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Full-Text Articles in Veterinary Medicine
The Role Of Viral Glycoproteins And Tegument Proteins In Herpes Simplex Virus Type 1 Cytoplasmic Virion Envelopment, Dmitry Vladimirovich Chouljenko
The Role Of Viral Glycoproteins And Tegument Proteins In Herpes Simplex Virus Type 1 Cytoplasmic Virion Envelopment, Dmitry Vladimirovich Chouljenko
LSU Doctoral Dissertations
Herpes simplex virus type 1 (HSV-1) is a ubiquitous neurotropic alphaherpesvirus transmitted by contact with mucocutaneous surfaces of infected individuals. HSV-1 enters the host by fusion of the viral envelope with the host cell plasma membrane, followed by translocation of the viral capsids to the nucleus where viral DNA is injected into the host cell nucleus to initiate viral replication. To generate infectious virions, newly assembled capsids travel to the cytoplasm and undergo a process called secondary envelopment by budding into cytoplasmic vesicles derived from the trans-Golgi network. Cytoplasmic envelopment is a complex process involving interactions between a multitude of …
The Role Of Gylcoprotein K (Gk) In The Ocular And Neuropathogenesis Of Herpes Simplex Virus-Type 1 (Hsv-1), Andrew Timothy David
The Role Of Gylcoprotein K (Gk) In The Ocular And Neuropathogenesis Of Herpes Simplex Virus-Type 1 (Hsv-1), Andrew Timothy David
LSU Doctoral Dissertations
Herpes simplex virus type 1 (HSV-1) is a DNA virus that is a ubiquitous pathogen of humans. The hallmark of the HSV-lifecycle is infection of a mucosal surface with spread to sensory neurons where the virus establishes a latent infection with periodic recurrences for the life of the host. The most common course of symptomatic disease with HSV-1 is the typical mucocutaneous lesion that is self-limiting. HSV-1 can also cause acute encephalitis and ocular pathology on reactivation. Both of these manifestations of the disease have severe consequences. Although ocular infection is less frequent, the extensive prevalence of HSV makes it …
Genetics And Functions Of Herpes Simplex Virus Type 1 Membrane Proteins In Virus-Induced Cell Fusion, Virion Morphogenesis And Egress, Jeffrey Michael Melancon
Genetics And Functions Of Herpes Simplex Virus Type 1 Membrane Proteins In Virus-Induced Cell Fusion, Virion Morphogenesis And Egress, Jeffrey Michael Melancon
LSU Doctoral Dissertations
The Herpes Simplex Virus life cycle contains a number of membrane fusion events that must function properly to ensure a productive infection, including: virus attachment and entry into susceptible cells, de-envelopment at the outer nuclear lamellae, and virus-induced cell-to-cell fusion. A virus-free cell fusion assay was recently developed in order to attempt to understand the underlying mechanisms that are responsible for viral fusion events and was utilized in order to investigate the effect of mutations targeted to the carboxyl terminus of gB. We showed that the predicted alpha helical domain H17b within the carboxyl-terminus of gB is involved in both …