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2017

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Full-Text Articles in Dentistry

The Effect Of Mechanical Vibration On Pain And Rate Of Tooth Movement During Initial Orthodontic Alignment, Leslie Ellingson Dec 2017

The Effect Of Mechanical Vibration On Pain And Rate Of Tooth Movement During Initial Orthodontic Alignment, Leslie Ellingson

Theses & Dissertations

Purpose: The purpose of this investigation was to evaluate the effect of mechanical vibration on pain experienced and rate of tooth movement (OTM) during the initial alignment phase of orthodontic treatment.

Materials and Methods: Participants were randomly allocated to control, low frequency or high frequency. An electric toothbrush was modified to provide high frequency vibration. A low frequency vibration device was acquired from a commercial vendor. Experimental groups applied vibration to the dentition for 20 minutes daily. All participants completed questionnaires using visual analog scales at five time points. Pain experience was measured in millimeters (mm) with the scale measuring …


Cpap-Mad Combination Therapy For Cpap Intolerant Patients With Moderate To Severe Osa, Jacob Stadiem Dec 2017

Cpap-Mad Combination Therapy For Cpap Intolerant Patients With Moderate To Severe Osa, Jacob Stadiem

Theses & Dissertations

The treatment of obstructive sleep apnea (OSA) allows for a multidisciplinary approach between dentistry and medicine. Continuous positive airway pressure (CPAP) is the gold standard for OSA treatment, but the non-adherence rates are high. The mandibular advancement device (MAD) has a higher acceptance rate than the CPAP, however the efficacy is much lower in cases of moderate to severe OSA. This thesis attempted to evaluate if there was a change in compliance when a MAD was added as a combination therapy to moderate to severe OSA subjects that were currently non-compliant with their CPAP. In addition, the change in air …


What 2017 Holds For Technology In Dentistry, Arshi Siddiqui Dec 2017

What 2017 Holds For Technology In Dentistry, Arshi Siddiqui

Honors College Theses

Dentistry in the United States is a field that grows and expands based on the needs of its consumers. This paper aims to highlight this very versatility through the analysis of specific demographics of dental practitioners, consumers, and the changes in technology that are predicted for the future of dentistry. With the rise of Generation X and the Millennial Generation, dentistry will undergo many changes alongside the rise of technology throughout the recent years. More evidently, the population is undergoing a very seismic shift in the way they view themselves. Because people are harboring more of an individualistic mindset, the …


The Analytical Methods Used To Detect Fluoride In Dental Pharmaceuticals, Amber Aboona Dec 2017

The Analytical Methods Used To Detect Fluoride In Dental Pharmaceuticals, Amber Aboona

Honors College Theses

My thesis, “The Analytical Methods Used to Detect Fluoride in Dental Pharmaceuticals” discusses the various analytical chemistry methods which are incorporated in the field of dentistry in order to detect fluoride in pharmaceuticals such as toothpaste and mouthwash. The oral cavity is exposed to various forms of bacteria, many of which enter through the consumption of foods and drinks that contain sugar and starch. The side effects of fluoride have been a controversial component of oral healthcare, however, many benefits have been discussed. Water fluoridation has been one of many significant methods of incorporating fluoride into the oral cavity, enhancing …


Ada News - 12/11/2017, American Dental Association, Publishing Division Dec 2017

Ada News - 12/11/2017, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.


The Assessment Of A School-Based Dental Program, Peggy H. Hyden Dec 2017

The Assessment Of A School-Based Dental Program, Peggy H. Hyden

Dental Hygiene ETDs

The Assessment of a School-Based Dental Program

by

Peggy H. Hyden

B.S., Dental Hygiene, Caruth School of Dental Hygiene, Texas A&M College of Dentistry, 1979 M.S., Dental Hygiene, University of New Mexico, 2018

ABSTRACT Purpose: The purpose of this study was to compare non-participants and participants of a school-based dental program and assess the utilization and satisfaction of services offered. Methods: Sixty-seven hundred questionnaires, containing 20 questions, were distributed to the parents/guardians of the Carlsbad and Loving school systems. Surveys were taken home by the students, given to the parent/guardians and returned within 1 week. Descriptive statistics was used to …


Relationship Between Self-Reported Oral Health And Self-Esteem In Two Columbia, Sc Populations, Matthew Ablonczy, Elizabeth Smith Dec 2017

Relationship Between Self-Reported Oral Health And Self-Esteem In Two Columbia, Sc Populations, Matthew Ablonczy, Elizabeth Smith

Senior Theses

The importance of oral health to overall health cannot be overstated. For example, oral health can be used for early diagnosis of diseases such as diabetes. Furthermore, it has been well studied that self-esteem is related to oral health. Individuals with proper oral health care have more confidence to interact with others, which results in higher self-esteem. Those who lack the ability to pay for oral healthcare are thus at a great disadvantage. The present study sought to investigate the relationship between oral health and self-esteem in two Columbia, SC populations through surveying. There were two study populations, students at …


Healthy Teeth: Building Dental Health Awareness Among Head Start Parents, Marisol Cruz Dec 2017

Healthy Teeth: Building Dental Health Awareness Among Head Start Parents, Marisol Cruz

Capstone Projects and Master's Theses

In the U.S and state of California, tooth decay is the most common chronic disease and concerning health issue among children. The Head Start program in Monterey County serves about 1, 245 children annually from birth to five years of age. One requirement is that children obtain dental health checkups every six months, and receive dental treatment, if needed, as part of adhering to California's dental periodicity schedule. Over the past years, an increase of failed dental health assessments was observed among many children enrolled in the program. Obtaining and following through with treatment was an obstacle. The purpose of …


Comparison Of Apical Centring Ability Between Incisal-Shifted Access And Traditional Lingual Access For Maxillary Anterior Teeth, Yoshio Yahata, Yoshiko Masuda, Takashi Komabayashi Dec 2017

Comparison Of Apical Centring Ability Between Incisal-Shifted Access And Traditional Lingual Access For Maxillary Anterior Teeth, Yoshio Yahata, Yoshiko Masuda, Takashi Komabayashi

Dental Medicine Faculty Publications

The aim of this study was to compare the apical centring ability of incisal-shifted access (ISA) with that of traditional lingual access (TLA). Fifteen three-dimensional printed resin models were prepared from the computed tomography data for a human maxillary central incisor and divided into ISA (n=7), TLA (n=7), and control (n=1) groups. After access preparation, these models were shaped to the working length using K-files up to #40, followed by step-back procedures. An apical portion of the model was removed at 0.5 mm coronal to the working length. Microscopic images of each cutting surface were taken to measure the preparation …


Clinical Cases In Endodontics; Chapter 1: Introduction, Takashi Komabayashi Dec 2017

Clinical Cases In Endodontics; Chapter 1: Introduction, Takashi Komabayashi

Dental Medicine Faculty Publications

Chapter 1 of Clinical Cases in Endodontics, a problem-based text that presents a wide range of real cases in endodontics. Clinical Cases in Endodontics presents actual clinical cases, accompanied by academic commentary, that question and educate the reader about essential topics in endodontic therapy. It begins with sets of cases illustrating the most common diagnoses and the steps involved in preparing a treatment plan. Subsequent chapters continue in this style, presenting exemplary cases as the basis of discussing various treatment options, including nonsurgical root canal treatment, re-treatment, periapical surgery, internal and external resorption, emergencies and trauma, and treating incompletely developed …


Heredity, Genetics And Orthodontics: How Much Has This Research Really Helped?, James K. Hartsfield Jr., George Jeryn Jacob, Lorri Ann Morford Dec 2017

Heredity, Genetics And Orthodontics: How Much Has This Research Really Helped?, James K. Hartsfield Jr., George Jeryn Jacob, Lorri Ann Morford

Oral Health Science Faculty Publications

Uncovering the genetic factors that correlate with a clinical deviation of previously unknown etiology helps to diminish the unknown variation influencing the phenotype. Clinical studies, particularly those that consider the effects of an appliance or treatment regimen on growth, need to be a part of these types of genetic investigations in the future. While the day-to-day utilization of "testing" for genetic factors is not ready for practice yet, genetic testing for monogenic traits such as Primary Failure of Eruption (PFE) and Class III malocclusion is showing more promise as knowledge and technology advances. Although the heterogeneous complexity of such things …


Pseudomyogenic Hemangioendothelioma: A Vascular Tumor Previously Undescribed In The Oral Cavity, Yeshwant B. Rawal, Kenneth M. Anderson, Thomas B. Dodson Dec 2017

Pseudomyogenic Hemangioendothelioma: A Vascular Tumor Previously Undescribed In The Oral Cavity, Yeshwant B. Rawal, Kenneth M. Anderson, Thomas B. Dodson

School of Dentistry Faculty Research and Publications

The pseudomyogenic hemangioendothelioma (PMH) is a low-grade malignant vascular neoplasm of different tissue planes including skin and soft tissue. Primary tumors in the skeletal muscle and bone have also been diagnosed. The PMH was introduced into the WHO classification of tumors of soft tissue and bone in 2013. This is the first description of oral involvement. A 21-year-old female presented with a 2-month old swelling of her gingiva. The swelling appeared red in color and was soft in consistency. A clinical diagnosis of a pyogenic granuloma was made and an incisional biopsy was submitted for histopathological evaluation. The lesion consisted …


Divergent Schwannoma-Like Phenotype In A Pleomorphic Adenoma, Srinivasa R. Chandra, Farah Karim, Yeshwant B. Rawal Dec 2017

Divergent Schwannoma-Like Phenotype In A Pleomorphic Adenoma, Srinivasa R. Chandra, Farah Karim, Yeshwant B. Rawal

School of Dentistry Faculty Research and Publications

The schwannoma-like pleomorphic adenoma is a rare histopathological variant of the pleomorphic adenoma. Five previous reports with seven cases exist in English language literature. These tumors present in the parotid gland most commonly. Intraparotid schwannomas of the facial nerve and schwannomas with glandular differentiation have also been reported. A 60-year-old male presented with an asymptomatic swelling over the left angle of the mandible. The swelling had been present for about 12 years with a recent increase in size. CT imaging showed a hyperdense circumscribed mass of the superficial lobe of the parotid. The working diagnosis was that of a benign …


Comparison Of Expression Of The Gdnf Family Neurotrophic Factors In Dental Pulp Stem Cells With Deciduous And Adult Teeth, Kamille Mercado, Nan (Tori) Xiao Dec 2017

Comparison Of Expression Of The Gdnf Family Neurotrophic Factors In Dental Pulp Stem Cells With Deciduous And Adult Teeth, Kamille Mercado, Nan (Tori) Xiao

All Dugoni School of Dentistry Faculty Articles

The glial cell line-derived neurotrophic factor (GDNF) family has a role in neuron growth within the peripheral and central nervous systems. This makes it a potential therapeutic agent for neurological conditions like Parkinson’s disease and epilepsy. GDNF has also been implicated in murine odontogenesis. In permanent and deciduous human dental pulp stem cells, this study found that GDNF family members and receptors are expressed, indicating neurotrophic factors may play a role in dental pulp regeneration.


The Role Of Kinases And Phosphatases In The Pathobiology Of Porphyromonas Gingivalis., Sarah Whitmore Dec 2017

The Role Of Kinases And Phosphatases In The Pathobiology Of Porphyromonas Gingivalis., Sarah Whitmore

Electronic Theses and Dissertations

Periodontal diseases result from the interplay between the dysregulation of the host inflammatory response and the actions of a dysbiotic bacterial community. These chronic inflammatory conditions affect persons on a worldwide scale. P. gingivalis is strongly implicated as a key periodontal pathogen in the more severe manifestations of periodontal diseases such as periodontitis. A core element of P. gingivalis pathogenicity is its dysregulation of innate immunity, including suppression of IL-8 production by gingival epithelial cells. The NF-κB family of related transcription factors plays a central role in regulating many important aspects of innate immune responses. NF-κB RelA/p65 homodimers regulate transcription …


Deficiency Of Rdh10 Causes Cleft Secondary Palate In Mouse., Swetha Raja Dec 2017

Deficiency Of Rdh10 Causes Cleft Secondary Palate In Mouse., Swetha Raja

Electronic Theses and Dissertations

The focus of this project is to understand the role of Retinoic Acid (RA) produced by RDH10-mediated metabolism of Vitamin A in palate development. For 80 years now, we have known that dietary restriction of RA/Vitamin A can cause cleft palate but we have failed to understand how RA deficiency causes cleft palate. Our gap in knowledge about how RA deficiency causes cleft palate is mainly owing to the fact that we lack a model system to study such defects. The aim of this thesis research project was to determine if conditional inactivation of the Vitamin A metabolic gene Rdh10 …


Type Ix Secretion System : Characterization Of An Effector Protein And An Insight Into The Role Of C-Terminal Domain Dimeration In Outer Membrane Translocation., Lahari Koneru Dec 2017

Type Ix Secretion System : Characterization Of An Effector Protein And An Insight Into The Role Of C-Terminal Domain Dimeration In Outer Membrane Translocation., Lahari Koneru

Electronic Theses and Dissertations

Porphyromonas gingivalis and Tannerella forsythia are two of the primary pathogens that are associated in the etiology and progression of chronic periodontitis. In T. forsythia, KLIKK proteases are the recently identified group of proteolytic enzymes that are secreted through Type IX secretion system (T9SS). Among, these KLIKK proteases a synergistic relationship was observed between karilysin and mirolysin in invading the host complement system for the survival of the bacteria. Since, karilysin has been already characterized, in this study we propose to study about mirolysin through structural, biochemical and biological characterization. The obtained results from the experiments has shown the …


Is Antimicrobial Photodynamic Therapy A Useful Therapeutic Protocol For Oral Decontamination? A Systematic Review And Meta-Analysis, Sergio Varelakellesarian, Faisal Qayyum, Paula C.De Freitas, Zohaib Akram, Fawad Javed Dec 2017

Is Antimicrobial Photodynamic Therapy A Useful Therapeutic Protocol For Oral Decontamination? A Systematic Review And Meta-Analysis, Sergio Varelakellesarian, Faisal Qayyum, Paula C.De Freitas, Zohaib Akram, Fawad Javed

Section of Dental-Oral Maxillofacial Surgery

BACKGROUND:
The aim of the present systematic review and meta-analysis was to assess the efficacy of antimicrobial photodynamic therapy (aPDT) as a therapeutic protocol for oral decontamination.
METHODS:
In order to address the focused question: Is aPDT a useful therapeutic protocol for oral decontamination?, an electronic search without time or language restrictions was conducted up to July 2017 in indexed databases using the combination of different key words including photochemotherapy, lasers, photodynamic therapy, disinfection, mouth, saliva and oral. The exclusion criteria included reviews, case-reports, case-series, commentaries, letters to the editor, interviews, and updates. Four randomized control trials were included and …


Comparison Of Antibacterial Activity Of Ozonated Olive Oil And Chlorhexidine Gluconate, Changmin Lee Dec 2017

Comparison Of Antibacterial Activity Of Ozonated Olive Oil And Chlorhexidine Gluconate, Changmin Lee

Loma Linda University Electronic Theses, Dissertations & Projects

Aim: The aim of this in vitro disk diffusion susceptibility test is to compare the antibacterial activity of ozonated olive oil (OzOO) with chlorhexidine gluconate (CHX) against periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter Actinomycetemcomitans. Materials and Methods: The antibacterial activity of two antiseptics, OzOO and CHX, and, two controls, olive oil and normal saline was assessed by disk diffusion susceptibility test. For disk diffusion susceptibility test, two periodontal pathogens, 20 petri dishes for P. gingivalis and 18 petri dishes for A. actinomycetemcomitans, were used. To assess the antibacterial activity, the diameters of the growth inhibition zone were measured with a …


Patients’ Willingness To Participate In Rapid Hiv Testing: A Pilot Study In Three New York City Dental Hygiene Clinics, Susan H. Davide, Anthony J. Santella, Winnie Furnari, Petal Leuwaisee, Marilyn Cortell, Bhuma Krishnamachari Dec 2017

Patients’ Willingness To Participate In Rapid Hiv Testing: A Pilot Study In Three New York City Dental Hygiene Clinics, Susan H. Davide, Anthony J. Santella, Winnie Furnari, Petal Leuwaisee, Marilyn Cortell, Bhuma Krishnamachari

Publications and Research

Purpose: One in eight people living with an HIV infection in the United States is unaware of their status. Rapid HIV testing (RHT) is an easily used and accepted screening tool that has been introduced in a limited number of clinical settings. The purpose of this study was to investigate patient acceptability, certainty of their decision, and willingness to pay for screening if RHT was offered in university-based dental hygiene clinics.

Methods: A cross-sectional survey was administered to 426 patients at three dental hygiene clinics in New York City over a period of four months. The survey questionnaire was based …


Mineral Particles Stimulate Innate Immunity Through Neutrophil Extracellular Traps Containing Hmgb1., Hsin-Hsin Peng, Yu-Ju Liu, David M. Ojcius, Chiou-Mei Lee, Ren-Hao Chen, Pei-Rong Huang, Jan Martel, John D. Young Nov 2017

Mineral Particles Stimulate Innate Immunity Through Neutrophil Extracellular Traps Containing Hmgb1., Hsin-Hsin Peng, Yu-Ju Liu, David M. Ojcius, Chiou-Mei Lee, Ren-Hao Chen, Pei-Rong Huang, Jan Martel, John D. Young

All Dugoni School of Dentistry Faculty Articles

Calcium phosphate-based mineralo-organic particles form spontaneously in the body and may represent precursors of ectopic calcification. We have shown earlier that these particles induce activation of caspase-1 and secretion of IL-1β by macrophages. However, whether the particles may produce other effects on immune cells is unclear. Here, we show that these particles induce the release of neutrophil extracellular traps (NETs) in a size-dependent manner by human neutrophils. Intracellular production of reactive oxygen species is required for particle-induced NET release by neutrophils. NETs contain the high-mobility group protein B1 (HMGB1), a DNA-binding protein capable of inducing secretion of TNF-α by a …


Aesthetic Outcome Of Maxillomandibular Advancement Surgery For The Treatment Of Obstructive Sleep Apnea, Jennifer Curran Nov 2017

Aesthetic Outcome Of Maxillomandibular Advancement Surgery For The Treatment Of Obstructive Sleep Apnea, Jennifer Curran

Electronic Thesis and Dissertation Repository

Introduction:

Obstructive sleep apnea (OSA) is a common sleep disorder in which complete or partial airway obstruction causes disruptive sleep and excessive daytime sleepiness. Highly successful treatment outcomes for OSA utilizing maxillomandibular advancement (MMA) surgery have been reported. However, due to the large degree of surgical advancement that is performed, concerns may exist regarding the final aesthetic result.

Objectives:

To evaluate facial profile changes in patients treated for OSA with MMA surgery utilizing panels of oral and maxillofacial surgeons (OMFS), orthodontists (ORTHO) and laypeople (LAY).

Methods:

This was a retrospective cohort analysis. Pre- and post-treatment silhouettes of patients who underwent …


Friction Testing Of Contemporary Self-Ligating Appliance Systems, Michael Greene Nov 2017

Friction Testing Of Contemporary Self-Ligating Appliance Systems, Michael Greene

Electronic Thesis and Dissertation Repository

Background: Resistance to tooth movement is multifactorial, with friction (FR) one of many important components. There is limited data comparing contemporary Passive and Active self-ligating bracket (SLB) systems in terms of FR created by archwire engagement. Aim: To compare classical FR in contemporary SLB systems and traditional twin brackets in vitro, and to identify the point of initiation of bracket-archwire engagement. Materials & Methods: Nine bracket systems of .022-in slot size were FR tested: Victory Series (3M Unitek) with elastic ligature (control); Passive SLB systems Damon Q (Ormco), Carriere SLX (Henry Schein), H4 (Ortho Classic), Altitude …


Ada News - 11/20/2017, American Dental Association, Publishing Division Nov 2017

Ada News - 11/20/2017, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.


Binding Of Salivary Proteins To Orthodontic Brackets, Maria Pia Canales Nov 2017

Binding Of Salivary Proteins To Orthodontic Brackets, Maria Pia Canales

Electronic Thesis and Dissertation Repository


Objectives:
The aim of this study was to investigate the effect of different orthodontic materials on the formation of the protein pellicle on the bracket surface.

Materials and Methods: We used X-ray Photoelectron Spectroscopy (XPS) to analyze the atomic composition of orthodontic metallic and ceramic brackets. Following XPS, the brackets were immersed in human whole saliva supernatant for 2-hour incubation at 37°C. Hydroxyapatite (HA) discs were used as control. Acquired pellicle was harvested with sonication for each group, and liquid chromatography electrospray ionisation mass spectrometry was used for protein identification.

Results: Differences reported by XPS and mass spectrometry were noted …


Ada News - 11/06/2017, American Dental Association, Publishing Division Nov 2017

Ada News - 11/06/2017, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.


Prosthetic Rehabilitation Following Lateral Resection Of The Mandible With A Long Cantilever Implant-Supported Fixed Prosthesis: A 3-Year Clinical Report, Georgios Maroulakos, William W. Nagy, Ayman Ahmed, Ioli I. Artopoulou Nov 2017

Prosthetic Rehabilitation Following Lateral Resection Of The Mandible With A Long Cantilever Implant-Supported Fixed Prosthesis: A 3-Year Clinical Report, Georgios Maroulakos, William W. Nagy, Ayman Ahmed, Ioli I. Artopoulou

School of Dentistry Faculty Research and Publications

This clinical report describes the prosthetic management of the surgical reconstruction of a patient after mandibular resection. Complete oral rehabilitation was achieved with a maxillary complete denture and a mandibular implant-supported fixed prosthesis with a custom titanium framework and a long unilateral cantilever.


3d Printed Tcp-Based Scaffold Incorporating Vegf-Loaded Plga Microspheres For Craniofacial Tissue Engineering, Farahnaz Fahimipour, Morteza Rasoulianboroujeni, Erfan Dashtimoghadam, Kimia Khoshroo, Mohammadreza Tahriri, Doug Lobner, Lobat Tayebi Nov 2017

3d Printed Tcp-Based Scaffold Incorporating Vegf-Loaded Plga Microspheres For Craniofacial Tissue Engineering, Farahnaz Fahimipour, Morteza Rasoulianboroujeni, Erfan Dashtimoghadam, Kimia Khoshroo, Mohammadreza Tahriri, Doug Lobner, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Objective

Vascularization is a critical process during bone regeneration/repair and the lack of tissue vascularization is recognized as a major challenge in applying bone tissue engineeringmethods for cranial and maxillofacial surgeries. The aim of our study is to fabricate a vascular endothelial growth factor (VEGF)-loaded gelatin/alginate/β-TCP composite scaffold by 3D printing method using a computer-assisted design (CAD) model.

Methods

The paste, composed of (VEGF-loaded PLGA)-containing gelatin/alginate/β-TCP in water, was loaded into standard Nordson cartridges and promptly employed for printing the scaffolds. Rheological characterization of various gelatin/alginate/β-TCP formulations led to an optimized paste as a printable bioink at room …


Nadph Oxidase 4 Modulates Hepatic Responses To Lipopolysaccharide Mediated By Toll-Like Receptor-4., Anand Singh, Bhargav Koduru, Cameron Carlisle, Hasina Akhter, Rui-Ming Liu, Katrin Schroder, Ralf P. Brandes, David M. Ojcius Oct 2017

Nadph Oxidase 4 Modulates Hepatic Responses To Lipopolysaccharide Mediated By Toll-Like Receptor-4., Anand Singh, Bhargav Koduru, Cameron Carlisle, Hasina Akhter, Rui-Ming Liu, Katrin Schroder, Ralf P. Brandes, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

Chronic inflammation plays a key role in development of many liver diseases. Stimulation of Toll-like receptor 4 (TLR4) by bacterial lipopolysaccharide (LPS) initiates inflammation and promotes development of hepatocellular carcinoma and other liver diseases. NADPH oxidases contribute to LPS-induced reactive oxygen species (ROS) production and modulate TLR responses, but whether these enzymes function in TLR4 responses of hepatocytes is unknown. In the present work, we examined the role of NADPH oxidase 4 (Nox4) in LPS-induced TLR4 responses in human hepatoma cells and wildtype and Nox4-deficient mice. We found that LPS increased expression of Nox4, TNF-α, and proliferating cell nuclear antigen …


Remaining Dentine Thickness Following Tooth Preparation And Its Impact On Dentine – Pulp Complex, Rudina Berani, Merita Barani Sveqla Oct 2017

Remaining Dentine Thickness Following Tooth Preparation And Its Impact On Dentine – Pulp Complex, Rudina Berani, Merita Barani Sveqla

UBT International Conference

There are many factors accused of causing pulpal damage, but studies indicate that endodontic complications after placement of fixed prosthetic crowns and bridges are entirely iatrogenic and as a consequence of a deep tooth preparation. In 2mm of the remaining dentine thickness after preparation, there are significant reductions in cellular cell adhesion molecules in the pulp of the prepared tooth data compared to those intact. Researchers confirm that even this decline may be an expression of early stages of pulp inflammation. According to Murray & co, the number of odontoblasts in a dentine thickness of 2.5-0.5mm, was reduced by 13.6%; …