Working Out The Kinks: Creating Solutions To Assist Health Care Workers To Take Vital Signs Through Effective Cable Management, 2022 Purdue University
Working Out The Kinks: Creating Solutions To Assist Health Care Workers To Take Vital Signs Through Effective Cable Management, Carl R. Russell Iii, Emily J. Linder, Maya A. Godbole
Purdue Journal of Service-Learning and International Engagement
EPICS (Engineering Projects in Community Service) is a service-learning design program run through Purdue University. It strives to teach students design skills through providing solutions for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. BME (Bio-medical Engineering) is a team within EPICS that strives to serve community partners through biomedical applications. Members of a health care team often spend valuable time organizing cables associated with machines used to take patients’ vital signs. Due to time constraints and the fast-paced work environment, these cables may be mismanaged and damaged. The BME team is working on a …
Functionality Of The Gracilis Collateral Is Impaired Following Arteriogenesis And Cell Transplantation, 2022 California Polytechnic State University, San Luis Obispo
Functionality Of The Gracilis Collateral Is Impaired Following Arteriogenesis And Cell Transplantation, Ada A. Tadeo
Biomedical Engineering
Peripheral Arterial Disease involves narrowed arteries, reducing blood flow to limbs. Increasing blood flow to those extremities is possible by redirecting the blood to flow through natural bypasses (i.e. collateral arteries), which can enlarge via arteriogenesis to maintain blood supply once the prominent arteries have become occluded. This study aims to investigate how arteriogenesis affects collateral function, if myoblast transplantation can stimulate collateral growth, and how that in turn may affect collateral function. Femoral artery ligation was performed to mimic the blockage that occurs in patients with ischemic diseases on lean mice and mice with diet induced obesity (DIO). A …
Morphology And Strain In The Subchondral Trabeculae Of Osteoarthritic Humeral Heads, 2022 Western University
Morphology And Strain In The Subchondral Trabeculae Of Osteoarthritic Humeral Heads, Anna Yang
Undergraduate Student Research Internships Conference
This project compares the strains and morphological parameters of subchondral bone in osteoarthritic and non-pathogenic cadaveric humeral heads.
The Development Of A Motion Sensing Device For Use In A Home Setting, 2022 The University of Western Ontario
The Development Of A Motion Sensing Device For Use In A Home Setting, Jaspreet K. Kalsi
Electronic Thesis and Dissertation Repository
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, with over 10 million individuals diagnosed with PD world-wide. The most common symptom characterized by PD is tremor. Tremor is an involuntary oscillatory motion that most prominently occurs in upper limb, specifically in the hand and wrist that has a measurable frequency and amplitude. This thesis aims to evaluate the usability and functionality of a tremor sensing device designed to collect quantitative data on individuals with PD. The designed device uses 23 commercially-available inertial measuring units (IMUs) located between 21 joints: distal interphalangeal (DIP) joints, proximal interphalangeal (PIP) joints, Interphalangeal …
Morphology Of The Acromion And Scapular Spine With Special Interest In The Strength & Failure Prediction After Reverse Total Shoulder Replacement, 2022 Western University
Morphology Of The Acromion And Scapular Spine With Special Interest In The Strength & Failure Prediction After Reverse Total Shoulder Replacement, Andrei M. Matusa, Cole Fleet, George S. Athwal, James A. Johnson
Undergraduate Student Research Internships Conference
Scapular spine fractures following a reverse arthroplasty are a significant clinical concern. This ongoing study looks at the morphology of the acromion and scapular spine with an interest in the strength and failure prediction of the bone. Digital 3D models of the scapular spine were created from cadaver CTs, then bone density and distribution data was obtained. It was found that the cortical bone was most dense just medial of the lateral angle. The cross-sectional area here was also the largest and decreased medially. This has important implications for implant fixation hardware as cortical bone --compared to cancellous bone-- is …
Behavioral And Histological Inflammatory Analysis Of A Single, Mild Traumatic Brain Injury And Repeated Subconcussive Brain Injury Using A Rodent Model., 2022 Mississippi State University
Behavioral And Histological Inflammatory Analysis Of A Single, Mild Traumatic Brain Injury And Repeated Subconcussive Brain Injury Using A Rodent Model., Anna Marie Clay
Theses and Dissertations
Subconcussive (SC) impacts have become a growing concern within the neuroscience community regarding the immediate and long-lasting effects of sports-related injuries. While a single low-level impact, i.e., a subconcussion, may not cause cerebral perturbations, it has been increasingly recognized that repeated SC exposure can induce deleterious effects. Therefore, determining the lower limits of systematic perturbation resulting from multiple SC impacts is of critical importance in expanding our understanding of cerebral vulnerability and recovery. Currently, there is a lack of correlation between a mild traumatic brain injury (mTBI) and repeated SC impacts with respect to injury biomechanics. Moreover, the cumulative threshold …
Restoring An Iso:5840-Compliant Pulse Duplicator Device For Hydrodynamic Performance Characterization Of Artificial Cardiac Valves, 2022 University of Arkansas, Fayetteville
Restoring An Iso:5840-Compliant Pulse Duplicator Device For Hydrodynamic Performance Characterization Of Artificial Cardiac Valves, Denver Eagar
Biomedical Engineering Undergraduate Honors Theses
During the summer of 2021, I was employed as an intern at Dynatek Labs, an implantable prosthetics testing company located in southern Missouri. My primary project was to modernize an abandoned pulse duplicator device and protocol to allow the company to re-enter a market area which they left nearly 15 years prior: heart valve testing. The company halted this initiative due to changes in international testing standards in previous years. The International Standards Organization Cardiac Valves Working Group released the latest version of standards concerning artificial heart valve testing (ISO 5840) in January of 2021. Accordingly, my project required that …
Optimization Of A Novel Barnes Maze Protocol For Assessing Antioxidant Treatment Of Traumatic Brain Injury, 2022 University of Nebraska-Lincoln
Optimization Of A Novel Barnes Maze Protocol For Assessing Antioxidant Treatment Of Traumatic Brain Injury, Connor C. Gee
Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research
Current preclinical research into traumatic brain injury focuses heavily upon cellular and molecular testing to determine the effects of injury and potential benefits of neuroprotective treatments. While this may be a useful method, some argue that an increased focus on behavioral testing could lead to better clinical translation as these assays assess the longer term, downstream effects from a brain injury. The most characterized behavioral tests used in traumatic brain injury research are the spatial learning and memory paradigms, Morris Water Maze and Barnes Maze. The Morris Water Maze is the most used of theses paradigms and relies on spatial …
Biomechanical Investigation Of Complete And Partial Medial Collateral Ligament Injuries, 2022 The University of Western Ontario
Biomechanical Investigation Of Complete And Partial Medial Collateral Ligament Injuries, Callahan Doughty
Electronic Thesis and Dissertation Repository
The medial collateral ligament (MCL) is composed of two major components: the deep MCL (dMCL) and superficial MCL (sMCL). Recent indications have raised questions as to the validity of previous descriptions of the MCL’s role in knee stability. Despite the relative likelihood of partial injuries to the sMCL, as opposed to complete tears, the impact of these injuries remains largely misunderstood. This thesis set out to (1) interpret the roles of the sMCL and dMCL; and (2) investigate the effect of partial sMCL injuries on knee stability.
A joint motion simulator was used to determine the role of the dMCL …
Self-Balancing Bicycle Device, 2022 California Polytechnic State University, San Luis Obispo
Self-Balancing Bicycle Device, Charles Cole, Raffy Lorenzo, Neil Boyal
Biomedical Engineering
The sponsor, Justin Shaw, is currently developing a bicycle for an athlete who has lost movement in their legs. This athlete can no longer experience the unmatched feeling of naturally banking a bicycle at corners. The Self-Balancing Bike Device Team will create a device that can self-balance an electric recumbent bicycle at low speeds while being almost undetectable while turning. This document will outline the team’s background research into self-balancing vehicles, define the needs that must be solved, and delineate a schedule for future milestones.
Study Of Cardiovascular Dynamics During Graded Head-Up Tilt Test In The Young With Syncope Tendency, 2022 Pontificia Universidad Catolica de Chile
Study Of Cardiovascular Dynamics During Graded Head-Up Tilt Test In The Young With Syncope Tendency, Martin A. Miranda Sr
Biology and Medicine Through Mathematics Conference
No abstract provided.
Developing New Crutch Tip Design For Overall Increased Stability And Improved Movement On Different Terrains, 2022 University of Mississippi
Developing New Crutch Tip Design For Overall Increased Stability And Improved Movement On Different Terrains, Lauren Skinner
Honors Theses
Crutches are a mobility assistive device that are often used in various situations, such as post- surgical rehabilitation and recovery after injury. The current crutch tip design that is used on today’s crutches are often unstable and do not provide quality movement on different terrains, such as snow, ice, mud, and wet surfaces. These problems would be solved with a new tip design that could be attached to existing crutches or manufactured with the crutch itself. The team’s solution to this problem is a crutch tip with modular parts. The tip would attach to the shaft of the crutch like …
Th1, Th2, And Th17 Inflammatory Pathways Predict Cardiometabolic Protein Expression In Serum Of Covid-19 Patients, 2022 University of Mississippi
Th1, Th2, And Th17 Inflammatory Pathways Predict Cardiometabolic Protein Expression In Serum Of Covid-19 Patients, James Richard Michels
Honors Theses
A predominant source of complications in SARS-CoV-2 patients arises from severe systemic inflammation contributed to by Helper T-cell associated cytokines, potentially leading to tissue damage and organ failure. The high inflammatory burden of this viral infection often results in cardiovascular comorbidities. A better understanding of the interaction between the cytokine storm and cardiovascular proteins might inform medical decisions and therapeutic approaches. We hypothesized that all major helper T-cell inflammatory pathways (Helper T 1, Helper T 2 and Helper T 17) synergistically contribute to cardiometabolic pathways in serum of COVID-19 patients, and that both of these factors correlate to COVID-19 severity. …
Additive Manufacturing Of Variable Contrast Computed Tomography Anatomical Phantoms Using A Single Feedstock In Fused Filament Fabrication, 2022 University of New Orleans
Additive Manufacturing Of Variable Contrast Computed Tomography Anatomical Phantoms Using A Single Feedstock In Fused Filament Fabrication, Cory J. Darling
University of New Orleans Theses and Dissertations
Anatomical phantoms used in biomedical education and training benefit greatly from Fused filament fabrication’s (FFF) ability to rapidly produce complex and unique models. Current materials and methods used in FFF have limited ability to accurately produce phantoms that can mimic the radiological properties of multiple biological tissues. This research demonstrates that the CT contrast of FFF produced models can be modified by varying the concentration of bismuth oxide in acrylonitrile butadiene styrene (ABS) filaments and a tunable CT contrast that mimics the CT contrast ranging from fatty tissue to cortical bone using a single composite filament without introducing artificial image …
Virtual Reality As An Education Tool In Biomedical Engineering, 2022 University of Arkansas, Fayetteville
Virtual Reality As An Education Tool In Biomedical Engineering, Megan Wilkerson
Biomedical Engineering Undergraduate Honors Theses
Virtual Reality (VR) has become more accessible in recent years, both to experience and to create. Various studies have shown that incorporating VR in an educational setting can yield positive results. Virtual reality videos created using course-specific content could prove to be a beneficial educational tool. VR videos were implemented in a remote biomolecular engineering laboratory course. 180° VR videos of lab procedures were recorded and viewed by students using a Google Cardboard headset and their smartphones. After viewing all the VR lab videos, students were given a survey to report their experiences. The survey contained questions used to measure …
Developing A Semester-Long Project In A Biomechanical Engineering Course To Instill The Entrepreneurial Mindset In The Next-Generation Biomedical Engineering Students, 2022 University of Arkansas, Fayetteville
Developing A Semester-Long Project In A Biomechanical Engineering Course To Instill The Entrepreneurial Mindset In The Next-Generation Biomedical Engineering Students, Loren Hedgecock
Biomedical Engineering Undergraduate Honors Theses
Entrepreneurial-Minded Learning (EML) is an emerging pedagogy progressively gaining popularity in the engineering education community. Coincided with project-based learning (PBL), EML illustrates an essential dimension to the instruction of next-generation engineers, equipping them with various perspectives and approaches to relate societal challenges with technical concepts. Nationwide initiatives, such as the Kern Entrepreneurial Engineering Network (KEEN), have developed a learning framework specifically designed to create engineers such as these. The implementation of EML aims to stimulate connections, create value, and ignite curiosity. This study introduced a semester-long project based on these EML skillsets in a sophomore-level biomechanical engineering course. To evaluate …
The Influence Of Mmp14 On Angiogenesis In Chemotherapy-Treated Tumors, 2022 University of Arkansas, Fayetteville
The Influence Of Mmp14 On Angiogenesis In Chemotherapy-Treated Tumors, Abdussaboor Muhammad
Biomedical Engineering Undergraduate Honors Theses
Colorectal cancer is the third most common cancer in the world, and it is the fourth most common cause of cancer related death (1). There have been many significant advancements regarding the treatment of cancer which aim to shrink the size of tumors in patients. However, there is still more that needs to be understood about the many different factors that play a role in colorectal cancer development.
Angiogenesis is the process of forming new blood vessels from existing ones and it requires breaking down and remodeling of the extracellular matrix (ECM) in order to allow endothelial cells to migrate …
Nonlinear Optical Microscopy Assessment Of Tissue Structure And Chondrocyte Viability Of Articular Cartilage, 2022 Clemson University
Nonlinear Optical Microscopy Assessment Of Tissue Structure And Chondrocyte Viability Of Articular Cartilage, Michael Le
All Theses
Articular cartilage functions to protect the ends of bones by providing a surface that can withstand compressive forces and minimize friction during movement. Collagen fibers form the organizational backbone of the extracellular matrix (ECM) in cartilage. Proteoglycans within the ECM function to retain water and provide the tissue with the swelling pressure needed to withstand compressional forces. Chondrocytes, the only type of cell found in articular cartilage, produces these collagen fibers and proteoglycans to maintain the tissue structure and function. Significant injuries to articular cartilage can damage the chondrocytes and disrupt their ability to maintain homeostasis in the tissue. Therefore, …
A Modeling Platform To Predict Cancer Survival And Therapy Outcomes Using Tumor Tissue Derived Metabolomics Data., 2022 University of Louisville
A Modeling Platform To Predict Cancer Survival And Therapy Outcomes Using Tumor Tissue Derived Metabolomics Data., Hunter Allan Miller
Electronic Theses and Dissertations
Cancer is a complex and broad disease that is challenging to treat, partially due to the vast molecular heterogeneity among patients even within the same subtype. Currently, no reliable method exists to determine which potential first-line therapy would be most effective for a specific patient, as randomized clinical trials have concluded that no single regimen may be significantly more effective than others. One ongoing challenge in the field of oncology is the search for personalization of cancer treatment based on patient data. With an interdisciplinary approach, we show that tumor-tissue derived metabolomics data is capable of predicting clinical response to …
Development And Application Of 3d Kinematic Methodologies For Biomechanical Modelling In Adaptive Sports And Rehabilitation, 2022 Clemson University
Development And Application Of 3d Kinematic Methodologies For Biomechanical Modelling In Adaptive Sports And Rehabilitation, Anne Marie Severyn
All Dissertations
Biomechanical analysis is widely used to assess human movement sciences, specifically using three-dimensional motion capture modelling. There are unprecedented opportunities to increase quantitative knowledge of rehabilitation and recreation for disadvantaged population groups. Specifically, 3D models and movement profiles for human gait analysis were generated with emphasis on post-stroke patients, with direct model translation to analyze equivalent measurements while horseback riding in use of the alternative form of rehabilitation, equine assisted activities and therapies (EAAT) or hippotherapy (HPOT). Significant improvements in gait symmetry and velocity were found within an inpatient rehabilitation setting for patients following a stroke, and the developed movement …