Dopamine Effects Of Stimulant And Non-Stimulant Drugs Used In The Treatment Of Attention Deficit Hyperactivity Disorder,
2016
Illinois State University
Dopamine Effects Of Stimulant And Non-Stimulant Drugs Used In The Treatment Of Attention Deficit Hyperactivity Disorder, Preeti Chalwadi
Theses and Dissertations
Attention deficit hyperactivity disorder (ADHD) is thought to be associated with dysfunction of ascending catecholamine neuronal systems, particularly dopamine (DA) and norepinephrine (NE). Dysfunction of these catecholamine neurons innervating the prefrontal cortex is hypothesized to underlie impaired executive functions. Dysfunction of the DA neurons innervating the striatum is additionally hypothesized to underlie deficits in motivation and reinforcement learning. However, mechanisms of action of therapeutic drugs used for treating ADHD have mainly focused on catecholamines in the prefrontal cortex and have not adequately addressed the role played by DA signaling in the striatum. Stimulants such as Adderall® and Ritalin® are chemically …
Increased Mitochondrial Superoxide In The Brain, But Not Periphery, Sensitizes Mice To Angiotensin Ii-Mediated Hypertension.,
2016
University of Nebraska Medical Center
Increased Mitochondrial Superoxide In The Brain, But Not Periphery, Sensitizes Mice To Angiotensin Ii-Mediated Hypertension., Adam J. Case, Jun Tian, Matthew C. Zimmerman
Journal Articles: Cellular & Integrative Physiology
Angiotensin II (AngII) elicits the production of superoxide (O2(•-)) from mitochondria in numerous cell types within peripheral organs and in the brain suggesting a role for mitochondrial-produced O2(•-) in the pathogenesis of hypertension. However, it remains unclear if mitochondrial O2(•-) is causal in the development of AngII-induced hypertension, or if mitochondrial O2(•-) in the absence of elevated AngII is sufficient to increase blood pressure. Further, the tissue specific (i.e. central versus peripheral) redox regulation of AngII hypertension remains elusive. Herein, we hypothesized that increased mitochondrial O2(•-) in the absence of pro-hypertensive stimuli, such as AngII, elevates baseline systemic mean arterial …
Water Loss Rates And Desiccation Tolerances For Spiders And Crickets,
2016
Bowling Green State University
Water Loss Rates And Desiccation Tolerances For Spiders And Crickets, Matthew Zach, Kevin E. Mccluney
Honors Projects
Despite the importance of water to living organisms, access varies across the globe with high variability over space and time. Seventy-five percent of the world’s freshwater alone is ice while 99% of unfrozen freshwater is underground (Winter et al. 1998). Understanding how terrestrial species respond to water availability and compensate for water stress can provide insight to their behavior, ecology and physiology. The goal of this research was to examine the differences in the evaporative water loss rates and desiccation tolerances of Hogna carolinensis and Acheta domesticus. First, an experiment was conducted to quantify the rate of evaporative water …
Hypercapnic Hyperoxia Increases Free Radical Production And Cellular Excitability In Rat Caudal Solitary Complex Brain Slice Neurons,
2016
University of South Florida
Hypercapnic Hyperoxia Increases Free Radical Production And Cellular Excitability In Rat Caudal Solitary Complex Brain Slice Neurons, Geoffrey Edward Ciarlone
USF Tampa Graduate Theses and Dissertations
The caudal solitary complex (cSC) is a cardiorespiratory integrative center in the dorsal medulla oblongata that plays a vital role in the central CO2-chemoreceptive network. Neurons in this area respond to hypercapnic acidosis (HA) by a depolarization of the membrane potential and increase in firing rate, however a definitive mechanism for this response remains unknown. Likewise, CO2-chemoreceptive neurons in the cSC respond to hyperoxia in a similar fashion, but via a free radical mediated mechanism. It remains unknown if the response to increased pO2 is merely an increase in redox signaling, or if it’s the …
Intranasal Oxytocin Enhances Connectivity In The Neural Circuitry Supporting Social Motivation And Social Perception In Children With Autism.,
2016
George Washington University
Intranasal Oxytocin Enhances Connectivity In The Neural Circuitry Supporting Social Motivation And Social Perception In Children With Autism., Ilanit Gordon, Allison Jack, Charlotte M Pretzsch, Brent Vander Wyk, James F Leckman, Ruth Feldman, Kevin A. Pelphrey
Pharmacology and Physiology Faculty Publications
Oxytocin (OT) has become a focus in investigations of autism spectrum disorder (ASD). The social deficits that characterize ASD may relate to reduced connectivity between brain sites on the mesolimbic reward pathway (nucleus accumbens; amygdala) that receive OT projections and contribute to social motivation, and cortical sites involved in social perception. Using functional magnetic resonance imaging and a randomized, double blind, placebo-controlled crossover design, we show that OT administration in ASD increases activity in brain regions important for perceiving social-emotional information. Further, OT enhances connectivity between nodes of the brain's reward and socioemotional processing systems, and does so preferentially for …
Effect Of Microgravity On The Contraction And Cytoskeletal Remodeling Of A7r5 Smooth Muscle Cells,
2016
Morehead State University
Effect Of Microgravity On The Contraction And Cytoskeletal Remodeling Of A7r5 Smooth Muscle Cells, Danielle N. Gibson, Mark Will Casto Jr., Michael E. Fultz
Posters-at-the-Capitol
Smooth muscle presents several unique contractile properties when compared to striated muscle. Data suggests that differential remodeling of the alpha-actin and beta-actin and the regulation of such remodeling may play an essential role in smooth muscle contraction. At rest both alpha- and beta-actin both exhibit a cable-like appearance. During contraction, alpha-actin appears to undergo significant remodeling with dissolution on the majority of the cables and the formation of podosomes where it demonstrates co-localization with myosin while beta-actin retains a cable-like appearance. While the remodeling of the two actin domains has been characterized under normal gravity little is known regarding cytoskeletal …
Early Nutritional Programming To Enhance The Utilization Of Plant Based Diets In Fish (Largemouth Bass, Micropterus Salmoides),
2016
Kentucky State University
Early Nutritional Programming To Enhance The Utilization Of Plant Based Diets In Fish (Largemouth Bass, Micropterus Salmoides), Maya Rene Jackson, Cora Teets, Amit Kumar Yadav, Waldemar Rossi
Posters-at-the-Capitol
Aquaculture has been the fastest growing animal food-producing sector for over half a century. Sustainable aquaculture should include replacement of fish-based feed sources by plant-based ingredients. However, this approach is often impeded by poor growth in carnivorous fish such as largemouth bass (LMB, Micropterus salmoides) fed high levels of plant-based protein. Therefore, our overall goal of the present work was to develop alternative methods of utilizing the plant-based diets (PBD) for sustainable LMB production. When fish is exposed to PBD early in their life, they may accept them more efficiently at later stages (so called Nutritional Programing, NP). Therefore, …
Design Of Novel Ion Channel Modulators,
2016
University of California, Davis
Design Of Novel Ion Channel Modulators, Vladimir Yarov-Yarovoy
Science Seminar Series
Function and modulation of neuronal sodium channels are critical for the neuromodulation of electrical excitability and synaptic transmission in neurons - the basis for many aspects of signal transduction, learning, memory and physiological regulation. Mutations in neuronal voltage-gated sodium channel genes are responsible for various human neurological disorders. Furthermore, human neuronal voltage-gated sodium channels are primary targets of therapeutic drugs used as local anesthetics and for treatment of neurological and cardiac disorders. Yarov-Yarovoy's lab is working on rational design of novel therapeutically useful blockers of voltage-gated sodium channels for treatment of pain and epilepsy. Serious, chronic pain affects at least …
90 Minutes Of Moderate-Intensity Exercise Does Not Attenuate Postprandial Triglycerides In Older Adults,
2016
California Baptist University
90 Minutes Of Moderate-Intensity Exercise Does Not Attenuate Postprandial Triglycerides In Older Adults, Nathaniel G. Bodell, Trevor Gillum
International Journal of Exercise Science
International Journal of Exercise Science 9(5): 677-684, 2016. To determine whether 90 minutes of moderate-intensity exercise, prior to a high fat meal, attenuates postprandial triglycerides (PPT) in older adults. Eight sedentary older adult volunteers (mean ± SD age = 58 ± 8 years, BMI 26.5 ± 4.2); completed two trials consisting of exercise and a no-exercise control. Exercise trials involved 90 minutes of moderate-intensity exercise 60% heart rate reserve (HHR). Following exercise, an overnight fast of 12-16 hours was performed. Participants were given a high fat meal that consisted of 146 grams of CHO, and 92 grams of fat and …
Effects Of A Pre-Workout Energy Drink Supplement On Upper Body Muscular Endurance Performance,
2016
Oklahoma State University - Main Campus
Effects Of A Pre-Workout Energy Drink Supplement On Upper Body Muscular Endurance Performance, Mitchel A. Magrini, Ryan J. Colquhoun, J Jay Dawes, Doug B. Smith
International Journal of Exercise Science
International Journal of Exercise Science 9(5): 667-676, 2016. The use of pre-workout beverages is becoming an increasingly common method of improving performance during exercise in athletic and recreationally active populations. Therefore, the purpose of this study was to investigate the effects of a commercially available energy drink on exercise performance. Thirty-one healthy males (n=23) and females (n=8) participated in this study and were separated into two groups: supplement (SU; n=16) or placebo (PL; n=15). Subjects visited the laboratory on 2 occasions separated by no more than 7 days. The first visit consisted of completing a push up to fatigue protocol …
The Effects Of Eccentric, Velocity-Based Training On Strength And Power In Collegiate Athletes,
2016
Nebraska Wesleyan University
The Effects Of Eccentric, Velocity-Based Training On Strength And Power In Collegiate Athletes, Samantha M. Dolezal, Tamra L. Llewellyn, Derek L. Frese
International Journal of Exercise Science
International Journal of Exercise Science 9(5): 657-666, 2016. The purpose of this study was to determine if combining velocity-based training with eccentric focus (VEB) and velocity-based training (VBT) results in power and strength gains. Nineteen men and women collegiate track and field athletes participated in this study. The subjects completed a 12-week intervention with either a VEB program or a VBT program. To determine the effectiveness of each program, the subjects completed four exercise tests before and after the training period: vertical jump, medicine ball put test, 1RM projected bench press and 1RM projected squat. There were no significant differences …
Quantifying Inter-Segmental Coordination During The Instep Soccer Kicks,
2016
University of Georgia
Quantifying Inter-Segmental Coordination During The Instep Soccer Kicks, Yumeng Li, Marion Alexander, Cheryl Glazebrook, Jeff Leiter
International Journal of Exercise Science
International Journal of Exercise Science 9(5): 646-656, 2016. In order to generate a high ball speed in soccer, the inter-segmental coordination of the kicking leg is critical. The purpose of this study was to quantify the coordination between the thigh and shank movement in the sagittal plane during instep kicks. Eleven female soccer players were video recorded using a high-speed (80 Hz) video camera during penalty kicks. Hip, knee and ankle joint centers of the right leg were digitized, and the movement was analyzed using Dartfish TeamPro (6.0). The thigh and shank segment angles were generated, and the coordination was …
Inter-Correlations Between Laboratory Inter-Correlations Between Laboratory And Field-Based Tests Of Muscle Contractile Power,
2016
Charles Sturt University
Inter-Correlations Between Laboratory Inter-Correlations Between Laboratory And Field-Based Tests Of Muscle Contractile Power, Mitchell J. Cameron, Robert Robergs
International Journal of Exercise Science
International Journal of Exercise Science 9(5): 635-645, 2016. Muscle contractile properties have previously been distinguished by fiber typing muscle samples obtained from needle biopsy; however due to conflicting evidence regarding sampling bias and the related need for multiple biopsies, it is not certain if these results are a reliable reflection of whole muscle fiber type expression. Inter-correlations between laboratory and field-based measures of muscle contractile power were used to determine which assessments best discriminate between participants of varying sprint performance, and indirectly reveal potential for power vs. endurance exercise performance. Healthy active male (n=32) and female (n=17) participants were recruited …
The Relationship Between Aerobic And Anaerobic Performance In Recreational Runners,
2016
Midwestern State University
The Relationship Between Aerobic And Anaerobic Performance In Recreational Runners, Zachary M. Gillen, Frank B. Wyatt, Jason B. Winchester, Dalton A. Smith, Vidhi Ghetia
International Journal of Exercise Science
International Journal of Exercise Science 9(5): 625-634, 2016. Research has indicated that combined aerobic and anaerobic training (concurrent training) may improve aerobic performance greater than aerobic training alone. The purpose of this investigation was to establish any associations between aerobic and anaerobic performance. Eleven participants (n = 11, age = 34.1 ± 13 years, VO2max = 58.4 ± 7.8) volunteered for this study. Participants were asked for endurance training experience (4.7 ± 3.7 years) and resistance training experience (4.1 ± 4.6 years). To meet training status, participants were to have a VO2max in the 80th percentile as …
Relationships Between Motor Coordination And Academic Achievement In Middle School Children,
2016
State University of Rio de Janeiro
Relationships Between Motor Coordination And Academic Achievement In Middle School Children, Daniel V. Chagas, Gustavo Leporace, Luiz Alberto Batista
International Journal of Exercise Science
International Journal of Exercise Science 9(5): 616-624, 2016. Although it is recognized that children with a marked impairment in the development of motor coordination may show difficulty in gaining academic achievement, research examining the relationship between gross motor coordination and academic achievement in children without intellectual disabilities is limited. This study aimed to examine whether gross motor coordination is associated with academic achievement among children. Middle school children (n=122) were recruited. Writing, reading, and mathematics performance were used to attribute academic achievement. Gross motor coordination was assessed using the Körperkoordinationstest für Kinder test. Pearson and partial correlations were used to …
Effects Of Acute Vaporized Nicotine In Non-Tobacco Users At Rest And During Exercise,
2016
The University of Texas at San Antonio
Effects Of Acute Vaporized Nicotine In Non-Tobacco Users At Rest And During Exercise, Donovan L. Fogt, Michael A. Levi, Caroline A. Rickards, Steven P. Stelly, William H. Cooke
International Journal of Exercise Science
International Journal of Exercise Science 9(5): 607-615, 2016. Smokers, and even non-smokers, may utilize vaporized nicotine delivered by electronic cigarette (EC) due to the perception that EC are “healthier” than traditional tobacco cigarettes. The effects of vaporized nicotine delivered by EC on resting blood pressure (BP) and resting metabolic rate (RMR), or BP and aerobic power during exercise have not been studied. This investigation tested the effects of acute vaporized nicotine inhalation by EC on resting BP and RMR and cycle exercise BP, metabolic responses, and aerobic power in young, normotensive non-smokers. Using a double-blind design, 20 subjects (10 female) …
Spatial Awareness Is Related To Moderate Intensity Running During A Collegiate Rugby Match,
2016
University of Central Florida
Spatial Awareness Is Related To Moderate Intensity Running During A Collegiate Rugby Match, Kyle S. Beyer, David H. Fukuda Ph.D., Amelia M. Miramonti, Mattan W. Hoffman, Ran Wang, Michael B. La Monica, Josh J. Riffe, Satoru Tanigawa Ph.D., Jeffrey R. Stout Ph.D., Jay R. Hoffman Ph.D.
International Journal of Exercise Science
International Journal of Exercise Science 9(5): 599-606, 2016. The purpose of the present study was to evaluate the relationship between spatial awareness, agility, and distance covered in global positioning system (GPS) derived velocity zone classifications during a collegiate rugby match. Twelve American collegiate rugby union players (mean±SD; age: 21.2±1.4 y; weight: 85.0±16.0 kg; 7 forwards & 5 backs) on a single team volunteered to participate in this investigation. The distances travelled at low (walking/jogging; <2.7m/s), moderate (cruising/striding; 2.7-5.0 m/s), and high intensities (running/sprinting; >5.0 m/s) were measured for each player using GPS sensors and normalized according to playing time during an official USA Rugby match. Spatial awareness was measured …
Adolescents And Self-Reported Physical Activity: An Evaluation Of The Modified Godin Leisure-Time Exercise Questionnaire,
2016
University of California, Irvine
Adolescents And Self-Reported Physical Activity: An Evaluation Of The Modified Godin Leisure-Time Exercise Questionnaire, Jacqueline Zelener, Margaret Schneider
International Journal of Exercise Science
International Journal of Exercise Science 9(5): 587-598, 2016. The Godin Leisure-Time Exercise Questionnaire assesses self-reported physical activity (PA) among adults, and was later modified for children. However, the modified version (Godin-Child Questionnaire) has not been validated among adolescents. This study evaluates the construct validity and test-retest reliability of the Godin-Child Questionnaire among adolescents. The study participants, sixth graders (age M= 11.06 ± 0.436; 48% males, 48% Latino), were assessed at 2 time points (fall and spring: N= 139). First, the study determined whether adolescents accurately reported exercise intensity based on adolescents' ratings of perceived exertion (RPE) during moderate- and hard-intensity …
Natural Training Hydration Status, Sweat Rates, And Perception Of Sweat Losses During Crossfit Training,
2016
University of North Alabama
Natural Training Hydration Status, Sweat Rates, And Perception Of Sweat Losses During Crossfit Training, Christina C. Cronin, Eric O'Neal, Jeffrey Simpson, Brandon L. Miller, Matt Green, Jean A. Helm Allen, Shelby Boman
International Journal of Exercise Science
International Journal of Exercise Science 9(5): 576-586, 2016. This study assessed 30 male and 20 female well-trained CrossFit (XF) athletes’ natural hydration statuses, fluid intake, and absolute and estimated sweat losses during training sessions lasting 30-47 min. Participants provided a pre-workout urine sample for assessment of hydration by urine specific gravity (USG). Nude pre- and post-workout body mass and fluid intakes were measured to determine sweat losses. To evaluate perception of total sweat loss, participants were asked to estimate their total sweat loss to compare against actual sweat loss. Mean sweat losses did not exceed 1% body mass for men …
Influence Of Baseball Catcher Mask Design, Impact Location And Ball Trajectory On Head Acceleration,
2016
Western University of Health Sciences
Influence Of Baseball Catcher Mask Design, Impact Location And Ball Trajectory On Head Acceleration, Jordan Siu, Alex Okonek, Philip K. Schot
International Journal of Exercise Science
International Journal of Exercise Science 9(5): 567-575, 2016. The general aim was to contrast accelerations caused by baseball impacts for different catcher mask designs. Study1 focused on impact locations for a perpendicular ball trajectory. Study2 examined perpendicular and oblique trajectories striking a single mask location. A 5.9 kg head model instrumented with a 3-d accelerometer recording at 512 Hz was mounted upright with springs in a shallow ball joint. A pitching machine fired a standard baseball at ~28 m/s for all tests. Transverse plane resultant peak acceleration was gathered from 5 trials in each experimental combination. In Study1, effects of …
