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Articles 1 - 12 of 12
Full-Text Articles in Veterinary Medicine
Chondrocyte Death In Canine Osteochondral Explants Exposed To 0.5 Percent Bupivacaine, Geoffrey Stuart Hennig
Chondrocyte Death In Canine Osteochondral Explants Exposed To 0.5 Percent Bupivacaine, Geoffrey Stuart Hennig
LSU Master's Theses
Objective: Our in vitro study evaluated chondrocyte death in canine articular cartilage exposed to 0.5% bupivacaine without (B) and with methylparaben (BP) and compared the viability with intact (SI) and mechanically debrided surfaces (SR). We hypothesized that B or BP would cause chondrocyte death in vitro in a time dependent manner and that chondrocyte death would be increased in SI osteochondral cores compared to SR. Materials and Methods: Intact cartilage cores with underlying subchondral bone were collected aseptically from both humeral heads of 16 fresh canine cadavers. Joints from each dog were randomly assigned to SI or SR. Ten osteochondral …
Biomechanical Evaluation Of A 6.5-Mm Headless, Tapered Variable Pitch Screw (Acutrak Plus) In Equine And Synthetic Bone, Andrew James Czak Lewis
Biomechanical Evaluation Of A 6.5-Mm Headless, Tapered Variable Pitch Screw (Acutrak Plus) In Equine And Synthetic Bone, Andrew James Czak Lewis
LSU Master's Theses
Objectives – To compare compression pressure (CP) of 6.5mm Acutrak Plus (AP) and 4.5mm AO cortical screws (AO) when placed in simulated lateral condylar fractures of variable thickness in cadaveric equine third metacarpal (MC3) bones, and to compare pullout force and strength of AP and AO screws when placed in a synthetic bone substitute. Results – The AO screw configurations generated significantly greater compressive pressure compared to the AP configurations. The ratio of mean CP for AP screws to AO screws at 20, 12, and 8-mm, were 21.6%, 26.2%, and 34.2% respectively. For the pullout study, the AP constructs generated …
Influence Of Tick Transmission On The Host Response To Rickettsial Infection, Soma Chowdhury
Influence Of Tick Transmission On The Host Response To Rickettsial Infection, Soma Chowdhury
LSU Master's Theses
Several members of the spotted fever group (SFG) of Rickettsia are transmitted to the host through infected ixodid (hard) ticks, which can serve as both vectors and reservoirs. Multiple studies have demonstrated that ticks secrete proteins into the bite site of the host that suppress innate and adaptive immune responses. While this suppression of immune responses is beneficial to the tick, it may also be beneficial to the transmitted Rickettsia. We hypothesize that Rickettsia utilize the tick’s ability to alter the host immune response at the tick feeding site to successfully establish infection. In the current study, we analyzed how …
Antiviral Chemotherapeutic Agents Against Equine Herpesvirus Type 1: The Mechanism Of Antiviral Effects Of Porphyrin Derivatives, Galena V. Rybachuk
Antiviral Chemotherapeutic Agents Against Equine Herpesvirus Type 1: The Mechanism Of Antiviral Effects Of Porphyrin Derivatives, Galena V. Rybachuk
LSU Doctoral Dissertations
Equine Herpesvirus-1 (EHV-1) is an important ubiquitous enzootic equine pathogen, causing significant economic losses to the horse industry. Despite extensive vaccination protocols, EHV-1 continues to be a major cause of epidemic abortion, perinatal mortality, respiratory disease and neurologic disease. EHV-1 infections are usually dealt with by using management practices that limit spread of the disease and secondary complications, providing symptomatic relief to infected horses, but no specific treatment is available. New therapeutic or virucidal agents could have great utility in slowing both the progression and spread of the disease in an epidemic situation. A number of porphyrins and their derivatives …
Ecological Risk Models For Visceral Leishmaniais [Sic] In Bahia, Brazil And Diagnosis Of Trypanosoma Cruzi Infection In Dogs In South Central Louisiana, Prixia Nieto
LSU Doctoral Dissertations
Three predictive models were developed within a geographic information system using earth observing satellite remote sensing (RS), the Genetic Algorithm for Rule-Set Prediction (GARP) and the growing degree day-water budget (GDD-WB) concept to predict the distribution and potential risk of visceral leishmaniasis (VL) in the State of Bahia, Brazil. The objective was to define the environmental suitability of the disease as well as to obtain a deeper understanding of the eco-epidemiology of VL by associating environmental and climatic variables with disease prevalence. The RS, the GARP model and the GDD-WB model, using different analysis approaches and with the same human …
Innate Immune Responses In The Central Nervous System Following Toll-Like Receptor (Tlr) 7 And Tlr9 Activation, Niranjan Babu Butchi
Innate Immune Responses In The Central Nervous System Following Toll-Like Receptor (Tlr) 7 And Tlr9 Activation, Niranjan Babu Butchi
LSU Doctoral Dissertations
Activation of astrocytes and microglia and the production of proinflammatory cytokines and chemokines are often associated with virus infection in the central nervous system (CNS) as well as a number of neurological diseases of unknown etiology. These inflammatory responses may be initiated by recognition of pathogen-associated molecular patterns that stimulate toll-like receptors (TLRs). Recent studies demonstrated that TLR9 family receptors play a role in neuropathogenesis and the agonists of these receptors may be used in therapeutics treatment of brain tumors and viral infections. However, we lack the basic understanding of how these receptors function in the CNS. In the present …
Arthropod And Vertebrate Determinants For Horizontal Transmission Of Rickettsia Felis, Kathryn Elizabeth Reif
Arthropod And Vertebrate Determinants For Horizontal Transmission Of Rickettsia Felis, Kathryn Elizabeth Reif
LSU Doctoral Dissertations
Rickettsia felis is a gram-negative bacterium predominantly described in the cat flea, Ctenocephalides felis. Since first described in 1990 in a commercial cat flea colony in the United States, R. felis has been detected in numerous arthropod species in 28 countries around the world. Additionally, as the etiologic agent of flea-borne rickettsiosis, R. felis can cause disease in humans, with patients presenting with clinical symptoms typical of rickettsial diseases including: fever, headache, and myalgia. Transmission of R. felis within flea colonies is predominantly via vertical (transovarial and transstadial) transmission and mechanisms of horizontal transmission are undescribed. Studies are needed to …
Effects Of Clenbuterol On Skeletal And Cardiac Muscle In Horses, Jessica Thompson
Effects Of Clenbuterol On Skeletal And Cardiac Muscle In Horses, Jessica Thompson
LSU Master's Theses
Clenbuterol is a commonly prescribed β2-adrenergic agonist approved for veterinary use as a bronchodilator in horses with reactive and obstructive airway disease. Potential for abuse of this drug in the horse industry is substantial, due to the perceptions that clenbuterol increases performance and lean muscle mass. Although anabolic effects have been confirmed in multiple species, recent studies into the effects of clenbuterol in exercising horses suggest that clenbuterol doses within therapeutic ranges negatively impact aerobic capacity and cardiac function. Results of studies in murine models demonstrate that clenbuterol directly induces skeletal and cardiac muscle cell death at high doses. Three …
Matrix Metalloproteinases In The Equine Systemic Inflammatory Response: Implications For Equine Laminitis, Lee Ann Fugler
Matrix Metalloproteinases In The Equine Systemic Inflammatory Response: Implications For Equine Laminitis, Lee Ann Fugler
LSU Doctoral Dissertations
Laminitis is a crippling and often life-threatening disease of the equine foot. Soft tissue damage characteristic of this disease has been associated with increased MMP activity. Therefore, it seems likely that MMPIs could be potential therapeutic agents for laminitis. Further characterization of equine MMPs and evaluation of the effectiveness of MMPIs in the horse are needed. Equine MMP-9 was harvested from neutrophils, purified by affinity chromatography, and evaluated using western blotting and gelatin zymography. The Biotrak MMP-9 Activity Assay was evaluated for use with equine samples using equine neutrophil MMP-9 as a standard, and was determined to have insufficient sensitivity …
Characterizing The Epidemiology Of Isospora Amphiboluri In Captive Bearded Dragons (Pogona Vitticeps), Michael Robison Walden
Characterizing The Epidemiology Of Isospora Amphiboluri In Captive Bearded Dragons (Pogona Vitticeps), Michael Robison Walden
LSU Doctoral Dissertations
First described in 1967, Isospora amphiboluri has become recognized as an important pathogen of bearded dragons. To date, no cross-sectional, pathogenesis, or treatment study has been performed to shed light on the epidemiology or treatment of I.amphiboluri. Two large breeding populations of bearded dragons were examined for the presence of I. amphiboluri oocysts using sucrose flotation and fecal direct saline smears. Parasites were more likely to be identified on fecal flotation (p= 0.03). A previously unidentified Eimeria species was examined and described as a new species for which we suggest the name Eimeria pogonae. To develop an understanding of the …
Expression Of The Edwardsiella Ictaluri Type Iii Secretion System And Its Relationship To The Native Plasmids, Matthew Lee Rogge
Expression Of The Edwardsiella Ictaluri Type Iii Secretion System And Its Relationship To The Native Plasmids, Matthew Lee Rogge
LSU Doctoral Dissertations
Edwardsiella ictaluri encodes a type III secretion system (T3SS) required for intracellular replication. Analysis of in vitro gene expression indicates the T3SS translocon proteins express and secrete in acidic pH. Expression of other T3SS genes, however, requires that phosphate be limited in the culture media, in addition to acidic pH. Responses to environmental stimuli are mediated through the T3SS-encoded regulatory proteins EsrA, EsrB, and EsrC. Mutations in these genes result in differing phenotypes. Mutation of EsrA results in moderately reduced expression of T3SS genes, but translocon protein secretion is retained in the mutant. However, the EsrA mutant is attenuated intracellularly …
Quantitative Real-Time Polymerase Chain Reaction (Qpcr) Assay As A Molecular Tool To Assess Rickettsial Replications In Tick Hosts, Andrea S. Zanetti
Quantitative Real-Time Polymerase Chain Reaction (Qpcr) Assay As A Molecular Tool To Assess Rickettsial Replications In Tick Hosts, Andrea S. Zanetti
LSU Master's Theses
During the past century, many species of the Spotted Fever Group Rickettsia (SFGR)have been described, especially, through the introduction of a variety of molecular techniques applied to detect rickettsiae inside of their host. In this study we developed a quantitative realtime polymerase chain reaction (qPCR) assay (1) to characterize the growth and the distribution of a SFGR of unrecognized pathogenicity in naturally infected Amblyomma americanum ticks during physiological events; and (2) to terminate the influence of the host cell specificity in the replication patterns of recognized and unrecognized SFGR during a reciprocal rickettsiae challenge in both mammalian and tick cell …