Dentistry Commons^™

Il-34 Exacerbates Pathogenic Features Of Alzheimer's Disease And Calvaria Osteolysis In Triple Transgenic (3x-Tg) Female Mice., Anny Ho, Bidii Ngala, Chiaki Yamada, Christopher Garcia, Carolina Duarte, Juliet Akkaoui, Dumitru Ciolac, Amilia Nusbaum, William Kochen, Daniela Efremova, Stanislav Groppa, Lubov Nathanson, Stephanie Bissel, Adrian Oblak, Melissa A. Kacena, Alexandru Movila

HPD Articles

Hallmark features of Alzheimer's disease (AD) include elevated accumulation of aggregated Aβ40 and Aβ42 peptides, hyperphosphorylated Tau (p-Tau), and neuroinflammation. Emerging evidence indicated that interleukin-34 (IL-34) contributes to AD and inflammatory osteolysis via the colony-stimulating factor-1 receptor (CSF-1r). In addition, CSF-1r is also activated by macrophage colony-stimulating factor-1 (M-CSF). While the role of M-CSF in bone physiology and pathology is well addressed, it remains controversial whether IL-34-mediated signaling promotes osteolysis, neurodegeneration, and neuroinflammation in relation to AD. In this study, we injected 3x-Tg mice with mouse recombinant IL-34 protein over the calvaria bone every other day for 42 days. Then, …

Group 4 Iti Consensus Report: Patient Benefits Following Implant Treatment In Partially And Fully Edentulous Patients., Martin Schimmel, Mauricio Araujo, Samir Abou-Ayash, Ramona Buser, Supriya Ebenezer, Manrique Fonseca, Lisa J. Heitz-Mayfield, Lucrezia Paterno Holtzman, Porawit Kamnoedboon, Robert Levine, Gerry Mckenna, Sabrina Maniewicz, Flavia Matarazzo, Nikos Mattheos, Panos Papaspyridakos, André Barbisan De Souza, Murali Srinivasan, Charlotte Stilwell, Hans Peter Weber

HPD Articles

OBJECTIVES: The aim of Working Group 4 was to address patient benefits associated with implant dentistry. Focused questions on (a) dental patient-reported outcomes (dPROs), (b) improvement in orofacial function, and (c) preservation of orofacial tissues in partially and fully edentulous patients following provision of implant-retained/supported dental prostheses were addressed.

MATERIALS AND METHODS: Three systematic reviews formed the basis for discussion. Participants developed statements and recommendations determined by group consensus based on the findings of the systematic reviews. These were then presented and accepted following further discussion and modifications as required by the plenary of the 7th ITI Consensus Conference, taking …

Covid-19: Variants, Immunity, And Therapeutics For Non-Hospitalized Patients., Cameron Y.S. Lee, Jon B. Suzuki

HPD Articles

The continuing transmission of coronavirus disease 2019 (COVID-19) remains a world-wide 21st-century public health emergency of concern. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused greater than 600 million cases of COVID-19 and over 6 million deaths globally. COVID-19 continues to be a highly transmissible disease despite efforts by public health officials and healthcare providers to manage and control the disease. Variants identified in selected worldwide epicenters add to the complexity of vaccine efficacy, overage, and antibody titer maintenance and bioactivity. The identification of the SARS-CoV-2 variants is described with respect to evading protective efficacy of COVID-19 vaccines and …

Cpg Odn/Mangiferin Dual Delivery Through Calcium Alginate Hydrogels Inhibits Immune-Mediated Osteoclastogenesis And Promotes Alveolar Bone Regeneration In Mice., Yingzhi Gu, Yang Hu, Shengyuan Huang, Sunniva Ruiz, Toshihisa Kawai, Yuxing Bai, Xiaozhe Han

HPD Articles

The immune system plays an important role in the skeletal system during bone repair and regeneration. The controlled release of biological factors from the immune system could facilitate and optimize the bone remodeling process through the regulation of the activities of bone cells. This study aimed to determine the effect of the controlled delivery of immunomodulatory biologicals on bone regeneration. Immunostimulatory cytosine-phosphate-guanosine oligodeoxynucleotides (CpG ODN) and glucosylxanthone Mangiferin (MAG)-embedded microbeads were incubated with P. gingivalis-challenged splenocytes, or co-cultured with RAW264.7 cells. The effect of CpG ODN/MAG-containing microbeads on bone regeneration was then tested in vivo in a mouse alveolar bone …

Repair Of An Extensive External Cervical Resorption Lesion Using Intentional Replantation With Crown Rotation., Motoki Okamoto, Yoko Asahi, Henry Fergus Duncan, Nanako Kuriki, Yusuke Takahashi, Mikako Hayashi

HPD Articles

Treatment of large external cervical resorption (ECR) lesions may be compromised, rendering the tooth unrestorable. Intentional replantation is a potential treatment option depending on the site and extent of ECR. We present a case of a large ECR successfully managed with intentional replantation with rotation of the tooth. The female patient consulted the hospital clinic, with an extensive palatal ECR on the maxillary lateral incisor. Routine planar radiographs and cone-beam computed tomography demonstrated a larger palatal than the ECR lesion (Heithersay Class III and Patel's Class 2Bp) not amenable to nonsurgical treatment. Intentional replantation after short-term extrusion was planned. The …

Association Between Symptoms Of Severe Periodontitis And Post-Bronchodilator Lung Function: Results From The China Pulmonary Health Study., Zhiqiang Liu, Xuan Zhou, Lirong Liang, Xiaozhe Han, Ting Yang, Kewu Huang, Yingxiang Lin, Zuomin Wang, Chen Wang

HPD Articles

BACKGROUND: The association between periodontitis and post-bronchodilator lung function is unclear. We aimed to determine the associations between symptoms of severe periodontitis (SSP) and post-bronchodilator lung function in the Chinese population.

METHODS: A cross-sectional study (China Pulmonary Health study) was conducted from 2012 to 2015 in a large Chinese nationally representative sample of 49,202 participants aged 20-89 years. Data on demographic characteristics and periodontal symptoms of participants were collected by questionnaire. Participants who had at least one of the two severe symptoms (tooth mobility and natural tooth loss) in the past year were defined to have SSP, which was set …

Periodontal Regeneration Risk Assessment In The Treatment Of Intrabony Defects., Robert A. Levine, Muhammad H A Saleh, Debora R. Dias, Jeffrey Ganeles, Maurício G. Araújo, Franck Renouard, Harold M. Pinsky, Preston D. Miller, Hom-Lay Wang

HPD Articles

BACKGROUND: Regenerative approaches performed in periodontics seems to be efficient in treating intrabony defects. There are, however, many factors that may affect the predictability of the regenerative procedures. The present article aimed to propose a new risk assessment tool for treating periodontal intrabony defects by regenerative therapy.

METHODS: Different variables that could affect the success of a regenerative procedure were considered based on their impact on (i) the wound healing potential, promoting wound stability, cells, and angiogenesis, or (ii) the ability to clean the root surface and maintain an optimal plaque control or (iii) aesthetics (risk for gingival recession).

RESULTS: …

Preprocedural Viral Load Effects Of Oral Antiseptics On Sars-Cov-2 In Patients With Covid-19: A Systematic Review., Miriam Ting, Alex Dahlkemper, Jeremy J. Schwartz, Manzel Woodfork, Jon B. Suzuki

HPD Articles

(1) There are limited clinical trials to support the effectiveness of mouth rinses when used as a preprocedural rinse against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This systematic review aims to evaluate the efficacy of antiseptic mouth rinses as a preprocedural rinse in reducing SARS-CoV-2 oral viral load in-vivo. (2) Methods: A literature search was conducted through November 2022 for the following databases: PubMed, Web of Science, Cochrane Library, and Google Scholar. The evaluated outcomes were quantitative changes in viral load and the statistical significance of that change after using antiseptic mouth rinses. (3) Results: 14 randomized controlled trials …

Parental Acceptance Of Silver Diamine Fluoride Treatment For Carious Lesions, Mitchell Miller, Kelly Hart, Maria A. Levi-Minzi, Jennifer Chung, Judith Chin, Oscar Padilla, Romer Ocanto

HPD Articles

Objectives The purpose of this study was to determine parental acceptability of the use of Silver Diamine Fluoride (SDF) as an alternative treatment for carious legions. In addition, we examined potential factors influencing higher levels of SDF acceptance. Methods Project was approved by the institutional review board. Parents of patients receiving care at Nova Southeastern University’s dental clinics were asked to review an educational document related to the use and side effects of SDF; surveys were then distributed to assess willingness to use this treatment for their child. SDF acceptance was measured by mean scores on the SDF Feasibility Questionnaire; …

Using Motivational Interviewing To Increase Confidence In Nutritional Counseling Among Dental Hygienists: A Pilot Study, Heather M. Anderson, Sarah Jackson, Lisa Bilich, Craig Hunt, Elizabeth Tipton

Internet Journal of Allied Health Sciences and Practice

Purpose: Dental hygienists have the unique opportunity to educate patients on connections between nutrition and oral health. Dental hygiene students are introduced to these concepts but struggle to gain confidence to share this knowledge with patients. This pilot study looked at an educational module on motivational interviewing (MI) and an assessment and counseling tool to build student confidence with nutritional counseling. Methods: Dental hygiene students participated in an educational module to review MI and introduce a nutritional risk assessment and counseling tool. Prior to the module, participants completed a pretest about confidence levels regarding MI and nutritional counseling. After three …

Assessing Faculty Preference Regarding Online Tools For Assessment In Medical Education: A Cross-Sectional Multi-Center Study, Zarreen Raza, Samira Adnan, Sanaa Ahmed, Zahid Memon, Saad Saleem, Ziyad Sanaullah

Internet Journal of Allied Health Sciences and Practice

Purpose: E-assessment is a novel practice in developing countries; hence it is essential to determine the online platforms and tools preferred by health sciences education faculty for online assessment. The purpose of this study was to assess the preference of faculty in medical and dental education regarding the online tools for e-assessment of undergraduate students. Methods: This cross-sectional, descriptive study was conducted from June until August 2020 on the faculty of medical and dental undergraduate programs of private and public sector institutes across Karachi, with a sample size of 152. Data was collected through convenience sampling using a validated questionnaire …

Impact Of Interleukin-34 On The Promotion Of Bone Osteolysis And Neuroinflammation In Experimental Models Of Alzheimer’S Disease, Anny Ho

All HCAS Student Capstones, Theses, and Dissertations

Alzheimer’s disease (AD) is a growing health concern and is the most common type of dementia worldwide. Emerging evidence indicates that aggregated amyloid-beta (Aβ) peptides, one of the hallmark features of AD neuropathology, can increase RANKL-mediated osteoclast activity leading to the prevalence and severity of inflammatory osteolysis, e.g., osteoporosis and periodontal bone loss. Conversely, osteolytic lesions are associated with increased risk of dementia diagnosis indicating that there is a direct link between dementia and inflammatory osteolysis. It was demonstrated that the neuronal cells primarily produce interleukin-34 (IL-34) and microglia, macrophages, and osteoclast precursors express colony-stimulating factor 1 receptor (CSF-1R), a …

Can Youtube Videos Be Helpful In Promoting Self-Performed Denture Hygiene?, Kubra Degirmenci, Serkan Saridag

Internet Journal of Allied Health Sciences and Practice

Purpose: The longevity and success of dentures depend on clinical factors and the appropriate application of various techniques as well as on patients’ denture hygiene. Recently, the Internet has become an attractive information source for individuals searching for answers to their questions on health-related subjects. The aim of this study was to evaluate the information provided by YouTube videos on denture hygiene and analyze their content in terms of scientific validity. Method: Various key words related to denture cleaning, hygiene, and care were used to search for videos on YouTube. Based on their scientific content, the included videos were classified …

Perceptions Of Two Older Adults Regarding The Factors And Barriers That Influence Their Oral Health Care: A Case Study, Dinorah Munira Hernández-Santos Msg., Irma Fabiola Díaz-García Phd.

The Qualitative Report

This paper presents the results of a case study about the perceptions of oral health care, factors that influenced current oral health, and barriers to dental attention of two older adults; the study was conducted by researchers from a hospital-school of dentistry at a public university in Mexico. Two adults aged 64 and 70 years participated in this study. First, the oral health status was clinically evaluated using the Decayed/Missing/Filled/Teeth (DMFT) Index. A semi-structured interview was then conducted to learn about the perceptions of oral health care. Thematic content analysis was used to explore the data obtained using the ATLAS.ti …

Assessing Participant Feedback To Dental Screenings Provided By Dental Hygiene Students And Follow-Up Dental Hygiene Care In New York City, Susan H. Davide, Margarita Rivera

Internet Journal of Allied Health Sciences and Practice

Objectives: The purpose of this study was to validate the association between dental screenings and follow-up care to support the level of awareness of dental hygiene services available in the community by increasing access to care and determine patients’ knowledge of dental insurance status. Methods: A first-time dental screening was conducted, and complimentary care was provided for those who followed through with dental hygiene care at the clinic. Survey questionnaires were administered to participants following screening and clinic care. Results: Ten participants of the 50 screened received care at the clinic. Less than half of those screened (41 %) had …

Are Youtube Videos In Turkish Useful As An Information Source For Dental Treatment During The Covid-19 Pandemic?, Gözde Işık, Meltem Özden Yüce

Internet Journal of Allied Health Sciences and Practice

Purpose: Since the start of the coronavirus disease-19 (COVID-19) pandemic, patients with dental conditions find it difficult to consult their physicians and to preserve the continuity of dental treatment. All routine appointments were suspended and postponed indefinitely so that infection control procedures could be administered. This study aimed to assess the value of Turkish videos for patients seeking information on dental treatments during the COVID-19 outbreak. Methods: Videos on YouTube were screened using the following keywords: ‘Coronavirus, diş tedavileri’, ‘COVID-19, diş tedavileri’ and ‘SARS-Cov-2, diş tedavileri’. The search results were limited to the first 100 videos. Videos were analysed independently …

Transitioning From Individualized Pediatric Dental Care Of Children With Autism Spectrum Disorder At The Mailman Segal Dental Clinic To Traditional Dental Settings, Toni-Marie Small

Student Theses, Dissertations and Capstones

Background: Children with special healthcare needs (SHCN) such as Autism Spectrum Disorder (ASD) usually develop strong bonds with their pediatric dental care provider. However, as they mature, transitioning to other services or providers is necessary. Low rates of successful transition of children with SHCN have gained national attention especially since their lifelong conditions require continuous care. It is important to facilitate a smooth transition among providers; dental care providers specifically. These transitions are imperative to prevent these children from losing access to dental care as they mature. This pilot study seeks to describe the proportion of children with ASD seen …

Reliability Of Methods To Evaluate Sensitivity Caused By In-Office Bleaching Procedures, Ahmed Abuzinadah

Student Theses, Dissertations and Capstones

Objective: To evaluate and compare the reliability of different methods to measure sensitivity caused by in-office bleaching procedures.

Methodology: A convenience sample of 34 patients from the dental clinics at Nova Southeastern University participated in the study upon IRB approval, signing consent forms and complying the inclusion/exclusion criteria. All procedures were provided by the same operator (Dr. Abuzinadah) according to the manufacturer’s instructions using Opalescence® Boost® PF 40% (Ultradent, South Jordan, UT). No additional treatments were provided for desensitization. A visual analogue scale (VAS) was used to assess the level of sensitivity during the procedure, 1-hour, 24-hours, 48-hours, 1-week and …

Dental Visual Support Schedule App For Behavior Management Of Pediatric Dental Patients With Autism: Pilot Study, Ana Lina Gonzalez Caceres

Student Theses, Dissertations and Capstones

Background: Autism Spectrum Disorder (ASD) is a prevalent neurodevelopmental disorder in the U.S (about 1 in 54 children). Treating children with ASD in the dental office can be challenging due to their impairments in social interactions, communication and aversive behavior. Visual Support Schedules are visual aids or picture cues that have been beneficial for the behavior management of patients with ASD. There are limited studies regarding effective behavior management techniques that could help those patients have a better experience at the dentist. Methods: A Visual Support Schedule App was used for behavior management compared to Tell Show DO (TSD) on …

Oral Probiotic Supplementation As An Adjunct To Non-Surgical Therapy In Peri-Implantitis Lesions: A Pilot Study, Po-Ning Polly Huang

Student Theses, Dissertations and Capstones

Introduction: During the last decade, the results of several clinical studies suggested that oral probiotics may potentially improve oral health. The first study examining the effects of probiotics on oral health demonstrated that almost every patient with gingivitis, periodontitis or pregnancy gingivitis, had significant improvements in measurable periodontal indices when they were treated with a locally administered culture supernatant of a Lactobacillus acidophilus strain. This finding sparked several other studies to further examine the potential for treating oral diseases, such as, combating halitosis, oral candidiasis, and dental caries with probiotics. Of our interest, Fernandez et al. and Hollstrom et al. …

Dentists’ Communication Skills As Determinants Of Patient Initiation Of Treatment, Nojoud Omar A Balubaid

Student Theses, Dissertations and Capstones

In the medical field literature, studies allude to the importance of interpersonal relationships between the caregiver and the patient. Communication has been highlighted as a key factor that mediates the doctor to patient relationship. This study investigated the relationship between patient initiation of treatment with the patients’ perceptions of the quality of the dentist-patient communication. A cross-sectional study that solicited from patients seeking services at Nova Southeastern University Post-Graduate Dental Programs responses to a questionnaire that measured patient’s perception of the quality of communication of the attending dentist. The participants of the study were patients of the NSU Post-graduate dental …

Heat Generation Of Bulk-Fill Composites Polymerized By Multipeak Versus Single Peak Light Curing Units, Fahad Baabdullah

Student Theses, Dissertations and Capstones

Background: Multipeak light-curing units (LCUs) are gaining popularity due to potential need to activate different photoinitiators. One of the risks associated with using LCUs is heat generation which can reach the pulp chamber through restorative materials and may cause an adverse pulp reaction. However, there is a limited data on heat generation potential of multipeak as compared to single peak LCUs.

Objective: Evaluate the difference in heat generation, and transmission from single peak versusmultipeak LED-LCUs through dentin and different bulk-fill resin-based composites (BFRCs) at pulpal wall (PW).

Materials and Methods: A single extracted sound human molar was used for standardized …

Effect Of Silver Diamine Fluoride On Candida Albicans Associated With Early Childhood Caries, Sarah Al Kukash

Student Theses, Dissertations and Capstones

BACKGROUND: Early childhood caries (ECC) is one of the most prevalent infectious diseases in childhood worldwide. It afflicts 23% of the preschoolers in the U.S. It most frequently targets children from poor socioeconomic families and racial/ethnic minority backgrounds and becomes a serious public health problem. The major pathogen of ECC is Streptococcus mutans (S. mutans). However, the occurrence of ECC is positively associated with the presence of Candida albicans (C. albicans). It is well established that Silver Diamine Fluoride (SDF), a recent Food and Drug Administration (FDA)-off labeled approved agent for arresting dental caries, exhibits a robust antibacterial effect on …

The Effect Of Dental Probiotic Use On The Inhibition Of Streptococcus Mutans: A Clinical Study, Halah Thanoon

Student Theses, Dissertations and Capstones

Brief Background: Streptococcus mutans (S.mutans) is the pioneering pathogenic bacteria responsible for the initiation of dental caries. Controlling S.mutans activity using dental probiotics may have an impact on caries incidence and oral health in general. Objective: To evaluate the effects of commercially available dental probiotics (PRO-Dental, Hyperbiotics Inc.) usage for 60 days in a row on the cariogenic bacterium S.mutans in high caries risk patients with high or low S.mutans counts at baseline and 30 days after the discontinuation of use. Methodology: A total of 30 consenting adult patients with high caries risk (according to NSU CAMBRA protocol) without any …

Global Interest For Health Professions Education: A Geographic And Temporal Analyses Through Web Search Differences From 2010-2019, Junhel Dalanon, Yoshizo Matsuka

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this study was to analyze the spatio-temporal differences in web search trends for dental degrees (DD), medical degrees (MD), and nursing degrees (ND) across 197 countries from 2010 to 2019. Method: A search string was used to initiate a search query using Google Trends. The parameters used were DD, MD, and ND as search terms; worldwide as Location; 2010 to 2019 as time range; health education & medical training as category; and web search as database. Data were downloaded and analyzed. Results: Via one-way ANOVA and post hoc Dunnett test, the searches for DD were found …

Lasting Impressions College Of Dental Medicine, Nova Southeastern University

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No abstract provided.

Lasting Impressions College Of Dental Medicine, Nova Southeastern University

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No abstract provided.

Physical And Optical Properties Of Provisional Crown And Bridge Materials Fabricated Using Cad/Cam Milling Or 3d Printing Technology, Niranjan Joshi

Student Theses, Dissertations and Capstones

Objective: This study compared the physical and optical properties of provisional crown and bridge materials fabricated using CAD/CAM or 3D printing technology. Aim: To compare the biaxial flexural strength, microhardness, translucency parameter and gloss of provisional resin discs fabricated by milling PMMA blocks, versus two different resins printed using 3D printers. Hypothesis: There is no difference in the flexural strength, hardness, translucency and gloss of provisional resins fabricated by different digital technologies. Materials and methods: 90-disc shaped specimens for provisional resins were fabricated using a common digital file. These samples were equally distributed in three groups of 30 each. Group …

Possible Pathologic Effect Of Hmgb1 On P. Gingivalis Induced Inflammatory Response By Macrophages, Michelle Marie Torres Santos

Student Theses, Dissertations and Capstones

BACKGROUND: Periodontitis is an inflammatory disease caused by poly-microbial infection that leads to destruction of connective tissue and alveolar bone. It is well documented that bacteria-derived virulent factors that can act on Toll-like receptors (TLRs), represented by Lipopolysaccharides (LPS), are engaged in the initiation of inflammatory responses. However, while LPS is also produced by the bacteria colonized in the healthy periodontal tissue, inflammation is not induced by LPS in those periodontal healthy subjects, suggesting the requirement of additional factor to upregulate the LPS-mediated inflammatory response in periodontal tissue. Recent studies revealed that novel class of endogenous proinflammatory mediator, high mobility …

Influence Of Abutment Macro-Design On Peri-Implant Tissue Dimensions For Guided Placed And Restored Implants, Bashar Adeinat

Student Theses, Dissertations and Capstones

Introduction: For optimal dental implant esthetics the transition of a circumferential implant platform to a proper cervical anatomy has been emphasized. This transition is facilitated by the macro-design of the transmucosal portion of the abutment-restoration complex at the provisional and final stages of implant prosthetic therapy. There is limited information from human studies assessing the impact of abutment macro-design on periimplant tissue dimensional changes. Therefore, the aim of this study was to evaluate prospectively the effect of abutment macro-design on peri-implant tissue dimensional changes. Methods: This is an ongoing randomized control clinical trial in which twentyeight (28) patients with a …