Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- Acid resistance (1)
- Airway epithelial cells (1)
- Analgesia (1)
- C57Bl/6J (1)
- Canine (1)
-
- Chelonian (1)
- Coprophagic (1)
- Coronavirus (1)
- Cranial cruciate ligament rupture (1)
- Delayed uterine clearance (1)
- Diet and exercise (1)
- Edwardsiella ictaluri (1)
- Endometritis (1)
- Et-1 (1)
- Fibrinolysis (1)
- Fusion (1)
- Gavage (1)
- Gene expression (1)
- Glycoprotein (1)
- Heptad repeat (1)
- Hippocampus (1)
- Hotshot (1)
- Hysteroscopic insemination (1)
- Il-4 (1)
- In vivo gene expression system (1)
- Inhalant anesthetics (1)
- Interferon (ifn)-g (1)
- Interleukin (il)-8 (1)
- Intracellular replication (1)
- Keystone species (1)
Articles 1 - 11 of 11
Full-Text Articles in Veterinary Medicine
Cytokines And Aeroallergens In The Pathogenesis Of Summer-Pasture Associated Obstructive Pulmonary Disease: Effects On Endothelin Production, Neutrophil Activation And Chemotaxis, Lais Rosa Rodrigues Costa
Cytokines And Aeroallergens In The Pathogenesis Of Summer-Pasture Associated Obstructive Pulmonary Disease: Effects On Endothelin Production, Neutrophil Activation And Chemotaxis, Lais Rosa Rodrigues Costa
LSU Doctoral Dissertations
Summer pasture-associated obstructive pulmonary disease (SPAOPD), a naturally occurring airway disease of horses, is characterized by clinical exacerbation associated with exposure to pasture environment during the summer. Aeroallergens are believed to trigger exacerbation of SPAOPD, cytokines are likely associated with the anamnestic response to aeroallergens, and endothelin (ET)-1 is a potential mediator of airway obstruction. The goal of this dissertation was to describe and explore the interaction of aeroallergens triggering inflammation and T lymphocytes cytokine profile with the recruitment and activation of neutrophils and synthesis of ET-1 by mononuclear leukocytes and airway epithelial cells. The temporal pattern of clinical exacerbation …
Evaluation Of Helicobacter Hepaticus Bacterial Shedding In Fostered And Strategically Housed C57bl/6 Mice, J. Robin Crisler Roberts
Evaluation Of Helicobacter Hepaticus Bacterial Shedding In Fostered And Strategically Housed C57bl/6 Mice, J. Robin Crisler Roberts
LSU Master's Theses
The murine pathogen Helicobacter hepaticus has important confounding effects on research. Neonatal fostering has been studied in our laboratory for elimination of infection in mice. The purpose of our study was to examine fostering of pups from experimentally infected dams in male-absent parturition, and to determine the significance of gender and time on quantity of bacterial colonization in the cecum and feces of C57BL/6 mice. Approximately 20 C57BL/6 mice were fostered per day from one to four days of age. None of the C57BL/6 pups tested positive by PCR in fecal or cecal samples through four days of age. This …
Characterizing The Health Status Of The Louisiana Gopher Tortoise (Gopherus Polyphemus), Orlando Diaz-Figueroa
Characterizing The Health Status Of The Louisiana Gopher Tortoise (Gopherus Polyphemus), Orlando Diaz-Figueroa
LSU Master's Theses
Gopher tortoise (Gopherus polyphemus) populations have experienced precipitous declines from habitat loss, and human and disease related mortality. The goal of this study was to characterize the health status of free-ranging Louisiana gopher tortoises. Gopher tortoises were collected during two distinct trapping seasons: fall (August-October 2002) and spring (April-June 2003). Captured tortoises were given a physical exam and the carapace and plastron length and width, weight, and body temperature were recorded. Blood was collected from the subcarapacial vein and submitted for the following testing procedures: complete blood count, plasma chemistry, infectious disease serology (Mycoplasma), and toxicologic screen (copper, mercury, zinc, …
Genetics And Functions Of The Sars Coronavirus Spike Protein, Chad Michael Petit
Genetics And Functions Of The Sars Coronavirus Spike Protein, Chad Michael Petit
LSU Doctoral Dissertations
The SARS-Coronavirus (SARS-CoV) is the etiological agent of the severe acute respiratory syndrome (SARS). The SARS-CoV spike (S) glycoprotein mediates membrane fusion events during virus entry and virus-induced cell-to-cell fusion. Investigations, described herein, have focused on the genetic manipulation of the SARS-CoV S glycoprotein in order to delineate functional domains within the protein. This was accomplished by incorporating single point mutations, cluster-to-lysine and cluster-to-alanine mutations, as well as carboxyl terminal truncations into the protein and investigating these mutants in transient expression experiments. Mutagenesis of either the coiled-coil domain of the S glycoprotein amino terminal heptad repeat, the predicted fusion peptide, …
Matrix Metalloproteinase 3, Matrix Metalloproteinase 13, And Tissue Inhibitor Of Metalloproteinase 1 Concentrations In Normal And Naturally-Occurring Osteoarthritic Canine Stifles, Blaine Allen Burkert
Matrix Metalloproteinase 3, Matrix Metalloproteinase 13, And Tissue Inhibitor Of Metalloproteinase 1 Concentrations In Normal And Naturally-Occurring Osteoarthritic Canine Stifles, Blaine Allen Burkert
LSU Master's Theses
Osteoarthritis is arguably the most common ailment in both dogs and people in the developed World. Treatment for osteoarthritis is currently symptomatic. Development of therapies designed at stopping the progression of osteoarthritis, require a method of evaluating efficacy. Objective analysis by measuring joint metabolism via clinical trials of the cross-over design is currently not possible with the methods utilized. Extracellular matrix degradation is a hallmark of osteoarthritis. The matrix metalloproteinases are major degradative enzymes. There are currently no commercially available assays to measure canine matrix metalloproteinases. Human and canine matrix metalloproteinases are highly homologous. The use of antibodies and assays …
Post-Breeding Endometritis After Low Dose Insemination In The Mare, MaríA Soledad Ferrer
Post-Breeding Endometritis After Low Dose Insemination In The Mare, MaríA Soledad Ferrer
LSU Master's Theses
Hysteroscopic insemination in mares with delayed uterine clearance (DUC mares) is controversial. While some authors proposed that insemination with a reduced volume and number of spermatozoa may reduce post-mating endometritis, others proposed that the hysteroscopic procedure is inflammatory and should not be used in DUC mares. The overall objectives of this study were to evaluate the incidence and severity of post-mating endometritis in reproductively normal and DUC mares after hysteroscopic insemination at the uterotubal junction, and to determine if hysteroscopic insemination could be used in DUC mares to reduce post-mating endometritis. The mares were classified as normal or DUC based …
The Role Of Urease In The Pathogenesis Of Edwardsiella Ictaluri, Natha Joy Booth
The Role Of Urease In The Pathogenesis Of Edwardsiella Ictaluri, Natha Joy Booth
LSU Doctoral Dissertations
An Edwardsiella ictaluri strain with disruption of ureG was identified through the use of signature tagged insertion mutagenesis as being attenuated for virulence in the channel catfish host. Sequencing of the flanking regions surrounding the insert showed that the gene was part of a urease gene complex that included ureE, ureF, ureG, ureD, ureI, and an ammonium transporter homologue. The ureG gene encodes a GTP-binding accessory protein which is thought to function in energy-dependent urease assembly. The ureG mutant strain was found to be attenuated for mortality, persistence, and for the ability to establish infection in a competition challenge during …
Urokinase And Urokinase Receptor In The Urinary Tract Of The Dog, Trina Racquel Bailey
Urokinase And Urokinase Receptor In The Urinary Tract Of The Dog, Trina Racquel Bailey
LSU Master's Theses
Urokinase (uPA) and urokinase receptor (uPAR) are present in the urinary tract of people, mice, rats and cows. The presence of urokinase and urokinase receptor in the urinary tract of dogs has not been documented. Documenting the presence of uPA and uPAR in the urinary tract of healthy dogs will help determine the role these proteins play in pathology of the urinary tract in further research. Urine was collected from fifty-four healthy dogs. A fluorescence assay was developed using the fluorogenic substrate Z-Gly-Gly-Arg-AMC, HCl. This assay documented presence of active uPA-like protein in concentrated urine. A direct sandwich ELISA assay …
The Influence Of Transdermally Administered Fentanyl On Isoflurane Requirements In Normothermic And Hypothermic Dogs, Diane Wilson
The Influence Of Transdermally Administered Fentanyl On Isoflurane Requirements In Normothermic And Hypothermic Dogs, Diane Wilson
LSU Master's Theses
Intraoperative reductions in serum fentanyl levels in dogs with induced moderate hypothermia and transdermal fentanyl patches (TDF) in place has been documented. The impact of such reductions has not been evaluated nor has the anesthetic sparing effect of the TDF. Reductions in serum levels may be the result of either a decreased uptake of fentanyl from the dermal depot, or a biophase shift. The objective of this investigation was to determine whether the minimum alveolar concentration (MAC) of isoflurane was altered in the presence of TDF in normothermic and hypothermic dogs. Six mature, healthy, mixed breed dogs were anesthetized on …
Neural Stem Cells As A Delivery Vector For Chemokine Expression In The Central Nervous System, Mark Winston Stalder
Neural Stem Cells As A Delivery Vector For Chemokine Expression In The Central Nervous System, Mark Winston Stalder
LSU Master's Theses
Increased expression of cytokines and chemokines in the central nervous system (CNS) is closely associated with the development of retroviral-induced neurological diseases such as HIV-associated dementia, as well as other neuropathologies such as Alzheimer’s Disease and Multiple Sclerosis. The specific functions of many of these pro-inflammatory factors have yet to be elucidated in the disease process, and it is unclear whether the nature of their effects is protective, pathogenic, or both. Additionally, current models of chemokine function have inherent limitations, with direct injection resulting in a brief response that doesn’t accurately represent the effects of chronic production, and transgenic mice …
Voluntary Exercise In The C57b1/6j Mouse: Phenotypic Effects Of Varying Dietary Fat Levels And Hippocampal Gene Expression Differences Between High-Level And Low-Level Exercisers, Leslie Debardeleben Mclaughlin
Voluntary Exercise In The C57b1/6j Mouse: Phenotypic Effects Of Varying Dietary Fat Levels And Hippocampal Gene Expression Differences Between High-Level And Low-Level Exercisers, Leslie Debardeleben Mclaughlin
LSU Doctoral Dissertations
The drive to exercise voluntarily likely results from complex interactions between genes in many organ systems and various psychological parameters, such as motivation and the perception of fatigue. Reproducible variations in exercise intensity and duration are well established in laboratory rodents, but the genes responsible remain largely unknown. Also, to date, studies addressing the adaptive changes to exercise that might prevent dietary-induced obesity have focused primarily on energy intake and nutrient oxidation/partitioning, as opposed to genetics. We hypothesize that increased voluntary physical activity may be a normal mechanism in certain rodent strains to deter dietary-induced obesity and that in an …