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Team Omnimouse, Derek J. Halman, Josh B. Porter, Steven A. Silver, Ian S. Stemper 2014 California Polytechnic State University - San Luis Obispo

Team Omnimouse, Derek J. Halman, Josh B. Porter, Steven A. Silver, Ian S. Stemper

Computer Engineering

INFORMATION, DATA, FIGURES AND DRAWINGS EMBODIED IN THIS DOCUMENT ARE STRICTLY CONFIDENTIAL AND ARE SUPPLIED ON THE UNDERSTANDING THAT THEY WILL NOT BE DISCLOSED TO THIRD PARTIES WITHOUT THE PRIOR WRITTEN CONSENT OF QUALITY OF LIFE PLUS.


Developing Defined And Scalable 3d Culture Systems For Culturing Human Pluripotent Stem Cells At High Densities, Yuguo Lei, Daeun Jeong, Jifang Xiao, David V. Schaffer 2014 University of Nebraska-Lincoln

Developing Defined And Scalable 3d Culture Systems For Culturing Human Pluripotent Stem Cells At High Densities, Yuguo Lei, Daeun Jeong, Jifang Xiao, David V. Schaffer

Chemical and Biomolecular Engineering -- All Faculty Papers

Human pluripotent stem cells (hPSCs)—including embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs)—are very promising candidates for cell therapies, tissue engineering, high throughput pharmacology screens, and toxicity testing. These applications require large numbers of high quality cells; however, scalable production of human pluripotent stem cells and their derivatives at a high density and under well-defined conditions has been a challenge. We recently reported a simple, efficient, fully defined, scalable, and good manufacturing practice (GMP) compatible 3D culture system based on a thermoreversible hydrogel for hPSC expansion and differentiation. Here, we describe additional design rationale and characterization ...


Developent Of A Phospholipid Encapsulation Process For Quantum Dots To Be Used In Biologic Applications, Logan Grimes 2014 California Polytechnic State University, San Luis Obispo

Developent Of A Phospholipid Encapsulation Process For Quantum Dots To Be Used In Biologic Applications, Logan Grimes

Master's Theses and Project Reports

The American Cancer Society predicts that 1,665,540 people will be diagnosed with cancer, and 585,720 people will die from cancer in 2014. One of the most common types of cancer in the United States is skin cancer. Melanoma alone is predicted to account for 10,000 of the cancer related deaths in 2014. As a highly mobile and aggressive form of cancer, melanoma is difficult to fight once it has metastasized through the body. Early detection in such varieties of cancer is critical in improving survival rates in afflicted patients. Present methods of detection rely on visual ...


Mr To Ultrasound Registration For Image-Guided Prostate Biopsy, Yue Sun 2014 The University of Western Ontario

Mr To Ultrasound Registration For Image-Guided Prostate Biopsy, Yue Sun

Electronic Thesis and Dissertation Repository

Transrectal ultrasound (TRUS) guided prostate biopsy is the standard approach for diagnosis of prostate cancer (PCa). However, due to the lack of image contrast of prostate tumors, it often results in false negatives. Magnetic Resonance Imaging (MRI) has been considered to be a promising imaging modality for noninvasive identification of PCa, since it can provide a high sensitivity and specificity for the detection of early stage PCa. Our main objective is to develop a registration method of 3D MR-TRUS images, allowing generation of volumetric 3D maps of targets identified in 3D MR images to be biopsied using 3D TRUS images ...


Investigating The Shelf Life Of Benzoyl Peroxide Coated Nozzles For Bone Cement Application, Alysen Leigh Demzik 2014 Syracuse University

Investigating The Shelf Life Of Benzoyl Peroxide Coated Nozzles For Bone Cement Application, Alysen Leigh Demzik

Syracuse University Honors Program Capstone Projects

Two-solution bone cements (TSBC) were developed to address the limitations of current powder-liquid bone cements, however are characterized by a limited shelf life due to spontaneous free radical polymerization. As a solution to pre-polymerization concerns, the initiator benzoyl peroxide (BPO) was removed from the cement solution and incorporated into a thin film coating within the static mixing nozzle, allowing the BPO to integrate with the TSBC as it is mixed for use. Only short-term storage of BPO-coated nozzles and the subsequent effects on bone cement properties is known. The goal of this study was to investigate the effects of time ...


A Study Of Ciliary Beating In Chlamydomonas, Xin Li 2014 Syracuse University

A Study Of Ciliary Beating In Chlamydomonas, Xin Li

Syracuse University Honors Program Capstone Projects

The goal of this research is to understand how a unicellular green alga, Chlamydomonas-reinhardtii, responds to red light (670nm) and sound waves, by monitoring the beating frequency of its two cilia, which control cell motility. Ciliary beating frequency (BF) is proportional to the production of ATP, mainly generated by photosynthesis. A photosynthesis inhibitor, 3-(3-, 4-dichlorophenyl)-1, 1-dimethylurea (DCMU) decreases ATP production by photosynthesis. I used DCMU as a tool to analyze the red light effect on BF.

In the process of studying the effect of red light, I unexpectedly discovered experimental conditions for unstable ciliary beating (as shown in ...


Preterm Birth: Prediction, Prevention, Care, Brandon Wesley Alleman 2014 University of Iowa

Preterm Birth: Prediction, Prevention, Care, Brandon Wesley Alleman

Theses and Dissertations

Preterm birth (PTB) is defined as birth before 37 weeks gestational age. PTB is a common outcome and one that may be increasing in prevalence with serious individual and public health implications both immediately and long term. While PTB is a pregnancy specific outcome it is more appropriately viewed as the culmination of risk factors present both before pregnancy and possibly in past generations. This thesis attempts to review the implications, risk factors and current prevention strategies directed at PTB while placing it in an intergenerational and life cycle context. Three novel investigations are presented and their consequences are discussed ...


Application Of Limited Mixing In The Hele-Shaw Geometry In Fabrication Of Janus Hydrogels, Md Mahmudur Rahman 2014 University of Nebraska-Lincoln

Application Of Limited Mixing In The Hele-Shaw Geometry In Fabrication Of Janus Hydrogels, Md Mahmudur Rahman

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

It is widely accepted that cells behave differently responding to the stiffness of their extracellular matrix (ECM). Such observations were made by culturing cells on hydrogel substrates of tunable stiffness. However, it was recently proposed that cells may sense how strongly they are tethered to ECM, not the local stiffness of ECM. To investigate both hypotheses, we developed a method to fabricate Janus polyacrylamide (PAAM) gels. We squeeze two drops of different concentrations in the Hele-Shaw geometry to generate radial Stokes flow. When the drops coalesce, limited mixing occurs at the interface due to the narrow confinement, and diffusion normal ...


Material Differences In Equine Cortical And Trabecular Bone, Ryan B. Allen 2014 California Polytechnic State University, San Luis Obispo

Material Differences In Equine Cortical And Trabecular Bone, Ryan B. Allen

Master's Theses and Project Reports

A greater understanding of bone materials would be beneficial in creating more accurate computer models and in the making of biomedical products involving bone. This study set out to determine whether cortical and trabecular bone are two separate materials, or whether they are the same material with a variance in porosity. To answer this question, samples were taken from different sections of the equine metacarpus, underwent densitometry analysis and were statistically analyzed. The majority of results suggest that the material is the same between varying densities of bone and thus the same between cortical and trabecular bone. These particular results ...


Investigating The Role Of A Less Uranium Tolerant Strain, Isolated From The Hanford Site Soil, On Uranium Interaction In Polyphosphate Remediation Technology, Paola Sepulveda Medina 2014 Florida International University

Investigating The Role Of A Less Uranium Tolerant Strain, Isolated From The Hanford Site Soil, On Uranium Interaction In Polyphosphate Remediation Technology, Paola Sepulveda Medina

FIU Electronic Theses and Dissertations

Bacteria are key players in the processes that govern fate and transport of contaminants. Previous assessment showed that the Arthrobacter oxydans (A.oxydans) G968 strain has a lower ability to tolerate U(VI) toxicity in bicarbonate-free media compared to other isolate A.oxydans G975. The study experimentally investigated several parameters such as the potential of bicarbonate to accelerate U(VI) release from autunite mineral in the presence of a less U(VI) tolerant bacterial strain, in the conditions mimicking Hanford Site subsurface environments. Results showed that despite morphological differences between the two bacterial strains, A.oxydans G968 and G975, they ...


Human Cardiovascular Responses To Artificial Gravity Variables: Ground-Based Experimentation For Spaceflight Implementation, Mark Howarth 2014 University of Kentucky

Human Cardiovascular Responses To Artificial Gravity Variables: Ground-Based Experimentation For Spaceflight Implementation, Mark Howarth

Theses and Dissertations--Biomedical Engineering

One countermeasure to cardiovascular spaceflight deconditioning being tested is the application of intermittent artificial gravity provided by centripetal acceleration of a human via centrifuge. However, artificial gravity protocols have not been optimized for the cardiovascular system, or any other physiological system for that matter. Before artificial gravity protocols can be optimized for the cardiovascular system, cardiovascular responses to the variables of artificial gravity need to be quantified.

The research presented in this document is intended to determine how the artificial gravity variables, radius (gravity gradient) and lower limb exercise, affect cardiovascular responses during centrifugation. Net fluid (blood) shifts between body ...


Novel Technologies For The Detection And Mitigation Of Drowsy Driving, Samuel Lawoyin 2014 Virginia Commonwealth University

Novel Technologies For The Detection And Mitigation Of Drowsy Driving, Samuel Lawoyin

Theses and Dissertations

In the human control of motor vehicles, there are situations regularly encountered wherein the vehicle operator becomes drowsy and fatigued due to the influence of long work days, long driving hours, or low amounts of sleep. Although various methods are currently proposed to detect drowsiness in the operator, they are either obtrusive, expensive, or otherwise impractical. The method of drowsy driving detection through the collection of Steering Wheel Movement (SWM) signals has become an important measure as it lends itself to accurate, effective, and cost-effective drowsiness detection. In this dissertation, novel technologies for drowsiness detection using Inertial Measurement Units (IMUs ...


Analysis And Modeling Of The Roles Of Actin-Myosin Interactions In Bladder Smooth Muscle Biomechanics, Seyed Omid komariza 2014 Virginia Commonwealth University

Analysis And Modeling Of The Roles Of Actin-Myosin Interactions In Bladder Smooth Muscle Biomechanics, Seyed Omid Komariza

Theses and Dissertations

Muscle mechanical behavior potentially plays an important role in some of the most common bladder disorders. These include overactive bladder, which can involve involuntary contractions during bladder filling, and impaired contractility or underactive bladder, which may involve weak or incomplete contractions during voiding. Actin-myosin cross-bridges in detrusor smooth muscle (DSM) are responsible for contracting and emptying the bladder. The total tension produced by muscle is the sum of its preload and active tensions. Studies suggest that actin-myosin cross-links are involved in adjustable preload stiffness (APS), which is characterized by a preload tension curve that can be shifted along the length ...


The Effect Of Various Pathologies On Bone Quality, Daniel S. Porter 2014 University of Kentucky

The Effect Of Various Pathologies On Bone Quality, Daniel S. Porter

Theses and Dissertations--Biomedical Engineering

Bone’s ability to resist fracture is often ignored until a low-energy fracture occurs. Patients with Chronic Kidney Disease (CKD) or osteoporosis are at an increased risk of low-energy fracture. Generally, fracture risk is evaluated by using a bone mineral density (BMD) test. BMD values; however, do not fully predict bone’s ability to resist fracture. This suggests that other parameters may be involved. Bone quality is the term used to describe these parameters, which are categorized into three groups: structural, material, and microdamage. The aim of this dissertation research was to examine whether bone quality was altered in patients ...


From Cardiac Optical Imaging Data To Body Surface Ecg: A Three Dimensional Ventricle Model, Yihua Zhao 2014 University of Kentucky

From Cardiac Optical Imaging Data To Body Surface Ecg: A Three Dimensional Ventricle Model, Yihua Zhao

Theses and Dissertations--Biomedical Engineering

Understanding the mechanisms behind unexplained abnormal heart rhythms is important for diagnosis and prevention of arrhythmias. Many studies have investigated the mechanisms at organ, tissue, cellular and molecular levels. There is considerable information available from tissue level experiments that investigate local action potential properties and from optical imaging to observe activity propagation properties at an organ level. By combining those electrophysiological properties together, in the present study we developed a simulation model that can help in estimation of the resulting body surface potentials from a specific electrical activity pattern within the myocardium. Some of the potential uses of our model ...


Reconstruction Of Patient-Specific Bone Models From X-Ray Radiography, Hatem Amin Abdel Fattah El Dakhakhni 2013 University of Tennessee - Knoxville

Reconstruction Of Patient-Specific Bone Models From X-Ray Radiography, Hatem Amin Abdel Fattah El Dakhakhni

Doctoral Dissertations

The availability of a patient‐specific bone model has become an increasingly invaluable addition to orthopedic case evaluation and planning [1]. Utilized within a wide range of specialized visualization and analysis tools, such models provide unprecedented wealth of bone shape information previously unattainable using traditional radiographic imaging [2]. In this work, a novel bone reconstruction method from two or more x‐ray images is described. This method is superior to previous attempts in terms of accuracy and repeatability. The new technique accurately models the radiological scene in a way that eliminates the need for expensive multi‐planar radiographic imaging systems ...


Automated Fragmentary Bone Matching, Ali Saad Mustafa 2013 University of Tennessee - Knoxville

Automated Fragmentary Bone Matching, Ali Saad Mustafa

Masters Theses

Identification, reconstruction and matching of fragmentary bones are basic tasks required to accomplish quantification and analysis of fragmentary human remains derived from forensic contexts. Appropriate techniques for three-dimensional surface matching have received great attention in computer vision literature, and various methods have been proposed for matching fragmentary meshes; however, many of these methods lack automation, speed and/or suffer from high sensitivity to noise. In addition, reconstruction of fragementary bones along with identification in the presence of reference model to compare with in an automatic scheme have not been addressed. In order to address these issues, we used a multi-stage ...


Mechanical Properties Of Bone Due To Sost Expression: Nanoindentation Assessment Of Murine Femurs, Amir Rafie 2013 Cal Poly San Luis Obispo

Mechanical Properties Of Bone Due To Sost Expression: Nanoindentation Assessment Of Murine Femurs, Amir Rafie

Master's Theses and Project Reports

In the human genome, the SOST gene codes for a protein sclerostin. Sclerostin is an osteocyte-expressed negative regulator of bone formation. When the SOST gene is not coded, bone formation is reduced in individuals during skeletal maturation. This study utilizes nanoindentation methods to test for the mechanical properties of bones that both express and do not express the SOST gene. 100 transgenic murine femurs were obtained from Lawrence Livermore Labs in the form of 6 and 8 month SOST transgenic mice, 6 and 12 month SOST knockout mice, and wild type control littermates for each of the 4 age groups ...


Analysis, Segmentation And Prediction Of Knee Cartilage Using Statistical Shape Models, Joseph Michael Johnson 2013 University of Tennessee - Knoxville

Analysis, Segmentation And Prediction Of Knee Cartilage Using Statistical Shape Models, Joseph Michael Johnson

Doctoral Dissertations

Osteoarthritis (OA) of the knee is one of the leading causes of chronic disability (along with the hip). Due to rising healthcare costs associated with OA, it is important to fully understand the disease and how it progresses in the knee. One symptom of knee OA is the degeneration of cartilage in the articulating knee. The cartilage pad plays a major role in painting the biomechanical picture of the knee. This work attempts to quantify the cartilage thickness of healthy male and female knees using statistical shape models (SSMs) for a deep knee bend activity. Additionally, novel cartilage segmentation from ...


Physiological Fluid Specific Agglomeration Patterns Diminish Gold Nanorod Photothermal Characteristics, Kristen K. Comfort, Jared W. Speltz, Bradley M. Stacy, Larry R. Dosser, Saber M. Hussain 2013 University of Dayton

Physiological Fluid Specific Agglomeration Patterns Diminish Gold Nanorod Photothermal Characteristics, Kristen K. Comfort, Jared W. Speltz, Bradley M. Stacy, Larry R. Dosser, Saber M. Hussain

Chemical and Materials Engineering Faculty Publications

Investigations into the use of gold nanorods (Au-NRs) for biological applications are growing exponentially due to their distinctive physicochemical properties, which make them advantageous over other nanomaterials. Au-NRs are particularly renowned for their plasmonic characteristics, which generate a robust photothermal response when stimulated with light at a wavelength matching their surface plasmon resonance. Numerous reports have explored this nanophotonic phenomenon for temperature driven therapies; however, to date there is a significant knowledge gap pertaining to the kinetic heating profile of Au-NRs within a controlled physiological setting. In the present study, the impact of environmental composition on Au-NR behavior and degree ...


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