Physiology Commons^™

Novel Mechanisms Of Β-Adrenergic Signaling In Prostate Cancer Progression, Mohit Hulsurkar

Dissertations and Theses (Open Access)

Prostate cancer is the second leading cause of cancer death among American men. The American Cancer Society estimates that 180,890 men will be will be diagnosed with prostate cancer in 2016 in the USA. (http://www.cancer.org/cancer/prostatecancer/detailedguide/prostate-cancer-key-statistics). Androgen deprivation therapy (ADT) is the standard treatment for early stage prostate cancer. But most patients relapse with aggressive variants of prostate cancer, with survival time between 1-3 years. In order to develop cure for such aggressive variants of prostate cancer, our present understanding of the mechanisms underlying its progression needs to be advanced.

Recently, it has been found that activation of β-adrenergic signaling pathway …

Effect Of A Recovery Supplement On Weight Lifting Performance, Muscle Fiber Morphology And Muscle Protein Accretion, Christopher B. Taber

Electronic Theses and Dissertations

The purposes of this dissertation were to examine the effect of a protein and carbohydrate recovery beverage versus a placebo on weightlifting performance, its effect on muscle morphological changes and specific muscle protein accretion. The following are major finding from the dissertation: 1) Protein and carbohydrate recovery supplementation does not appear to have influence on performance measure in trained weightlifters. This finding may be associated with the short-term nature of this study and the trained population used. 2) Compared with placebo, a protein and carbohydrate beverage provided greater benefits on cross sectional area of type I and type II muscle …

Seasonal Perceived Training Load In Ncaa Di Men’S Soccer: Is There A Dose-Response Relationship?, Andrew A. Pustina

Electronic Theses and Dissertations

The purpose of this dissertation was to determine if a there was a dose-response relationship across an NCAA Division I men’s soccer season. Specifically, this dissertation serves to: 1.) assess the validity of duration measurements that have previously been used to calculate session RPE during competitive matches, 2.) determine the degree and magnitude of change in intermittent endurance performance across a season and to observe how change in endurance relates with training load, 3.) determine the degree and magnitude of change in strength and explosiveness across a season, and to see how these strength changes relate to training load. 1.) …

Exploring The Relationship Between Behaviour And Neurochemistry In The Polyphenic Spider, Anelosimus Studiosus (Araneae: Theridiidae), Jennifer B. Price

Electronic Theses and Dissertations

The importance of social behaviour is evident in human society, but there are both costs and benefits associated with cooperation and sociality throughout the animal kingdom. At what point do the benefits outweigh the costs, and when do selective pressures favour sociality and colonization over solitude and independence? To investigate these questions, we have focused on an anomalous species of spider, Anelosimus studiosus, also known now as the northern social spider. Throughout its broad range, A. studiosus is solitary and aggressive, but recently, colonies of cooperative and social individuals have been observed at northern latitudes. This leads to two …

The Proteomic Response Of Gill Tissue In Tidally And Subtidally-Acclimated California Mussels, Mytilus Californianus, To Acute Emersion-Induced Anoxia, Aubrie N. Fowler, Lars Tomanek

Master's Theses

Intertidal mussels regularly experience emersion-induced anoxia, in contrast to normoxic conditions experienced during submersion. We therefore hypothesized that acclimation to a tidal rhythm, as opposed to a rhythm of constant submersion, preconditions the proteome of the California mussel, Mytilus californianus, to respond differently to emersion-induced anoxia. Following acclimation, mussels either continued to receive the acclimation conditions (control) or were exposed to 100% nitrogengas (anoxia) during aerial emersion. We collected gill tissue for subsequent analysis of protein abundance with 2D gel electrophoresis and protein identification with tandem mass spectrometry. Relative to subtidally-acclimated mussels, tidally-acclimated mussels showed a greater propensity to …

A Comparison Of Cervical And Trunk Musculoskeletal Characteristics Between Female And Male Army Helicopter Pilots, Takashi Nagai, Karen A. Keenan, John P. Abt, Timothy C. Sell, Brian W. Smalley, Michael D. Wirt, Scott M. Lephart

International Journal of Aviation, Aeronautics, and Aerospace

Introduction: Neck pain (NP) and low back pain (LBP) are prevalent among military helicopter pilots. Although there have been few studies on sex differences in the NP/LBP prevalence in this population, females are shown to be at a greater risk of NP/LBP in civilian studies. This disparity may be due to musculoskeletal characteristics differences that predispose females for NP/LBP. The purpose of this study was to compare cervical and trunk musculoskeletal characteristics between male and female pilots. Methods: A total of 8 female pilots (Age: 27.6 ± 4.2yrs, HT: 166.1 ± 7.7cm, WT: 67.9 ± 10.6kg) were tested, and they …

Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, Md, Thomas Melvin, Brandon Merritt, Charles Bishop, Md, Franklin D. Shuler, Md, Phd

Marshall Journal of Medicine

Vitamin K is known to play an essential role in the coagulation cascade; however, a growing body of research has found that a subtype of this vitamin, vitamin K₂ (menaquinone) may have a beneficial effect in osteoporosis, cardiovascular disease, and cancer. This purpose of this article is to provide a comprehensive review of recent literature regarding menaquinone and its role in human health. This review discusses the physiology of menaquinone, its clinical benefits in cardiovascular disease, osteoporosis, and cancer, and how it may interact with certain medications. The authors conclude that menaquinone supplementation has been shown to improve carboxylation …

Altered Differential Control Of Sympathetic Outflow Following Sedentary Conditions: Role Of Subregional Neuroplasticity In The Rvlm, Madhan Subramanian, Patrick J. Mueller

Physiology Faculty Research Publications

Despite the classically held belief of an “all-or-none” activation of the sympathetic nervous system, differential responses in sympathetic nerve activity (SNA) can occur acutely at varying magnitudes and in opposing directions. Sympathetic nerves also appear to contribute differentially to various disease states including hypertension and heart failure. Previously we have reported that sedentary conditions enhanced responses of splanchnic SNA (SSNA) but not lumbar SNA (LSNA) to activation of the rostral ventrolateral medulla (RVLM) in rats. Bulbospinal RVLM neurons from sedentary rats also exhibit increased dendritic branching in rostral regions of the RVLM. We hypothesized that regionally specific structural neuroplasticity would …

Repeated Closed Head Injury In Mice Results In Sustained Motor And Memory Deficits And Chronic Cellular Changes, Amanda Nicholle Bolton Hall, Binoy Joseph, Jennifer M. Brelsfoard, Kathryn E. Saatman

Spinal Cord and Brain Injury Research Center Faculty Publications

Millions of mild traumatic brain injuries (TBIs) occur every year in the United States, with many people subject to multiple head injuries that can lead to chronic behavioral dysfunction. We previously reported that mild TBI induced using closed head injuries (CHI) repeated at 24h intervals produced more acute neuron death and glial reactivity than a single CHI, and increasing the length of time between injuries to 48h reduced the cumulative acute effects of repeated CHI. To determine whether repeated CHI is associated with behavioral dysfunction or persistent cellular damage, mice receiving either five CHI at 24h intervals, five CHI at …

A Bayesian Inference Comparing Collegiate Female Cyclists To Elite Female Cyclists From A Meta-Analysis, Frank B. Wyatt, Mihir Dhimar, Yesha Shah

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 368-375, 2016. The aim of this study was to evaluate the physiological characteristics of competitive, collegiate female cyclists (CFC) to data of elite female cyclists (EFC) obtained from a meta-analytic review. Eleven (n=11) CFC volunteered as subjects. Subjects signed a university approved informed consent. Means and standard deviation (+ SD) were obtained from the following measurements: age (y), 22.5± 5.1; height (cm) 167.22 ± 6.2; body mass (kg) 63.78 ± 9.71; body fat (%) 22.9 ± 3.6. Subjects performed a maximal cycling ergometer test to volitional fatigue. Maximal oxygen consumption (VO2 max, mL*kg1*min.-1) …

Effects Of Static Stretching On Squat Performance In Division I Female Athletes, Clare F. Heisey, J. Derek Kingsley

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 359-367, 2016. Static stretching was once recognized as a method of preparation for physical activity that would inhibit performance and increase risk of injury. However, a growing body of research suggests that static stretching may not have an inhibitory effect. Regardless, the data have not examined gender differences or the fatigue index (FI) and flexibility effects of static stretching on the back squat over multiple sets. Therefore, the purpose of this study was to examine the relationship between a static-stretch condition (SC) and control condition (CC) on flexibility and the FI of Division I …

Individual Differences In The Programming Of Rapid Bimanual Movements: Are Two Modes Better Than One?, Ashley N. Vander Does, David E. Sherwood

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 347-358, 2016. One of the challenges in performing simultaneous bimanual movements is to prevent interference from one limb to the other, thereby maintaining spatial accuracy in both limbs. Prior research has shown that when a longer distance movement is performed with a shorter movement, the shorter movement overshoots its target and the longer movement undershoots its target relative to control conditions where two shorter or two longer movements are made. The current experiment investigated the motor control strategies used by participants when performing simultaneous aiming movements combining both different and same distances. Participants (N …

Exercise-Induced Glycogen Reduction Increases Muscle Activity, Matthew S. Tenan, J. Troy Blackburn, Robert G. Mcmurray

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 336-346, 2016. Intramuscular glycogen stores are an important energy source during extended bouts of strenuous exercise. A substantial reduction in glycogen could influence neural muscular drive and result in a decreasing quality of exercise performance and potentially increased injury rates. The aim of this study was to examine the effect of glycogen reduction on motor drive as determined by the surface electromyogram (EMG) amplitude and median frequency during a cycling graded exercise test. Eight trained cyclists performed a discontinuous cycling graded exercise test to exhaustion under both normal and glycogen reduced conditions. EMG …

Power Training And Functional Performance In Middle Aged Women: A Pilot Study, Mitchel A. Magrini, J. Jay Dawes, Craig Elder, Mary Ann Kluge

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 327-335, 2016. Muscular power is a key component of functional performance (FP) and fall risk reduction. The present study investigated the effect that power training with medicine balls had on body composition and FP in middle-age females. 10 women were divided into a control group (n=4, age=59.8+3.6) and an intervention group (n=6, age=59.5+3.6) in this 6-week study. The intervention group completed a medicine ball training program two times a week. Body composition and FP tests were administered prepost. Data was analyzed using a series of Wilcoxon Signed Ranks test and Cohen’s d test for …

Do Girls With Excess Adiposity Perform Poorer Motor Skills Than Their Leaner Peers?, Daniel V. Chagas, Joyce F. Carvalho, Luiz A. Batista

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 318-326, 2016. The main aim of this study was to analyze the joint association of body fat percentage and physical activity levels on motor coordination scores in girls with different adiposity status. Sixty-eight school-aged children between 12 and 14 years participated in the study. Skinfold thickness was measured and the Körperkoordinationstest für Kinder test was administered. Participants completed a selfreporting questionnaire on physical activity. Children’s adiposity status was attributed in according to age-specific cutoff points of a Brazilian database. Analysis of Variance was used to compare motor coordination scores among groups with different status …

Factors Influencing Muscular Strength And Endurance In Disadvantaged Children From Low-Income Families, Yi Fang, Ryan D. Burns, James C. Hannon, Timothy A. Brusseau

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 306-317, 2016. Examining the correlates of muscular strength and endurance in children from low-income families will provide evidence for interventions to improve these parameters. The purpose of this study was to determine the predictors and trends of muscular strength and endurance in at-risk school-aged children. The sample included 1,232 children (Mean age = 8.8 ± 1.6 years; 625 girls, 607 boys; 60% Hispanic) recruited from three U.S. low-income schools. Children performed health-related fitness testing and wore pedometers for one school week. A stratified random subsample (n = 533) also wore accelerometers to record sedentary …

Perceptions Of Motivational Climate, Goal Orientations, And Light- To Vigorous-Intensity Physical Activity Engagement Of A Sample Of Finnish Grade 5 To 9 Students, Arto Gråstén, Anthony P. Watt

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 291-305, 2016. The aim of this study was the examination of relationships between children’s perceptions of motivational climate, goal orientation, and their engagement in light- to vigorous-intensity physical activity. The sample comprised 585 school children at age of 11 to 16-year-old from three small cities located in Northeast-Finland. The cross-sectional data was collected using online questionnaires in April 2014. The findings indicated that the higher task-involving motivational climate in physical education the children reported, the higher total light- and moderate-intensity levels they accumulated. Task-involving climate also indicated higher task orientation and ego-involving climate higher …

The Acute Effect Of Pilates Exercise On Lower Extremity Maximal Strength, Heather Monger, Blain C. Harrison

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 283-290, 2016. In recent years, the effects of chronic core training on athletic performance have been examined with mixed results; however, the acute effects of core training on athletic performance variables have yet to be examined. Therefore, the purpose of this study was to determine the relationship between an acute bout of core training and lower extremity maximal strength. Seventeen healthy males (weight 90.1 ± 17.2 kg; height 176.7 ± 11.2 cm; age 20.9 ± 1.3 years) performed maximal deadlift assessments following 2 testing conditions. A general cardiovascular warm-up was used as the control …

Physiological Characteristics Of Youth Synchronized Skaters, Laura E. Fischer M.Ed., Lynn A. Darby Ph.D., Amy L. Morgan Ph.D., David A. Tobar Ph.D.

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 270-282, 2016. Figure skating is a lifelong sport with participation rates increasing for skaters of all ages. Development within the five disciplines of figure skating (individual skating, synchronized skating, pairs skating, ice dancing, and theater on ice) has led to increased physical demands placed on skaters’ bodies. As a result, focus on sport performance testing, training, and injury prevention specific to figure skating is increasing. The purpose of this study was to use field tests to describe the physical characteristics of synchronized skaters and to determine the relationships between these physiological characteristics and skating …

Evaluation Of The Basis Band Fitness Tracker, Pier-Alexandre Desilets, Matthew T. Mahar

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 258-269, 2016. Self-monitoring is a widely recommended behavioral strategy to promote regular physical activity. Commercially available activity monitors are becoming increasingly popular and provide users with the opportunity to self-monitor physical activity. The purpose of this study was to examine the ability of the Basis Band Fitness Tracker to measure heart rate and movement compared to research-grade activity monitors. Twenty participants (14 females and 6 males) aged 18-23 yrs (mean = 20.0 ± 1.1 yrs) wore a Basis Band, an NL-1000 pedometer, an ANT+ Motorola HRM1G chest strap heart rate monitor, and an …