Higher First 30-Day Dose Of Buprenorphine For Opioid Use Disorder Treatment Is Associated With Decreased Mortality, Feitong Lei, Michelle R. Lofwall, Jana Mcanich, Reuben Adatorwovor, Emily Slade, Patricia R. Freeman, Daniela Moga, Nabarun Dasgupta, Sharon L. Walsh, Rachel Vickers-Smith, Svetla Slavova

Biostatistics Faculty Publications

Objective: Buprenorphine is a medication for opioid use disorder that reduces mortality. This study aims to investigate the less well-understood relationship between the dose in the early stages of treatment and the subsequent risk of death.

Methods: We used Kentucky prescription monitoring data to identify adult Kentucky residents initiating transmucosal buprenorphine medication for opioid use disorder (January 2017 to November 2019). Average daily buprenorphine dose for days covered in the first 30 days of treatment was categorized as ≤8 mg, >8 to ≤16 mg, and >16 mg. Patients were followed for 365 days after the first 30 days of buprenorphine …

Synergetic Effects Of Democracy And Economic Development On Income Inequality And The Role Of Relative Political Capacity, Nazif Sali

CGU Theses & Dissertations

Diving into the complex dynamics of income inequality, this dissertation studies the multifaceted relationships between democracy, economic development, and inequality, placing a spotlight on the mediating influence of Relative Political Capacity (RPC). Uncovering the pivotal role of RPC as democracies advance and economies progress, this research navigates the contours of income inequality. By dissecting distinct sub-samples of OECD and non-OECD countries, nuanced insights surface. Employing robust methodologies such as ordinary least squares regressions and fixed effects analysis, I argue that targeted policies addressing inequality can not only foster inclusive economic growth but also fortify the foundations of democratic institutions. As …

Intelligent Capabilities Of Traditional Knowledge Organization Methods, Xinning Su

Journal of Scientific Information Research

[Purpose/significance]By analyzing the system and rules of traditional knowledge organization methods, the intelligent capabilities of traditional knowledge organization methods are refined and integrated into artificial intelligence（AI） technology, to enhance the precision and efficiency of AI in information processing. [Method/process]This paper reviews the development of knowledge organization and analyses the inherit structure and mechanisms of traditional knowledge organization methods. [Result/conclusion]Research suggests that over centuries of development and evolution, knowledge organization has gained the ability to reflect knowledge systems and disciplinary systems across different disciplines from diverse perspectives, establish semantic relations from diverse knowledge associations, and associate and integrate knowledge of different …

A Quantitative Analysis Of Seaplane Accidents From 1982-2021, David C. Ison

International Journal of Aviation, Aeronautics, and Aerospace

This study aimed to assess and analyze all historical National Transportation Safety Board accident reports since 1982. For analysis, reports were bisected into seaplane (float, amphibian, and hull) and non-seaplane groups. Findings showed that there is a deficiency in the level of available detail on the seaplane fleet and cadre of seaplane pilots in the U.S. During the most recent ten years of complete data (2012-2021) showed a negative trend in all accidents and fatal accidents, although only the latter being statistically convincing. During this timeframe, seaplane accident pilots had significantly higher total time and age than other groups (non-seaplane …

Bar-Code Variable: A Novel Approach To Efficiently Find Interaction Effects, Lee Sak Park

Theses and Dissertations--Statistics

This paper introduces the bar-code variable, a novel method for processing a sequence of binary explanatory variables efficiently in the linear regression modeling framework. Represented as an integer or a sequence of bits, the bar-code variable captures infor- mation on original binary variables and their potential interaction effects. Utilizing the bar-code variable, the study explores streamlined feature selection in linear re- gression modeling with binary explanatory variables. The paper demonstrates how the bar-code variable, through re-parameterization, facilitates the transition from cell means estimates, µ̂, in the cell-means ANOVA model to coefficient estimates, β̂, in the linear regression model, and vice …

On Generative Models And Joint Architectures For Document-Level Relation Extraction, Aviv Brokman

Theses and Dissertations--Statistics

Biomedical text is being generated at a high rate in scientific literature publications and electronic health records. Within these documents lies a wealth of potentially useful information in biomedicine. Relation extraction (RE), the process of automating the identification of structured relationships between entities within text, represents a highly sought-after goal in biomedical informatics, offering the potential to unlock deeper insights and connections from this vast corpus of data. In this dissertation, we tackle this problem with a variety of approaches.

We review the recent history of the field of document-level RE. Several themes emerge. First, graph neural networks dominate the …

Difs And Bayescluster: Novel Methods For Single_Cell Rna Sequencing Analysis, Kun Liu

Theses and Dissertations--Statistics

Single-cell RNA sequencing (scRNA-seq) has transformed our understanding of cellular heterogeneity and gene expression dynamics. Despite its potential, the inherent noise and sparsity of scRNA-seq data pose significant challenges in clustering cells into biologically meaningful groups. This dissertation addresses these challenges through two novel methodologies aimed at enhancing the accuracy and robustness of scRNA-seq data analysis.

First, we introduce the Differential Feature Selection (DIFS) framework, designed to improve the identification of differential features in scRNA-seq data. DIFS employs a two-stage marker identification process. In the first stage, a modified Dip Test is used to filter and identify genes with significant …

A Case Report On A Women’S Residential Substance Use Program In A Rural And Urban Setting, Deborah Winders Davis, Yana Feygin, Madeline Shipley, Tiffany Cole Hall, Chaly Downs, Stephanie Hoskins, Natalie Pasquenza, Scott D. Duncan, Liza M. Creel

Biostatistics Faculty Publications

Purpose To describe program characteristics and outcomes of a residential substance use recovery program serving pregnant and parenting women in a rural and urban location.

Description This assessment of administrative records from April 1, 2020 through March 31, 2022, included women in a rural (n = 140) and urban (n = 321) county in Kentucky.

Assessment This retrospective case study used descriptive and non-parametric analyses to assess the population and examine differences between locations, race, and ethnicity for women served. Logistic regression tested predictors of goal achievement by community. Of 461 women served, 65 (14.1%) delivered a baby while in …

Health Care For People Who Are Incarcerated: Teaching Third-Year Medical Students About Rights, Challenges, And Avenues Of Advocacy, Anna-Maria South, Kelsey N. Karnik, Sara Hieneman, Anthony A. Mangino, Michelle R. Lofwall

Biostatistics Faculty Publications

Introduction: Incarcerated patients are a vulnerable patient population with unique barriers to health care that physicians in every specialty encounter. Current medical school curricula lack universal education on health care for incarcerated people.

Methods: We developed an interactive workshop to provide third-year medical students at the University of Kentucky with information about delivering care outside of dedicated carceral settings to individuals who are incarcerated. The workshop included education on the demographic characteristics and medical conditions present in these populations along with understanding incarcerated persons’ rights to health care and how to interact with them and the associated jail/prison workforce often …

Contrastive Learning, With Application To Forensic Identification Of Source, Cole Ryan Patten

Electronic Theses and Dissertations

Forensic identification of source problems often fall under the category of verification problems, where recent advances in deep learning have been made by contrastive learning methods. Many forensic identification of source problems deal with a scarcity of data, an issue addressed by few-shot learning. In this work, we make specific what makes a neural network a contrastive network. We then consider the use of contrastive neural networks for few-shot learning classification problems and compare them to other statistical and deep learning methods. Our findings indicate similar performance between models trained by contrastive loss and models trained by cross-entropy loss. We …

Row-Column Designs: A Novel Approach For Analyzing Imprecise And Uncertain Observations, Abdulrahman Alaita, Muhammad Aslam, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

Classical row-column designs cannot be applied when the underlying data set contains some imprecise, uncertain, or undetermined observations. In this paper, we discuss row-column design under a neutrosophic statistical framework. A significant contribution of our study is to propose a novel approach to analyzing row-column designs using neutrosophic data. This approach involves calculating the neutrosophic analysis of variance (NANOVA) table for the proposed design and using it to derive the FN -test in an uncertain environment. Two numerical examples have been used to assess the proposed design’s performance. Results from the study indicated that a row column design under …

Investigation Of Space Charge Effects On Co2 Electrocatalytic Reduction On Gd-Doped Ceria Via Scanning Kelvin Probe And Model-Based Bayesian Analysis, Alejandro Mejia

Graduate Theses, Dissertations, and Problem Reports (ETD)

In studying novel energy conversion and storage systems, such as high-temperature electrolysis, numerous underlying fundamental physical processes remain unclear or inadequately understood. Among these, the modeling and comprehension of surface reaction mechanisms, coupled with the intricate effects of space‑charge interfaces, remains an unclear and challenging area of research.

The work of this dissertation involves the development of a 2D finite element analysis model, leveraging the robust MOOSE framework from INL. This model, featuring inhomogeneous defect thermodynamics for near-surface chemistry, formulated through Poisson‑Cahn variational theory, has been exploited for studying the electrocatalytic reduction of CO₂ on gadolinia doped ceria. The …

Data-Driven Modeling Of Oxygen Kinetics In La0.6sr0.4co0.2fe0.8o3−Δ (Lscf) For High-Temperature Reduction Of Co2 In An Electrolysis Cell, Ferron Campbell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Electrolysis systems are critical to several societal applications, particularly energy storage and conversion. Developing these systems requires a detailed knowledge of the chemistry and thermodynamics of the materials used in the electrolysis cell. This work focuses on using embedded scientific machine learning as an efficient way to build an interpretable model for the reaction and transport kinetics in the LSCF electrode, whose performance directly influences the electrolysis system’s performance. The models developed in this study are trained using the publicly available machine learning package, FoKL-GP. This package incorporates a robust Gibbs sampler that employs a forward variable selection process to …

Statistical Modeling Of Bankruptcy Data, Andrew Elsfelder

Williams Honors College, Honors Research Projects

My project uses a dataset of bankrupt and non-bankrupt companies in Taiwan from 1999 to 2009. This data was collected from the Taiwan Economic Journal. The statistical methods I used to model the data are CHAID, CART, and logistic regression. The models created are tools that can predict if a company is bankrupt, or not-bankrupt based on other data about the company. I created multiple models for each of the methods to find the best model for each method. I then analyzed the output from each method. Lastly, I determined which model was the best for this data based on …

Tropical Fish Study In Tahiti, French Polynesia, Miranda Brainard, Caitlyn Swango, Paityn Houglan, Richard Londraville

Williams Honors College, Honors Research Projects

In May of 2023, I embarked on an exciting research journey to Moorea, French Polynesia, alongside fellow students and faculty members from the University of Akron and Syracuse University. This expedition was part of the university-sponsored Tropical Vertebrate Biology course, where we delved into the exploration of various tropical species inhabiting the island, including sea urchins, geckos, and my primary focus, the blackspotted rockskipper.

My research team, composed of my co-authors and me, was particularly intrigued by the unique refuge-seeking behavior displayed by blackspotted rockskippers. These amphibious fish are renowned for their remarkable ability to inhabit tide pools and rocky …

Regional Price Index 2023, Department Of Primary Industries And Regional Development, Western Australia

Statistics

The 2023 Regional Price Index (RPI) is the eleventh State Government Index contrasting the cost of a common basket of goods and services at a number of regional locations to the Perth metropolitan region. The RPI is used as the basis for the construction of the public sector district allowance, and by the private sector when considering remuneration packages for remotely located staff.

The RPI provides an insight into differences in regional consumer costs. The 2023 RPI basket of 185 goods and services was priced in 39 regional centres around Western Australia.

The 2023 RPI results show that, overall, prices …

Towards A More Engaged Democracy: Using Statistical Methods To Detect Election Fraud In The 2022 Philippine National Elections, Juan Miguel Cardaño, Bryan Patrick Mande, Seth William Tionko, Aldrich Ellis C. Asuncion, Jeric C. Briones

Mathematics Faculty Publications

This paper aims to show how citizens can further participate in the elections, aside from just voting. Given the accusations of fraud, this study demonstrates how existing election fraud detection methods can be used in the 2022 Philippine National Elections (PNE) context. Specifically, histograms known as 2D vote turnout distributions were first utilized to model the frequency of the winner's percentage of votes based on the voter turnout in each electoral unit, with key parameters introduced to detect fraud. Vote turnout distributions were then simulated using parametric models involving the aforementioned fraud parameters, with the goal of replicating the actual …

Bayesian Estimation Of Hierarchical Linear Models From Incomplete Data: Cluster-Level Non-Linear Effects And Small Sample Sizes, Dongho Shin

Theses and Dissertations

We consider Bayesian estimation of a hierarchical linear model (HLM) from small sample sizes. The continuous response Y and covariates C are partially observed and assumed missing at random. With C having linear effects, the HLM may be efficiently estimated by available methods. When C includes cluster-level covariates having interactive or other nonlinear effects given small sample sizes, however, maximum likelihood estimation is suboptimal, and existing Gibbs samplers are based on a Bayesian joint distribution compatible with the HLM, but impute missing values of C by a Metropolis algorithm via a proposal density having a constant variance while the target …

Development Of Probabilistic Dynamic Model Building And Bayesian Machine Learning Approaches, Samuel Oladayo Adeyemo

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Development of Probabilistic Dynamic Model Building and Bayesian Machine Learning Approaches

Samuel Adeyemo

The recent years have seen a tremendous increase in the use of artificial intelligence (AI) and machine learning (ML) for the development of data-driven mathematical models needed for performing real-time optimization, model-based control, performance optimization, dynamic data reconciliation, and process performance monitoring. However, the development of data-driven models is faced with some challenges including lack of model interpretability, sensitivity of algorithm to noise in training data, limited extrapolation capabilities and violation of conservation laws. Drawing motivation from these existing gaps, this work aims to develop robust …

Advanced Techniques In Time Series Forecasting: From Deterministic Models To Deep Learning, Xue Bai

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation discusses three instances of temporal prediction, applied to population dynamics and deep learning.

In population modeling, dynamic processes are frequently represented by systems of differential equations, allowing for the analysis of various phenomena. The first application explores modeling cloned hematopoiesis in chronic myeloid leukemia (CML) via a nonlinear system of differential equations. By tracking the evolution of different cell compartments, including cycling and quiescent stem cells, progenitor cells, differentiated cells, and terminally differentiated cells, the model captures the transition from normal hematopoiesis to the chronic and accelerated-acute phases of CML. Three distinct non-zero steady states are identified, representing …