păunică 2016 Valparaiso University, Department of Psychology

The Postfinasteride Syndrome; An Overview, David L. Rowland, Ion G. Motofei, Florian Popa, Vlad D. Constantin, Adriana Vasilache, Ioana Păunică, Cristian Bălălău, Georgeta P. Păunică, Petrisor Banu, Stana Păunică

Journal of Mind and Medical Sciences

As a 5-α reductase inhibitor, Finasteride has proven effective in ameliorating two conditions documented to be androgen dependent, namely male androgenic alopecia and benign prostatic hyperplasia. Therapeutic results are maintained as long as the drug is administered, with treatment cessation generally leading to the return of symptomatology for each condition. In addition, during the therapeutic phase, several adverse effects have been reported, some of which persist long or indefinitely after treatment cessation, known as “post-finasteride syndrome.”

Herein we present and discuss the most common finasteride side effects, along with a psycho-neuroendocrine rationale that could explain the persistence of many adverse ...


A Comparison Of Imaging Modalities For The Diagnosis Of Osteomyelitis, Brandon J. Smith, MD, Grant S. Buchanan, MD, Franklin D. Shuler, MD, PhD 2016 Marshall University, Joan C. Edwards School of Medicine

A Comparison Of Imaging Modalities For The Diagnosis Of Osteomyelitis, Brandon J. Smith, Md, Grant S. Buchanan, Md, Franklin D. Shuler, Md, Phd

Marshall Journal of Medicine

Osteomyelitis is an increasingly common pathology that often poses a diagnostic challenge to clinicians. Accurate and timely diagnosis is critical to preventing complications that can result in the loss of life or limb. In addition to history, physical exam, and laboratory studies, diagnostic imaging plays an essential role in the diagnostic process. This narrative review article discusses various imaging modalities employed to diagnose osteomyelitis: plain films, computed tomography (CT), magnetic resonance imaging (MRI), ultrasound, bone scintigraphy, and positron emission tomography (PET). Articles were obtained from Pubmed and screened for relevance to the topic of diagnostic imaging for osteomyelitis. The authors ...


Unconfessing Transgender: Dysphoric Youths And The Medicalization Of Madness In John Gower’S “Tale Of Iphis And Ianthe”, M W. Bychowski 2016 The George Washington University

Unconfessing Transgender: Dysphoric Youths And The Medicalization Of Madness In John Gower’S “Tale Of Iphis And Ianthe”, M W. Bychowski

Accessus

On the brink of the twenty-first century, Judith Butler argues in “Undiagnosing Gender” that the Diagnostic and Statistical Manual of Mental Disorders (DSM) defines the psychiatric condition of “Gender Identity Disorder” (or “Gender Dysphoria”) in ways that control biological diversity and construct “transgender” as a marginalized identity. By turning the study of gender away from vulnerable individuals and towards the broader systems of power, Butler works to liberate bodies from the medical mechanisms managing difference and precluding potentially disruptive innovations in forms of life and embodiment by creating categories of gender and disability.

Turning to the brink of the 15 ...


A Systematic Review Of Dual-Sensory Impairment In Older Adults, Abby F. Malawer 2016 Graduate Center, City University of New York

A Systematic Review Of Dual-Sensory Impairment In Older Adults, Abby F. Malawer

All Graduate Works by Year: Dissertations, Theses, and Capstone Projects

The elderly population (ages 65 years and older) in the United States is estimated to double between 2000 and 2030 to approximately 72 million people. Among this population, sensory impairment is a chronic disability. The combination of both hearing and vision impairment, referred to as dual-sensory impairment (DSI) is a chronic condition on the rise. The prevalence of DSI ranges from a low of 1.6% to as high as 22.5% depending on the population (Appollonio et al., 1995). Higher prevalence rates tend to emerge in populations receiving rehabilitative and hospital care. DSI impacts independent physical function and verbal ...


Diagnostic Practices Of Autism Spectrum Disorders In Brazil, Ana Claudia Vesper Manier Dias 2016 Andrews University

Diagnostic Practices Of Autism Spectrum Disorders In Brazil, Ana Claudia Vesper Manier Dias

Honors Theses

In Brazil, in spite of over half a million students with special needs in primary education, little research has been conducted about ASD diagnostic practices. This involves learning about the training that professionals are receiving, what diagnostic practices are being implemented on the field, and whether those are being contextualized according to the Brazilian culture. Students with special needs are directly affected by the results of diagnostic practices, since identifying the individuals is one of the first steps. Lack of understanding about that stage may lead to the problematic realities of underidentification or overidentification, exclusion of children who should receive ...


Urethral Solitary Fibrous Tumor: A Rare Pathologic Diagnosis Of A Periurethral Mass, Gaby N. Moawad, Elias Abi Khalil, Cheryl Silverbrook, Stephanie Barak, Alice Semerjian, Michael Phillips 2016 George Washington University

Urethral Solitary Fibrous Tumor: A Rare Pathologic Diagnosis Of A Periurethral Mass, Gaby N. Moawad, Elias Abi Khalil, Cheryl Silverbrook, Stephanie Barak, Alice Semerjian, Michael Phillips

Obstetrics and Gynecology Faculty Publications

Solitary fibrous tumors (SFTs) may occur at any site in the body. SFTs can only be conclusively diagnosed based on histopathologic and immunohistochemical characteristics of the tumor. The presence of SFTs in the abdomen and pelvis is extremely rare. To our knowledge no cases of urethral solitary fibrous tumor in the literature have been reported so far. We present a case of a solitary fibrous tumor arising from the urethra in a twenty-three-year-old female presenting with vaginal mass.


Acute Appendicitis: Transcript Profiling Of Blood Identifies Promising Biomarkers And Potential Underlying Processes, Lakhmir S. Chawla, Ian Toma, Danielle L. Davison, Khashayar Vaziri, Juliet Lee, Raymond Lucas, Michael G. Seneff, Aobhinn Nyhan, Timothy A. McCaffrey 2016 George Washington University

Acute Appendicitis: Transcript Profiling Of Blood Identifies Promising Biomarkers And Potential Underlying Processes, Lakhmir S. Chawla, Ian Toma, Danielle L. Davison, Khashayar Vaziri, Juliet Lee, Raymond Lucas, Michael G. Seneff, Aobhinn Nyhan, Timothy A. Mccaffrey

Anesthesiology and Critical Care Medicine Faculty Publications

Background

The diagnosis of acute appendicitis can be surprisingly difficult without computed tomography, which carries significant radiation exposure. Circulating blood cells may carry informative changes in their RNA expression profile that would signal internal infection or inflammation of the appendix.

Methods

Genome-wide expression profiling was applied to whole blood RNA of acute appendicitis patients versus patients with other abdominal disorders, in order to identify biomarkers of appendicitis. From a large cohort of emergency patients, a discovery set of patients with surgically confirmed appendicitis, or abdominal pain from other causes, was identified. RNA from whole blood was profiled by microarrays, and ...


Patient-Specific Inference Of Average Glucose From Glycated Hemoglobin, Roy Malka, David M. Nathan, John M. Higgins 2016 Massachusetts General Hospital

Patient-Specific Inference Of Average Glucose From Glycated Hemoglobin, Roy Malka, David M. Nathan, John M. Higgins

Biology and Medicine Through Mathematics Conference

No abstract provided.


Characterization Of Neutrophils And Macrophages From Ex Vivo Cultured Murine Bone Marrow For Morphologic Maturation And Functional Responses By Imaging Flow Cytometry, Klaudia Szymczak, Margery G.H. Pelletier, Anna M. Barbeau, Kevin O'Fallon, Peter Gaines 2016 University of Massachusetts Lowell

Characterization Of Neutrophils And Macrophages From Ex Vivo Cultured Murine Bone Marrow For Morphologic Maturation And Functional Responses By Imaging Flow Cytometry, Klaudia Szymczak, Margery G.H. Pelletier, Anna M. Barbeau, Kevin O'Fallon, Peter Gaines

UMass Center for Clinical and Translational Science Research Retreat

Neutrophils and macrophages differentiate from common myeloid progenitors in the bone marrow, where they undergo unique nuclear morphologic changes as they mature into fully functional phagocytes. These changes include condensation of chromatin, the most pronounced exhibited by mature neutrophils. Both myeloid cells acquire multiple functions critical to their ability to kill pathogens, including phagocytosis, the production of proteolytic enzymes and reactive oxygen species (ROS), and in the case of neutrophils, release of nuclear material known as nuclear extracellular traps (NETs). Studies on these functions often rely on the use of cells acquired from mature mouse tissues, but these tend to ...


Rapid Diagnostics For Infectious Disease Using Noble Metal Nanoparticles, Chun-Wan Yen, Helena de Puig, Justina Tam, José Gómez-Márquez, Irene Bosch, Lee Gehrke, Kimberly Hamad-Schifferli 2016 Massachusetts Institute of Technology

Rapid Diagnostics For Infectious Disease Using Noble Metal Nanoparticles, Chun-Wan Yen, Helena De Puig, Justina Tam, José Gómez-Márquez, Irene Bosch, Lee Gehrke, Kimberly Hamad-Schifferli

UMass Center for Clinical and Translational Science Research Retreat

Rapid point-of-care (POC) diagnostic devices are needed for field-forward screening of severe acute systemic febrile illnesses such as dengue, Ebola, chikungunya, and others. Multiplexed rapid lateral flow diagnostics have the potential to distinguish among multiple pathogens, thereby facilitating diagnosis and improving patient care. We present a platform for multiplexed pathogen detection which uses gold or silver nanoparticles conjugated to antibodies to sense the presence of biomarkers for different infectious diseases. We exploit the size-dependent optical properties of Ag NPs to construct a multiplexed paperfluidic lateral flow POC sensor. AgNPs of different sizes were conjugated to antibodies that bind to specific ...


"What's App?" Utilizing Evidence Based Medicine Apps In The Clinical Setting, Kathryn C. O'Donovan 2016 Butler University

"What's App?" Utilizing Evidence Based Medicine Apps In The Clinical Setting, Kathryn C. O'Donovan

BU Well

The medical community has utilized evidence-based medicine, or EBM, in practice for decades, and healthcare personnel are used to the idea of utilizing research and statistics to determine the treatment of patients. However, as technology advances, the use of electronics and EBM apps has increased in the clinical setting. While there are advantages to clinicians having resources at their fingertips as they talk with patients, there are also hurdles that could harm or offend patients. So as healthcare inevitably becomes more and more electronic, can providers strike the balance needed to effectively use EBM apps in practice to provide optimum ...


Effects Of Antiepileptic Medications On Bone Density In Individuals With Intellectual And Developmental Disabilities, Carly R. Gregory, Hannah L. Stedge, Robyn K. Brandenburg 2016 Cedarville University

Effects Of Antiepileptic Medications On Bone Density In Individuals With Intellectual And Developmental Disabilities, Carly R. Gregory, Hannah L. Stedge, Robyn K. Brandenburg

The Research and Scholarship Symposium

Individuals with intellectual and developmental disabilities (IDD) are commonly prescribed antiepileptic drugs (AEDs) to manage seizures, manage behavior, and stabilize mood. Though research has been done on the effects of antiepileptic medications in patients with epilepsy, little study has been done on the persons with intellectual and developmental disabilities population. After surveying IDD patients with a history and current use of AEDs on osteoprotective behaviors, we were unable to use SPSS due to incomplete surveys and low sample sizes. However, we were still able to analyze for common themes, and we found that the most prevalent use of AEDs was ...


Modern Evaluation Of Abdominal Trauma, Errington C. Thompson, MD, Chadwick J. Knight, MD 2016 Marshall University

Modern Evaluation Of Abdominal Trauma, Errington C. Thompson, Md, Chadwick J. Knight, Md

Marshall Journal of Medicine

Abdominal trauma can be mysterious to some physicians. If patients are evaluated for being stable or unstable, then abdominal trauma can be easily managed. Using a combination of physical examination, ultrasound and CT scans, patients can be quickly and efficiently evaluated.


Exploration Of Franklin D. Roosevelt's Paralytic Illness, Tara Malik 2016 Georgia State University

Exploration Of Franklin D. Roosevelt's Paralytic Illness, Tara Malik

Georgia State Undergraduate Research Conference

No abstract provided.


Is Ca-125 The Leading Biomarker In Determining Early-Onset Ovarian Cancer Diagnosis In 2016?, Alexa Clark 2016 University of Rhode Island

Is Ca-125 The Leading Biomarker In Determining Early-Onset Ovarian Cancer Diagnosis In 2016?, Alexa Clark

Senior Honors Projects

Epithelial ovarian cancer is the most lethal gynecologic malignancy with very ineffective efforts at early detection and therapeutic methodologies to reduce mortality. The origin and pathogenicity of ovarian cancer is vastly unclear, which is why diagnosing the disease early on is difficult. CA-125 is a used as therapeutic tumor marker for ovarian cancer, but it is not diagnostic or specific. The role of CA-125 in the early detection of ovarian cancer is extremely controversial and has not been widely accepted for screening in women who do not show any symptoms. In order to enhance the sensitivity for early disease detection ...


Prediction Of Communication Risk Before 12 Months With The Iscbs: Group Outcomes At 3 Years, Kristi Leutzinger, Maggie Steinhauser, Emma Fleisher 2016 University of Nebraska-Lincoln

Prediction Of Communication Risk Before 12 Months With The Iscbs: Group Outcomes At 3 Years, Kristi Leutzinger, Maggie Steinhauser, Emma Fleisher

UCARE Research Products

This study reports communication outcomes of typically developing infants given the Infant Social and Communication Behavior Scales (ISCBS) at 2-12 months. Results indicate patterns of infant behaviors on the ISCBS that differed between infants who later demonstrated language impairments or autism at age three years from those who did not.


Detecting Heart Failure Decompensation By Measuring Transthoracic Bioimpedance In The Outpatient Setting: Rationale And Design Of The Sentinel-Hf Study, Silviu Dovancescu, Jane Saczynski, Chad Darling, Jarno Riistema, Fatima Kuniyoshi, Theo Meyer, Robert Goldberg, David McManus 2016 Philips Research

Detecting Heart Failure Decompensation By Measuring Transthoracic Bioimpedance In The Outpatient Setting: Rationale And Design Of The Sentinel-Hf Study, Silviu Dovancescu, Jane Saczynski, Chad Darling, Jarno Riistema, Fatima Kuniyoshi, Theo Meyer, Robert Goldberg, David Mcmanus

David D. McManus

BACKGROUND: Recurrent hospital admissions are common among patients admitted for acute decompensated heart failure (ADHF), but identification of patients at risk for rehospitalization remains challenging. Contemporary heart failure (HF) management programs have shown modest ability to reduce readmissions, partly because they monitor signs or symptoms of HF worsening that appear late during decompensation. Detecting early stages of HF decompensation might allow for immediate application of effective HF therapies, thereby potentially reducing HF readmissions. One of the earliest indicators of HF decompensation is intrathoracic fluid accumulation, which can be assessed using transthoracic bioimpedance.

OBJECTIVE: The SENTINEL-HF study is a prospective observational ...


Severity Of Pain Is Not Associated With Urgency Of Diagnosis In Ed Patients With Abdominal Pain, Ryan Brunetti, Caitlin David, Lorna Richards, Melissa J. McCarthy, Andrew C. Meltzer 2016 George Washington University

Severity Of Pain Is Not Associated With Urgency Of Diagnosis In Ed Patients With Abdominal Pain, Ryan Brunetti, Caitlin David, Lorna Richards, Melissa J. Mccarthy, Andrew C. Meltzer

GW Research Days 2016 - Present

Background

Abdominal Pain is the most common cause of visits to US Emergency Departments (EDs) and the causes range from urgent to non-urgent diagnoses. Distinguishing urgent versus non-urgent causes of abdominal pain is done through the use of clinical exam, lab studies and diagnostic imaging such as CT scans. There are no validated clinical decision rules to assist physicians in discriminating urgent from non-urgent causes of abdominal pain or which patient needs a CT scan. There is controversy regarding the use of CT scans for patients with abdominal pain due to the increased cost, radiation exposure and length of stay ...


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