Statistics and Probability Commons^™

Reports Of Autosomal Recessive Disease And Consanguineous Mating Within The Human Population, Johnathon L. Schluter

Master's Theses

It is anecdotally evident when investigating published reports of autosomal recessive disease that a substantial number of cases are the result of related (consanguineous) mating. This research seeks to quantify the percent of manuscripts describing autosomal recessive diseases published between 2000 and 2020 in which consanguineous mating is indicated. We analyzed 602 peer-reviewed manuscripts to identify the percentage of cases presented in which consanguineous mating was indicated, the underlying genes (novel gene or new mutation) and geographical region. These papers were accessed through a specific set of parameters on the free access PubMed Central (PMC) database. A total of 552 …

Context Aware Music Recommendation And Playlist Generation, Elias Mann

SMU Journal of Undergraduate Research

There are many reasons people listen to music, and the type of music is largely determined by what the listener may be doing while they listen. For example, one may listen to one type of music while commuting, another while exercising, and yet another while relaxing. Without access to the physiological state of the user, current music recommendation methods rely on collaborative filtering - recommending music based on what other similar users listen to - and content based filtering - recommending songs based on their similarities to songs the user already prefers. With the rise in popularity of smart devices …

Perspective—Surface-Display Techniques In Electrochemical Biosensor Designs For Health Monitoring, Courtney J. Weber, Megan D. Whisonant, Olivia M. Clay, Olja Simoska

Faculty Publications

Enzymatic and microbial electrochemical biosensors integrate enzymes and microorganisms as biological recognition elements into the sensor design and functionality. Enzyme-based sensors offer high sensitivity and selectivity for target analyte detection. However, these have limited stability necessary for continuous analyte monitoring. Contrarily, microbe-based electrochemical sensors provide a means for continuous analyte sensing but are associated with challenges related to analyte selectivity in complex samples. To address these limitations, surface-display methods, which bind enzymes to microbial surfaces, enhance biosensor selectivity and sensitivity. This perspective outlines the application of surface-display techniques, offering a promising avenue for health monitoring.

Employing Digital Pcr For Enhanced Detection Of Perinatal Toxoplasma Gondii Infection: A Cross-Sectional Surveillance And Maternal-Infant Outcomes Study In El Salvador, Mary K. Lynn, Marvin Stanley Rodriguez Aquino, Pamela Michelle Cornejo Rivas, Xiomara Miranda, David F. Torres-Romero, Hanson Cowan, Madeleine M. Meyer, Willber D. Castro-Godoy, Mufaro Kanyangarara Ph.D., Stella Coker Watson Self Ph.D., Ms, Berry A. Campbell, Melissa Nolan Ph.D., Mph

Faculty Publications

Toxoplasma gondii is a parasitic infection that can be transmitted in utero, resulting in fetal chorioretinitis and other long-term neurological outcomes. If diagnosed early, pregnancy-safe chemotherapeutics can prevent vertical transmission. Unfortunately, diagnosis of acute, primary infection among pregnant women remains neglected, particularly in low-and-middle-income countries. Clinically actionable diagnosis is complex due to the commonality of infection during childhood and early adulthood which spawn long-last antibody titers and historically unreliable direct molecular diagnostics. The current study employed a cross-sectional T. gondii perinatal surveillance study using digital PCR, a next generation molecular diagnostic platform, and a maternal-fetal outcomes survey to ascertain …

Towards A New Role Of Mitochondrial Hydrogen Peroxide In Synaptic Function, Cliyahnelle Z. Alexander

Student Theses and Dissertations

Aerobic metabolism is known to generate damaging ROS, particularly hydrogen peroxide. Reactive oxygen species (ROS) are highly reactive molecules containing oxygen that have the potential to cause damage to cells and tissues in the body. ROS are highly reactive atoms or molecules that rapidly interact with other molecules within a cell. Intracellular accumulation can result in oxidative damage, dysfunction, and cell death. Due to the limitations of H₂O₂ (hydrogen peroxide) detectors, other impacts of ROS exposure may have been missed. HyPer7, a genetically encoded sensor, measures hydrogen peroxide emissions precisely and sensitively, even at sublethal levels, during …

Time Scale Separation In Life-Long Ovarian Follicles Population Dynamics Model, Romain Yvinec, Frédérique Clément, Guillaume Ballif

Biology and Medicine Through Mathematics Conference

No abstract provided.

Multi-Type Branching Processes In Time-Varying Environments, Arash Jamshidpey

Biology and Medicine Through Mathematics Conference

No abstract provided.

Exchangeability And A Model Of Biological Evolution, Renee Haddad

Honors Scholar Theses

A sequence of random variables (RVs) is exchangeable if its distribution is invariant under permutations. For example, every sequence of independent and identically distributed (IID) RVs is exchangeable. The main result on exchangeable sequences of random variables is de Finetti's theorem, which identifies exchangeable sequences as conditionally IID. In this thesis, we explore exchangeability, provide an elementary proof of de Finetti's theorem, and present two applications: the classical Polya's urn model and a toy model for biological evolution.

Modeling Human Temporal Eeg Responses To Vr Visual Stimuli, Richard R. Foster, Connor Delaney, Dean J. Krusienski, Cheng Ly

Biology and Medicine Through Mathematics Conference

No abstract provided.

Improved Rational Approximation Of Near-To-Far Propagation Kernels For The Wave Equation, Sampson Owusu

Mathematics & Statistics ETDs

The 3-space, 1-time dimensional scalar wave equation, or 3+1 wave equation, describes the propagation of scalar or acoustic waves. The unforced homogeneous equation admits a class of outgoing solutions relative to a chosen fixed center, so called “multipole” solutions. This thesis examines near-to-far signal propagation in the context of these multipole solutions. Given a time-series (history of values) for a multipole solution recorded at a radius r1, near- to-far signal propagation recovers the corresponding time-series at larger radius r2 ≫ r1. This propagation takes into account both the appropriate time delay r2 − r1 and corrections to the wave shape. …

Nidus Idearum. Scilogs, Xiii: Structure / Neutrostructure / Antistructure, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

In this thirteenth book of scilogs – one may find topics on Neutrosophy, Plithogeny, Physics, Mathematics, Philosophy – email messages to research colleagues, or replies, notes, comments, remarks about authors, articles, or books, spontaneous ideas, and so on. It presents new types of soft sets and new types of topologies.

Exchanging ideas with Mohammad Abobala, Ishfaq Ahmad, Ibrahim M. Almanjahie, Fatimah Alshahrani, Nizar Altounji, Muhammad Aslam, Said Broumi, Victor Christianto, R. Diksh, Feng Liu, Frank Julian Gelli, Erick Gonzalez Caballero, Riad Hamido, Yaser Al-Hasan, Ahmed Hatip, Yasin Karmouta, Nivetha Martin, Preda Mihăilescu, V. Lakshmana Gomathi Nayagam, Ze Carlos Tiago de …

Assessing Reproducibility Of Brain-Behavior Associations Using Bootstrap Aggregation Methods, Zhetao Chen

Arts & Sciences Graduate Student Theses and Dissertations

在本论文中，随着越来越多地利用静息态功能连接 MRI (rs-fcMRI) 将神经活动与病理状况联系起来，我们面临着对此类数据可靠性的普遍担忧。我们的探索集中于提高人类连接组计划（HCP）数据集框架内大脑行为关联的可重复性。我们采用两种不同的引导聚合方法来研究功能连接可靠性的增强：使用循环块引导（CBB）的单独时间序列装袋和使用线性支持向量回归（LSVR）模型的主题级装袋。我们对 CBB 个体时间序列 bagging 的调查表明，这种方法并不能显着增强大脑行为关联的可重复性。这一发现指出了实现可靠的功能连接措施的复杂性以及某些聚合方法在克服这一挑战方面的局限性。相比之下，我们的学科水平考试 通过 LSVR 模型装袋呈现出更有希望的结果。这种方法显着增强了分析之间模型权重的可靠性，证明了其在提高数据稳健性和可重复性方面的功效。两种方法的这种不同影响强调了适当的分析策略在提高神经影像数据可靠性方面的关键作用。通过描述这两种方法的结果，本论文有助于对神经影像领域的数据可靠性进行更广泛的讨论。它强调了在不同数据集上持续进行方法创新和验证的必要性，以提高 rs-fcMRI 研究的可靠性和可解释性。

Statistical Approaches For The Early Detection Of Colorectal Cancer Using Longitudinal Biomarkers, Emily Berry

Statistical Science Theses and Dissertations

Colorectal cancer (CRC) is the third leading cause of cancer-related death in the United States [45]. CRC is believed to advance from adenomatous polyps creating a unique opportunity for both early detection and cancer prevention [4, 23]. Like other diseases, CRC screening reduces mortality by detecting cancer at earlier, more treatable stages; however, it can also reduce incidence through the removal of precancerous lesions [4]. As a result, screening is recommended for average-risk adults ≥ 45 years of age and includes a variety of tests [4, 12]. Despite alternate screening options, colonoscopy capacity is often cited as a barrier to …

Capturing Higher-Order Relationships Through Information Decomposition, Aobo Lyu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Mutual information between two random variables is a well-studied notion, whose understanding is fairly complete. Mutual information between one random variable and a pair of other random variables, however, is a far more involved notion. Specifically, Shannon's mutual information does not capture fine-grained interactions between those three variables, resulting in limited insights in complex systems. To capture these fine-grained higher-order interactions among variables, Williams and Beer proposed a framework called Partial Information Decomposition (PID) to decompose this mutual information to information atoms, called unique, redundant, and synergistic, and proposed several operational axioms that these atoms must satisfy. This conceptual …

Robust Prediction Of Charpy Toughness Of Additively Manufactured Kovar Using Deep Convolutional Neural Networks, Nathan R. Bianco

Mathematics & Statistics ETDs

Understanding the reason for mechanical failures of manufactured parts in their operating environments is critical to prevention of future failures. However, in-situ post-mortem evaluation of physical properties, such as fracture toughness, is time consuming and alters the condition of the material, leading to potentially misleading findings. In this study, additively manufactured test coupons were produced over a wide range of process conditions to test the impact toughness of a material. The Charpy V-Notch toughness was measured on over 200 samples alongside corresponding optical images of both sides of the fracture surface. Convolutional neural network models were trained to correlate fracture …

The Performance Of Arima And Arfima In Modelling The Exchange Rate Of Nigeria Currency To Other Currencies, Adewole Ayoade I.

Al-Bahir

Economic performance of a nation depends majorly on the stability of foreign exchange rate; the economic viability hangs on the exchange rate of local currencies against other currencies across the globe. Box – Jenkins Approach was employed to model the Naira exchange rate to other major currencies using Autoregressive Integrated Moving Average (ARIMA) and The autoregressive fractional integral moving average (ARFIMA) models. This studies aimed on measuring forecast ability of Autoregressive Integrated Moving Average (ARIMA) (p,d,q) and autoregressive fractional integral moving average (ARFIMA) (p, fd, q) models for stationary type series that exhibit features of Long memory properties. Results indicate …

Testing The Hypothesis That Tennis Points Are Independent And Identically Distributed Using Statistical Methods, Ernesto Ugona Santana

Senior Honors Theses

Most research on the probability of winning a tennis match is based on the assumption that the points are independent and identically distributed, treating each point as a Bernoulli trial with fixed probability of success. This assumption, however, seems to contradict experience. Players' performance appears to fluctuate as the match progresses due to the psychological effect of past performance. To test this counterintuitive yet central assumption, previous research has attempted to test the independence hypothesis. However, there exists a research gap in evaluating the identicality-of-distribution hypothesis, a question of broader scope than that of independence. Hence, the purpose of this …

Mechanical And Deformation Characteristics Of Piles In Coastal Soft Soil Areas Considering Softening Effect, Wang Fei, Yan Yu, Jiao Lidong, Shen Fengqi, Chen Lu, Liu Jianhua

Journal of China & Foreign Highway

In order to discuss the mechanical and deformation behavior of piles in coastal soft soil areas under horizontal load，the corresponding simplified mechanical model was established according to the loading characteristics of piles in coastal soft soil areas.Secondly，the softening effect of coastal soft soil was considered to modify the existing p-y curve model.On this basis，the differential equation of pile deflection in coastal soft soil areas was derived，and its internal force and displacement were solved by the transfer matrix method.A nonlinear calculation method of piles in coastal soft soil areas considering the softening effect was obtained.Finally，the influence of softening parameters，pile diameter，and elastic …

Research On Road Performance Of Carbonaceous Shale Subgrade Filler, Zhang Mengjin, Huang Yafei, Wu Qian, Mao Xuesong, Zhang Jianxun, Chen Xinyi, Wang Yueyue

Journal of China & Foreign Highway

The application of carbonaceous shale for subgrade filling not only alleviates the shortage of subgrade filler in carbonaceous shale distribution areas but also meets the strategic requirements of “resource conservation and saving ” and “green development ” for infrastructure construction in China.However，such rocks are weak and susceptible to weathering and disintegration，and they exhibit significant strength deterioration when exposed to water.To fully apply them，their performance must be comprehensively understood.In this paper，the basic properties of the carbonaceous shale were studied，and filler gradation was designed.The tests on compaction characteristics of the filler and particle crushing characteristics after compaction，RCBR （California bearing ratio ） variation …

Test And Analysis On Stress And Deformation Of Assembled Geocell Retaining Wall, Kong Yongbo, Li Hao, Zhang Jianwei, Li Junjie, Yang Xiaohua

Journal of China & Foreign Highway

The variable cross-section geocell retaining wall of the Chengdu –Yibin Expressway test road in Sichuan Province of China was studied.First，the construction method of the new-type assembled geocell retaining wall was introduced，and the new-type glass fiber reinforced plastic lightweight panel was used to effectively solve the problem that the panel of the retaining wall is not neat and easy to be damaged.Secondly，the supporting effect of the retaining wall was analyzed by field monitoring.The field monitoring results show that the earth pressure at different parts of the retaining wall is nonlinearly distributed along the height of the retaining wall.The earth pressure at …