Statistical Models Commons^™

Computational Insights Into Nucleosome Dynamics In Epigenetics Using Molecular Dynamics Simulations, Rutika Patel

Dissertations, Theses, and Capstone Projects

Nucleosome core particles (NCP) are the building blocks that form a highly organized and compact chromatin structure. Nucleosomes package DNA in the nucleus of eukaryotic cells. The NCP consists of about 147 base pairs of DNA wrapped around the histone octamer, with 1.65 superhelical turns in a left-handed manner. The histone octamer is composed of two copies of H3, H4, H2A, and H2B. Together with histone H1 and linker DNA, they further assemble into a higher-order chromatin structure. The nucleosome complex is stabilized by electrostatic interactions between positively charged histone residues and the negatively charged DNA backbone. To effectively access …

A Predictive Coding Account Of Spatial Working Memory Following Prophylactic Levetiracetam Administration Prior To Traumatic Brain Injury, Omeima Mutwali

Dissertations, Theses, and Capstone Projects

Traumatic brain injury (TBI) symptom prevention and remediation is an important area of research that would benefit vulnerable groups, including active-duty and veteran soldiers. These patients can sustain penetrative forces in fields of combat or in training, which result in focal lesions that trigger inflammatory and degenerative processes in the brain. Both primary and secondary injuries are associated with changes to cognition, behavior and affective state. This disease poses increased risk of epileptogenesis, as well. Given these outcomes, prior research has evaluated levetiracetam (LEV) as a prophylactic treatment for seizures, cognitive deficits and negative emotionality. LEV acts as a presynaptic …

Reexamining The Croton Aqueduct: A Ward-Level Microhistorical Analysis Of Infrastructure And Cholera Mortality In 1849 New York City, Alexandria R. Toothman

Dissertations, Theses, and Capstone Projects

This work reexamines the Croton Aqueduct’s role in public health by shifting analysis from the citywide level to the ward level, revealing that infrastructure expansion did not produce uniform benefits across New York City. When the Croton Aqueduct opened in 1842, it was celebrated as an achievement that would deliver pure water and eliminate disease. However, only seven years after its opening, in 1849, cholera returned with greater force in the Sixth Ward. This work shows that the uneven distribution of Croton infrastructure corresponded with uneven cholera mortality rates, challenging narratives that present Croton as a singular triumph of urban …

Bayesian Spatiotemporal Model For Counterfactual Estimation In Socioeconomic Studies, Duwani W. Gonzalez

Statistical Science Theses and Dissertations

Impact evaluations of regional development programs often require estimating counterfactual outcomes for a small number of treated regions using survey-based areal data. In practice, evaluators typically rely on two-group quasi-experimental methods such as propensity score matching (PSM) and Difference-in-Differences (DiD). These approaches perform poorly when only a few regions receive treatment, and when the set of observed covariates is limited or only partially relevant. Moreover, they typically do not explicitly exploit the spatial and temporal dependence present in survey-based areal data such as in ACS (American Community Survey). This dissertation develops a family of Bayesian spatial predictive models for directly …

Bayesian Designs For Two-Arm Clinical Trials With Time-To-Event Endpoints: Incorporating Historical Data Through Power Priors, Sara Hajraf H. Almutiri

Mathematics & Statistics ETDs

Bayesian methods provide a flexible framework for time-to-event analysis by incorporating prior information. The power prior offers a systematic way to borrow information from historical data. This approach is especially valuable in clinical research, where historical data can enhance inference in early-phase trials with limited sample sizes. This dissertation develops Bayesian approaches for two-arm survival studies using both closed-form and simulation-based methods. The closed-form inference is derived under exponential and Weibull survival models. Under the proportional hazards framework, the posterior is derived through a normal approximation to the log hazard ratio, allowing inference on the treatment effect when the variance …

Delineating Differences In Firing Rate Estimates Of Healthy And Parkinsonian Single-Unit Basal Ganglia Recordings, Richard R. Foster, Cheng Ly

Biology and Medicine Through Mathematics Conference

No abstract provided.

Using Effect Sizes, Confidence Intervals, And The Bayes Factor To Better Understand The T-Test, Analysis Of Variance, And Regression Results, Holmes Finch

Perspectives on Early Childhood Psychology and Education

Null hypothesis testing is a widely used paradigm for assessing research hypotheses across the social sciences. Despite their ubiquity, researchers have discussed a number of problems and limitations to hypothesis testing and have suggested alternatives that might provide greater depth and explanation of research results. The purpose of this paper is to describe the use of several such alternatives and to show how they can be integrated with one another and with null hypothesis testing in order to provide a more holistic view of research hypotheses.

Freshman 15? Freshman 50?? The Reality Of Daily Life Habits Of A First Year College Student, Gregorio R. Salgado

Student Scholar Symposium Abstracts and Posters

This project presents a personal data tracking study in which I collected daily self-reported metrics over the course of the Spring semester using Excel. The variables tracked include sleep duration, caloric intake, screen time, social media usage, phone checks per day, family communication, and personal spending. The goal of this project is to identify meaningful patterns and correlations between daily habits and personal well-being.

Data was collected through a combination of manual logging and smartphone-generated daily reports. This study explores potential relationships between variables such as sleep duration and social media usage, as well as the association between family communication …

The Impatience Of Winning: An Analysis Of Time Discounting, Predictive Modeling, And The Nba Draft, Alec R. Plante

Business and Economics Honors Papers

This paper examines whether NBA draft decisions can be better explained by incorporating non-geometric time discounting into a model of general manager decision making. Using a dataset of 285 NBA draft prospects over a 12-year period, the impact of college statistics on Value Over Replacement Player (VORP) is determined, and these impact values are then used to create a “predicted” VORP for the first 4 seasons of each player’s career: a projection of what a general manager might think of a prospect’s future value given their college statistics. Following this, geometric and hyperbolic time discounting models are applied to estimate …

Do Dreams Reflect Our Culture? A Statistical Analysis On Dream Narratives, Michal Kuderski

Honors Capstones

Dreams are often viewed as personal experiences, but they may also reflect cultural influences. This project investigates whether dream content varies across cultures by analyzing written dream reports from American, Japanese, and Peruvian college students using data from DreamBank.net. The study applies text analysis techniques to identify common themes and compares language patterns, including the use of ‘I’ and 'We,' to examine differences in self-focus. Statistical methods for count data are used to evaluate these patterns, along with resampling to address differences in sample size. Preliminary findings suggest that both dream themes and language use may vary by cultural …

Base Running: A Lost Art In Baseball, Ethan York

Departmental Honors & Graduate Capstone Projects

In an era of baseball dominated by home runs and launch angles, the subtle art of baserunning is often overlooked, despite its measurable impact on winning games. Baserunning Runs (BsR) addresses this gap by quantifying the number of runs a player contributes through performance on the basepaths, capturing value beyond traditional metrics like stolen bases. This study constructs multiple regression models that predict BsR for Major League Baseball (MLB) players based on baserunning-related statistics. The primary objective is to examine the association between BsR and key predictors, including stolen bases (SB), extra bases taken (EB), and sprint speed (SS), while …

Pyspqr: A Python Package For Density Estimation Using Deep Learning, Cameron Eddy, Reetam Majumder

Electrical Engineering and Computer Science Undergraduate Honors Theses

Splines are used for representing complex functions. In statistics, splines can be used for distributional shapes that are difficult to model by traditional parametric approaches. Ramsay (1) uses M-Spline bases to estimate continuous distributions. Semi-Parametric Quantile Regression (SPQR), developed by Xu and Reich (2), models conditional distributions where a neural network is used to estimate the basis function weights that depend on covariates. (3) implements a package for SPQR in R. We build on this by implementing a version of SPQR in Python with PyTorch. By using PyTorch, we can use more sophisticated deep learning architectures than those available in …

Multi-Population Sufficient Dimension Reduction, Xuerong Meggie Wen, Yuexiao Dong, Li Xing Zhu

Mathematics and Statistics Faculty Research & Creative Works

A novel dimension-reduction method is introduced for multi-population data. The approach conducts a joint analysis that exploits information shared across populations while accommodating population-specific effects. Unlike partial dimension reduction methods, which identify related directions across all populations, or conditional analyses conducted independently within each population, the proposed two-step procedure leverages cross-population information to enhance estimation accuracy. The methodology is demonstrated through simulations and two real-data applications.

Factors Affecting Pedestrian-Vehicle Conflicts: An Empirical Analysis, Christo D. Jamo

Honors Scholar Theses

The number of pedestrian deaths increased by 78% between 2009 and 2023, while other motor vehicle crash deaths increased by 13% in the same period [1]. To identify potential pedestrian safety measures, this study analyzed the effects of location-based demographics, pedestrian phasing type, and other physical infrastructure and behavior variables on the probability of pedestrian-vehicle conflicts at signalized intersections, which is a surrogate measure of crash risk. Data were collected from 55 intersections in Connecticut, and the pedestrian-vehicle interactions were classified by severity based on the Swedish Traffic Conflict Technique: undisturbed passage, potential conflict, minor conflict, or serious conflict. Because …

Pattern Dynamics And Stochasticity Of Brain Rhythms And Spike Trains In A Tauopathy Mouse Model Of Alzheimer’S Disease, Clarissa M. Hoffman

Dissertations and Theses (Open Access)

Systems neuroscience posits that every aspect of perceived physical reality, every aspect of animal and human behavior, and every cognitive phenomenon emerges from patterns of neuronal activity. While most researchers embrace this idea, there are major difficulties in describing and analyzing these complex neuronal dynamics—spike flows produced by cells ensembles, synchronized extracellular field oscillations, and other patterns—which limits our understanding of how the activity of individual neurons and the whole-animal cognition and behavior might be connected. In particular, we lack the approaches and even the semantics for connecting the individual cell outputs and the integrated results of their activity. Current …

A New Approach To Generate Combinatorial Patterns In Logical Analysis Of Data And Its Application To Predict College Retention, Salihah Ahmed E. Jaafari

Theses and Dissertations

Student retention and degree completion remain central challenges for higher-education institutions, with significant implications for student success, institutional effectiveness, and public accountability. While advances in predictive analytics have enabled earlier identification of students at risk of withdrawal, many commonly used machine learning approaches suffer from limited interpretability, constraining their practical usefulness for advising, intervention, and policy decision making. This dissertation addresses the problem of predicting student persistence by developing and evaluating optimization based, interpretable classification models within the Logical Analysis of Data (LAD) framework. Building on existing LAD formulations, this research introduces two novel pattern generation models, the Best Term …

High Throughput Phenomics Pipeline For Pulse Crop Nutritional Breeding, Amod Udayanga Madurapperumage

All Dissertations

Dry pea (Pisum sativum L.), lentil (Lens culinaris Medik.), and chickpea (Cicer arietinum L.) are major pulse crops valued for their high nutritional composition and importance to global food systems. Pulses are rich in carbohydrates, protein, and essential minerals, making them ideal whole foods and critical contributors to food and nutrition security. Due to these advantages, pulse breeding programs are increasingly focusing on enhancing nutritional traits, such as protein quality, amino acid balance, and micronutrient density, through the process of biofortification. However, improvement of agronomic traits remains equally essential. Characteristics such as plant height, standability, stress tolerance, …

The Item Response Warehouse: What It Is, How To Use It, And Targets For Potential Improvements, Savira D. Nadela, Hansol Lee, Nishka Jain, Ayaan Gupta, Xingyi Zhang, Benjamin W. Domingue

Chinese/English Journal of Educational Measurement and Evaluation | 教育测量与评估双语期刊

The Item Response Warehouse (IRW) is a repository of harmonized item response datasets designed to support secondary analysis and methodological research in psychological and educational measurement. This paper serves as a practical guide for researchers interested in using the IRW. We describe the structure of IRW datasets and the quantitative and qualitative metadata available for dataset selection, and we demonstrate how researchers can navigate the IRW website to explore and compare available tables. We further show how the IRW R and Python packages can be used to filter datasets programmatically, download response-level data, and generate standardized citations for reproducible research …

Ownership Duration In The U.S. Business Jet Market, Yuchen Hu

SACAD: Scholarly Activities

This study analyzes ownership duration in the U.S. business jet market using FAA registry data as of February 16, 2026 (N=12,359). The analysis reveals a structured distribution with a mean of 5.86 years and a median of 5.00 years. Crucially, retention varies by acquisition status: new aircraft owners exhibit an average hold of 7.36 years, whereas pre-owned aircraft holders show a significantly higher turnover of 5.11 years, with most resales occurring within a 3–7-year window. These findings suggest that ownership behavior is driven by structured asset management and lifecycle planning, providing a predictive framework for identifying aircraft replacement and trade-in …

Drainage Proximity And Sinkhole Occurrence In Sivrihisar (Central Turkey): A Comparative Analysis Of Linear, Poisson, And Negative Binomial Regression Models, Bilge Bingül, Emrah Pekkan, Resul Çömert

International Journal of Speleology

This study investigates the relationship between sinkhole occurrence and distance to drainage in the Sivrihisar region (Central Turkey) and evaluates the suitability of different regression approaches for modeling clustered count data in karst terrains. A comprehensive inventory of 104 sinkholes developed within the Neogene lacustrine limestones of the Akpınar Formation was compiled using official records, remote sensing analyses, and detailed field surveys. Sinkhole occurrences were analyzed relative to a drainage network derived from a high-resolution Digital Surface Model and grouped by proximity to drainage lines. Linear Regression (LM), Poisson Regression (PR), and Negative Binomial Regression (NBR) models were comparatively applied …