Statistical Methodology Commons^™

Towards Reliable Clinical Applications Of Ai Models In Radiotherapy, Biling Wang

Statistical Science Theses and Dissertations

Over the past decade, artificial intelligence (AI), particularly through deep learning (DL) techniques, has made significant strides in fields like computer vision (CV) and natural language processing (NLP), leading to transformative advancements across numerous applications. This progress has sparked considerable enthusiasm within the medical field, where DL-related research has grown exponentially since 2015. However, despite these promising developments, the real-world deployment of DL models in healthcare remains limited, especially in safety-critical domains such as radiotherapy (RT), where reliability, safety, and sustained performance are critical. This thesis addresses three core challenges associated with the clinical application of DL models: (1) post-deployment …

Performance Of The Two Sample Likelihood Ratio Test Under A Nested Dirichlet: A Simulation Study, Edwina Agyeman

Electronic Theses and Dissertations

Compositional data analysis (CoDA) addresses multivariate data constrained to a constant sum, such as proportions or percentages. Originating from early warnings regarding misinterpretation by Pearson (1897), the field was formalized by John Aitchison in 1986, whose foundational work remains highly influential. Over time, new modeling techniques and visualization tools have advanced the field, as noted by Greenacre et al. More recently, Turner et al. proposed an approach based on the Nested Dirichlet Distribution (NDD), which accommodates more flexible dependence structures than the standard Dirichlet model. This thesis builds on the methodology of Turner et al. Chapter 1 introduces the nature …

Evaluating Alpha Spending Functions Applied To Observational Time-To-Event Analysis, Moses Torgbenu

Electronic Theses and Dissertations

This thesis explores the theoretical foundation of the alpha spending approach and extends its application beyond the conventional setting of randomized controlled trials (RCTs) to observational studies with time to event analyses. In these less structured environments, key design parameters such as the total number of events are often unknown, posing challenges for the standard implementation of sequential analysis methods.

Through simulation studies, this research delivers several important contributions. First, it presents a modified approach that uses calendar time to define the timing of interim analyses while relying on event-based information to estimate the correlation among test statistics. This adjustment …

Experimental Design And Analysis For Decision Making: Methodology And Applications, Yezhuo Li

All Dissertations

This dissertation develops and applies advanced statistical and optimization frameworks to enhance decision-making under uncertainty, particularly in engineering and manufacturing contexts. First, we introduce an approach for the optimal design of controlled experiments that accounts for observational covariates, enabling more precise and personalized decisions. Second, we explore the application of constrained Bayesian optimization, using Gaussian process surrogate models, to optimize composite cure processes, significantly reducing computational effort while maintaining high predictive accuracy. Building on this foundation, we extend Bayesian optimization to bivariate Gaussian process models that capture correlations between objective and constraint functions, offering new insights into multidimensional decision landscapes. …

Multivariate Mixture Regression Models With Known Group Membership And Informative Priors, Pahalapathirage Dona Kalani Hasanthika

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

We introduced couple different novel approaches to incorporate latent variable information to multivariate mixture regression models with both Gaussian and count data. We also evaluated the performance of these models with existing best approaches with simulated data from various sampling structures and also evaluated one of the models performance with rice metabolite data that provided some novel insights as well as validating existing literature about performance and behavior of these metabolites. We validated the method using extensive simulations and a real-world application. In both quantitative covariate designs and complex treatment design simulations, our method consistently outperformed established tools like limma, …

Estimation Methods For Bayesian Exponential Random Graph Models Under The Horseshoe Prior., Pamela Linares

Electronic Theses and Dissertations

Networks are powerful tools for modeling the complexity of social interactions, biological systems, and information spread. A leading statistical frameworks for analyzing network data are Exponential Random Graph Models (ERGMs), which provide a principled approach to capturing structural dependencies. However, ERGMs remain challenging to estimate, especially in sparse or high-dimensional settings where models suffer from degeneracy and unstable parameter inference. This paper proposes a penalized Bayesian approach to ERGMs that utilizes the horseshoe prior, a sparsity-inducing global-local shrinkage prior. This prior offers robust regularization while preserving important signals, improving estimation by shrinking irrelevant parameters and reducing the impact of extreme …

Study On Reasonable Parameters Of Natural Smoke Exhaust Shafts In Tunnels With Different Longitudinal Slopes, Yang Tao, Zeng Yuekai, Li Peijun, Ren Rui, Deng Min, Zhang Aoyu

Journal of China & Foreign Highway

To obtain the reasonable parameters of a smoke exhaust shaft in a tunnel under different longitudinal slope conditions,the temperature,flow velocity,and smoke exhaust efficiency of the tunnel were taken as indexes,and the numerical model was established by using fire dynamics simulator (FDS ) software to study the influence of the longitudinal slope of the tunnel,shaft width,and shaft length on the ventilation and smoke exhaust in case of a fire.The results show that under the longitudinal slope conditions,with the increase in the shaft width and length,the maximum temperature in the tunnel decreases,and the smoke exhaust efficiency of the shaft increases.However,the influence of …

Study On Salt Release Mechanism Of Self-Melting Ice Asphalt Mixture And Its Impact On Road Performance, Li Tao, Zhang Xiu ’Ang

Journal of China & Foreign Highway

To study the long-term salt release characteri stics of self-melting ice asphalt mixture and the impact of the complete salt release on pavement durability,an accelerated salt release method was developed using a Los Angeles abrasion tester.The salt release mechanism under varying asphalt types,deicing agent contents,and gradation types was revealed.The impact of the complete salt release on road performance was analyzed.Results show that the Los Angeles abrasion tester-based salt release method achieves 91 times and 114 times higher salt release efficiency than the magnetic stirrer and natural immersion methods,respectively.SBS-modified asphalt mixture exhibits a longer salt release duration.The salt release duration is …

Research On Size Effect On Cubic Compressive Strength Of Ground Granulated Blast Furnace Slag-Fly Ash Stabilized Large-Size Macadam, Liu Qunyan, Liu Liping, He Miao, Yuan Lingqing, Zhang Liang

Journal of China & Foreign Highway

To analyze the effect of specimen size on the compressive strength of ground granulated blast furnace slag-fly ash (GGBFS-FA ) stabilized large-size macadam,the 200 mm × 200 mm × 200 mm cubic specimen and 3 d compressive strength were designated as a reference specimen and strength in this study,and numerical simulations of compressive strength were performed by using a discrete element method for GGBFS-FA stabilized large-size macadam specimens with a maximum particle size (dmax) of 73 mm and five side lengths of 2.0dmax,2.5dmax,3.0dmax,3.5dmax,and 4.0dmax.The size effect mechanism on the mixture ’s compressive strength was revealed from the perspective of energy.By …

Effect Of Mineral Admixtures On Properties Of Shotcrete, Ma Kaikai, Zhao Feng, Sun Rongxiao, Han Song, Hu Peng, Wang Kun

Journal of China & Foreign Highway

To study the influence of different mineral admixtures on the properties of shotcrete,the effects of four kinds of mineral admixtures including fly ash,silica fume,metakaolin,and carbon black on the rebound rate,one-shot thickness,and compressive strength of shotcrete were analyzed through tests on concrete rebound rate,one-shot thickness,and compressive strength.The results show that:① as the content of carbon black,silica fume,and metakaolin increases from 5% to 10%,the rebound rate of shotcrete decreases by 25.76%,16.46%,and 16.70%,respectively;② carbon black and silica fume have a good effect on increasing the one-shot thickness of concrete.When the content of carbon black and silica fume is 10%,the one-shot thickness exceeds 35 …

Study On Rheological Properties Of Basalt Fiber Asphalt Mastic Modified With Silane Coupling Agent, Liu Yuande, Zheng Nanxiang, Zhang Xiang, Gao Haiwei, Zhang Bowen

Journal of China & Foreign Highway

To investigate the rheological properties of basalt fiber asphalt mastic,a silane coupling agent was used as a modifier for basalt fibers,and the effects of varying fiber contents were analyzed. Cone penetration tests,bending beam rheological tests,and dynamic shear rheometer tests were conducted to evaluate the rheological properties of asphalt mastic consistency, high-temperature stability,and low-temperature cracking resistance under different temperatures and fiber contents.The findings show that the silane-coupled basalt fibers enhance the shear strength and consistency of asphalt mastic.After modification,the phase angle decreases;elastic response increases,and complex modulus improves.Adsorption capacity between fibers and asphalt increases significantly,enhancing high-temperature deformation resistance and low-temperature cracking resistance …

Analysis Of Mechanical Properti Es Of Integral Jacking Basket Arch Bridge During C Onstruction, Chen Tao, Qiu Jingkui, Wang Ji

Journal of China & Foreign Highway

Taking the Xindian Bridge in Ni ngbo as the background,this paper analyzed the mechanical properties of the integral jacking basket arch bridge during construction.Midas finite element software was used to establish the spatial model of the main bridge,and the deviation of the suspender force and support reaction force of the completed bridge from the design was 1.84% and 1.8%,respectively.The maximum deviation of the displacement calculation of the tie beam at the bridge completion stage was 22 mm,and the maximum deviation of the displacement of the arch rib at the same stage was ‒ 12 mm,which showed that the finite element …

Internal Force Optimization In Com Pleted Stage And Construction Alignment Control Of Super Long-Span Extradosed Cable-Stayed Bridge, Ba Wenpeng

Journal of China & Foreign Highway

This paper is based on a super long-span extradosed cable-stayed bridge with a main span of 400 m.In view of the technical challenges of high negative bending moment at the quarter point of the bridge and large deformation during the cantilever assembly process in the non-cable area,a systematic solution was proposed in combination with the entire construction process.This paper proposed three schemes:permanent cable over-tensioning,temporary cable setting,and large segment closure.The bending moment ratio (λM) and structural deformation were used as quantitative indicators,and a finite element model was established to compare the three schemes.The results show that all three schemes can improve …

Comparative Study On Differences In Asphalt Pavement Design Between China And Southern Africa, Wang Qing, Lin Yangyang, Yan Hongxiang, Zhao Bin, Xia Moxuan, Li Ning, Si Wei

Journal of China & Foreign Highway

To facilitate the successful implementation of projects in the Southern Africa region and promote the application and internationalization of China ’s standards,this study compared the asphalt pavement design systems,construction materials,design parameters,and structural design methods of both regions based on the main asphalt pavement design specifications currently in use in China and Southern Africa.The results show that among Southern African countries,South Africa has a comprehensive and widely applied standard system,while other Southern African countries adopt more varied and less theoretical standards.In contrast,China ’s standard system is complete and highly practical.Due to differences in regional climates,the selection principles and mechanical requirements for …

Discontinuous Deforma Tion Analysis Of Progressive Toppling Of Rock Slopes With Fractured Slab Structure, Yuan Sifan, Li Tonglu, Haider Mumtaz, Zhang Changliang, Li Ping

Journal of China & Foreign Highway

Progressive toppling of rock sl opes with fractured slab structures is quite common in the slopes of hydropower and highway engineering,posing a potential safety risk during both construction and operational phases.The field investigation found that progressive toppling mostly occurs on slopes with concentrated tectonic stress,intense river incision,and high steepness.Typically,these slopes are composed of hard,thinly-layered,and overthrusted rock mass with a fractured slab structure.From a macroscopic point of view,progressive toppling failure is neither a collapse nor a slide but a form of discontinuous deformation.The traditional limit equilibrium method for slope stability analysis is not suitable for evaluating such slopes.In this paper,by taking …

Prediction For Humidity Adjustment Factor And Dry-Wet Cycle Reduction Factor Of Resilient Modulus Of Subgrade Soil Based On Ann, Wang Xufeng, Fu Wei, Peng Junhui, Hu Jiankun, Zhang Junhui, Li Zhiguang

Journal of China & Foreign Highway

Existing methods for determining the humidity adjustment factor and dry-wet cycle reduction factor of the resilient modulus of subgrade soil are mostly based on laboratory tests that consume a large amount of manpower and time,and the prediction accuracy is limited due to the constraints of specification value ranges.In order to achieve fast and accurate prediction of these two factors,the effects of stress state,moisture content,and the number of dry-wet cycles on the resilient modulus of subgrade soil were investigated through laboratory dynamic triaxial tests.Based on existing literature,physical parameters,state parameters,and stress parameters of subgrade soil were selected,and an artificial neural network prediction …

Semi-Flexible Pavement Structure Analysis Based On Double Modulus Theory, Pan Qinxue, Zhou Shurui, Hu Jia, Zhang Long, Song Xiaojin, Liu Hongfu

Journal of China & Foreign Highway

Semi-flexible pavement materials have significant differences in tension and compression.If the mechanical response analysis of pavement structures is conducted by using the traditional linear elastic theory with a single modulus,there will be a considerable deviation from actual situations.To analyze and optimize semi-flexible pavement structures,this paper compared the changes in key mechanical responses of pavement structures under six different semi-flexible layer positions and thickness combinations based on the double modulus theory.The results show that there is a significant difference in the calculation results of key mechanical responses of the pavement based on the double modulus theory and the single modulus theory,with …

Structural System Reliability Analysis Method For Cable-Supported Bridges Based On Deep Belief Networks, Chen Zhenyu, Xie Bo, Lu Naiwei

Journal of China & Foreign Highway

Aiming at the high-precision reconstruction of structural function functions caused by the strong nonlinearity of cable load-bearing bridge structures,this study presented a structural system reliability analysis method based on a deep belief network (DBN ).A long-span suspension bridge was used as the engineering background to identify the dominant fault path of the structural system and analyze the law of structural fault path transfer caused by the deterioration of the suspender strength.Numerical analysis results show that DBN can capture the nonlinear mechanical behavior of the finite element model of the suspension bridge,thereby making the implicit statically indeterminate functional function explicit and …

Experimental Study On Engineering Performance Of Post-Planted Precast Concrete Pile With Prebored Grouting, Zhao Yu, Wang Wei, Jiang Lei, Song Zhenya, Zhang Hao

Journal of China & Foreign Highway

The traditional piling methods of precast concrete (PC) piles are difficult to pass through the hard soil layers and tend to induce severe soil squeezing effects.To address this issue,the technology of a post-planted PC pile with prebored grouting was analyzed.Based on the project of the Hefei‒ Zongyang section of G3W Dezhou ‒ Shangrao Expressway,the bearing characteristics of post-planted PC piles were researched by the load tests of five piles in two different field test sections.The results show that the bearing capacity of the PC piles can be effectively improved by setting the cement mortar coating layer around the PC piles.The …

Research On Evaluation Index Of Low-Temperature Semi-Circular Bending Test Of Asphalt Mixtures, Lyu Songtao, Chen Qi, Lu Weiwei, Zhao Pei, Wang Jinping

Journal of China & Foreign Highway

This article aims to investigate the low-temperature crack resistance performance of asphalt mixtures under different aging conditions and loading rates and select appropriate indicators to accurately characterize and quantify their performance.Based on the semi-circular bending test,the influence of different aging degrees (unaged,short-term aged,long-term aged for three days,and long-term aged for five days ) and loading rates (50 mm/min,5 mm/min,0.5 mm/min,and 0.1 mm/min ) on the low-temperature performance of asphalt mixtures was investigated.The evaluation effect and applicable range of five crack resistance performance indicators,namely fracture energy (Gf),stress intensity factor (KIC),flexibility index (IFI),crack resistance index (ICRI),and balanced cracking index (IBCI),were studied through …