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Articles 1 - 14 of 14
Full-Text Articles in Veterinary Medicine
Enhancement Of Ehrlichia Canis Infection Of Canine Blood Monocytes In Vitro Through The Addition Of Seropositive And Monoclonal Antibody, John Paul Gniady
Enhancement Of Ehrlichia Canis Infection Of Canine Blood Monocytes In Vitro Through The Addition Of Seropositive And Monoclonal Antibody, John Paul Gniady
Honors Theses
No abstract provided.
Equine Immunity To Cyathostome Infections, Marie Alexandra Baudena
Equine Immunity To Cyathostome Infections, Marie Alexandra Baudena
LSU Doctoral Dissertations
To study the protective responses of cyathostome-infected ponies, two challenges were performed employing animals with different histories of exposure to these parasites. The hypothesis developed and to be tested in these experiments was that ponies that had longer exposure to cyathostome contaminated pastures would express acquired resistance to infection. The assumption behind this hypothesis was that helminth-naïve ponies infected with cyathostomes would eliminate the infection using only innate immune responses. Whereas previously exposed ponies would eliminate the infection with acquired immune responses, and these would be more effective in ponies with longer exposure to cyathostomes. Thus, helminth-naïve animals would acquire …
The Development Of Molecular Diagnostics For Breast Cancer, Anna Henrik Israyelyan
The Development Of Molecular Diagnostics For Breast Cancer, Anna Henrik Israyelyan
LSU Master's Theses
Breast cancer is one of the most common malignancies in women. It continues to be a major burden and cause of death among women worldwide. Molecular oncology is now one of the most promising fields that may contribute considerably to diagnosis of breast cancer and its metastases addressing major problems with early detection, accurate staging, and monitoring of breast cancer patients. The overall objective of these feasibility studies was to contribute to improved diagnosis, prognosis, and prediction of breast cancer disease through the development of reagents and protocols for the use of molecular biological advances and the assessment of the …
Optimal Age At Fostering For The Derivation Of Helicobacter Hepaticus-Free Mice, Kem Boullion Singletary
Optimal Age At Fostering For The Derivation Of Helicobacter Hepaticus-Free Mice, Kem Boullion Singletary
LSU Master's Theses
Helicobacter hepaticus is well established as an unwanted variable in laboratory rodent colonies. Historically, caesarean section and embryo transfer have been used to derive Helicobacter-free mouse colonies. Neonatal transfer of newborn mice onto Helicobacter-free foster dams was recently reported as an alternative method of deriving Helicobacter-free mice, but until now, the age by which pups must be fostered to remain Helicobacter-free was unknown. The purpose of this study was to determine the age by which mouse pups must be fostered to remain H. hepaticus-free. Beginning on the day of birth, 20 C57BL/6 mice were fostered from H. hepaticus-positive parents onto …
The Effects Of Intra-Articular Silicone Polymer On Synovial Fluid, Synovial Tissue, And Articular Cartilage In The Equine Middle Carpal Joint, Marilyn Rumbaugh
The Effects Of Intra-Articular Silicone Polymer On Synovial Fluid, Synovial Tissue, And Articular Cartilage In The Equine Middle Carpal Joint, Marilyn Rumbaugh
LSU Master's Theses
There is anecdotal documentation that intra-articular administration of liquid silicone is used as a lubricant for equine joints. Effects of silicone polymer on equine articular cartilage and synovial fluid have not been evaluated. The objectives were to characterize the effects of intra-articular administration of liquid silicone polymer on clinical, synovial fluid, and microscopic features in normal middle carpal joints of horses, and to determine if silicone migrates to the axillary lymph nodes. Eight adult horses were used in this study. Two mLs of 1,000 centistoke, medical-grade silicone was injected into one randomly selected middle carpal joint. The opposite middle carpal …
Immunological, Hematological, And Serum Biochemical Effects Of High Level Dietary Fish Oil And Vitamin E Supplementation In The Dog, Casey J. Leblanc
Immunological, Hematological, And Serum Biochemical Effects Of High Level Dietary Fish Oil And Vitamin E Supplementation In The Dog, Casey J. Leblanc
LSU Doctoral Dissertations
Inflammation is a component of the innate immune response. However, severe or prolonged inflammation can be detrimental. Dietary n-3 fatty acid supplementation has proven clinical benefits in chronic inflammatory diseases, most likely due to reduced synthesis of inflammatory mediators and inhibition of lymphocyte proliferation and function. The purposes of this study were to characterize alterations in inflammatory mediator production, and lymphocyte proliferation, in dogs fed a diet consisting of 0.65% n-3 fatty acids (DMB) with an n-6:n-3 fatty acid ratio of 3.4:1. Fifteen dogs were randomly assigned to one of three dietary groups for twelve weeks. Group Sunflower oil received …
Role Of Endothelin In The Pathogenesis Of Acute Laminitis In Horses, Ashley Michelle Stokes
Role Of Endothelin In The Pathogenesis Of Acute Laminitis In Horses, Ashley Michelle Stokes
LSU Doctoral Dissertations
Acute laminitis is a severely debilitating disease of the laminae of the equine digit; however, the mechanism(s) of pathogenesis have yet to be fully elucidated. In physiologic states, the endothelium synthesizes substances, such as nitric oxide (NO; vasodilator) and endothelin-1 (ET-1; profound vasoconstrictor), which play a crucial role in vasomotor regulation. The overall hypothesis is that the initiating factor in the onset of acute laminitis is a disruption in the balance between NO and ET-1, which leads to digital vasoconstriction and subsequent laminar ischemic necrosis. In vitro studies with digital vessels from healthy horses and horses with naturally-acquired laminitis determined …
Development Of The Neonatal Rat As A Model For Sudden Infant Death Syndrome: Cardiorespiratory Effects Of Ethanol, Rhett Whitman Stout
Development Of The Neonatal Rat As A Model For Sudden Infant Death Syndrome: Cardiorespiratory Effects Of Ethanol, Rhett Whitman Stout
LSU Doctoral Dissertations
The current pathogenesis of Sudden Infant Death Syndrome (SIDS) is unknown. Elevated endogenous ethanol production by gastrointestinal yeast has been proposed as a possible mechanism for SIDS. To investigate the role of ethanol in SIDS, three studies were undertaken. In the first study, transcutaneous blood gas technology was evaluated for repeated monitoring of arterial blood gases. The second study identified the cardiorespiratory responses to inhaled CO2 challenge in juvenile rats, to determine the age corresponding to the age range of peak incidence of SIDS in human infants. Finally, utilizing the optimized juvenile rat model, the cardiorespiratory responses to ethanol and …
Role Of Endothelin-1 In The Gastrointestinal Tract Of Horses In Health And Disease, Ramaswamy Monickarasi Chidambaram
Role Of Endothelin-1 In The Gastrointestinal Tract Of Horses In Health And Disease, Ramaswamy Monickarasi Chidambaram
LSU Doctoral Dissertations
Gastrointestinal tract disease is the leading natural cause of death in horses and horses with ischemic intestinal disease have the greatest mortality. We hypothesized there is basal synthesis of endothelin-1 (ET-1) in the intestinal tract of healthy horses that is likely involved in regulating vasomotor tone, secretion and motility and that ET-1 synthesis increases with gastrointestinal tract disease, which may be involved in the pathophysiology of these disorders. Plasma ET-like immunoreactivity was increased in horses with naturally-acquired gastrointestinal disease, compared with normal horses; values were greatest in horses with large intestinal strangulation obstruction, enterocolitis and peritonitis. There was an association …
Characterization Of Protein Secretion In Mycobacterium Leprae Using Phoa Fusions In Escherichia Coli And Mycobacterium Smegmatis, Marina Noemi Torrero
Characterization Of Protein Secretion In Mycobacterium Leprae Using Phoa Fusions In Escherichia Coli And Mycobacterium Smegmatis, Marina Noemi Torrero
LSU Doctoral Dissertations
Complete sequencing and annotation of the M. leprae genome has provided new information related to proteins constituting its hypothetical proteome. Since M. leprae can not be grown in vitro, novel approaches are needed to determine which proteins are expressed during infection and whether these proteins are related to pathogenesis. Secreted proteins represent a distinct group of protein with respect to their structure and function, contribution to virulence and are of particular importance for vaccine development because they are often immunogenic and have the potential to be recognized early in infection. The objectives of this study were: 1) to identify putatively …
Developing Risk Assessment Maps For Schistosoma Haematobium In Kenya Based On Climate Grids And Remotely Sensed Data, Kelsey Lee Mcnally
Developing Risk Assessment Maps For Schistosoma Haematobium In Kenya Based On Climate Grids And Remotely Sensed Data, Kelsey Lee Mcnally
LSU Master's Theses
It is important to be able to predict the potential spread of water borne diseases when building dams or redirecting rivers. This study was designed to test whether the use of a growing degree day (GDD) climate model and remotely sensed data (RS) within a geographic information system (GIS), could be used to predict both the distribution and severity of Schistosoma haematobium. Growing degree days are defined as the number of degrees centigrade over the minimum temperature required for development. The base temperature and the number of GDD required to complete one generation varies for each species. A monthly climate …
Susceptibility Of Bacillus Anthracis To Gamma And Cherry Bacteriophage, Preston A. Fulmer
Susceptibility Of Bacillus Anthracis To Gamma And Cherry Bacteriophage, Preston A. Fulmer
LSU Master's Theses
Bacillus anthracis is a bacterium that causes severe disease mainly in ruminants, but can affect any mammal, including humans. A popular method for the detection of this organism is susceptibility of the bacterial isolate to g bacteriophage. However, to date no study on the resistance of a wide variety of B. anthracis isolates has been conducted. The following study examines the rate of resistance of a wide range of B. anthracis isolates to g phage as well as another phage specific for B. anthracis known as Cherry phage. We also compared susceptibility to phage with another detection method, susceptibility to …
The Effect Of Aging On The Immune Response To Vaccination In The Horse, Daniel H. Fermaglich
The Effect Of Aging On The Immune Response To Vaccination In The Horse, Daniel H. Fermaglich
LSU Master's Theses
Vaccination programs are designed to protect an animal from infection, however, depending upon the age and health of the animal vaccination may not stimulate a protective humoral response. It is possible that, as in the human and mouse models, geriatric equines may be less responsive than their younger counterparts to current vaccination protocols. The purpose of this study was to identify an age related diminution in the primary and secondary immune responses of geriatric horses in response to vaccination. Two groups of horses were sampled. The first group consisted of an open herd of 39 privately owned horses, varying in …
Effectiveness Of Copper-Oxide Wire Particles On The Control Of Haemonchus Contortus In Sheep, Ariane Diane Watkins
Effectiveness Of Copper-Oxide Wire Particles On The Control Of Haemonchus Contortus In Sheep, Ariane Diane Watkins
LSU Master's Theses
Among the gastrointestinal nematode parasites that cause the most problems to small ruminants, Haemonchus contortus is one of major concern. Currently, the control of H. contortus and others is almost entirely based on the use of anthelmintics. Consequently, anthelmintic resistance has developed worldwide and this has become a serious problem in small ruminant nematode parasite control programs. In view of this, there is a need for alternative control methods. The use of Copper-Oxide Wire Particles (COWP) to help reduce parasite burden is one such alternative. Three trials were conducted to determine the effect of COWP on the reduction of H. …