Statistical Theory Commons^™

On Two-Stage Hypothesis Testing Procedures Via Asymptotically Independent Statistics, James Dai, Charles Kooperberg, Michael L. Leblanc, Ross Prentice

UW Biostatistics Working Paper Series

Kooperberg and LeBlanc (2008) proposed a two-stage testing procedure to screen for significant interactions in genome-wide association (GWA) studies by a soft threshold on marginal associations (MA), though its theoretical properties and generalization have not been elaborated. In this article, we discuss conditions that are required to achieve strong control of the Family-Wise Error Rate (FWER) by such procedures for low or high-dimensional hypothesis testing. We provide proof of asymptotic independence of marginal association statistics and interaction statistics in linear regression, logistic regression, and Cox proportional hazard models in a randomized clinical trial (RCT) with a rare event. In case-control …

Stratifying Subjects For Treatment Selection With Censored Event Time Data From A Comparative Study, Lihui Zhao, Tianxi Cai, Lu Tian, Hajime Uno, Scott D. Solomon, L. J. Wei

Harvard University Biostatistics Working Paper Series

No abstract provided.

On Two-Stage Hypothesis Testing Procedures Via Asymptotically Independent Statistics, James Y. Dai, Charles Kooperberg, Michael Leblanc, Ross L. Prentice

UW Biostatistics Working Paper Series

Kooperberg08 proposed a two-stage testing procedure to screen for significant interactions in genome-wide association (GWA) studies by a soft threshold on marginal associations (MA), though its theoretical properties and generalization have not been elaborated. In this article, we discuss conditions that are required to achieve strong control of the Family-Wise Error Rate (FWER) by such procedures for low or high-dimensional hypothesis testing. We provide proof of asymptotic independence of marginal association statistics and interaction statistics in linear regression, logistic regression, and Cox proportional hazard models in a randomized clinical trial (RCT) with a rare event. In case-control studies nested within …

A Perturbation Method For Inference On Regularized Regression Estimates, Jessica Minnier, Lu Tian, Tianxi Cai

Harvard University Biostatistics Working Paper Series

No abstract provided.

Principled Sure Independence Screening For Cox Models With Ultra-High-Dimensional Covariates, Sihai Dave Zhao, Yi Li

Harvard University Biostatistics Working Paper Series

No abstract provided.

Optimizing Randomized Trial Designs To Distinguish Which Subpopulations Benefit From Treatment, Michael Rosenblum, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

It is a challenge to evaluate experimental treatments where it is suspected that the treatment effect may only be strong for certain subpopulations, such as those having a high initial severity of disease, or those having a particular gene variant. Standard randomized controlled trials can have low power in such situations. They also are not optimized to distinguish which subpopulations benefit from a treatment. With the goal of overcoming these limitations, we consider randomized trial designs in which the criteria for patient enrollment may be changed, in a preplanned manner, based on interim analyses. Since such designs allow data-dependent changes …

The Strength Of Statistical Evidence For Composite Hypotheses: Inference To The Best Explanation, David R. Bickel

COBRA Preprint Series

A general function to quantify the weight of evidence in a sample of data for one hypothesis over another is derived from the law of likelihood and from a statistical formalization of inference to the best explanation. For a fixed parameter of interest, the resulting weight of evidence that favors one composite hypothesis over another is the likelihood ratio using the parameter value consistent with each hypothesis that maximizes the likelihood function over the parameter of interest. Since the weight of evidence is generally only known up to a nuisance parameter, it is approximated by replacing the likelihood function with …

Model-Robust Regression And A Bayesian `Sandwich' Estimator, Adam A. Szpiro, Kenneth M. Rice, Thomas Lumley

UW Biostatistics Working Paper Series

The published version of this paper in Annals of Applied Statistics (Vol. 4, No. 4 (2010), 2099–2113) is available from the journal web site at http://dx.doi.org/10.1214/10-AOAS362.

We present a new Bayesian approach to model-robust linear regression that leads to uncertainty estimates with the same robustness properties as the Huber-White sandwich estimator. The sandwich estimator is known to provide asymptotically correct frequentist inference, even when standard modeling assumptions such as linearity and homoscedasticity in the data-generating mechanism are violated. Our derivation provides a compelling Bayesian justification for using this simple and popular tool, and it also clarifies what is being estimated …

Asymptotic Properties Of The Sequential Empirical Roc And Ppv Curves, Joseph S. Koopmeiners, Ziding Feng

UW Biostatistics Working Paper Series

The receiver operating characteristic (ROC) curve, the positive predictive value (PPV) curve and the negative predictive value (NPV) curve are three common measures of performance for a diagnostic biomarker. The independent increments covariance structure assumption is common in the group sequential study design literature. Showing that summary measures of the ROC, PPV and NPV curves have an independent increments covariance structure will provide the theoretical foundation for designing group sequential diagnostic biomarker studies. The ROC, PPV and NPV curves are often estimated empirically to avoid assumptions about the distributional form of the biomarkers. In this paper we derive asymptotic theory …

Estimating Causal Effects In Trials Involving Multi-Treatment Arms Subject To Non-Compliance: A Bayesian Frame-Work, Qi Long, Roderick J. Little, Xihong Lin

Harvard University Biostatistics Working Paper Series

No abstract provided.

Super Learner In Prediction, Eric C. Polley, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

Super learning is a general loss based learning method that has been proposed and analyzed theoretically in van der Laan et al. (2007). In this article we consider super learning for prediction. The super learner is a prediction method designed to find the optimal combination of a collection of prediction algorithms. The super learner algorithm finds the combination of algorithms minimizing the cross-validated risk. The super learner framework is built on the theory of cross-validation and allows for a general class of prediction algorithms to be considered for the ensemble. Due to the previously established oracle results for the cross-validation …

Assessing Noninferiority In A Three-Arm Trial Using The Bayesian Approach, Pulak Ghosh, Farouk S. Nathoo, Mithat Gonen, Ram C. Tiwari

Memorial Sloan-Kettering Cancer Center, Dept. of Epidemiology & Biostatistics Working Paper Series

Non-inferiority trials, which aim to demonstrate that a test product is not worse than a competitor by more than a pre-specified small amount, are of great importance to the pharmaceutical community. As a result, methodology for designing and analyzing such trials is required, and developing new methods for such analysis is an important area of statistical research. The three-arm clinical trial is usually recommended for non-inferiority trials by the Food and Drug Administration (FDA). The three-arm trial consists of a placebo, a reference, and an experimental treatment, and simultaneously tests the superiority of the reference over the placebo along with …

Derivation Of Mass Independent Quantum Treatment Of Phenomenon, David Parker

Journal of Modern Applied Statistical Methods

The derivation and applications is presented of a spatial variable or spatial radius which is related to the inertia or mass-energy of any quantum body by a Lorentz invariant relation. Mass independent DeBroglie and Schroedinger equations are derived and applied to the resolution of the linguistic incompatibility between quantum theory and the geometrical weak equivalence principle. The equivalence principle is restated in terms of the spatial radius. The gravitational attraction between bodies and the relativistic energy are both presented in terms of the spatial radius follows. The ratio of the gravitational force to the Coulomb force at the Planck scale …

Ranked Set Sampling Using Auxiliary Variables Of A Randomized Response Procedure For Estimating The Mean Of A Sensitive Quantitative Character, Carlos N. Bouza

Journal of Modern Applied Statistical Methods

The analysis of the behavior of estimators of the mean of a sensitive variable is considered when a randomized response procedure is used. The results deal with the inference based on simple random sampling with replacement study design. A study of the behavior of the procedures for a ranked set sampling design is developed. A gain in accuracy is generally associated with the proposed alternative model.

An Equivalence Test Based On N And P, Markus Neuhäeuser

Journal of Modern Applied Statistical Methods

An equivalence test is proposed which is based on the P-value of a test for a difference and the sample size. This test may be especially appropriate for an exploratory re-analysis if only a non-significant test for a difference was reported. Thus, neither a confidence interval is available, nor is there access to the raw data. The test is illustrated using two examples; for both applications the smallest equivalence range for which equivalence could be demonstrated is calculated.

The Effectiveness Of Stepwise Discriminant Analysis As A Post Hoc Procedure To A Significant Manova, Erik L. Heiny, Daniel J. Mundform

Journal of Modern Applied Statistical Methods

The effectiveness of SWDA as a post hoc procedure in a two-way MANOVA was examined using various numbers of dependent variables, sample sizes, effect sizes, correlation structures, and significance levels. The procedure did not work well in general except with small numbers of variables, larger samples and low correlations between variables.

Model Based Vs. Model Independent Tests For Cross-Correlation, H.E.T. Holgersson, Peter S. Karlsson

Journal of Modern Applied Statistical Methods

This article discusses the issue of whether cross correlation should be tested by model dependent or model independent methods. Several different tests are proposed and their main properties are investigated analytically and with simulations. It is argued that model independent tests should be used in applied work.

On Exact 100(1-Α)% Confidence Interval Of Autocorrelation Coefficient In Multivariate Data When The Errors Are Autocorrelated, Madhusudan Bhandary

Journal of Modern Applied Statistical Methods

An exact 100(1−α)% confidence interval for the autocorrelation coefficient ρ is derived based on a single multinormal sample. The confidence interval is the interval between the two roots of a quadratic equation in ρ . A real life example is also presented.

The Performance Of Multiple Imputation For Likert-Type Items With Missing Data, Walter Leite, S. Natasha Beretvas

Journal of Modern Applied Statistical Methods

The performance of multiple imputation (MI) for missing data in Likert-type items assuming multivariate normality was assessed using simulation methods. MI was robust to violations of continuity and normality. With 30% of missing data, MAR conditions resulted in negatively biased correlations. With 50% missingness, all results were negatively biased.

Median-Unbiased Optimal Smoothing And Trend Extraction, Dimitrios D. Thomakos

Journal of Modern Applied Statistical Methods

The problem of smoothing a time series for extracting its low frequency characteristics, collectively called its trend, is considered. A competitive approach is proposed and compared with existing methods in choosing the optimal degree of smoothing based on the distribution of the residuals from the smooth trend.