Statistics and Probability Commons^™

Tdp-43 Proteinopathy In Aging: Associations With Risk-Associated Gene Variants And With Brain Parenchymal Thyroid Hormone Levels, Peter T. Nelson, Zsombor Gal, Wang-Xia Wang, Dana M. Niedowicz, Sergey C. Artiushin, Samuel Wycoff, Angela Wei, Gregory A. Jicha, David W. Fardo

Pathology and Laboratory Medicine Faculty Publications

TDP-43 proteinopathy is very prevalent among the elderly (affecting at least 25% of individuals over 85 years of age) and is associated with substantial cognitive impairment. Risk factors implicated in age-related TDP-43 proteinopathy include commonly inherited gene variants, comorbid Alzheimer's disease pathology, and thyroid hormone dysfunction. To test parameters that are associated with aging-related TDP-43 pathology, we performed exploratory analyses of pathologic, genetic, and biochemical data derived from research volunteers in the University of Kentucky Alzheimer's Disease Center autopsy cohort (n = 136 subjects). Digital pathologic methods were used to discriminate and quantify both neuritic and intracytoplasmic TDP-43 pathology …

Understanding Water Consumption And Energy Trends In New York City, Wen Yong Huang, Johann Thiel

Publications and Research

In this study, we will be using the NYC Open Data website to examine publicly available data sets on water and energy consumption in New York City. In particular, we will use various scientific programming and machine learning modules in Python to analyze and visualize trends in water and energy usage within the five boroughs.

Sampling Studies For Longitudinal Functional Data, Toni Jassel

Theses, Dissertations and Culminating Projects

We study the data setting consisting of functional data sets repeatedly observed over time. The focus is on the dynamic prediction of the future trajectory for a subject. Regression methods based on dynamic functional models are used for dynamic prediction of individual trajectories. We propose strategies for the selection of the study sampling design in the context of longitudinal functional data. An application to simulated child growth data is presented. The height-for-age z-score (HAZ) was the response variable in the functional dynamic models for prediction. The intent was to recommend four months for removal in our initial historic data set. …

Statistical Modeling Of Count Data With Over-Dispersion Or Zero-Inflation Problems, Chengxin Zhang

Theses, Dissertations and Culminating Projects

In this study, we will analyze a supply retailing company’s data to model the relationship between their customer’s past purchase behavior to predict their future online purchase behavior. The data was divided into time periods from 2016: P1-P6(January 31st to July 30th) and P7(July 31st to August 27th ). Based on customer’s past purchase information from the P1-P6 period, such as money spent, number of cart additions, transactions type, number of unique purchase dates, number of unique purchase skus, number of page views, number browse dates, company size, and number of products purchased, we aim to find if these information …

Do Misperceptions Of Peer Drinking Influence Personal Drinking Behavior? Results From A Complete Social Network Of First-Year College Students, Melissa J. Cox, Angelo M. Dibello, Matthew K. Meisel, Miles Q. Ott, Shannon R. Kenney, Melissa A. Clark, Nancy P. Barnett

Statistical and Data Sciences: Faculty Publications

This study considered the influence of misperceptions of typical versus self-identified important peers' heavy drinking on personal heavy drinking intentions and frequency utilizing data from a complete social network of college students. The study sample included data from 1,313 students (44% male, 57% White, 15% Hispanic/Latinx) collected during the fall and spring semesters of their freshman year. Students provided perceived heavy drinking frequency for a typical student peer and up to 10 identified important peers. Personal past-month heavy drinking frequency was assessed for all participants at both time points. By comparing actual with perceived heavy drinking frequencies, measures of misperceptions …

What Can We Do? Puzzling Over The Interpretation Of Heredity And Variation From Galton To Genetic Engineering, Peter J. Taylor

Working Papers on Science in a Changing World

First six chapters of a book motivated as follows: When I had mentioned to colleagues that I was exploring some significant issues overlooked by both sides in nature-nurture debates, the typical response was “we know, of course, that nature and nurture are intertwined”; they never asked “which nature-nurture science are you referring to?” It occurred to me that, in the long history of nature-nurture debates, opposing sides had always assumed or implied that these different scientific approaches were speaking to the same issues. If that were the case, then the challenge—something I was already puzzling over—was how best to draw …

A Bayesian Framework For Estimating Seismic Wave Arrival Time, Hua Zhong

Graduate Theses and Dissertations

Because earthquakes have a large impact on human society, statistical methods for better studying earthquakes are required. One characteristic of earthquakes is the arrival time of seismic waves at a seismic signal sensor. Once we can estimate the earthquake arrival time accurately, the earthquake location can be triangulated, and assistance can be sent to that area correctly. This study presents a Bayesian framework to predict the arrival time of seismic waves with associated uncertainty. We use a change point framework to model the different conditions before and after the seismic wave arrives. To evaluate the performance of the model, we …

Telomeres, Nutrition And Mortality: Risk Factors For The Rate Of Telomere Length Decline And The Associations Between Telomere Length, Nutrition And Mortality, Saruna Ghimire

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Telomeres are nucleoprotein structures located at the ends of eukaryotic chromosomes, thought to protect the DNA from damage. As a person experiences stressors, harmful exposures, and other diseases throughout their life, telomeres are thought to become damaged and their length shortened, decreasing their ability to protect the DNA. Nutrition is an important aspect of healthy aging. Preservation of telomere length (TL) is thought to be one of the mechanisms by which good nutrition can delay or prevent the development of chronic disease and death. Recent evidence of preservation of TL with good nutrition is promising. Thus, the aim of …

K-Tuple Sampling From Partially Rank-Ordered Sets, Marvin Javier

UNLV Theses, Dissertations, Professional Papers, and Capstones

With the introduction of Ranked Set Sampling (RSS), McIntyre (1952) demonstrated that using ranking information to select units for measurement can lead to estimators with reduced variance when compared to their counterparts based on a simple random sample of the same size. This is done by selecting a set of units, and without direct measurement, ranking the units in the set before identifying one unit for measurement. This ranking of the units can be done through judgement ranking (such as visual assessment), or by using a correlated auxiliary variable.

In its original form, RSS does not allow for ties when …

Health Disparities Among Sexual And Gender Minorities, Jennifer Keeley

UNLV Theses, Dissertations, Professional Papers, and Capstones

Decades of research has shown that sexual and gender minorities (SGMs) experience adverse health and mental health outcomes to a greater extent than their heterosexual peers. The need to better understand and eliminate health disparities in the SGM population was recognized by the National Institute on Minority Health and Health Disparities (NIMHD) at NIH. The Secretary of Health at the Department of Health and Human Services approved the designation of the SGM population as a health disparities population in 2016 and called for SGM studies to examine the health needs of the SGM population across SGM subgroups via large representative …

The Effects Of Injury On Running Status And Gait Biomechanics, Kristyne Wiegand

UNLV Theses, Dissertations, Professional Papers, and Capstones

Over the past several decades, endurance running has grown steadily as a popular form of physical activity. Running is easily accessible, does not require expensive equipment, and can be performed without specific skill training. Individuals who run also experience health benefits like increased cardiovascular health and reduced risk of all-cause morbidity. Despite these benefits, running is also associated with high rates of musculoskeletal injury. Although researchers have attempted to identify injury risks and mitigate the incidence of running injury, there is still no consensus as to why runners become injured. Research has also attempted to identify biomechanical movement patterns that …

Dynamic Sampling Versions Of Popular Spc Charts For Big Data Analysis, Samuel Anyaso-Samuel

Boise State University Theses and Dissertations

The statistical process control (SPC) chart is an effective tool for the analysis, interpretation, and visualization of data from sequential processes. Commonly used SPC charts such as the Shewhart, CUSUM and EWMA charts are widely implemented in detecting distributional shifts in various processes. With recent scientific and technological advancements, massive amounts of data continue to be generated by production, medical, agricultural and many other industrial processes. Conventional SPC charts have significant drawbacks in monitoring such processes, specifically when the velocity of the data flow is greater than the run time of the monitoring procedure. In the literature, dynamic sampling control …

Ergodicity For The 3d Stochastic Navier-Stokes Equations Perturbed By Lévy Noise, Manil T. Mohan, K. Sakthivel, Sivaguru S. Sritharan

Faculty Publications

In this work we construct a Markov family of martingale solutions for 3D stochastic Navier–Stokes equations (SNSE) perturbed by Lévy noise with periodic boundary conditions. Using the Kolmogorov equations of integrodifferential type associated with the SNSE perturbed by Lévy noise, we construct a transition semigroup and establish the existence of a unique invariant measure. We also show that it is ergodic and strongly mixing.
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A Hidden Markov Factor Analysis Framework For Seizure Detection In Epilepsy Patients, Mahboubeh Madadi

Graduate Theses and Dissertations

Approximately 1% of the world population suffers from epilepsy. Continuous long-term electroencephalographic (EEG) monitoring is the gold-standard for recording epileptic seizures and assisting in the diagnosis and treatment of patients with epilepsy. Detection of seizure from the recorded EEG is a laborious, time consuming and expensive task. In this study, we propose an automated seizure detection framework to assist electroencephalographers and physicians with identification of seizures in recorded EEG signals. In addition, an automated seizure detection algorithm can be used for treatment through automatic intervention during the seizure activity and on time triggering of the injection of a radiotracer to …

Feasibility Of Multi-Year Forecast For The Colorado River Water Supply: Time Series Modeling, Brian Plucinski

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

The Colorado River is one of the largest resources for water in the United States, as well as being an important asset to the economy. Previous studies have shown a connection between the Great Salt Lake and the Colorado River. This study used time series analysis to build models to predict the water supply of the Colorado River ten years out. These models used data from the Colorado River in addition to Great Salt Lake water elevation. Several models suggest a decline in water supply from 2013 – 2020, before starting to increase. These predictions differ from predictions published by …

Raman And Surface Enhanced Raman Spectroscopy For Forensic Analysis: Case Studies On The Identification Of Illicit Substances And Artist Pigments, Abed Haddad

Dissertations, Theses, and Capstone Projects

Raman spectroscopy is an effective tool for detecting trace amounts of material by fingerprint-like vibrational spectra. At times, the weak intensity of Raman scattering can make it difficult to distinguish trace materials. This shortcoming is addressed by surface‐enhanced Raman spectroscopy (SERS), which produces strong signal enhancements when target compounds are near metal nanoparticles. For the first part of this thesis, the identification of fentanyl and carfentanil, main culprits in the opioid epidemic, was done using normal Raman and the SERS spectroscopy. As an aid in the assignment of the spectral lines, a computational model was built using Density Functional Theory …

A Systematic Assessment Of Socio-Economic Impacts Of Prolonged Episodic Volcano Crises, Justin Peers

Electronic Theses and Dissertations

Uncertainty surrounding volcanic activity can lead to socio-economic crises with or without an eruption as demonstrated by the post-1978 response to unrest of Long Valley Caldera (LVC), CA. Extensive research in physical sciences provides a foundation on which to assess direct impacts of hazards, but fewer resources have been dedicated towards understanding human responses to volcanic risk. To evaluate natural hazard risk issues at LVC, a multi-hazard, mail-based, household survey was conducted to compare perceptions of volcanic, seismic, and wildfire hazards. Impacts of volcanic activity on housing prices and businesses were examined at the county-level for three volcanoes with a …

Comparison Of Imputation Methods For Mixed Data Missing At Random, Kaitlyn Heidt

Electronic Theses and Dissertations

A statistician's job is to produce statistical models. When these models are precise and unbiased, we can relate them to new data appropriately. However, when data sets have missing values, assumptions to statistical methods are violated and produce biased results. The statistician's objective is to implement methods that produce unbiased and accurate results. Research in missing data is becoming popular as modern methods that produce unbiased and accurate results are emerging, such as MICE in R, a statistical software. Using real data, we compare four common imputation methods, in the MICE package in R, at different levels of missingness. The …

Generalizations Of The Arcsine Distribution, Rebecca Rasnick

Electronic Theses and Dissertations

The arcsine distribution looks at the fraction of time one player is winning in a fair coin toss game and has been studied for over a hundred years. There has been little further work on how the distribution changes when the coin tosses are not fair or when a player has already won the initial coin tosses or, equivalently, starts with a lead. This thesis will first cover a proof of the arcsine distribution. Then, we explore how the distribution changes when the coin the is unfair. Finally, we will explore the distribution when one person has won the first …

A Comparison Of Standard Denoising Methods For Peptide Identification, Skylar Carpenter

Electronic Theses and Dissertations

Peptide identification using tandem mass spectrometry depends on matching the observed spectrum with the theoretical spectrum. The raw data from tandem mass spectrometry, however, is often not optimal because it may contain noise or measurement errors. Denoising this data can improve alignment between observed and theoretical spectra and reduce the number of peaks. The method used by Lewis et. al (2018) uses a combined constant and moving threshold to denoise spectra. We compare the effects of using the standard preprocessing methods baseline removal, wavelet smoothing, and binning on spectra with Lewis et. al’s threshold method. We consider individual methods and …