Immunology and Infectious Disease Commons^™

Global Trends And Gaps In Research Related To Latent Tuberculosis Infection, Liling Chaw, Lung-Chang Chien, Justin Wong, Ken Takahashi, David Koh, Ro-Ting Lin

Environmental & Global Health Faculty Research

Background There is a global commitment to eliminating tuberculosis (TB). It is critical to detect and treat cases of latent TB infection (LTBI), the reservoir of new TB cases. Our study assesses trends in publication of LTBI-related research. Methods We used the keywords (“latent tuberculosis” OR “LTBI” OR “latent TB”) to search the Web of Science for LTBI-related articles published 1995–2018, then classified the results into three research areas: laboratory sciences, clinical research, and public health. We calculated the proportions of LTBI-related articles in each area to three areas combined, the average rates of LTBI-related to all scientific and TB-related …

March 17, 2020: Covid-19 Update, Kettering University

Communication Updates

No abstract provided.

Evaluation Of The Impact Of Social Collaborations On Sexual And Reproductive Health Knowledge, Lucki Word, Jaila Campbell, Manar T. Edriss, Destiny Stroman, Jewel Evans, Melanie Hanna-Johnson, Md, Anil N. F. Aranha, Phd

Medical Student Research Symposium

Introduction: Developments in technology, such as the popularity of mobile devices and social media outlets, have enhanced the ability of individuals to communicate. Currently, search engines allow for easy exploration of information related to every topic of interest. Our study purpose was to evaluate the impact of technological and social collaborations on sexual and reproductive health knowledge (SRHK).

Methods: A 50-item survey instrument, integrating factors of sociodemographics, number/type of social collaborations, technological communication use, and SRHK, was developed to assess familiarity with sexual and reproductive health perceptions. The survey was provided to consenting patients in an ambulatory, primary care setting. …

March 16, 2020: Covid-19 Update, Letter From The President, Kettering University

Communication Updates

No abstract provided.

March 12, 2020: Covid-19 Update, Letter From The President, Kettering University

Communication Updates

No abstract provided.

March 11, 2020: Covid-19 Update, Letter From The President, Kettering University

Communication Updates

No abstract provided.

Perplexing Role Of P-Glycoprotein In Tumor Microenvironment, Kianna Robinson, Venkataswarup Tiriveedhi

Biology Faculty Research

Development of multidrug resistance (MDR) still remains a major obstacle to the long-term success of cancer therapy. P-glycoprotein (P-gp) is a well-identified membrane transporter with capability to efflux drug molecules out of the cancer cell leading to reduced efficiency of chemotherapy. Cancer cells upregulate P-gp expression as an adaptive response to evade chemotherapy mediated cell death. While several P-gp inhibitors have been discovered by in silico and pre-clinical studies, very few have successfully passed all phases of the clinical trials. Studies show that application of P-gp inhibitors in cancer therapy regimen following development of MDR achieved limited beneficial outcomes. While, …

March 3, 2020: Memo To Campus On Covid-19 Restrictions, Kettering University

Communication Updates

No abstract provided.

Two New Nematodes From The Families Molineidae And Strongyloididae (Nemata): Parasites Of Caenolestes (Mammalia: Paucituberculata: Caenolestidae) From The Andes Of Ecuador, Ricardo Guerrero

MANTER: Journal of Parasite Biodiversity

A new genus and species of Molineinae (Nemata: Trichostrongyloidea) is described. It is similar to Molineus but differs in ray 4 being longest instead of shortest. In addition, a new species of Parastrongyloides is described that is characterized by a short digitiform appendix on the tail and spicule tips with fine points. It is the second species known with two morphotypes of the females.

Resumen:

Se describe un nuevo género y especie de Molineinae (Nemata: Trichostrongyloidea), similar a Molineus pero difiere en que en la bolsa caudal el rayo 4 es el más largo en lugar de sewr el …

Hiv-1 Did Not Contribute To The 2019-Ncov Genome, Chuan Xiao, Xiaojun Li, Shuying Liu, Yongming Sang, Shou-Jiang Gao, Feng Gao

Agricultural and Environmental Sciences Faculty Research

No abstract provided.

Defining Parental Resistance: The Social Determinants Of Measles Vaccine Hesitancy, Michael C. Goates, M. Lelinneth B. Novilla, Mallory Showalter, L. Kirsten Novilla, Russell Doria, Michael Dang, Tyler Leffler, Katelyn Aldridge

Faculty Publications

The increase in vaccine-preventable disease (VPD) outbreaks has caused great alarm to the public health community. In recent years, VPD outbreaks have occurred across the globe in both developed and developing countries. Particularly troubling has been the resurgence of diseases formerly eradicated through years of concerted vaccination and other public health campaigns. Higher vaccination exemption rates have been implicated in the resurgence of VPDs. This is particularly evident in the United States where measles outbreaks reached 1,250 individual cases in 2019 alone, the most confirmed cases since 1992. Central to the discussion about measles resurgence is a better understanding of …

Cysteine Dioxygenase Enzyme Activity And Gene Expression In The Dimorphic Pathogenic Fungus Histoplasma Capsulatum Is In Both The Mold And Yeast Morphotypes And Exhibits Substantial Strain Variation, Melissa Adams, Glen Shearer

Faculty Publications

In the dimorphism (mold/yeast) Histoplasma capsulatum (Hc) literature are reports that yeast (the so-called pathogenic form) uniquely expresses a cysteine dioxygenase (CDO, approx. 10,500 dal) activity which the mold morphotype (the so-called saprophytic soil form) does not express (C.F., Kumar et al., Biochem 22, 762, 1983). This yeast-specific CDO activity is postulated to play a critical role in the mold-to-yeast shift. A number of years ago, our lab isolated the gene encoding the Hc cysteine dioxygenase (CDO1, Genbank accession AY804144) and noted significant expression in the mold morphotype of several Histoplasma strains and also determined that the predicted protein would …

February 11, 2020: Covid-19 Update, Kettering University

Communication Updates

As an international community of faculty, staff, and students, we recognize that some are anxious, uncertain, or have family dealing with this now global health crisis, commonly known as coronavirus.

Even as no cases of the novel coronavirus (2019-nCoV) have been reported at Kettering University or in the state of Michigan, we continue to closely monitor the latest developments and reports.

Checklist Of The Hard Tick (Acari: Ixodidae) Fauna Of Hungary With Emphasis On Host‑Associations And The Emergence Of Rhipicephalus Sanguineus, Sándor Hornok, Dávid Kováts, Gábor Horváth, Jenő Kontschán, Róbert Farkas

Harold W. Manter Laboratory of Parasitology: Library Materials

Hungary is situated in the southern part of Central Europe, next to the northern boundary of the Mediterranean region. This geographical position may allow the northward expansion of Mediterranean ixodid tick species into Hungary, particularly in the era of warming climate. During the past 14 years numerous surveys have been published on the species and activity of hard ticks occurring in the country. However, it was 60 years ago that the last comprehensive review of ixodid ticks of Hungary was published, and only in Hungarian language. The purpose of the present checklist is to provide a comprehensive and complete overview …

Differentiation Of Mannheimia Haemolytica Genotype 1 And 2 Strains By Visible Phenotypic Characteristics On Solid Media, Emily L. Wynn, Gennie Schuller, John D. Loy, Aspen M. Workman, T. G. Mcdaneld, Michael L. Clawson

School of Veterinary and Biomedical Sciences: Faculty Publications

Genotype 2 Mannheimia haemolytica associate with the lungs of cattle with bovine respiratory disease more frequently than genotype 1 strains. Different colony colors and morphologies were identified between genotype 1 and 2 solid media cultures. Genotype of strains, and frequency differences between them in mixed cultures are discernable by visual inspection.

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Mutational Analysis And Domain Characterization Of The Apolipoprotein L-1 Ion Channel, Charles M. Schaub

Dissertations, Theses, and Capstone Projects

The human innate immunity factor Apolipoprotein L-1 (APOL1) protects against Trypanosoma brucei brucei infection. Recent studies have shown recombinant APOL1 (rAPOL1) inserts into planar lipid bilayers at an acidic pH 5.6 and forms a cation-selective channel, which opens upon subsequent neutralization, pH 7.2. This corresponds with the pH changes APOL1 would encounter during endosome recycling, suggesting that APOL1 forms a pH-gated ion channel in the plasma membrane of the parasite, leading to uncontrolled ion flux and osmotic imbalance. However, structural and domain characteristics of the APOL1 channel are poorly understood, despite potential similarities to diphtheria and colicin toxins. Utilizing E. …

10th Annual Postdoctoral Science Symposium, University Of Texas Md Anderson Cancer Center Postdoctoral Association

Annual Postdoctoral Science Symposium Abstracts

The Annual Postdoctoral Science Symposium (APSS) was initiated on August 4, 2011, by the MD Anderson Postdoctoral Association to provide a platform for talented postdoctoral fellows throughout the Texas Medical Center to present their work to a wider audience.

APSS is a scientific symposium organized by postdoctoral fellows from The University of Texas MD Anderson Cancer Center that welcomes submissions and presentations from postdoctoral fellows from all Texas Medical Center affiliated institutions and other Houston area institutions. The APSS provides a professional venue for postdoctoral scientists to develop, clarify and refine their research as result of formal reviews and critiques …

Phylogenetic Afficity Of Genolopa (Digenea: Monorchiidae) With Descriptions Of Two New Species, Apryle J. Panyi, Stephen S. Curran, Robin M. Overstreet

Faculty Publications

The validity of Genolopa Linton, 1910 has been controversial because the observation of presently recognized critical diagnostic morphological features (spines in the genital atrium and a bipartite, anteriorly spined terminal organ) were omitted from the original diagnosis, and these features were not universally appreciated as important diagnostic features until 2008. Modern taxonomists have been further challenged by inappropriate fixation techniques that have resulted in various interpretations of morphological features. Consequently, named species in the genus have fluctuated among other monorchiid genera depending on various interpretations by taxonomists, and a modern consensus on classifying these species is lacking. This study …

Predicting The Potential Distribution Of Amblyomma Americanum (Acari: Ixodidae) Infestation In New Zealand, Using Maximum Entropy‑Based Ecological Niche Modelling, R. K. Raghavan, A. C.G. Heath, K. E. Lawrence, R. R. Ganta, A. T. Peterson, W. E. Pomroy

Harold W. Manter Laboratory of Parasitology: Library Materials

Although currently exotic to New Zealand, the potential geographic distribution of Amblyomma americanum (L.), the lone star tick, was modelled using maximum entropy (Max- Ent). The MaxEnt model was calibrated across the native range of A. americanum in North America using present-day climatic conditions and occurrence data from museum collections. The resulting model was then projected onto New Zealand using both present-day and future climates modelled under two greenhouse gas emission scenarios, representative concentration pathways (RCP) 4.5 (low) and RCP 8.5 (high). Three sets of WorldClim bioclimatic variables were chosen using the jackknife method and tested in MaxEnt using different …

The Enigmatic Spelaeorhynchidae Oudemans, 1902 (Acari: Mesostigmata) Blood-Feeding Ectoparasites Infesting Neotropical Bats, With Catalog And Notes On A Collection From The Manú Biosphere Reserve In Peru, Donald Gettinger, Madalyne Epperson, Candy Hermasillo, Scott L. Gardner

MANTER: Journal of Parasite Biodiversity

A survey of ectoparasites associated with bats collected along an elevational transect in the Manú Biosphere Reserve, Peru, includes specimens of two species of an unusual and rarely collected family of parasitic mites, the Spelaeorhynchidae Oudemans, and reveals information on the natural occurrence of these infections. In lowland rainforest (450–1,000 m) along the Rio Alto Madre de Dios, Spelaeorhynchus soaresi Peracchi was recorded exclusively infecting two species of frugivorous Carollia, C. brevicauda and C. perspicillata. At higher elevations in the mountains and cloud forests, Spelaeorhynchus praecursor Neumann exclusively infected two species of nectarivorous Anoura, A. cultrata and A. …