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Articles 151 - 180 of 223
Full-Text Articles in Veterinary Medicine
Carprofen Compromises The Integrity And Barrier Function Of The Colonic Mucosa Of The Dog, Catherine Alix Briere
Carprofen Compromises The Integrity And Barrier Function Of The Colonic Mucosa Of The Dog, Catherine Alix Briere
LSU Master's Theses
Effects of carprofen on colon of dog have not been investigated. Objectives 1) Measure conductance and permeability to mannitol of transverse, proximal descending and distal descending colonic mucosa of dog. 2) Measure conductance and permeability to mannitol of colonic mucosa of dog in presence of carprofen. Design In vitro experimental - nested, randomized block design Animals Colonic mucosa from 6 (objective 1) and 7 (objective 2) mature mixed-breed dogs. Methods Objective 1) Control - Three sections of mucosa from each region of colon were mounted in Ussing chamber units. Conductance was calculated every 15 min for 240 min. Flux of …
Influence Of Tumor Necrosis Factor-Alpha And Minocycline On Microglia And Macrophage Activation During Polytropic Retrovirus Infection, Meryll E. Corbin
Influence Of Tumor Necrosis Factor-Alpha And Minocycline On Microglia And Macrophage Activation During Polytropic Retrovirus Infection, Meryll E. Corbin
LSU Master's Theses
Microglia/macrophage activation has been associated with the pathogenesis of various neurological diseases including human immunodeficiency virus encephalitis, transmissible spongiform encephalitis, and Alzheimer's disease (AD). In vitro studies have indicated a role for TNFα in activating these cells which leads to their migration, proliferation, and secretion of proinflammatory cytokines and chemokines that may potentially damage brain tissue. In the current study, we analyzed the phenotype of microglia and macrophages enriched from wild type and TNFα deficient mice infected with a neurovirulent murine retrovirus. Although TNF receptors CD120a and CD120b were expressed on both microglia and macrophage population, unaltered by either retrovirus …
Evaluation Of Selected Immune Response To Haemonchus Contortus In Gulf Coast Native Compared To Suffolk Lambs, Krishna P. Shakya
Evaluation Of Selected Immune Response To Haemonchus Contortus In Gulf Coast Native Compared To Suffolk Lambs, Krishna P. Shakya
LSU Doctoral Dissertations
Haemonchus contortus is one of the major nematode parasites causing substantial economic losses in small ruminant farming worldwide. Recently, effect of anthelmintic treatment has decreased due to an increasing problem of nematode populations that have developed resistance to anthelmintics. There are certain breeds of sheep that are identified as being relatively resistant to the parasite including Gulf Coast Native (Native) sheep. Understanding the mode of immune response that helps these breeds of sheep control infection could help design vaccines and enhance control programs. This experiment was designed to evaluate the immunological responses of Native, compared with susceptible Suffolk sheep that …
Lymphohistiocytic Proliferative Syndrome Of Alligators (Alligator Mississippiensis): A Cutaneous Manifestation Of West Nile Virus, Javier G. Nevarez
Lymphohistiocytic Proliferative Syndrome Of Alligators (Alligator Mississippiensis): A Cutaneous Manifestation Of West Nile Virus, Javier G. Nevarez
LSU Doctoral Dissertations
ABSTRACT In 1999, there were reports of a new type of lesion in the hides of captive reared alligators from Florida. Similar lesions were first reported from alligator hides in Louisiana in 2001; however, it wasn’t until 2002 that small epizootics became apparent. In 2002, the Louisiana Department of Wildlife and Fisheries began a collaborative effort with the Louisiana State University School of Veterinary Medicine (LSU SVM) to help elucidate the etiology of “PIX” disease, later renamed Lymphohistiocytic Proliferative Syndrome of Alligators (LPSA). Preliminary work concluded that LPSA was a systemic disease affecting multiple tissues. Based on the results of …
Brucella Melitensis: The Evaluation Of A Putative Hemagglutinin Gene's Effect On Virulence In The Caprine Model, Quinesha Laticia Perry
Brucella Melitensis: The Evaluation Of A Putative Hemagglutinin Gene's Effect On Virulence In The Caprine Model, Quinesha Laticia Perry
LSU Doctoral Dissertations
Brucella melitensis is a facultative intracellular bacterial pathogen that causes abortions in goats and sheep and Malta fever in humans. The zoonotic disease brucellosis causes severe economic losses in the Mediterranean region and parts of Africa, Asia, and Latin America. With the completion of the genomic sequences of B. abortus 2308 and B. melitensis 16M, no classical virulence factors were found; and the chromosomes were virtually identical. However, in B. melitensis, a putative hemagglutinin gene was identified which is absent in B. abortus. The possibility of the hemagglutinin gene being a potential virulence factor was evaluated via gene replacement/deletion in …
Genetics Of Herpes Simplex Virus Type-1 Tegument Proteins Involved In Virion Morphogenesis And Egress, Preston A. Fulmer
Genetics Of Herpes Simplex Virus Type-1 Tegument Proteins Involved In Virion Morphogenesis And Egress, Preston A. Fulmer
LSU Doctoral Dissertations
Herpes simplex virus type-1 (HSV-1) morphogenesis occurs in multiple stages within infected cells. Initially, the virion capsid assembles within the nucleus and buds through the nuclear membrane into the cytoplasm. Within the cytoplasm, additional tegument proteins attach to the capsid and the fully tegumented capsids bud into trans-Golgi network (TGN) derived vesicles. Enveloped virions are ultimately secreted to extracellular spaces. The process by which the cytoplasmic capsids bud into TGN-derived vesicles is not well understood. The prevalent model calls for specific interactions among viral tegument proteins and membrane proteins and glycoproteins embedded within TGN membranes. To further investigate the roles …
Characterizing Salmonella Fecal Shedding Among Racehorses In Louisiana, Anna Marie Chapman
Characterizing Salmonella Fecal Shedding Among Racehorses In Louisiana, Anna Marie Chapman
LSU Master's Theses
Salmonella is an important intestinal pathogen in horses capable of infecting populations without demonstrating clinical illness. This study was performed to determine the prevalence of Salmonella fecal shedding among racehorses in Louisiana. Three serial fecal samples were collected from 429 Thoroughbred horses housed at four racetracks. Feces were tested for Salmonella by microbiologic culture with selective primary enrichment and delayed secondary enrichment (DSE). Samples were also evaluated for the presence of Salmonella by polymerase chain reaction (PCR) using genus-specific oligonucleotide primers. A total of 7 (1.6%) horses were positive for Salmonella by either primary bacterial culture or DSE and an …
Brugia Phangi: Effects Of Third Stage Larvae Es Immunization On Early Migration And Parasite Establishment In Mongolian Gerbils (Meriones Unguiculatus), Ginger Ann Robertson
Brugia Phangi: Effects Of Third Stage Larvae Es Immunization On Early Migration And Parasite Establishment In Mongolian Gerbils (Meriones Unguiculatus), Ginger Ann Robertson
LSU Master's Theses
Brugia infections occur via the bite of an infected mosquito. Third stage infective larvae (L3) deposited on the skin during feeding migrate into the bite wound, through skin and into the lymphatic system. It is hypothesized that L3 excretory/secretory products (ES) are important in this initial phase of the infection. A model for these early migrations has been established by inoculating L3s into the dermis (ID) of the permissive gerbil host. In this model, most L3s injected ID in the louer hind limb travel to the popliteal lymph node by 3 days post infection. Adult parasites are located primarily in …
Effect Of Vaccination Of Goats With H-Gal-Gp And H11 Antigens From Intestinal Membrane Cells Of Haemonchus Contortus, Donya Dupree Olcott
Effect Of Vaccination Of Goats With H-Gal-Gp And H11 Antigens From Intestinal Membrane Cells Of Haemonchus Contortus, Donya Dupree Olcott
LSU Master's Theses
Extracts of adult Haemonchus contortus were purified and used as a vaccine against the blood feeding parasite in goats as previously studied in sheep. The proteins used were H11 and H-gal-GP, hidden gut antigens from the microvillar membrane of the gut of the worm and combined with Quil A as adjuvant, then administered to a group of goats kept on concrete then artificially infected with H. contortus. The control group received Quil A injections and also infected. This study was performed to analyze the effects of the H11/H-gal-GP vaccine when given to goats as compared to sheep. The trial showed …
Racial Disparities, Birth Outcomes, And Changing Demographics Of East Baton Rouge Parish, Louisiana, Misty D. Richard
Racial Disparities, Birth Outcomes, And Changing Demographics Of East Baton Rouge Parish, Louisiana, Misty D. Richard
LSU Doctoral Dissertations
Racial and socioeconomic disparities persist throughout the country regardless of which specific disparity is studied; however, some geographic regions experience more significant racial disparities. East Baton Rouge Parish, Louisiana has a large racial disparity among birth outcomes. Many factors impact the degree of racial disparities, some of which include racial segregation, isolation, or centralization, access to and quality of medical care, and factors of the neighborhood environment. EBRP has undergone dramatic shifts in the demographics of its residents. The purpose of this dissertation was to study the demographic changes in the population; as well as to study the disparities among …
The Epidemiology Of West Nile Virus In Louisiana, Karen Ruth Gruszynski
The Epidemiology Of West Nile Virus In Louisiana, Karen Ruth Gruszynski
LSU Doctoral Dissertations
West Nile virus (WNV), a member of the genus Flavivirus transmitted by mosquitoes, first appeared in the New York in 1999. Within five years WNV was detected throughout the contiguous 48 states causing disease in reservoirs and accidental hosts alike. In Louisiana, WNV was first detected in 2001 with one human case, ten equine cases, and six dead birds reported. The introduction of WNV into Louisiana presented an unique opportunity to observe an emerging disease unfold, so a study was launched to gain insight into the epidemiology of WNV in Louisiana. The first component, an environmental predictive model for West …
Power Analysis For A Mixed Effects Logistic Regression Model, Yinmei Li
Power Analysis For A Mixed Effects Logistic Regression Model, Yinmei Li
LSU Doctoral Dissertations
In herd health studies, the mixed effects logistic regression model with random herd effects are commonly used for modeling clustered binary data. These models are well developed and widely used in the literature, among which is the logistic-normal regression model. In contrast to the rich literature in modeling methods, the sample size/power analysis methods for such mixed effects models are sparse. The sample size/power analysis method for the logistic-normal regression model is not readily available. This study is to develop a power analysis/sample size estimation method for the logistic-normal regression model. Extended from the sample size method for the likelihood …
Characterizing The Health Status Of The Louisiana Gopher Tortoise (Gopherus Polyphemus), Orlando Diaz-Figueroa
Characterizing The Health Status Of The Louisiana Gopher Tortoise (Gopherus Polyphemus), Orlando Diaz-Figueroa
LSU Master's Theses
Gopher tortoise (Gopherus polyphemus) populations have experienced precipitous declines from habitat loss, and human and disease related mortality. The goal of this study was to characterize the health status of free-ranging Louisiana gopher tortoises. Gopher tortoises were collected during two distinct trapping seasons: fall (August-October 2002) and spring (April-June 2003). Captured tortoises were given a physical exam and the carapace and plastron length and width, weight, and body temperature were recorded. Blood was collected from the subcarapacial vein and submitted for the following testing procedures: complete blood count, plasma chemistry, infectious disease serology (Mycoplasma), and toxicologic screen (copper, mercury, zinc, …
The Influence Of Transdermally Administered Fentanyl On Isoflurane Requirements In Normothermic And Hypothermic Dogs, Diane Wilson
The Influence Of Transdermally Administered Fentanyl On Isoflurane Requirements In Normothermic And Hypothermic Dogs, Diane Wilson
LSU Master's Theses
Intraoperative reductions in serum fentanyl levels in dogs with induced moderate hypothermia and transdermal fentanyl patches (TDF) in place has been documented. The impact of such reductions has not been evaluated nor has the anesthetic sparing effect of the TDF. Reductions in serum levels may be the result of either a decreased uptake of fentanyl from the dermal depot, or a biophase shift. The objective of this investigation was to determine whether the minimum alveolar concentration (MAC) of isoflurane was altered in the presence of TDF in normothermic and hypothermic dogs. Six mature, healthy, mixed breed dogs were anesthetized on …
Evaluation Of Helicobacter Hepaticus Bacterial Shedding In Fostered And Strategically Housed C57bl/6 Mice, J. Robin Crisler Roberts
Evaluation Of Helicobacter Hepaticus Bacterial Shedding In Fostered And Strategically Housed C57bl/6 Mice, J. Robin Crisler Roberts
LSU Master's Theses
The murine pathogen Helicobacter hepaticus has important confounding effects on research. Neonatal fostering has been studied in our laboratory for elimination of infection in mice. The purpose of our study was to examine fostering of pups from experimentally infected dams in male-absent parturition, and to determine the significance of gender and time on quantity of bacterial colonization in the cecum and feces of C57BL/6 mice. Approximately 20 C57BL/6 mice were fostered per day from one to four days of age. None of the C57BL/6 pups tested positive by PCR in fecal or cecal samples through four days of age. This …
Urokinase And Urokinase Receptor In The Urinary Tract Of The Dog, Trina Racquel Bailey
Urokinase And Urokinase Receptor In The Urinary Tract Of The Dog, Trina Racquel Bailey
LSU Master's Theses
Urokinase (uPA) and urokinase receptor (uPAR) are present in the urinary tract of people, mice, rats and cows. The presence of urokinase and urokinase receptor in the urinary tract of dogs has not been documented. Documenting the presence of uPA and uPAR in the urinary tract of healthy dogs will help determine the role these proteins play in pathology of the urinary tract in further research. Urine was collected from fifty-four healthy dogs. A fluorescence assay was developed using the fluorogenic substrate Z-Gly-Gly-Arg-AMC, HCl. This assay documented presence of active uPA-like protein in concentrated urine. A direct sandwich ELISA assay …
Matrix Metalloproteinase 3, Matrix Metalloproteinase 13, And Tissue Inhibitor Of Metalloproteinase 1 Concentrations In Normal And Naturally-Occurring Osteoarthritic Canine Stifles, Blaine Allen Burkert
Matrix Metalloproteinase 3, Matrix Metalloproteinase 13, And Tissue Inhibitor Of Metalloproteinase 1 Concentrations In Normal And Naturally-Occurring Osteoarthritic Canine Stifles, Blaine Allen Burkert
LSU Master's Theses
Osteoarthritis is arguably the most common ailment in both dogs and people in the developed World. Treatment for osteoarthritis is currently symptomatic. Development of therapies designed at stopping the progression of osteoarthritis, require a method of evaluating efficacy. Objective analysis by measuring joint metabolism via clinical trials of the cross-over design is currently not possible with the methods utilized. Extracellular matrix degradation is a hallmark of osteoarthritis. The matrix metalloproteinases are major degradative enzymes. There are currently no commercially available assays to measure canine matrix metalloproteinases. Human and canine matrix metalloproteinases are highly homologous. The use of antibodies and assays …
Neural Stem Cells As A Delivery Vector For Chemokine Expression In The Central Nervous System, Mark Winston Stalder
Neural Stem Cells As A Delivery Vector For Chemokine Expression In The Central Nervous System, Mark Winston Stalder
LSU Master's Theses
Increased expression of cytokines and chemokines in the central nervous system (CNS) is closely associated with the development of retroviral-induced neurological diseases such as HIV-associated dementia, as well as other neuropathologies such as Alzheimer’s Disease and Multiple Sclerosis. The specific functions of many of these pro-inflammatory factors have yet to be elucidated in the disease process, and it is unclear whether the nature of their effects is protective, pathogenic, or both. Additionally, current models of chemokine function have inherent limitations, with direct injection resulting in a brief response that doesn’t accurately represent the effects of chronic production, and transgenic mice …
Post-Breeding Endometritis After Low Dose Insemination In The Mare, MaríA Soledad Ferrer
Post-Breeding Endometritis After Low Dose Insemination In The Mare, MaríA Soledad Ferrer
LSU Master's Theses
Hysteroscopic insemination in mares with delayed uterine clearance (DUC mares) is controversial. While some authors proposed that insemination with a reduced volume and number of spermatozoa may reduce post-mating endometritis, others proposed that the hysteroscopic procedure is inflammatory and should not be used in DUC mares. The overall objectives of this study were to evaluate the incidence and severity of post-mating endometritis in reproductively normal and DUC mares after hysteroscopic insemination at the uterotubal junction, and to determine if hysteroscopic insemination could be used in DUC mares to reduce post-mating endometritis. The mares were classified as normal or DUC based …
Voluntary Exercise In The C57b1/6j Mouse: Phenotypic Effects Of Varying Dietary Fat Levels And Hippocampal Gene Expression Differences Between High-Level And Low-Level Exercisers, Leslie Debardeleben Mclaughlin
Voluntary Exercise In The C57b1/6j Mouse: Phenotypic Effects Of Varying Dietary Fat Levels And Hippocampal Gene Expression Differences Between High-Level And Low-Level Exercisers, Leslie Debardeleben Mclaughlin
LSU Doctoral Dissertations
The drive to exercise voluntarily likely results from complex interactions between genes in many organ systems and various psychological parameters, such as motivation and the perception of fatigue. Reproducible variations in exercise intensity and duration are well established in laboratory rodents, but the genes responsible remain largely unknown. Also, to date, studies addressing the adaptive changes to exercise that might prevent dietary-induced obesity have focused primarily on energy intake and nutrient oxidation/partitioning, as opposed to genetics. We hypothesize that increased voluntary physical activity may be a normal mechanism in certain rodent strains to deter dietary-induced obesity and that in an …
Genetics And Functions Of The Sars Coronavirus Spike Protein, Chad Michael Petit
Genetics And Functions Of The Sars Coronavirus Spike Protein, Chad Michael Petit
LSU Doctoral Dissertations
The SARS-Coronavirus (SARS-CoV) is the etiological agent of the severe acute respiratory syndrome (SARS). The SARS-CoV spike (S) glycoprotein mediates membrane fusion events during virus entry and virus-induced cell-to-cell fusion. Investigations, described herein, have focused on the genetic manipulation of the SARS-CoV S glycoprotein in order to delineate functional domains within the protein. This was accomplished by incorporating single point mutations, cluster-to-lysine and cluster-to-alanine mutations, as well as carboxyl terminal truncations into the protein and investigating these mutants in transient expression experiments. Mutagenesis of either the coiled-coil domain of the S glycoprotein amino terminal heptad repeat, the predicted fusion peptide, …
Cytokines And Aeroallergens In The Pathogenesis Of Summer-Pasture Associated Obstructive Pulmonary Disease: Effects On Endothelin Production, Neutrophil Activation And Chemotaxis, Lais Rosa Rodrigues Costa
Cytokines And Aeroallergens In The Pathogenesis Of Summer-Pasture Associated Obstructive Pulmonary Disease: Effects On Endothelin Production, Neutrophil Activation And Chemotaxis, Lais Rosa Rodrigues Costa
LSU Doctoral Dissertations
Summer pasture-associated obstructive pulmonary disease (SPAOPD), a naturally occurring airway disease of horses, is characterized by clinical exacerbation associated with exposure to pasture environment during the summer. Aeroallergens are believed to trigger exacerbation of SPAOPD, cytokines are likely associated with the anamnestic response to aeroallergens, and endothelin (ET)-1 is a potential mediator of airway obstruction. The goal of this dissertation was to describe and explore the interaction of aeroallergens triggering inflammation and T lymphocytes cytokine profile with the recruitment and activation of neutrophils and synthesis of ET-1 by mononuclear leukocytes and airway epithelial cells. The temporal pattern of clinical exacerbation …
The Role Of Urease In The Pathogenesis Of Edwardsiella Ictaluri, Natha Joy Booth
The Role Of Urease In The Pathogenesis Of Edwardsiella Ictaluri, Natha Joy Booth
LSU Doctoral Dissertations
An Edwardsiella ictaluri strain with disruption of ureG was identified through the use of signature tagged insertion mutagenesis as being attenuated for virulence in the channel catfish host. Sequencing of the flanking regions surrounding the insert showed that the gene was part of a urease gene complex that included ureE, ureF, ureG, ureD, ureI, and an ammonium transporter homologue. The ureG gene encodes a GTP-binding accessory protein which is thought to function in energy-dependent urease assembly. The ureG mutant strain was found to be attenuated for mortality, persistence, and for the ability to establish infection in a competition challenge during …
Early Tissue Migration Of And Host Response To Brugia Pahangi In Gerbils, Kristina Houpe Porthouse
Early Tissue Migration Of And Host Response To Brugia Pahangi In Gerbils, Kristina Houpe Porthouse
LSU Master's Theses
The host-parasite interaction during early filarial nematode migration is poorly understood. The objective of this study was to develop a model of early cutaneous filarid migration using Brugia pahangi in the jird (gerbil) host and measure the histologic and cytokine responses during this period. Male gerbils were intradermally inoculated in the left hindlimb with 100 B. pahangi L3 then necropsied at 3 hours, 24 hours, 3 days, 7 days, and 28 days post-infection. Larvae were recovered and tissues collected for histology and cytokine measurement. At 3 hours, most larvae (96.3%) were recovered from tissues associated with the infection site. Migration …
A Novel Strategy Of Controlling Bovine Pneumonic Pasteurellosis: Transfecting The Upper Respiratory Tract Of Cattle With A Gene Coding For The Antimicrobial Peptide Cecropin B, Charles Mitchell Boudreaux
A Novel Strategy Of Controlling Bovine Pneumonic Pasteurellosis: Transfecting The Upper Respiratory Tract Of Cattle With A Gene Coding For The Antimicrobial Peptide Cecropin B, Charles Mitchell Boudreaux
LSU Master's Theses
The very potent antibacterial activity of cecropin B makes it a likely candidate to prevent and/or treat Mannheimia haemolytica 1:A infection in the upper respiratory tract (URT) of cattle. The purpose of this study was to ascertain if the URT could be transfected with a gene coding for the antimicrobial peptide cecropin B. By transfecting cattle with a gene coding for cecropin B, this study attempted to inhibit colonization of a virulent strain of M. haemolytica 1:A in the URT while investigating any possible changes in the indigenous and transient nasal flora. In this study the antibacterial efficacy of cecropin …
Improved Methods For The Isolation And Characterization Of Flavobacterium Columnare, Bradley Donovan Farmer
Improved Methods For The Isolation And Characterization Of Flavobacterium Columnare, Bradley Donovan Farmer
LSU Master's Theses
Columnaris disease, caused by the bacterium Flavobacterium columnare, is an economically significant problem in many warmwater fish species. Difficulties encountered in the isolation and culture of F. columnare have been an impediment to research on the organism and the disease it causes. The goal of this study was to improve the methods for isolation, culture, identification and maintenance of F. columnare. Following the evaluation of different culture media selective cytophaga agar was determined to be the optimum isolation medium, Flavobacterum columnare growth medium proved to be the optimum culture medium, and tryptone yeast extract agar with increased moisture was best …
Genetics And Functions Of Herpes Simplex Virus Type 1 Membrane Proteins In Virus-Induced Cell Fusion, Virion Morphogenesis And Egress, Jeffrey Michael Melancon
Genetics And Functions Of Herpes Simplex Virus Type 1 Membrane Proteins In Virus-Induced Cell Fusion, Virion Morphogenesis And Egress, Jeffrey Michael Melancon
LSU Doctoral Dissertations
The Herpes Simplex Virus life cycle contains a number of membrane fusion events that must function properly to ensure a productive infection, including: virus attachment and entry into susceptible cells, de-envelopment at the outer nuclear lamellae, and virus-induced cell-to-cell fusion. A virus-free cell fusion assay was recently developed in order to attempt to understand the underlying mechanisms that are responsible for viral fusion events and was utilized in order to investigate the effect of mutations targeted to the carboxyl terminus of gB. We showed that the predicted alpha helical domain H17b within the carboxyl-terminus of gB is involved in both …
The Effects Of Non-Focused Extracorporeal Shock Waves On Neuronal Morphology, Function And Analgesia In Horses, David Manuel Bolt
The Effects Of Non-Focused Extracorporeal Shock Waves On Neuronal Morphology, Function And Analgesia In Horses, David Manuel Bolt
LSU Master's Theses
These studies were conducted to elucidate the regional analgesic effect that is observed clinically after treatment of orthopedic disorders with application of extracorporeal shock waves in horses. Regional analgesia after treatment with extracorporeal shock waves presents a concern because it may eliminate protective limiting mechanisms and may place equine athletes with predisposing lesions at risk of sustaining career- or life-ending injuries. Direct percutaneous application of non-focused extracorporeal shock waves to palmar digital nerves in the pastern area of horses resulted in decreased sensory nerve conduction velocities compared with untreated control nerves at 3, 7, and 35 days after treatment. Transmission …
In Vitro Evaluation Of The Securos Cranial Cruciate Ligament Repair System And Fluorocarbon Leader Line For Use As Lateral Fabella-Tibial Sutures, Max Nielsen Banwell
In Vitro Evaluation Of The Securos Cranial Cruciate Ligament Repair System And Fluorocarbon Leader Line For Use As Lateral Fabella-Tibial Sutures, Max Nielsen Banwell
LSU Master's Theses
Cranial cruciate ligament (CCL) rupture is a common injury in the dog and major cause of degenerative joint disease. The pathophysiology of CCL rupture in the dog is well described. Osteoarthritis secondary to CCL rupture causes severe pain and lameness. There are many surgical techniques accepted for dogs with CCL rupture. A commonly performed technique is an extracapsular repair with a lateral fabella-tibial suture (LFS) using large diameter nylon leader line (NLL). Mechanical demands placed upon the LFS are high requiring the material used be able to withstand a high amount of force, undergo minimal elongation, and have a high …
Evaluation Of Rough Brucella Strains As Vaccines For Brucellosis And Pseudorabies In Swine, Lorraine Harrow Molin
Evaluation Of Rough Brucella Strains As Vaccines For Brucellosis And Pseudorabies In Swine, Lorraine Harrow Molin
LSU Master's Theses
Brucellosis and pseudorabies lead to abortion in pregnant sows and are perpetuated by feral swine reservoirs. A multivalent oral vaccine for these diseases would improve vaccination and eradication programs worldwide. Previous studies have shown that the rough attenuated Brucella strains RB51 and VTRS1, when administered subcutaneously to swine, stimulate host immune responses, transiently colonize tissues, and provide partial protection against virulent B. suis infection in pregnant sows. A plasmid encoding for the pseudorabies virus glycoprotein D (PRV gD) has also been added to these strains as part of this project. This study evaluates the use of these strains as oral …