Skeletal Muscle Mitophagy In Response To Cold Exposure During Exercise,
2019
University of Nebraska at Omaha
Skeletal Muscle Mitophagy In Response To Cold Exposure During Exercise, Megan Vande Hei
UNO Student Research and Creative Activity Fair
BACKGROUND: The signaling pathways generated during exercise elicit mitochondrial adaptation, which includes both biogenesis and removal of damaged mitochondria (also known as mitophagy). It has been established that training followed by cold exposure alters the transcription of genes associated with mitochondrial growth and division. However, it is currently unknown whether temperature intervention during exercise influences the mRNA expression of genes associated with mitophagy, which is essential to maintaining the quality of this organelle. PURPOSE: To determine the expression of PINK1, PARK2, BNIP3, and BNIP3L mRNA following exercise in a cold environmental temperature with recovery at room temperature compared to exercise …
Sex Comparisons Of Agonist And Antagonist Muscle Electromyographic Parameters During Two Different Submaximal Isometric Fatiguing Tasks,
2019
University of Mississippi
Sex Comparisons Of Agonist And Antagonist Muscle Electromyographic Parameters During Two Different Submaximal Isometric Fatiguing Tasks, Sunggun Jeon, Xin Ye, William M. Miller
Faculty and Student Publications
© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. To examine the task failure time of the force- and position-based submaximal elbow flexion fatiguing tasks for both sexes, twelve men and eight women visited the laboratory for two separate experimental occasions. During the experiment, they pulled against a rigid restraint for the force task and maintained a constant elbow joint angle to support an equivalent inertial load for the position task. For both fatiguing tasks (50% of the isometric strength at the elbow joint angle of 135 …
Alternative Nad(P)H Dehydrogenase And Alternative Oxidase: Proposed Physiological Roles In Animals,
2019
Wilfrid Laurier University
Alternative Nad(P)H Dehydrogenase And Alternative Oxidase: Proposed Physiological Roles In Animals, Allison Mcdonald, Dmytro V. Gospodaryov
Biology Faculty Publications
The electron transport systems in mitochondria of many organisms contain alternative respiratory enzymes distinct from those of the canonical respiratory system depicted in textbooks. Two of these enzymes, the alternative NADH dehydrogenase and the alternative oxidase, were of interest to a limited circle of researchers until they were envisioned as gene therapy tools for mitochondrial disease treatment. Recently, these enzymes were discovered in several animals. Here, we analyse the functioning of alternative NADH dehydrogenases and oxidases in different organisms. We propose that both enzymes ensure bioenergetic and metabolic flexibility during environmental transitions or other conditions which may compromise the operation …
Cardiorespiratory Responses To Shallow Water Exercise: A Sex Comparison,
2019
Central Washington University
Cardiorespiratory Responses To Shallow Water Exercise: A Sex Comparison, Mitchell Garant Fisher, Laura Jean Miller, Jerusalem Tesfaye, Karen Roemer, Debra Mary D'Acquisto, Leo Joseph D'Acquisto
International Journal of Aquatic Research and Education
This investigation examined physiological responses to shallow water exercise (SWE) and to a high-intensity interval SWE workout (HIISWE) in males (M, n=9) and females (F, n=9). Participants performed 5 X 5 min. SWE bouts (bts.) at ratings of perceived exertion (RPE) 9, 11, 13, 15 and 17 (Borg scale) and a maximal bout of SWE with metabolic, heart rate (HR), and blood lactate (BLa) responses monitored. The same measurements were performed during HIISWE (4 X 4-min bts., alternating 20-s “all-out” and 10-s rest). Peak oxygen uptake (V̇O2) and BLa were greater in M (3.6 ± 0.4 vs. 2.7 …
Bilateral Striatal Necrosis Due To Homoplasmic Mitochondrial 3697g>A Mutation Presents With Incomplete Penetrance And Sex Bias,
2019
Peking University People's Hospital
Bilateral Striatal Necrosis Due To Homoplasmic Mitochondrial 3697g>A Mutation Presents With Incomplete Penetrance And Sex Bias, Shanshan Zhong, Shumeng Wen, Yusen Qiu, Yanyan Yu, Ling Xin, Yang He, Xuguang Gao, Hezhi Fang, Daojun Hong, Jun Zhang
Faculty and Student Publications
© 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. Background: Heteroplasmic mitochondrial 3697G>A mutation has been associated with leber hereditary optic neuropathy (LHON), mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS), and LHON/MELAS overlap syndrome. However, homoplasmic m.3697G>A mutation was only found in a family with Leigh syndrome, and the phenotype and pathogenicity of this homoplasmic mutation still need to be investigated in new patients. Methods: The clinical interviews were conducted in 12 individuals from a multiple-generation inherited family. Mutations were screened through exome next-generation sequencing and subsequently confirmed by PCR-restriction fragment length …
Heat Exposure And Hypohydration Exacerbate Physiological Strain During Load Carrying,
2019
University of Connecticut
Heat Exposure And Hypohydration Exacerbate Physiological Strain During Load Carrying, Elizabeth L. Adams, Douglas J. Casa, Robert A. Huggins, Julie K. Demartini, Rebecca L. Stearns, Rachel M. Kennedy, Lindsay J. Distefano, Lawrence E. Armstrong, Carl M. Maresh
All PTHMS Faculty Publications
Heat exposure and hypohydration induce physiological and psychological strain during exercise; however, it is unknown if the separate effects of heat exposure and hypohydration are synergistic when co-occurring during loaded exercise. This study compared separate and combined effects of heat exposure and hypohydration on physiological strain, mood state, and visual vigilance during loaded exercise. Twelve males (mean±SD; age, 20±2 years; body mass, 74.0±8.2 kg; maximal oxygen uptake, 57.0±6.0 mLkg-1min-1) completed 4 trials under the following conditions: euhydrated temperate (EUT), hypohydrated temperate (HYT), euhydrated hot (EUH), and hypohydrated hot (HYH). Exercise was 90 min of treadmill walking (∼50% VO2 max, 5% …
Validation Of A New Incremental Swim Test As A Tool For Maximum Oxygen Uptake Analysis In Lifeguards,
2019
University of A Coruña, A Coruña, Spain
Validation Of A New Incremental Swim Test As A Tool For Maximum Oxygen Uptake Analysis In Lifeguards, Brais Ruibal-Lista, José Palacios-Aguilar, José Antonio Prieto, Sergio López-García, José Antonio Cecchini-Estrada, Miguel Santiago-Alonso, Cristian Abelairas-Gómez
International Journal of Aquatic Research and Education
This study was designed to validate an incremental test predicting maximum oxygen uptake for lifeguards. A maximum incremental test was performed in the laboratory (i.e., treadmill run) and in the pool (i.e., swim) by 10 certified lifeguards. The values of maximum oxygen uptake (VO2Max), maximum heart rate (HRMax), and lactate (LaMax) achieved during both tests were analyzed. The VO2Max (0.87, p =.001), HRmax (0.85, p = .002) and LaMax (0.67, p
Serum Amyloid A Binds To Gibrin(Ogen), Promoting Fibrin Amyloid Formation,
2019
Stellenbosch University, South Africa
Serum Amyloid A Binds To Gibrin(Ogen), Promoting Fibrin Amyloid Formation, Martin J. Page, Greig J. A. Thomson, J. Massimo Nunes, Anna-Mart Engelbrecht, Theo A. Nell, Willem J. S. De Villiers, Maria C. De Beer, Lize Engelbrecht, Douglas B. Kell, Etheresia Pretorius
Physiology Faculty Publications
Complex associations exist between inflammation and thrombosis, with the inflammatory state tending to promote coagulation. Fibrinogen, an acute phase protein, has been shown to interact with the amyloidogenic ß-amyloid protein of Alzheimer’s disease. However, little is known about the association between fibrinogen and serum amyloid A (SAA), a highly fibrillogenic protein that is one of the most dramatically changing acute phase reactants in the circulation. To study the role of SAA in coagulation and thrombosis, in vitro experiments were performed where purified human SAA, in concentrations resembling a modest acute phase response, was added to platelet-poor plasma (PPP) and whole …
Triple Hop For Distance As A Predictor Of Lower Extremity Performance In Firefighter Equipment,
2019
California State University, Northridge
Triple Hop For Distance As A Predictor Of Lower Extremity Performance In Firefighter Equipment, Sean M. Rogers, Zachary K. Winkelmann, Lindsey E. Eberman, Kenneth E. Games
International Journal of Exercise Science
International Journal of Exercise Science 12(6): 515-525, 2019. The objective of this study was to examine the predictive value of the Triple Hop for Distance (THD) physical performance test to assess lower extremity (LE) strength and power in individuals donning firefighter personal protective equipment (PPE). Thirty-one healthy participants completed the THD in firefighter PPE on both the dominant and non-dominant limb. Dependent variables included LE power (vertical jump height [cm]) on a jump mat, and LE strength of the quadriceps and hamstrings (peak torque [Nm]) on an isokinetic dynamometer. THD was a strong predictor of LE power on the dominant …
A Hindbrain Inhibitory Microcircuit Mediates Vagally-Coordinated Glucose Regulation,
2019
University of Kentucky
A Hindbrain Inhibitory Microcircuit Mediates Vagally-Coordinated Glucose Regulation, Carie R. Boychuk, Katalin Cs. Smith, Laura E. Peterson, Jeffery A. Boychuk, Corwin R. Butler, Isabel D. Derera, John J. Mccarthy, Bret N. Smith
Physiology Faculty Publications
Neurons in the brainstem dorsal vagal complex integrate neural and humoral signals to coordinate autonomic output to viscera that regulate a variety of physiological functions, but how this circuitry regulates metabolism is murky. We tested the hypothesis that premotor, GABAergic neurons in the nucleus tractus solitarius (NTS) form a hindbrain micro-circuit with preganglionic parasympathetic motorneurons of the dorsal motor nucleus of the vagus (DMV) that is capable of modulating systemic blood glucose concentration. In vitro, neuronal activation or inhibition using either excitatory or inhibitory designer receptor exclusively activated by designer drugs (DREADDs) constructs expressed in GABAergic NTS neurons increased …
Exercise Is Medicine®: Knowledge And Awareness Among Exercise Science And Medical School Students,
2019
University of Akron
Exercise Is Medicine®: Knowledge And Awareness Among Exercise Science And Medical School Students, Rachel Mealy, Laura Richardson, Brian Miller, Melissa Smith, Judith A. Juvancic-Heltzel
International Journal of Exercise Science
International Journal of Exercise Science 12(3): 505-514, 2019. The purpose of this exploratory study was twofold: to determine whether exercise science and medical students are aware of the Exercise is Medicine® (EIM®) program and to construct a tool that would permit assessment of EIM® variables with students enrolled in both programs. The study consisted of a quantitative, cross-sectional design, using a self-report electronic questionnaire. An Exploratory Factor Analysis (EFA) using principal component analysis extraction method with Varimax factor rotation was employed to validate the survey instrument based on the expected constructs, which posited five (5) contending …
Transcranial Direct Current Stimulation Of Motor Cortex Enhances Running Performance.,
2019
Rowan University
Transcranial Direct Current Stimulation Of Motor Cortex Enhances Running Performance., Seung-Bo Park, Dong Jun Sung, Bokyung Kim, Sojung Kim, Joung-Kyue Han
College of Science & Mathematics Departmental Research
Transcranial direct current stimulation (tDCS) is a technique used to modulate neuronal excitability through non-invasive brain stimulation that can enhance exercise performance. We hypothesize that tDCS would improve submaximal running time to exhaustion (TTE) and delay the increase in the rating of perceived exertion (RPE) over time. We also hypothesize that tDCS would not lead to difference in cardiorespiratory responses. We employed a randomized, single-blinded, and counterbalanced design in which 10 trained men participated. After receiving either 20 min of 1.98 mA anodal tDCS applied over the primary motor cortex (M1) or sham-operated control on separate days, participants completed a …
Evaluation Of Novel Hemocompatible Surface Coatings For Extracorporeal Life Support: A Biocompatible Alternative To Systemic Anticoagulation,
2019
University of South Florida
Evaluation Of Novel Hemocompatible Surface Coatings For Extracorporeal Life Support: A Biocompatible Alternative To Systemic Anticoagulation, Teryn Rose Roberts
USF Tampa Graduate Theses and Dissertations
Extracorporeal life support (ECLS) is a class of technologies used to support or replace the function of failing organs. During ECLS, blood is withdrawn from systemic circulation and circulated through an artificial organ or “treatment membrane” that performs the function of the failing organ, prior to return to systemic circulation. While ECLS provides life-saving therapy to wide patient populations from pre-term infants to combat-wounded soldiers, this therapy is limited due to secondary thrombotic and bleeding complications that result from: 1) exposure of blood to the foreign surfaces in the device circuit and 2) administration of anticoagulant drugs to prevent clot …
Effect Of An 8-Week Plyometric Training Program With Raised Forefoot Platforms On Agility And Vertical Jump Performance,
2019
Haute Ecole Louvain en Hainaut
Effect Of An 8-Week Plyometric Training Program With Raised Forefoot Platforms On Agility And Vertical Jump Performance, Matthieu Pj Voisin, Mikaël Scohier
International Journal of Exercise Science
International Journal of Exercise Science 12(6): 491-504, 2019. Some athletes use solid rubber platforms strapped onto the forefoot during plyometric exercises in order to increase their explosive performance including vertical jump height and agility. The purpose of this study was to compare the effects of a plyometric training program realized with these ‘raised forefoot platforms,’ designed to keep the heels off the ground, to the same program conducted with regular shoes. Forty-nine subjects performed 2 sessions of plyometric training for eight weeks, either with raised forefoot platforms (n=20) or regular shoes (n=29). Countermovement jump (CMJ) height and agility test time …
Monitoring Changes Of Cardio-Respiratory Parameters During 2000m Rowing Performance,
2019
Sports Authority of India, Bangalore
Monitoring Changes Of Cardio-Respiratory Parameters During 2000m Rowing Performance, Arnab Das, Malay Mandal, Alak K. Syamal, Pralay Majumdar
International Journal of Exercise Science
International Journal of Exercise Science 12(2): 483-490, 2019. The purpose of this study was to characterize the kinetics of cardio-respiratory parameters of elite male rowers during 2000m rowing time trial. 16 lightweight category (LWC) and 11 open category (OC) elite male rowers attending National camp were included in the study. Pulmonary gas exchange and heart rate (HR) during 2000m rowing ergometer test was determined through breath-by-breath analysis, with a portable metabolic gas analyzer and HR monitor. Time to completion, HR, oxygen uptake (V̇O2), minute ventilation (V̇E) and respiratory exchange ratio (RER) were recorded at 500m, 1000m, 1500m and …
Validity And Wearability Of Consumer-Based Fitness Trackers In Free-Living Children,
2019
University of South Carolina
Validity And Wearability Of Consumer-Based Fitness Trackers In Free-Living Children, Keith Brazendale, Lindsay Decker, Ethan T. Hunt, Michelle W. Perry, Allison B. Brazendale, R Glenn Weaver, Michael W. Beets
International Journal of Exercise Science
International Journal of Exercise Science 12(5): 471-482, 2019. Over the past decade wearable fitness trackers (WFTs) have grown in popularity with more recent versions able to capture the pulse rate noninvasively on the wrist of the wearer. Most of evidence on the validity of WFTs have explored adults in clinical settings. Thus, the purpose of this study is to 1) evaluate the validity of a wrist-placed WFT in determining heart rate, and 2) examine the wear compliance of a wrist-placed WFT, in children in free-living settings. In study 1, 19 children (5-12yrs) wore a Fitbit Charge HR© and a …
Effects Of Exercise Environment And Protocol Intensity On The Efficacy Of Rehabilitation Care For Patients With Huntington’S Disease: A Comprehensive Review,
2019
Lincoln Memorial University-DeBusk College of Osteopathic Medicine
Effects Of Exercise Environment And Protocol Intensity On The Efficacy Of Rehabilitation Care For Patients With Huntington’S Disease: A Comprehensive Review, James D. Dolbow, Hau Ly, Nicholas Elwert, John Gassler
International Journal of Exercise Science
International Journal of Exercise Science 12(3): 456-470, 2019. Huntington’s disease (HD) is a neurodegenerative disease caused by astrogliosis of the putamen and caudate nucleus. Motor symptoms include progressive chorea, leading to deficits in gait, motor function, and quality of life. While many studies have examined the effects of therapeutic exercise on these factors in individuals with HD, the efficacy of such protocols has yet to be analyzed. Purpose: The purpose of this review is to analyze trends in efficacy reported by studies examining the effects of exercise on motor function, gait quality, and quality of life in individuals with HD. …
Body Composition And Perceived Stress Through A Calendar Year In Ncaa I Female Volleyball Players,
2019
Auburn University
Body Composition And Perceived Stress Through A Calendar Year In Ncaa I Female Volleyball Players, Hayden W. Hyatt, Andreas N. Kavazis
International Journal of Exercise Science
International Journal of Exercise Science 12(5): 433-443, 2019. The aim of the study was to track changes of perceived stress and body composition across an entire calendar year in National Collegiate Athletic Association (NCAA) division I female volleyball players. We hypothesized that perceived stress and body composition would vary between the competitive season and off-season, with the largest changes occurring during time points prior to the onset and after the end of the competitive season. Eight female volleyball players participated in a longitudinal study. Body mass, body mass index (BMI), percent body fat, fat mass, and fat free mass were …
Acute Effects Of L-Arginine Supplementation On Oxygen Consumption Kinetics And Muscle Oxyhemoglobin And Deoxyhemoglobin During Treadmill Running In Male Adults,
2019
School of Physical Education of Army
Acute Effects Of L-Arginine Supplementation On Oxygen Consumption Kinetics And Muscle Oxyhemoglobin And Deoxyhemoglobin During Treadmill Running In Male Adults, Claudia M. Meirelles, Cristiane Matsuura, Roberto Silva Jr., Felipe F. Guimaraes, Paulo Sergio C. Gomes
International Journal of Exercise Science
International Journal of Exercise Science 12(2): 444-455, 2019. L-arginine is used as a nitric oxide related supplement intended to improve sports performance, and to enhance muscular recovery during exercise. However, the literature is inconclusive. The aim of this study was to determine the effects of acute oral L-arginine supplementation on O2 consumption kinetics and local muscle blood volume and oxygenation during treadmill running at two different intensities. Using a double-blind, crossover and placebo-controlled design, 11 young healthy male adults were randomly assigned to 6 g of L-arginine (ARG) or placebo (PLA) supplementation that was ingested 60 min before the exercise …
Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism And Lipid Droplet Formation,
2019
University of Kentucky
Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism And Lipid Droplet Formation, Brandon C. Farmer, Jude Kluemper, Lance A. Johnson
Physiology Faculty Publications
Lipid droplets (LDs) serve as energy rich reservoirs and have been associated with apolipoprotein E (APOE) and neurodegeneration. The E4 allele of APOE (E4) is the strongest genetic risk factor for the development of late onset Alzheimer’s disease (AD). Since both E4 carriers and individuals with AD exhibit a state of cerebral lipid dyshomeostasis, we hypothesized that APOE may play a role in regulating LD metabolism. We found that astrocytes expressing E4 accumulate significantly more and smaller LDs compared to E3 astrocytes. Accordingly, expression of perilipin-2, an essential LD protein component, was higher in E4 astrocytes. We then …
