Data Science Commons^™

Federated Generalized Linear Mixed Models For Collaborative Genome-Wide Association Studies, Wentao Li, Han Chen, Xiaoqian Jiang, Arif Harmanci

Faculty, Staff and Student Publications

Federated association testing is a powerful approach to conduct large-scale association studies where sites share intermediate statistics through a central server. There are, however, several standing challenges. Confounding factors like population stratification should be carefully modeled across sites. In addition, it is crucial to consider disease etiology using flexible models to prevent biases. Privacy protections for participants pose another significant challenge. Here, we propose distributed Mixed Effects Genome-wide Association study (dMEGA), a method that enables federated generalized linear mixed model-based association testing across multiple sites without explicitly sharing genotype and phenotype data. dMEGA employs a reference projection to …

Surface-Doped Zinc Gallate Colloidal Nanoparticles Exhibit Ph-Dependent Radioluminescence With Enhancement In Acidic Media, Navadeep Shrivastava, Jessa Guffie, Tamela L Moore, Burak Guzelturk, Amar S Kumbhar, Jianguo Wen, Zhiping Luo

Faculty, Staff and Student Publications

As abnormal acidic pH symbolizes dysfunctions of cells, it is highly desirable to develop pH-sensitive luminescent materials for diagnosing disease and imaging-guided therapy using high-energy radiation. Herein, we explored near-infrared-emitting Cr-doped zinc gallate ZnGa2O4 nanoparticles (NPs) in colloidal solutions with different pH levels under X-ray excitation. Ultrasmall NPs were synthesized via a facile hydrothermal method by controlling the addition of ammonium hydroxide precursor and reaction time, and structural characterization revealed Cr dopants on the surface of NPs. The synthesized NPs exhibited different photoluminescence and radioluminescence mechanisms, confirming the surface distribution of activators. It was observed that the colloidal NPs emit …

The Impact Framework And Implementation For Accessible In Silico Clinical Phenotyping In The Digital Era, Andrew Wen, Huan He, Sunyang Fu, Sijia Liu, Kurt Miller, Liwei Wang, Kirk E Roberts, Steven D Bedrick, William R Hersh, Hongfang Liu

Faculty, Staff and Student Publications

Clinical phenotyping is often a foundational requirement for obtaining datasets necessary for the development of digital health applications. Traditionally done via manual abstraction, this task is often a bottleneck in development due to time and cost requirements, therefore raising significant interest in accomplishing this task via in-silico means. Nevertheless, current in-silico phenotyping development tends to be focused on a single phenotyping task resulting in a dearth of reusable tools supporting cross-task generalizable in-silico phenotyping. In addition, in-silico phenotyping remains largely inaccessible for a substantial portion of potentially interested users. Here, we highlight the barriers to the usage of in-silico phenotyping …

Non-Invasive Arterial Blood Pressure Measurement And Spo2 Estimation Using Ppg Signal: A Deep Learning Framework, Yan Chu, Kaichen Tang, Yu-Chun Hsu, Tongtong Huang, Dulin Wang, Wentao Li, Sean I Savitz, Xiaoqian Jiang, Shayan Shams

Faculty, Staff and Student Publications

BACKGROUND: Monitoring blood pressure and peripheral capillary oxygen saturation plays a crucial role in healthcare management for patients with chronic diseases, especially hypertension and vascular disease. However, current blood pressure measurement methods have intrinsic limitations; for instance, arterial blood pressure is measured by inserting a catheter in the artery causing discomfort and infection.

METHOD: Photoplethysmogram (PPG) signals can be collected via non-invasive devices, and therefore have stimulated researchers' interest in exploring blood pressure estimation using machine learning and PPG signals as a non-invasive alternative. In this paper, we propose a Transformer-based deep learning architecture that utilizes PPG signals to conduct …

The Screening Of The Protective Antigens Of Aeromonas Hydrophila Using The Reverse Vaccinology Approach: Potential Candidates For Subunit Vaccine Development, Ting Zhang, Minying Zhang, Zehua Xu, Yang He, Xiaoheng Zhao, Hanliang Cheng, Xiangning Chen, Jianhe Xu, Zhujin Ding

Faculty, Staff and Student Publications

The threat of bacterial septicemia caused by Aeromonas hydrophila infection to aquaculture growth can be prevented through vaccination, but differences among A. hydrophila strains may affect the effectiveness of non-conserved subunit vaccines or non-inactivated A. hydrophila vaccines, making the identification and development of conserved antigens crucial. In this study, a bioinformatics analysis of 4268 protein sequences encoded by the A. hydrophila J-1 strain whole genome was performed based on reverse vaccinology. The specific analysis included signal peptide prediction, transmembrane helical structure prediction, subcellular localization prediction, and antigenicity and adhesion evaluation, as well as interspecific and intraspecific homology comparison, thereby screening …

Age-Related Changes In Circadian Regulation Of The Human Plasma Lipidome, Shadab A. Rahman, Rose M. Gathungu, Vasant R. Marur, Melissa St. Hilaire, Karine Scheuermaier, Marina Belenky, Jackson S. Struble, Charles A. Czeisler, Steven W. Lockley, Elizabeth B. Klerman, Jeanne F. Duffy, Bruce S. Kristal

Computer and Data Science Faculty Publications

Aging alters the amplitude and phase of centrally regulated circadian rhythms. Here we evaluate whether peripheral circadian rhythmicity in the plasma lipidome is altered by aging through retrospective lipidomics analysis on plasma samples collected in 24 healthy individuals (9 females; mean ± SD age: 40.9 ± 18.2 years) including 12 younger (4 females, 23.5 ± 3.9 years) and 12 middle-aged older, (5 females, 58.3 ± 4.2 years) individuals every 3 h throughout a 27-h constant routine (CR) protocol, which allows separating evoked changes from endogenously generated oscillations in physiology. Cosinor regression shows circadian rhythmicity in 25% of lipids in both …

Topological Data Analysis Of Convolutional Neural Networks Using Depthwise Separable Convolutions, Eliot Courtois

Dissertations

In this dissertation, we present our contribution to a growing body of work combining the fields of Topological Data Analysis (TDA) and machine learning. The object of our analysis is the Convolutional Neural Network, or CNN, a predictive model with a large number of parameters organized using a grid-like geometry. This geometry is engineered to resemble patches of pixels in an image, and thus CNNs are a conventional choice for an image-classifying model.

CNNs belong to a larger class of neural network models, which, starting at a random initialization state, undergo a gradual fitting (or training) process, often a …

Hyperspectral Point Cloud Projection For The Semantic Segmentation Of Multimodal Hyperspectral And Lidar Data With Point Convolution-Based Deep Fusion Neural Networks, Kevin T. Decker, Brett J. Borghetti

Faculty Publications

The fusion of dissimilar data modalities in neural networks presents a significant challenge, particularly in the case of multimodal hyperspectral and lidar data. Hyperspectral data, typically represented as images with potentially hundreds of bands, provide a wealth of spectral information, while lidar data, commonly represented as point clouds with millions of unordered points in 3D space, offer structural information. The complementary nature of these data types presents a unique challenge due to their fundamentally different representations requiring distinct processing methods. In this work, we introduce an alternative hyperspectral data representation in the form of a hyperspectral point cloud (HSPC), which …

The Impact Of Covid-19 On The Financial Performance Of Largest Teaching Hospitals, Karima Lalani, Jeffrey Helton, Francine R Vega, Marylou Cardenas-Turanzas, Tiffany Champagne-Langabeer, James R Langabeer

Faculty, Staff and Student Publications

The COVID-19 pandemic disrupted hospital operations. Anecdotal evidence suggests financial performance likewise suffered, yet little empirical research supports this claim. This study aimed to explore the impact of the pandemic on the financial performance of the most prominent academic hospitals in the United States. Data from the 115 largest major teaching hospitals in the United States were extracted from the American Hospital Directory for three years (2019-2021). We hypothesized that the year and region would moderate the relationship between a hospital's return on assets (financial performance) and specific operational variables. We found evidence through descriptive statistics and multivariate moderated regressions …

Future Trends And Directions For Secure Infrastructure Architecture In The Education Sector: A Systematic Review Of Recent Evidence, Isaac Atta Senior Ampofo, Isaac Atta Junior Ampofo

Journal of Research Initiatives

The most efficient approach to giving large numbers of students’ access to computational resources is through a data center. A contemporary method for building the data center's computer infrastructure is the software-defined model, which enables user tasks to be processed in a reasonable amount of time and at a reasonable cost. The researcher examines potential directions and trends for a secured infrastructure design in this article. Additionally, interoperable, highly reusable modules that can include the newest trends in the education industry are made possible by cloud-based educational software. The Reference Architecture for University Education System Using AWS Services is presented …

The Effect Of Sustainability Information Disclosure On The Cost Of Equity Capital: An Empirical Analysis Based On Gartner Top 50 Supply Chain Rankings, Lingyu Li, Xianrong Zheng, Shuxi Wang

Information Technology & Decision Sciences Faculty Publications

While disclosing financial information has been widely proved to reduce the financing cost of a company, the impact of non-financial information, such as sustainability information, disclosing on the financing cost of the company is still in debate. The goal of this paper is to explore the impact of disclosing sustainability-related information on the cost of equity for firms. The paper first introduces the concept of sustainability information disclosure, and then exhibits its benefit through exploring its impact on reducing a firm’s financing cost. It uses the Gartner supply chain top 50 rankings to construct the experiment environment to test for …

Exploring The Impact Of Students Demographic Attributes On Performance Prediction Through Binary Classification In The Kdp Model, Issah Iddrisu, Peter Appiahene, Obed Appiah, Inusah Fuseini

Knowledge Engineering and Data Science

During the course of this research, binary classification and the Knowledge Discovery Process (KDP) were used. The experimental and analytical capabilities of Rapid Miner's 9.10.010 instructional environment are supported by five different classifiers. Included in the analysis were 2334 entries, 17 characteristics, and one class variable containing the students' average score for the semester. There were twenty experiments carried out. During the studies, 10-fold cross-validation and ratio split validation, together with bootstrap sampling, were used. It was determined whether or not to use the Random Forest (RF), Rule Induction (RI), Naive Bayes (NB), Logistic Regression (LR), or Deep Learning (DL) …

Maximum Marginal Relevance And Vector Space Model For Summarizing Students' Final Project Abstracts, Gunawan Gunawan, Fitria Fitria, Esther Irawati Setiawan, Kimiya Fujisawa

Knowledge Engineering and Data Science

Automatic summarization is reducing a text document with a computer program to create a summary that retains the essential parts of the original document. Automatic summarization is necessary to deal with information overload, and the amount of data is increasing. A summary is needed to get the contents of the article briefly. A summary is an effective way to present extended information in a concise form of the main contents of an article, and the aim is to tell the reader the essence of a central idea. The simple concept of a summary is to take an essential part of …

Inter-Frame Video Compression Based On Adaptive Fuzzy Inference System Compression Of Multiple Frame Characteristics, Arief Bramanto Wicaksono Putra, Rheo Malani, Bedi Suprapty, Achmad Fanany Onnilita Gaffar, Roman Voliansky

Knowledge Engineering and Data Science

Video compression is used for storage or bandwidth efficiency in clip video information. Video compression involves encoders and decoders. Video compression uses intra-frame, inter-frame, and block-based methods. Video compression compresses nearby frame pairs into one compressed frame using inter-frame compression. This study defines odd and even neighboring frame pairings. Motion estimation, compensation, and frame difference underpin video compression methods. In this study, adaptive FIS (Fuzzy Inference System) compresses and decompresses each odd-even frame pair. First, adaptive FIS trained on all feature pairings of each odd-even frame pair. Video compression-decompression uses the taught adaptive FIS as a codec. The features utilized …

Ant Colony Optimization For Resistor Color Code Detection, Slamet Wibawanto, Kartika Candra Kirana, Hani Ramadhan

Knowledge Engineering and Data Science

In the early stages of learning resistors, introducing color-based values is needed. Moreover, some combinations require a resistor trip analysis to identify. Unfortunately, a resistor body color is considered a local solution, which often confuses resistor coloration. Ant Colony Optimization (ACO) is a heuristic algorithm that can recognize problems with traveling a group of ants. ACO is proposed to select commercial matrix values to be computed without preventing local solutions. In this study, each explores the matrix based on pheromones and heuristic information to generate local solutions. Global solutions are selected based on their high degree of similarity with other …

K-Means Clustering And Multilayer Perceptron For Categorizing Student Business Groups, Miftahul Walid, Norfiah Lailatin Nispi Sahbaniya, Hozairi Hozairi, Fajar Baskoro, Arya Yudhi Wijaya

Knowledge Engineering and Data Science

The research conducted in this study was driven by the East Java provincial government's requirement to assess the transaction levels of the Student Business Group (KUS) in the SMA Double Track program. These transaction levels are a basis for allocating supplementary financial aid to each business group. The system's primary objective is to assist the provincial government of East Java in making well-informed choices pertaining to the distribution of supplementary capital to the KUS. The classification technique employed in this study is the multilayer perceptron. However, the K-Means Clustering method is utilised to generate target data due to the limited …

Round-Robin Algorithm In Load Balancing For National Data Centers, I Kadek Wahyu Sudiatmika, Gede Indrawan, Sariyasa Sariyasa

Knowledge Engineering and Data Science

The Provincial Government of Bali assumes a crucial role in administering various public service applications to meet the requirements of its community, traditional villages, and regional apparatus. Nevertheless, the escalating magnitude of traffic and uneven distribution of requests have resulted in substantial server burdens, which may jeopardize the operation of applications and heighten the likelihood of downtime. Ensuring efficient load distribution is of utmost importance in tackling these difficulties, and the Round Robin algorithm is often utilized for this purpose. However, the current body of research has not extensively examined the distinct circumstances surrounding on-premise servers in the Bali Provincial …

Long-Term Traffic Prediction Based On Stacked Gcn Model, Atkia Akila Karim, Naushin Nower

Knowledge Engineering and Data Science

With the recent surge in road traffic within major cities, the need for both short and long-term traffic flow forecasting has become paramount for city authorities. Previous research efforts have predominantly focused on short-term traffic flow estimations for specific road segments and paths. However, applications of paramount importance, such as traffic management and schedule routing planning, demand a deep understanding of long-term traffic flow predictions. However, due to the intricate interplay of underlying factors, there exists a scarcity of studies dedicated to long-term traffic prediction. Previous research has also highlighted the challenge of lower accuracy in long-term predictions owing to …

Optimizing Random Forest Algorithm To Classify Player's Memorisation Via In-Game Data, Akmal Vrisna Alzuhdi, Harits Ar Rosyid, Mohammad Yasser Chuttur, Shah Nazir

Knowledge Engineering and Data Science

Assessment of a player's knowledge in game education has been around for some time. Traditional evaluation in and around a gaming session may disrupt the players' immersion. This research uses an optimized Random Forest to construct a non-invasive prediction of a game education player's Memorization via in-game data. Firstly, we obtained the dataset from a 3-month survey to record in-game data of 50 players who play 4-15 game stages of the Chem Fight (a test case game). Next, we generated three variants of datasets via the preprocessing stages: resampling method (SMOTE), normalization (min-max), and a combination of resampling and normalization. …

Characterization And Estimation Of Musculoskeletal Pain Using Machine Learning, Boluwatife Faremi

Master's Theses

Traditional scales utilized for recording pain are known to be highly subjective and biased due to inaccuracies in recollecting actual pain intensities. As a result, machine learning (ML) models that are trained using these scores as ground truth are reported to have low performance for objective pain classification because of the huge disparity between what was felt in moments of pain and the scores recorded afterward.

In the present study, two devices were designed for gathering real-time, continuous in-session subjective pain scores and the recording of the autonomic nervous system (ANS) altered endodermal (EDA) activity. 24 participants were recruited to …