Dentistry Commons^™

S4s8-Rpa Phosphorylation As An Indicator Of Cancer Progression In Oral Squamous Cell Carcinomas., Jeff Rector, Sasha Kapil, Kelly J. Treude, Phyllis Kumm, Jason G. Glanzer, Brendan M. Byrne, Shengqin Liu, Lynette M. Smith, Dominick J. Dimaio, Peter J. Giannini, Russell B. Smith, Greg G. Oakley

Journal Articles: College of Dentistry

Oral cancers are easily accessible compared to many other cancers. Nevertheless, oral cancer is often diagnosed late, resulting in a poor prognosis. Most oral cancers are squamous cell carcinomas that predominantly develop from cell hyperplasias and dysplasias. DNA damage is induced in these tissues directly or indirectly in response to oncogene-induced deregulation of cellular proliferation. Consequently, a DNA Damage response (DDR) and a cell cycle checkpoint is activated. As dysplasia transitions to cancer, proteins involved in DNA damage and checkpoint signaling are mutated or silenced decreasing cell death while increasing genomic instability and allowing continued tumor progression. Hyperphosphorylation of Replication …

Ada News - 02/06/2017, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Potential Ciliary Neurotrophic Factor Application In Dental Stem Cell Therapy, Patrick Suezaki, Nan (Tori) Xiao

All Dugoni School of Dentistry Faculty Articles

Neurotrophic factors have long been considered growth factors that promote survival and growth of various neuronal tissues. Recent studies showed that neurotrophic factors are also present in dental pulp and periodontal ligament. This paper reviews the literature about the ciliary neurotrophic factor (CNTF), a member of the neurotrophic factor family, and indicates the potential clinical application of CNTF in dental stem cell therapy.

Porous Magnesium-Based Scaffolds For Tissue Engineering, Mostafa Yazdimamaghani, Mehdi Razavi, Daryoosh Vashaee, Keyvan Moharamzadeh, Aldo R. Boccaccini, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Significant amount of research efforts have been dedicated to the development of scaffolds for tissue engineering. Although at present most of the studies are focused on non-load bearing scaffolds, many scaffolds have also been investigated for hard tissue repair. In particular, metallic scaffolds are being studied for hard tissue engineering due to their suitable mechanical properties. Several biocompatible metallic materials such as stainless steels, cobalt alloys, titanium alloys, tantalum, nitinol and magnesium alloys have been commonly employed as implants in orthopedic and dental treatments. They are often used to replace and regenerate the damaged bones or to provide structural support …

Oral Melanoma: Relevance To The Dental Team Members, Yeshwant B. Rawal, Thomas B. Dodson, Harbinder S. Bal

School of Dentistry Faculty Research and Publications

Background and Overview

Oral melanomas vary in color and morphology and resemble myriad other reactive, benign, or malignant conditions. The authors describe a case report of a patient with a primary oral melanoma that presented as a nonspecific ulcer, which showed nodal metastasis during resection.

Case Description

A 64-year-old man who was examined by his periodontist to assess implant healing had a reddish-purple ulcer of the maxillary mucosa of 3 to 4 weeks duration. The implant was placed 19 weeks earlier in the mandible. The provisional diagnosis was that this ulcer was a traumatic or inflammatory lesion. The clinician biopsied …

Caries Prevalence In Maine Based On College Of Dental Medicine (Une) Findings, Molly A. Kalish, Vasiliki Maseli

Dental Medicine Student Research Posters

Poster presentation outlining a retrospective study conducted in order to better understand the needs of Maine residents and provide the appropriate oral health care in the future.

Background and Overview: Dental caries is a progressive, irreversible microbial disease affecting the hard tissues of the tooth. It is the most prevalent chronic disease affecting the human race. Once it occurs, its manifestations persist throughout life even when the lesion is treated. It usually begins soon after the teeth erupt into the oral cavity, thus, it is a post eruptive disease. It affects people of both genders, all races, all ages, and …

Ada News - 01/23/2017, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Ada News - 01/09/2017, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Interprofessional Peer Teaching: Physical Therapy Students Teaching Dental Students To Transfer Patients, Kim Dunleavy, Pt, Phd, Ocs, Venita Sposetti, Dmd

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Background While the need for interprofessional education (IPE) has been clearly elucidated, (Interprofessional Education Collaborative, 2016), one of the major barriers is the logistical challenge of meeting curricular requirements for all involved. The organization and time required in an already full schedule are often deterrents. Ideal opportunities meet specific program curricular requirements as well as enhancing interprofessional competencies. Interprofessional competencies include developing skills to teach other health care providers about profession-specific skills and enhancing communication across the professions (Bridges, 2011; Interprofessional Education Collaborative, 2016). Active learning techniques have been advocated for adult learners to promote motivation and engagement (Knowles, 1984), …

Characteristics Associated With Successful Dental Treatment In Children With Autism Spectrum Disorder, Noah Turk

Student Theses, Dissertations and Capstones

Background. ASD is a neurodevelopmental disability, responsible for social, communicative and behavioral deficits. The prevalence of children diagnosed with ASD in the United States has more than doubled in the past two decades, from 1 in 150 to 1 in 68. Children diagnosed with ASD have a very high occurrence of certain comorbidities, such as developmental delay, intellectual disability and speech delay. Unmet dental needs remain high among children with special health care needs (SHCN), with 78% reporting the need for dental care within the last 12 months. Recent studies have focused on barriers to care for these patients; the …

Bmp2 Enhances Osteogenesis Of Gingival Stem Cells In Peptide Hydrogel, Annapurna Bondalapati

Student Theses, Dissertations and Capstones

Purpose: The aim of the study was to investigate effect of the growth factor, Bone Morphogenetic Protein 2 (BMP2), on the differentiation of Human gingiva derived stem cells (HGMSCs) in a self-assembled three-dimensional (3D) peptide hydrogel. The study has two parts; part 1 comprised of optimizing the dose of BMP2 and Part II was investigating the effective delivery method of BMP2 in enhancing the osteogenic differentiation of HGMSCs Methods: Human gingiva derived mesenchymal stem cells (HGMSCs) cultured in the peptide hydrogel (3-D cultures) were treated with 50, 100 and 200 ng/ml BMP2. The cells in the osteogenic differentiation of HGMSCs …

Indirect Bonding Of Orthodontic Brackets: A Comparison Of Positional Accuracy Between Software Vs. Stone Model Driven Techniques, Francesca Scilla Smith

Student Theses, Dissertations and Capstones

Background: Many orthodontic clinicians consider indirect bonding of orthodontic brackets as a method of achieving greater accuracy and effectiveness in orthodontic treatment. Currently, few features of our world have escaped the influence of technology. The indirect system of orthodontic bonding offers an example of technology’s power through a computer-driven system that enables customized bracket placement that optimizes esthetics, accuracy, precision and efficiency. The purpose of this study was to compare the positional accuracy and reliability between traditional and computer-generated indirect bonding techniques. Methods: A total of 210 brackets (STEP metal brackets with slot size .022x.028) were placed using a four …

Proteomic Approach For Extracting Cytoplasmic Proteins From Streptococcus Sanguinis Using Mass Spectrometry, Fadi Elrami, Kristina Nelson, Ping Xu

Philips Institute for Oral Health Research Publications

Streptococcus sanguinis is a commensal and early colonizer of oral cavity as well as an opportunistic pathogen of infectious endocarditis. Extracting the soluble proteome of this bacterium provides deep insights about the physiological dynamic changes under different growth and stress conditions, thus defining “proteomic signatures” as targets for therapeutic intervention. In this protocol, we describe an experimentally verified approach to extract maximal cytoplasmic proteins from Streptococcus sanguinis SK36 strain. A combination of procedures was adopted that broke the thick cell wall barrier and minimized denaturation of the intracellular proteome, using optimized buffers and a sonication step. Extracted proteome was quantitated …

Retention Systems For Extraoral Maxillofacial Prosthetic Implants: A Critical Review, M.V. Cobein, N.P. Coto, O. Crivello Junior, J.B.D. Lemos, L.M. Vieira, M.L. Pimentel, Hugh Byrne, R.B. Dias

Articles

We describe the techniques available for retention of implant-supported prostheses: bar-clips, O-rings, and magnets. We present reported preferences and, although this is limited by the heterogeneity of methods used and patients studied, we hope we have identified the best retention systems for maxillofacial prosthetic implants. If practitioners know the advantages and disadvantages of each system, they can choose the most natural and comfortable prosthesis. We searched the PubMed and Scopus databases, and restricted our search to papers published 2001–13. MeSH terms used were Maxillofacial prosthesis and Craniofacial prosthesis OR Craniofacial prostheses. We found a total of 2630 papers, and after …

Effect Of Ceramic Thickness On The Final Color Of Veneer Restorations, Zainab M. Alsadah

Student Theses, Dissertations and Capstones

Background: The integration of ceramic veneer thickness and substrate color are very challenging factors that dentists and lab technicians should control to achieve a good color match. The reproduction of a natural and homogenous color can be laborious when laminate veneers of 0.4 to 1.2 mm thick are cemented over a dark underlying substrate. Objective: The purpose of this in vitro study was to investigate the association of different ceramic veneer thicknesses cemented on different tooth substrate colors and its influence on final color match of ceramic veneers. Material and methods: Ninety slices IPS e-max CAD (Ivoclar Vivadent, Amherst, NY, …

Dental Practice Success Vol. 3 No. 4, American Dental Association, Publishing Division

Dental Practice Success

No abstract provided.

Ada News Convention Daily - 2017 Day 4, American Dental Association, Publishing Division

ADA News

The ADA News Daily (also called the ADA News Convention Daily) is a special edition of the ADA News published each day during American Dental Association Annual Sessions.

Ada News Convention Daily - 2017 Day 2, American Dental Association, Publishing Division

ADA News

The ADA News Daily (also called the ADA News Convention Daily) is a special edition of the ADA News published each day during American Dental Association Annual Sessions.

Ada Constitution & Bylaws (2017), American Dental Association

Constitution & Bylaws

The ADA Commons Constitution & Bylaws archival collection comprises printed issues of the American Dental Association's Constitution and Bylaws. The collection also includes the ADA Charter and the ADA Code of Ethics issued 1924-1946.

The Effect Of Grinding And Polishing Of Zirconia Surfaces On Surface Roughness, Gloss And Antagonist Wear, Manar Mohammed Alzahrani

Student Theses, Dissertations and Capstones

Objective. This study was conducted to evaluate the surface roughness and gloss of yttrium-stabilized tetragonal zirconia after grinding and/or polishing of the surfaces and to investigate the effects of grinding and/or polishing on wear rate of zirconia and its composite antagonist. Background. Many clinicians are extremely concern about delivering zirconia restorations after proper glazing procedure, but in some cases, chair-side modification of the occlusal surfaces is required after cementation in order to obtain proper occlusion, which produces rough surfaces. Loss of the original zirconia gloss and wear of opposing dentition or restorations are some of the drawbacks of rough surfaces. …

National Children’S Dental Health Month - Program Planning Guide (2017), American Dental Association Foundation

National Children's Dental Health Month

No abstract provided.

Libro De Actividades Por El Mes Nacional De La Salud Dental Infantil [Spanish Language Version: National Children's Dental Health Month Activity Book] (2017), American Dental Association Foundation

National Children's Dental Health Month

No abstract provided.

Short-Term Compliance With Stabilization Splints In A Group Of Thai Patients With Temporomandibular Disorders, Siriya Pakanimit, Atinuch Malakul, Suknipa Vongthongsri

Chulalongkorn University Dental Journal

Objectives To investigate short-term compliance rate in the usage of stabilization splint in temporomandibular disorders (TMD) patients and to analyze the difference in compliance rate classified by the treatment outcome of occlusal splint therapy. Materials and methods A prospective observational study was conducted. The sample group consisted of 90 TMD patients receiving stabilization splint treatment in the Department of Occlusion, Faculty of Dentistry, Chulalongkorn University during January to June 2016. Patients were asked to complete a questionnaire during a period of 14 days after splint insertion in order to determine the compliance to occlusal splint therapy, experience of adverse effects …

Curcumin Promotes Bone Marrow Stromal Cell Viability And Attenuates Tnf- -Induced Prostaglandin E2 Synthesis Via Cyclooxygenase-2 Suppression, Varittha Thongtan, Supaporn Suttamanatwong

Chulalongkorn University Dental Journal

Background Prostaglandin E2 (PGE2) is the main mediator for receptor activator of nuclear factor-κB ligand (RANKL)-mediated osteoclastogenesis and bone resorption in periodontitis. Bone marrow stromal cells (BMSCs) secrete PGE2 in response to pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α). Curcumin, a polyphenolic compound from the turmeric plant, possesses an anti-inflammatory effect by downregulating key mediators of inflammation. Objectives This study examined the effect of curcumin on the process of PGE2 biosynthesis in TNF-α-stimulated BMSCs. Materials and methods To investigate curcumin cytotoxicity, mouse ST2 BMSCs were treated with 1-50 μM curcumin and cell viability was determined by the MTT assay. …

Evaluation Of Technical Image Quality And Radiation Dose Of A Thai Cone-Beam Ct Scanner, Ruben Pauwels, Saowapak Thongvigitmanee, Sorapong Aootaphao, Chalinee Thanasupsombat, Walita Narkbuakaew, Reinhilde Jacobs, Hilde Bosmans, Soontra Panmekiate, Pairash Thajchayapong

Chulalongkorn University Dental Journal

Objectives The aim of this study is to evaluate the technical image quality and radiation dose of the DentiiScan 2.0 cone-beam computed tomography (CBCT) scanner before widespread clinical use. Materials and methods Image quality was measured for 4 scanning protocols of the DentiiScan 2.0, using 2 dedicated test objects: the SEDENTEXCT IQ phantom and the QRM-ConeBeam phantom. The following image quality parameters were evaluated: contrast-detail, contrast-to-noise ratio (CNR), spatial resolution, grey value uniformity, metal artefacts, and geometric accuracy. Radiation dose was measured using a calibrated ionization chamber placed at the isocenter of rotation, allowing for the calculation of the dose-area …

Effect Of Water Immersion On The Resistance To Sliding Of Coated Orthodontic Archwires, Jun Sik Kim

Student Theses, Dissertations and Capstones

Objectives: The objective of this in vitro study is to compare the resistance to sliding (RS) of coated and uncoated orthodontic archwires in ceramic brackets at various water-immersion times and bracket angulations. Background: Tooth-colored orthodontic systems have been developed to meet the patient’s esthetic needs. Ceramic brackets and polymer-coated archwires have been shown to demonstrate higher RS than metal brackets and archwires in dry conditions. However, there is no study to address the RS of coated archwires depending on water-immersion times as in the oral cavity. Therefore, it is necessary to examine RS of coated archwires sliding in ceramic brackets …

Investigating Lip Protrusion Aesthetics By Comparing The Facial Profile View With An Oblique View, Barak Jones

Student Theses, Dissertations and Capstones

Introduction: Orthodontists strive to enhance facial esthetics. Notable orthodontists including Holdaway, Ricketts, Merrifield and more each made contributions to help diagnose facial disharmonies and improve treatment outcomes. Numerous studies have evaluated the face from two perspectives, frontal and profile. Orthodontic treatment can significantly transform a facial profile. Orthodontic literature has time and again compared photos, line drawings and silhouettes in order to define a harmonious profile. Some have concluded that a more protrusive lip profile than what had been outlined traditionally is now preferred. However, while this debate continues, in this dynamic world the profile perspective is not the most …

Tooth Size Comparison Between Citizens Of The Chickasaw Nation And Caucasians, Tyler Chance Devaughan

Student Theses, Dissertations and Capstones

Objective The goal of this study is to establish normative tooth crown size (mesio-distal width) data for the Chickasaw Nation and demonstrate how it relates to Caucasian standards. Background: Tooth size ratios represent a diagnostic tool that allow for a prediction of treatment outcomes. A proper relationship of the total mesio-distal width of the maxillary dentition to the mesio- distal width of the mandibular dentition will favor an ideal post treatment occlusion. If a patient has a significant tooth size discrepancy between the dental arches, alignment of the teeth into this ideal occlusion may not be possible. Patients commonly receive …

Evaluation Of Microshear Bond Strength Of Light-Cured Composite For Cementation Of Ceramic Veneer, Khalid Motlaq

Student Theses, Dissertations and Capstones

Brief background and goal/ research question: Ceramic restorations were introduced as indirect restorative materials that combine high esthetics with superior mechanical properties. However, an important requirement for successful function of these restorations is adequate adhesion between the restoration material and tooth structure. The use of CAD/CAM restorations is steadily increasing, proper function and longevity of these restorations depends on good adhesion to the underlying substrate as well as operator technique. Preheated composite has been recommended by some clinicians and investigators for the adhesive luting of porcelain laminate veneers based on its good marginal adaptation and perceived superior mechanical durability when …

Dental Care For Older Adults: Regulatory Requirements In Long Term Care Settings, American Dental Association

Action for Dental Health

No abstract provided.