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Quality Management: A Global Case Study In Organ Transplantation, Cassie L. Rodriguez 2016 University of San Francisco

Quality Management: A Global Case Study In Organ Transplantation, Cassie L. Rodriguez

Master's Projects

Every year the US and European countries face an epidemic of organ failure from a multitude of reasons: cancer, genetic predisposition, exposure to harmful chemicals in home or surrounding areas or through drinking, drugs and smoking. Another problem faced, is the ratio of organ donors to organ recipients. Over 121,000 patients are on the waiting for an organ transplant, and a fraction of those waiting will die because of time. The Hanover Medical school and department of quality management, have created an integrated approach to organ transplant avenues. Quality management is a systematic guide for organ transplantation that allows ...


Sources Of Epidemiological Equivocacy, Timothy Sly 2016 University of New Hampshire

Sources Of Epidemiological Equivocacy, Timothy Sly

RISK: Health, Safety & Environment

Mr. Sly discusses five sources of uncertainty and ambiguity in health and medical research that can interfere with decision making.


Cranor's Reply, Carl F. Cranor 2016 University of New Hampshire

Cranor's Reply, Carl F. Cranor

RISK: Health, Safety & Environment

Dr. Cranor's reply to Merz and Frey.


[Review Of] Carl F. Cranor, Regulating Toxic Substances, Jon F. Merz, H. Christopher Frey 2016 University of New Hampshire

[Review Of] Carl F. Cranor, Regulating Toxic Substances, Jon F. Merz, H. Christopher Frey

RISK: Health, Safety & Environment

Review of: Carl F. Cranor, Regulating Toxic Substances (Oxford University Press 1993). Acknowledgments, appendices, bibliography, figures, foreword by The Honorable George E. Brown, Jr., index, notes, tables. LC 91-47046; ISBN 0-19- 507436-X. [272 pp. Cloth $45.00. 200 Madison Avenue, New York NY 10016.]


A Comparison Of Imaging Modalities For The Diagnosis Of Osteomyelitis, Brandon J. Smith, MD, Grant S. Buchanan, MD, Franklin D. Shuler, MD, PhD 2016 Marshall University, Joan C. Edwards School of Medicine

A Comparison Of Imaging Modalities For The Diagnosis Of Osteomyelitis, Brandon J. Smith, Md, Grant S. Buchanan, Md, Franklin D. Shuler, Md, Phd

Franklin D. Shuler

Osteomyelitis is an increasingly common pathology that often poses a diagnostic challenge to clinicians. Accurate and timely diagnosis is critical to preventing complications that can result in the loss of life or limb. In addition to history, physical exam, and laboratory studies, diagnostic imaging plays an essential role in the diagnostic process. This narrative review article discusses various imaging modalities employed to diagnose osteomyelitis: plain films, computed tomography (CT), magnetic resonance imaging (MRI), ultrasound, bone scintigraphy, and positron emission tomography (PET). Articles were obtained from Pubmed and screened for relevance to the topic of diagnostic imaging for osteomyelitis. The authors ...


Book Review, Darold T. Barnum 2016 University of New Hampshire

Book Review, Darold T. Barnum

RISK: Health, Safety & Environment

Review of the following: HELENA CHMURA KRAEMER, EVALUATING MEDICAL TESTS: OBJECTIVE AND QUANTITATIVE GUIDELINES. (Sage Publications 1992). [295 pp.] Foreword A. John Rush, M.D. Acknowledgments, index, list of statistical notations, preface, references, and about the author. ISBN 0- 8039-4611-2 (cloth); 0-8039-4612-0 (paper). [Cloth $45.00, paper $22.50. 2455 Teller Road, Newbury Park CA 91320.1


Barriers And Facilitators To Deaf Trauma Survivors’ Help-Seeking Behavior: Lessons For Behavioral Clinical Trials Research: A Master’S Thesis, Melissa L. Anderson 2016 University of Massachusetts Medical School

Barriers And Facilitators To Deaf Trauma Survivors’ Help-Seeking Behavior: Lessons For Behavioral Clinical Trials Research: A Master’S Thesis, Melissa L. Anderson

Melissa L. Anderson

Deaf individuals experience significant obstacles to participating in behavioral health research when careful consideration is not given to accessibility in the design of study methodology. To inform such considerations, we conducted a secondary analysis of a mixed-methods study that explored 16 Deaf trauma survivors’ help-seeking experiences. Our objective was to identify key findings and qualitative themes from consumers' own words that can be applied to the design of behavioral clinical trials methodology. In many ways, the themes that emerged are what we would expect of any research participant, Deaf or hearing – a need for communication access, empathy, respect, strict confidentiality ...


Characterization Of Left-Ventricular Thrombus Formation Using High Frequency Ultrasound, Kelsey A. Bullens, Arvin H. Soepriatna, Pavlos P. Vlachos, Craig J. Goergen 2016 Purdue University

Characterization Of Left-Ventricular Thrombus Formation Using High Frequency Ultrasound, Kelsey A. Bullens, Arvin H. Soepriatna, Pavlos P. Vlachos, Craig J. Goergen

The Summer Undergraduate Research Fellowship (SURF) Symposium

Heart failure is a leading cause of death in the United States, and cardiac thrombus, a common morbidity associated with heart failure, significantly increases a patient’s risk of embolic events. The objective of this project is to characterize left-ventricular (LV) thrombus development using high frequency ultrasound imaging in a murine model. C57BL/6J wild-type mice (n=6) were injected intraperitoneally with iron dextran five times a week for six weeks to increase oxidative stress in the heart. Granulocyte-colony stimulating factor (G-CSF) was subcutaneously injected daily during the second week to initiate stem cell migration and stimulate endothelial cell activation ...


A Comparison Of Imaging Modalities For The Diagnosis Of Osteomyelitis, Brandon J. Smith, MD, Grant S. Buchanan, MD, Franklin D. Shuler, MD, PhD 2016 Marshall University, Joan C. Edwards School of Medicine

A Comparison Of Imaging Modalities For The Diagnosis Of Osteomyelitis, Brandon J. Smith, Md, Grant S. Buchanan, Md, Franklin D. Shuler, Md, Phd

Marshall Journal of Medicine

Osteomyelitis is an increasingly common pathology that often poses a diagnostic challenge to clinicians. Accurate and timely diagnosis is critical to preventing complications that can result in the loss of life or limb. In addition to history, physical exam, and laboratory studies, diagnostic imaging plays an essential role in the diagnostic process. This narrative review article discusses various imaging modalities employed to diagnose osteomyelitis: plain films, computed tomography (CT), magnetic resonance imaging (MRI), ultrasound, bone scintigraphy, and positron emission tomography (PET). Articles were obtained from Pubmed and screened for relevance to the topic of diagnostic imaging for osteomyelitis. The authors ...


Text Mining From Drug Surveillance Report Narratives, Susmitha Wunnava, Tabassum Kakar, Xiao Qi, Elke A. Rudensteiner 2016 Worcester Polytechnic Institute

Text Mining From Drug Surveillance Report Narratives, Susmitha Wunnava, Tabassum Kakar, Xiao Qi, Elke A. Rudensteiner

UMass Center for Clinical and Translational Science Research Retreat

Analysis of postmarket drug surveillance reports is imperative to ensure drug safety and effectiveness. FAERS (FDA Adverse Event Reporting System) is a surveillance system that monitors Adverse Events (AEs) from drugs and biologic products. The AEs are reported through MedWatch voluntary reports (initiated from patients and healthcare providers) and mandatory reports (initiated from manufacturers). Much of the information in the voluntary AE reports is narratives or unstructured text. The increasing volume of individual reports, estimated at more than one million per year, poses a challenge for the staff to review large volume of narratives for drug clinical review. We are ...


Anthelminthic Screening For Parasitic Nematodes, Elfawal A. Mostafa, Dan Lawler, Dirk Albrecht, Raffi V. Aroian 2016 University of Massachusetts Medical School

Anthelminthic Screening For Parasitic Nematodes, Elfawal A. Mostafa, Dan Lawler, Dirk Albrecht, Raffi V. Aroian

UMass Center for Clinical and Translational Science Research Retreat

For many parasitic diseases, high-throughput phenotypic screening is an important tool in finding new drugs. Some of the most important parasitic diseases are caused by nematodes. However, these parasitic nematodes are not typically amenable to high throughput screening. Due to the ease of its maintenance and suitability for high throughput assay, the nematode Caenorhabditis elegans is instead used. To address whether C. elegans is a good model for nematode drug discovery, we compared the drug susceptibility of C. elegans relative to the human hookworm nematode parasite Ancylostoma ceylanicum at several developmental stages using a library of FDA approved drugs. I ...


Invitrometrix Qcm-Based Cell Biosensor: Research Tool To Accelerate Pharmaceutical Drug Discovery Success, Abiche H. Dewilde 2016 University of Massachusetts Lowell

Invitrometrix Qcm-Based Cell Biosensor: Research Tool To Accelerate Pharmaceutical Drug Discovery Success, Abiche H. Dewilde

UMass Center for Clinical and Translational Science Research Retreat

As part of the mini-symposium entitled "Shark Tank-UMass Spin-out Life Sciences Start-ups," Dr. Dewilde discusses an example of UMass life sciences technology that has been spun out into a start-up company -- Cell QCM from UMass Lowell.


Barriers And Facilitators To Deaf Trauma Survivors’ Help-Seeking Behavior: Lessons For Behavioral Clinical Trials Research: A Master’S Thesis, Melissa L. Anderson 2016 University of Massachusetts Medical School

Barriers And Facilitators To Deaf Trauma Survivors’ Help-Seeking Behavior: Lessons For Behavioral Clinical Trials Research: A Master’S Thesis, Melissa L. Anderson

GSBS Dissertations and Theses

Deaf individuals experience significant obstacles to participating in behavioral health research when careful consideration is not given to accessibility in the design of study methodology. To inform such considerations, we conducted a secondary analysis of a mixed-methods study that explored 16 Deaf trauma survivors’ help-seeking experiences. Our objective was to identify key findings and qualitative themes from consumers' own words that can be applied to the design of behavioral clinical trials methodology. In many ways, the themes that emerged are what we would expect of any research participant, Deaf or hearing – a need for communication access, empathy, respect, strict confidentiality ...


A Study On Automated Process For Extracting White Blood Cellular Data From Microscopic Digital Injured Skeletal Muscle Images, Bibek Karki 2016 University of Nevada, Las Vegas

A Study On Automated Process For Extracting White Blood Cellular Data From Microscopic Digital Injured Skeletal Muscle Images, Bibek Karki

UNLV Theses, Dissertations, Professional Papers, and Capstones

Skeletal muscle injury is one of the common injuries caused by high-intensity sports activities, military related works, and natural disasters. In order to discover better therapies, it is important to study muscle regeneration process. Muscle regeneration process tracking is the act of monitoring injured tissue section over time, noting white blood cell behavior and cell-fiber relations. A large number of microscopic images are taken for tracking muscle regeneration process over multiple time instances. Currently, manual approach is widely used to analyze a microscopic image of muscle cross section, which is time consuming, tedious and buggy.

Automation of this research methodology ...


Creating A Dynamic, Multi-Purpose Correction For Multiple Geometries And Field Sizes To Account For Off-Axis And Asymmetric Backscatter With Varian Portal Dosimetry, Remy Manigold 2016 University of Nevada, Las Vegas

Creating A Dynamic, Multi-Purpose Correction For Multiple Geometries And Field Sizes To Account For Off-Axis And Asymmetric Backscatter With Varian Portal Dosimetry, Remy Manigold

UNLV Theses, Dissertations, Professional Papers, and Capstones

Intensity modulated radiation therapy and volumetric modulated arc therapy are increasingly common in radiation therapy due to their benefits of target conformity and normal tissue sparing. Due to the complexities of plan delivery and the precision required, the dose delivered must be accurately measured for quality assurance (QA). One of the most efficient ways to perform patient-specific QA when using clinical linear accelerators (linac) is to use an electronic portal imaging device (EPID). Amorphous silicon (aSi) Electronic Portal Imaging Devices (EPIDs) are attached to the linac and can provide real-time feedback with spatial resolution on the order of sub-millimeter pixel ...


Microdialysis Studies Using Porcine Pancreatic Elastase To Guide Mathematical Modeling Of Microdialysis Sampling For In Vivo Measurements., Mason W. Young 2016 University of Arkansas, Fayetteville

Microdialysis Studies Using Porcine Pancreatic Elastase To Guide Mathematical Modeling Of Microdialysis Sampling For In Vivo Measurements., Mason W. Young

Biomedical Engineering Undergraduate Honors Theses

Microdialysis sampling uses a semi-permeable membrane to allow solute collection by diffusion. When used in conjunction with other instruments, analytes in question can be quantified. Matrix Metalloproteinases (MMPs) are enzymes involved in numerous biological processes where they serve the role of degrading extracellular matrix. Microdialysis sampling, in coordination with further analysis methods, can be used in order to measure the activity of these enzymes in a region of the body instantaneously. The intention of this project is to determine ways of measuring in vitro activity of elastase from porcine pancreas using determined activity values and the collection of elastase products ...


An Analysis Of Women’S Access To Acute Opioid Detoxification Services In Maine: Identifying The Barriers To Treatment, Karen E. Conley 2016 University of Southern Maine

An Analysis Of Women’S Access To Acute Opioid Detoxification Services In Maine: Identifying The Barriers To Treatment, Karen E. Conley

Muskie School Capstones

The lack of treatment facilities and services for opioid use disorder in Maine, combined with an increased prevalence of addiction, creates a potential for health inequity between men and women that may be intensified by barriers in access to care. This capstone study utilized detoxification screening inquiry forms and data obtained from the Milestone Foundation’s acute opioid detoxification program to assess and categorize barriers to access by gender. A barriers model was developed based on existing literature and was to identify potential associations among and between the known barriers to accessing treatment. Barriers were described as internally or externally ...


Detecting Heart Failure Decompensation By Measuring Transthoracic Bioimpedance In The Outpatient Setting: Rationale And Design Of The Sentinel-Hf Study, Silviu Dovancescu, Jane Saczynski, Chad Darling, Jarno Riistema, Fatima Kuniyoshi, Theo Meyer, Robert Goldberg, David McManus 2016 Philips Research

Detecting Heart Failure Decompensation By Measuring Transthoracic Bioimpedance In The Outpatient Setting: Rationale And Design Of The Sentinel-Hf Study, Silviu Dovancescu, Jane Saczynski, Chad Darling, Jarno Riistema, Fatima Kuniyoshi, Theo Meyer, Robert Goldberg, David Mcmanus

David D. McManus

BACKGROUND: Recurrent hospital admissions are common among patients admitted for acute decompensated heart failure (ADHF), but identification of patients at risk for rehospitalization remains challenging. Contemporary heart failure (HF) management programs have shown modest ability to reduce readmissions, partly because they monitor signs or symptoms of HF worsening that appear late during decompensation. Detecting early stages of HF decompensation might allow for immediate application of effective HF therapies, thereby potentially reducing HF readmissions. One of the earliest indicators of HF decompensation is intrathoracic fluid accumulation, which can be assessed using transthoracic bioimpedance.

OBJECTIVE: The SENTINEL-HF study is a prospective observational ...


Induced Hypothermia Post Cardiac Resuscitation Works In Hospitalized Patients But Not During Transport To Hospital, A Logical Inconsistency Of Evidence, Joshua Frederick 2016 Wayne State University

Induced Hypothermia Post Cardiac Resuscitation Works In Hospitalized Patients But Not During Transport To Hospital, A Logical Inconsistency Of Evidence, Joshua Frederick

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Kim F, Nichol G, Maynard C, et al. Effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest. JAMA 2013;311(1):45-52. doi:10.1001/jama.2013.282173


More For Collecting From Dc Tuesday, Sidney Fourteen, Kenneth Gleason 2016 bepress university

More For Collecting From Dc Tuesday, Sidney Fourteen, Kenneth Gleason

Kenneth Gleason

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