Data Science Commons^™

Balanced Blended Space: Proposing A Universal Theoretical Framework For Combinative Reality, David Smith, Frederick Bianchi

Publications and Research

In today's fragmented societies, a unified framework for communication and collaboration across different realities is crucial. We introduce Balanced Blended Space (BBS) as a framework for describing combinative reality, encompassing virtual, physical, and conceptual realms, all intrinsically connected. Interactions within these environments shape our perceptual space. This paper outlines key axiomatic assumptions, criteria for a universal framework, and fundamental terminology. We identify deep symmetries enabling the BBS framework, including Cognitive and Computational Symmetry, Physical and Virtual Symmetry, Mediation Pathway Symmetry, Space-Time Symmetry, and Sensory Symmetry. We propose tests to determine its viability, emphasizing virtual intelligence as a collaborative partner. We …

Web-Grading-A Tool To Test Personal Grading Of Renal And Prostate Cancer, Murali Varma, Kaan Inam, Hans-Jürgen Thiesen, Brett Delahunt, Yulin Dai

Faculty, Staff and Student Publications

Only a few pathologists have the opportunity to verify their personal grading through objective assessment. This study introduces a web-based grading platform to facilitate and validate the grading of renal cell carcinoma and prostate cancer. Two representative images of two clinically annotated cohorts of 100 cases each of prostate and renal cell carcinoma were used. Each participant was asked to grade a tumor series utilizing a three tiered grading system. Finally, a Kaplan-Meier curve was drawn, and the log-rank test was used for statistical testing of the p-value. The grading of 22 participants (68%) achieved prognostic significance. Further analysis highlighted …

Research Data Management In The Canadian Context: A Guide For Practitioners And Learners, Kristi Thompson, Elizabeth T. Hill, Emily Carlisle-Johnston, Danielle Dennie, Émilie Fortin

Western Libraries Publications

Research Data Management is a term for all the things that researchers do to structure, organize and maintain data before, during and after doing research. RDM is also an emerging discipline that is concerned with researching and developing ways to manage research data more effectively. But what is research data? Where is the push towards formal Research Data Management coming from? What are the requirements of good data management? Research Data Management in the Canadian Context: A Guide for Practitioners and Learners looks at these questions and more, all with a focus on Canadian guidelines, regulations and infrastructure.

Precise Method To Identify Kinase Drug Targets In Complex Diseases: The First Step Towards Sustainable And Effective Treatment, Hasbanny Irisson, Marzieh Ayati

Research Symposium

Background: Kinases are enzymes that have proven to be important drug targets due to their role in critical biological mechanisms such as phosphorylation. Phosphorylation happens when a kinase catalyzes the transfer of a phosphate group to a protein in a phosphorylated site, which then becomes known as the substrate of the kinase. Any dysregulation of protein phosphorylation causes a wide range of complex diseases including cancer. Thus, discovering the links between kinases and their substrates (i.e. predicting kinase-substrate associations (KSAs)) is crucial in developing effective and sustainable treatments. Presently, less than 5% of phosphorylated sites have an associated kinase, and …

A Case Report: A Patient Rescued By Va-Ecmo After Cardiac Arrest Triggered By Trigeminocardiac Reflex After Nasal Surgery, Liwei Wang

Faculty, Staff and Student Publications

Rationale:

Cardiac arrest (CA) caused by trigeminocardiac reflex (TCR) after endoscopic nasal surgery is rare. Hence, when a patient suffers from TCR induced CA in the recovery room, most doctors may not be able to find the cause in a short time, and standard cardiopulmonary resuscitation and resuscitation measures may not be effective. Providing circulatory assistance through venous-arterial extracorporeal membrane oxygenation (VA-ECMO) can help healthcare providers gain time to identify the etiology and initiate symptom-specific treatment.

Patient concerns:

We report a rare case of CA after endoscopic nasal surgery treated with VA-ECMO.

Diagnoses:

We excluded myocardial infarction, pulmonary embolism, allergies, …

Privacy-Preserving Federated Learning, Dumindu Samaraweera

Math Department Colloquium Series

AI's applicability across diverse fields is hindered by data sensitivity, privacy concerns, and limited training data availability. Federated Learning (FL) addresses this challenge by enabling collaborative machine learning while preserving data privacy. FL allows clients to engage in model training with their local data, avoiding centralized storage. However, even with FL, security threats persist, jeopardizing model integrity and client data privacy. In this presentation, we will explore our latest findings in this area of research, safeguarding sensitive data from attacks through techniques like secure multiparty computation, homomorphic encryption, and differential privacy within the FL framework, enhancing data protection, and expanding …

A Deep Bilstm Machine Learning Method For Flight Delay Prediction Classification, Desmond B. Bisandu, Irene Moulitsas

Journal of Aviation/Aerospace Education & Research

This paper proposes a classification approach for flight delays using Bidirectional Long Short-Term Memory (BiLSTM) and Long Short-Term Memory (LSTM) models. Flight delays are a major issue in the airline industry, causing inconvenience to passengers and financial losses to airlines. The BiLSTM and LSTM models, powerful deep learning techniques, have shown promising results in a classification task. In this study, we collected a dataset from the United States (US) Bureau of Transportation Statistics (BTS) of flight on-time performance information and used it to train and test the BiLSTM and LSTM models. We set three criteria for selecting highly important features …

Mapping The Delineation Of Practice To The Amia Foundational Domains For Applied Health Informatics, Annette L Valenta, Damian Borbolla, Gloria Deckard, Laverne Manos

Faculty, Staff and Student Publications

OBJECTIVE: This article reports on the alignment between the foundational domains and the delineation of practice (DoP) for health informatics, both developed by the American Medical Informatics Association (AMIA). Whereas the foundational domains guide graduate-level curriculum development and accreditation assessment, providing an educational pathway to the minimum competencies needed as a health informatician, the DoP defines the domains, tasks, knowledge, and skills that a professional needs to competently perform in the discipline of health informatics. The purpose of this article is to determine whether the foundational domains need modification to better reflect applied practice.

MATERIALS AND METHODS: Using an iterative …

Using Artificial Intelligence To Learn Optimal Regimen Plan For Alzheimer’S Disease, Yongbin Chen, Alzheimer’S Disease Neuroimaging Initiative, Australian Imaging Biomarkers And Lifestyle Flagship Study Of Ageing, Qiying Dai, Xiaoyang Li, Xiaoqian Jiang, Nansu Zong

Faculty, Staff and Student Publications

BACKGROUND: Alzheimer's disease (AD) is a progressive neurological disorder with no specific curative medications. Sophisticated clinical skills are crucial to optimize treatment regimens given the multiple coexisting comorbidities in the patient population.

OBJECTIVE: Here, we propose a study to leverage reinforcement learning (RL) to learn the clinicians' decisions for AD patients based on the longitude data from electronic health records.

METHODS: In this study, we selected 1736 patients from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. We focused on the two most frequent concomitant diseases-depression, and hypertension, thus creating 5 data cohorts (ie, Whole Data, AD, AD-Hypertension, AD-Depression, and AD-Depression-Hypertension). …

Organizing Pmode Dopplergrams Of Jupiter With Matlab, Brady T. Smith, Deborah Gulledge, Cody Shaw, Gerard Williger

The Cardinal Edge

The interiors of the giant planets are poorly known. At the time of writing, such investigations have been limited to measuring gravitational effects from a handful of orbital probes. The most recent attempt to map the interior is via PMODE (the Planetary Multilevel Oscillations and Dynamics Experiment), designed to explore Jupiter’s core by collecting Dopplergrams. Small radial velocity shifts in Jupiter’s upper cloud decks enable us to map its atmospheric dynamics and consequently its interior via Dioseismology (techniques similar to Helioseismology, applied to Jupiter). This campaign produced a vast dataset with more than 50,000 exposures, every 30 seconds, over 24 …

Effects Of Weight Initialization Methods On Ffn's, Ida K. Karem

The Cardinal Edge

Weight initialization is the method of determining starting values of weights in a neural network. The way this method is done can have massive effects on the network[2, 3, 6, 9] and can halt training if not handled properly. On the other hand, if initialization is chosen tactfully it can improve training and accuracy greatly. The initialization method usually called Normalized Xavier will be referred to as Nox in this paper to avoid confusion with the Xavier initialization method. This study analyzes five methods of weight initialization(Nox, He, Xavier, Plutonian, and Self-Root), two of them …

Sentiment Analysis Of Public Perception Towards Elon Musk On Reddit (2008-2022), Daniel Maya Bonilla, Samuel Iradukunda, Pamela Thomas

The Cardinal Edge

As Elon Musk’s influence in technology and business continues to expand, it becomes crucial to comprehend public sentiment surrounding him in order to gauge the impact of his actions and statements. In this study, we conducted a comprehensive analysis of comments from various subreddits discussing Elon Musk over a 14-year period, from 2008 to 2022. Utilizing advanced sentiment analysis models and natural language processing techniques, we examined patterns and shifts in public sentiment towards Musk, identifying correlations with key events in his life and career. Our findings reveal that public sentiment is shaped by a multitude of factors, including his …

Systematic Investigation Of The Homology Sequences Around The Human Fusion Gene Breakpoints In Pan-Cancer - Bioinformatics Study For A Potential Link To Mmej, Jiajia Liu, Xiaobo Zhou

Faculty, Staff and Student Publications

Microhomology-mediated end joining (MMEJ), an error-prone DNA damage repair mechanism, frequently leads to chromosomal rearrangements due to its ability to engage in promiscuous end joining of genomic instability and also leads to increasing mutational load at the sequences flanking the breakpoints (BPs). In this study, we systematically investigated the homology sequences around the genomic breakpoint area of human fusion genes, which were formed by the chromosomal rearrangements initiated by DNA double-strand breakage. Since the RNA-seq data is the typical data set to check the fusion genes, for the known exon junction fusion breakpoints identified from RNA-seq data, we have to …

Machine Learning And Causality For Interpretable And Automated Decision Making, Maria Lentini

Theses and Dissertations

This abstract explores two key areas in decision science: automated and interpretable decision making. In the first part, we address challenges related to sparse user interaction data and high item turnover rates in recommender systems. We introduce a novel algorithm called Multi-View Interactive Collaborative Filtering (MV-ICTR) that integrates user-item ratings and contextual information, improving performance, particularly for cold-start scenarios. In the second part, we focus on Student Prescription Trees (SPTs), which are interpretable decision trees. These trees use a black box "teacher" model to predict counterfactuals based on observed covariates. We experiment with a Bayesian hierarchical binomial regression model as …

Reu-Deim Classification Of Hispanic Voters In Hispanic Groups Using Name And Zip Code Data In Palm Beach, Florida, Kamila Soto-Ortiz

Beyond: Undergraduate Research Journal

When it comes to registering to vote, Hispanic voters can only register as “Hispanic” in the “Race/Ethnicity” category, causing difficulties when analyzing voting trends amongst the Hispanic community. Upon the recent idea that not all Hispanic Groups vote the same, the goal is to create a model that can possibly identify a voter’s Hispanic Group with the information provided on the public Florida voter file. This is accomplished using name and zip code data for all voters in Palm Beach, Florida. This paper will explore the model implemented, its findings and limitations. Palm Beach, Florida, is met with low confidence …

Codesigning A Big Data Analytic Tool For Girl Child Learner Drop Out From Eastern Cape Province -South Africa, Nobert Rangarirai Jere, Nosipho Carol Mavuso, Nelly Sharpley

African Conference on Information Systems and Technology

Developing sustainable solutions is critical for adoption of digital solutions. As the high number of learners dropping out of school continues to increase, it is critical to find innovative ways of predicting and preventing high drop out. Current literature has documented a number of factors that influence learner drop out. Innovative ideas, techniques and activities have been undertaken to motivate learners to stay at school. It is unfortunate that most of the initiatives have not helped to avoid drop out of learners. The study is based on a mixed approached that was used targeting female learns from Oliver Tambo District …

Mettl14 Is A Chromatin Regulator Independent Of Its Rna N6-Methyladenosine Methyltransferase Activity, Yini Li, Xinning Zhang, Lishan Yu, Ran Zhao, Lei Yang, Chuan Chen, Xianbin Yu, Boyang Gao, Meijie Qi, Yawei Gao, Bin Shen, Shuying Sun, Chuan He, Jun Liu

Faculty, Staff and Student Publications

METTL3 and METTL14 are two components that form the core heterodimer of the main RNA m6A methyltransferase complex (MTC) that installs m6A. Surprisingly, depletion of METTL3 or METTL14 displayed distinct effects on stemness maintenance of mouse embryonic stem cell (mESC). While comparable global hypo-methylation in RNA m6A was observed in Mettl3 or Mettl14 knockout mESCs, respectively. Mettl14 knockout led to a globally decreased nascent RNA synthesis, whereas Mettl3 depletion resulted in transcription upregulation, suggesting that METTL14 might possess an m6A-independent role in gene regulation. We found that METTL14 colocalizes with the repressive H3K27me3 modification. Mechanistically, METTL14, but not METTL3, binds …

A Low-Complexity Algorithm To Determine Spacecraft Trajectories, Sirani Perera

Math Department Colloquium Series

The growing traffic within the Cislunar region has created a need for computationally effective methods to obtain the trajectories of spacecraft in the Cislunar region. By developing algorithms with low time and arithmetic complexities, we can effectively address these needs.

In this talk, we will present a mathematical model that uses interpolation and boundary conditions to obtain trajectories for satellites based on the principles of three-body dynamics. Following the model, we propose a low- complexity algorithm to generate satellite trajectories. Once the algorithm is proposed, we will apply it to the relevant periodic orbits in the Cislunar region. Finally, we …

Pathogen-Driven Crispr Screens Identify Trex1as A Regulator Of Dna Self-Sensing During Influenza Virus Infection, Clayton Mickelson, Autumn E Sanders, Tony Hu, Srishti Gupta, Ryan A Langlois, Judith A Smith, Andrew Mehle

Faculty, Staff and Student Publications

Host:pathogen interactions dictate the outcome of infection, yet the limitations of current approaches leave large regions of this interface unexplored. Here, we develop a novel fitness-based screen that queries factors important during the middle to late stages of infection. This is achieved by engineering influenza virus to direct the screen by programming dCas9 to modulate host gene expression. Our genome-wide screen for pro-viral factors identifies the cytoplasmic DNA exonuclease TREX1. TREX1 degrades cytoplasmic DNA to prevent inappropriate innate immune activation by self-DNA. We reveal that this same process aids influenza virus replication. Infection triggers release of mitochondrial DNA into the …

Collagene Enables Privacy-Aware Federated And Collaborative Genomic Data Analysis, Xiaoqian Jiang, Arif Harmanci

Faculty, Staff and Student Publications

Growing regulatory requirements set barriers around genetic data sharing and collaborations. Moreover, existing privacy-aware paradigms are challenging to deploy in collaborative settings. We present COLLAGENE, a tool base for building secure collaborative genomic data analysis methods. COLLAGENE protects data using shared-key homomorphic encryption and combines encryption with multiparty strategies for efficient privacy-aware collaborative method development. COLLAGENE provides ready-to-run tools for encryption/decryption, matrix processing, and network transfers, which can be immediately integrated into existing pipelines. We demonstrate the usage of COLLAGENE by building a practical federated GWAS protocol for binary phenotypes and a secure meta-analysis protocol. COLLAGENE is available at https://zenodo.org/record/8125935 …