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Full-Text Articles in Dentistry

Mathematical Modeling For Dental Decay Prevention In Children And Adolescents, Mahdiyeh Soltaninejad Apr 2024

Mathematical Modeling For Dental Decay Prevention In Children And Adolescents, Mahdiyeh Soltaninejad

Dissertations

The high prevalence of dental caries among children and adolescents, especially those from lower socio-economic backgrounds, is a significant nationwide health concern. Early prevention, such as dental sealants and fluoride varnish (FV), is essential, but access to this care remains limited and disparate. In this research, a national dataset is utilized to assess sealants' reach and effectiveness in preventing tooth decay, particularly focusing on 2nd molars that emerge during early adolescence, a current gap in the knowledge base. FV is recommended to be delivered during medical well-child visits to children who are not seeing a dentist. Challenges and facilitators in …


Genetic Analysis Of Hereditary Gingival Fibromatosis Associated Sos1 Missense Variants Of Uncertain Significance In Caenorhabditis Elegans, Himani Patel Apr 2024

Genetic Analysis Of Hereditary Gingival Fibromatosis Associated Sos1 Missense Variants Of Uncertain Significance In Caenorhabditis Elegans, Himani Patel

Theses

Hereditary gingival fibromatosis (HGF) is a disease that can present as benign overgrowth of gingival tissue in the mouth. The overgrowth can enclose the entire mouth and teeth in severe cases or present itself in a concentrated area. Researchers have identified that mutations in the SOS1 gene can be responsible for HGF. This disease can impair basic functions related to the mouth. Eating, smiling, speaking can all be affected. Additionally, excess inflammation can cause periodontal disease because of the difficulty in maintaining proper oral health. Periodontal disease can lead to severe bone loss which can lead to complete loss of …


The Effect Of Dental Insurance Coverage And Economic Fluctuations On Oral Health Outcomes In The United States, Laura Singletary Apr 2024

The Effect Of Dental Insurance Coverage And Economic Fluctuations On Oral Health Outcomes In The United States, Laura Singletary

Senior Theses

Proper oral health is imperative to overall health, but obstacles often persist in

receiving proper oral health care. Lack of dental insurance coverage and economic recessions are two main factors contributing to oral health outcomes. Extended time without cleanings or addressing current oral health concerns exacerbates oral health problems into more costly procedures for the patient that are conveniently not covered by many insurance plans. This thesis investigates the oral health outcomes associated with periods following economic downturns, specifically citing the time of the Great Recession from 2007-2009.


Improving Dental Students' Knowledge And Confidence In Treating Tobacco Use, Victoria Pierce Jan 2024

Improving Dental Students' Knowledge And Confidence In Treating Tobacco Use, Victoria Pierce

DNP Projects

Background: Tobacco use can lead to numerous chronic health conditions. Healthcare professionals in the dental field are in a unique position to broach this issue with patients. Research shows that dental students do not feel equipped to provide tobacco cessation care, citing lack of education on the subject among their top reasons for this.

Purpose: The purpose of this project was to evaluate changes in dental students’ knowledge and confidence related to treating tobacco use after participation in an educational intervention about the 5A’s, behavioral counseling, and first-line prescription medications.

Methods: This quality improvement initiative utilized a quasi-experimental survey design …


Functional Analysis Of Mandibular Movements In Three Different Groups Including Patients With Total Joint Replacements, Previous Orthognathic Surgery, And A Control Group, Adriana Morales Buendia Jan 2024

Functional Analysis Of Mandibular Movements In Three Different Groups Including Patients With Total Joint Replacements, Previous Orthognathic Surgery, And A Control Group, Adriana Morales Buendia

All ETDs from UAB

Purpose: To Assess mandibular movements, including mouth opening, lateral excursion, and protrusion among patients with total joint replacements and orthognathic surgery compared to healthy control participants with no known TMJ disorders. Methods: Fifty-two subjects from 18 to 66 years of age were included in this cross-sectional study, distributed in three groups: patients with total joint replacement (n = 16), patients who underwent orthognathic surgery (n=17), and healthy control subjects (n = 19) to quantitatively determine whether there is statistically significant difference among the groups regarding opening, lateral excursion, and protrusion movements. The non-invasive system SiCAT JMT+ device was used to …


Oral Health Inequalities In Adolescents And Young Adults In Ontario, Maria Rahman Dec 2023

Oral Health Inequalities In Adolescents And Young Adults In Ontario, Maria Rahman

Electronic Thesis and Dissertation Repository

Oral health is consistently linked to physiological, psychological, and social aspects of well-being in adolescents and young adults. In this thesis, I aimed to examine the social determinants of oral health and dental care utilization. First, I conducted a scoping review of the literature, demonstrated the multifaceted nature of oral health and its connections to broader social and economic factors. Then, I conducted a cross-sectional analysis of the Canadian Community Health Survey which showed a social gradient in oral health and dental care utilization among adolescents and young adults in Ontario. When stratified by age, there was a protective association …


E-Cigarettes: What Is The Relationship Between E-Cigarette Usage And Periodontal Disease?, Deborah Rose Dec 2023

E-Cigarettes: What Is The Relationship Between E-Cigarette Usage And Periodontal Disease?, Deborah Rose

Electronic Theses and Dissertations

The dental community has a broad understanding of how traditional combustible cigarettes affect the oral cavity of the dental patient but there is little research available on the effects that e-cigarettes have on the patient’s dental health. Vaping products have been marketed as a healthier option over traditional combustible cigarettes. Since they were first introduced in 2003, very little research has been performed to understand their dental implications. This project was executed to investigate the chemicals associated with these vaping products and how they possibly contribute to the progression of periodontal disease. This research project was conducted with the contribution …


Strategies To Encourage Recall And Prevent Relapse After Full Mouth Rehabilitation Under General Anesthesia In Children, Claire Koukol Dec 2023

Strategies To Encourage Recall And Prevent Relapse After Full Mouth Rehabilitation Under General Anesthesia In Children, Claire Koukol

Capstone Experience

Background: Dental caries are preventable. Dentists utilize many prevention strategies in the office and provide at-home education to families. However, once a child develops Early Childhood Caries (ECC), especially in more severe cases, they may need general anesthesia (GA) to complete treatment. While this is an effective way to achieve full mouth dental rehabilitation (FMDR), this burdens the healthcare systems and families and does not come without risk to the patient. Patients with high caries experience remain at high risk of caries relapse after FMDR under GA, sometimes necessitating additional FMDR under GA. While there has been a significant amount …


Genetically Engineering Gingipains For High Yield Large Scale Purification., Andrew E. Fuchs Dec 2023

Genetically Engineering Gingipains For High Yield Large Scale Purification., Andrew E. Fuchs

Electronic Theses and Dissertations

Porphyromonas gingivalis is a keystone oral pathogen in the progression of periodontal disease and has been implicated in the etiology of many other systemic human diseases. P. gingivalis produces primary virulence factors termed the gingipains, a group of cysteine proteases. There is a high demand for high purity gingipains for downstream in vitro studies where P.g. is implicated, both oral and systemic. Gingipain production candidate mutant P.g. strains were generated to isolate each gingipain for large scale purification and the purified gingipains characterized. Two mutants were determined not to be viable for large scale purification of gingipains, each for different …


Cheiloscopy Examination And Classification Of Lip Prints With And Without Parafunctional Oral Habits: A Cross-Sectional Observation Study, Emily Smith Regan Oct 2023

Cheiloscopy Examination And Classification Of Lip Prints With And Without Parafunctional Oral Habits: A Cross-Sectional Observation Study, Emily Smith Regan

Dental Hygiene Theses & Dissertations

Problem: Lip prints are unique and have potential for use as a human identifier. The purpose of this study was to observe possible cheiloscopy differences of individuals with and without parafunctional oral habits. Additionally, inter-rater reliability (IRR) of lip print examiners was observed. Methods: This IRB approved blinded cross-sectional observational study collected lip prints from sixty-six individuals using lipstick and adhesive tape to transfer lip prints to white bond paper for viewing purposes. Each set of included lip prints was divided into quadrants and dichotomized as those with or without an oral parafunctional habit. Each quadrant sample was manually analyzed …


The Prevalence Of Burnout In Saudi Arabia Dental Hygienists, Nouf Hamad Aldayel Oct 2023

The Prevalence Of Burnout In Saudi Arabia Dental Hygienists, Nouf Hamad Aldayel

Dental Hygiene Theses & Dissertations

Purpose: The purpose of this pilot study was to assess the prevalence of burnout in Saudi Arabian dental hygienists and identify risk factors associated with burnout. Methods: A descriptive survey design using the Copenhagen Burnout Inventory (CBI) assessed burnout among a convenience sample of n=123 Saudi dental hygienists. The survey was disseminated electronically to 1,000 Saudi Arabian dental hygienists. The CBI measures three subscales: personal, work-related, and client/patient-related burnout on a five-point Likert-type scale. The survey also included six demographic questions, two Likert-type, one “yes/no,” and one openended question, related to burnout. Descriptive statistics, one-way between subject’s ANOVA, independent samples …


Dental Hygiene Students Reported Physiological Symptoms Associated With Wearing An N95 Respirator Mask, Peyton Shea Butler Oct 2023

Dental Hygiene Students Reported Physiological Symptoms Associated With Wearing An N95 Respirator Mask, Peyton Shea Butler

Dental Hygiene Theses & Dissertations

Purpose: Physiological symptoms and comfort levels while wearing an N95 respiratory mask has not been examined with dental hygienists. The purpose of this study was to investigate dental hygiene students reported physiological symptoms and comfort perception while wearing an N95 respirator mask during patient care appointments. Methods: After IRB approval (IRB #1987754-2), a 16-item questionnaire was distributed through email to a convenience sample of 65 dental hygiene students. Questions assessed respiratory, dermatologic, cardiac, mask mouth and general physiological symptoms, as well as comfort levels. Additionally, participants were asked to respond to demographic questions and one open ended question inquiring about …


Exploring The Lived Experiences Of Dental Hygiene Faculty Using Simulation With Dental Manikin Head Devices To Teach Local Anesthesia, Allison Castro Sep 2023

Exploring The Lived Experiences Of Dental Hygiene Faculty Using Simulation With Dental Manikin Head Devices To Teach Local Anesthesia, Allison Castro

Doctor of Education Program Dissertations

This study employed a qualitative phenomenological methodology to explore the lived experiences of dental hygiene faculty using simulation with dental manikin head devices to teach local anesthesia. This study aimed to address the gap in the literature given the lack of discussion regarding dental manikin head simulation use in teaching local anesthesia within dental hygiene education. The purpose extended to explore if educators could guide students and ease anxieties by incorporating simulation in the development of treatment skills on a manikin before applying these skills to real-life interactions. John Dewey’s (1938) concept of interconnectedness between education and experience and David …


The Impact Of Access To Oral Health Care On Inadequate Oral Health And Multimorbidity, Luis Limo Aug 2023

The Impact Of Access To Oral Health Care On Inadequate Oral Health And Multimorbidity, Luis Limo

Electronic Thesis and Dissertation Repository

The connection between oral health and other non-communicable chronic conditions—commonly referred in the dental literature as the oral-systemic health connection—emphasizes the role of oral health care on both oral diseases and chronic conditions, particularly in vulnerable populations like the elderly. This thesis comprises 2 studies: the first is a systematic review on the impact of oral health care interventions, as an indicator of access to oral health care, on chronic conditions of which their co-existence would result in multimorbidity; the second study is a cross-sectional investigation of the associations between oral health, access to oral health care, and multimorbidity among …


Association Of Inflammatory Markers And Growth Factors With Radiographically Assessed Wound Healing Of Extraction Sockets, Sasha Mohammadi Aug 2023

Association Of Inflammatory Markers And Growth Factors With Radiographically Assessed Wound Healing Of Extraction Sockets, Sasha Mohammadi

Theses & Dissertations

The purpose of this prospective cohort pilot study was to investigate the association of the periodontal status and inflammatory markers from the gingival crevicular and wound fluid with the healing outcomes following tooth extraction. The central research hypothesis is that extraction sites and the adjacent teeth that exhibit increased markers of inflammation, or decreased growth factors, at baseline or 2 weeks will be associated with reduced healing outcomes observed radiographically 3 months following surgery. Nine patients at the UNMC College of Dentistry who were seeking care to extract a posterior tooth due to advanced periodontal bone loss, non-restorable caries or …


Analysis Of Interprofessional Education Inclusion Within U.S. Dental Hygiene Programs’ Curricula, Jennifer M. Pacheco Aug 2023

Analysis Of Interprofessional Education Inclusion Within U.S. Dental Hygiene Programs’ Curricula, Jennifer M. Pacheco

Dental Hygiene ETDs

The purpose of this study was to collect information on the implementation of IPE activities within U.S. dental hygiene programs and whether program faculty are implementing these components into their program curricula. Furthermore, the study would identify which types of IPE activities were being conducted and if these activities met the CODA standards. An original survey was sent out to dental hygiene program directors and faculty. Results revealed both programs agreed that IPE is a significant component to include in hygiene curricula to better equip students as members of the healthcare team to deliver comprehensive care. IPE activities implemented were …


Immigrational Trauma: An Assessment Of Dental Phobia And Access To Care In Undocumented Individuals, Nora J. Vences Ortiz Aug 2023

Immigrational Trauma: An Assessment Of Dental Phobia And Access To Care In Undocumented Individuals, Nora J. Vences Ortiz

Dental Hygiene ETDs

The purpose of this study is to assess immigrational trauma as it relates to dental phobia in accessing care from undocumented individuals. Immigrating from a country to the United States presents with unique challenges. These challenges include language barriers, traumatic experiences and cultural factors. These individuals also have perceived notions regarding their treatment with a physician or dentist as their immigration status may or may not be revealed during their care. If reported, they face deportation to their country of origin placing them in the danger they originally fled from. Survey data was collected using REDCap and distributed to students …


Examining The Effects Of Iron-Oxide Nanoparticles On Primary Gingival Keratinocytes For The Prevention Of Oral Disease, Jennifer C. Carranza Aug 2023

Examining The Effects Of Iron-Oxide Nanoparticles On Primary Gingival Keratinocytes For The Prevention Of Oral Disease, Jennifer C. Carranza

Dental Hygiene ETDs

Oral plaque biofilm has been identified as the primary contributor to dental conditions such as dental caries and periodontal disease that promotes a diverse and pervasive collection of microbial species to inhabit the oral cavity. Disrupting the plaque matrix early could help combat this global disease burden. This study evaluated the effect of IONPs on primary gingival keratinocytes.

Purpose: This study aimed to examine existing research regarding nanoparticles and determine if IONPs affect the PGK cell membranes with preliminary research to find the maximum lysis possible with PGK cells.

Methods: IONP core/shell syntheses were performed. Considering keratinocyte characteristics, examining data …


Exploring The Experiences Of Underrepresented Students Pursuing Health-Related Graduate Or Professional Programs, Alison Williams Aug 2023

Exploring The Experiences Of Underrepresented Students Pursuing Health-Related Graduate Or Professional Programs, Alison Williams

Electronic Theses and Dissertations

For many years graduate and professional education programs for the health professions have sought to increase the diversity of their student body to include students from a wider variety of backgrounds. Increasing the diversity of healthcare providers is an essential component of addressing inequities in healthcare. However, despite initiatives to increase racial and ethnic diversity in the health professions, these professions remain largely White and female. Previous researchers have sought to identify the reasons that racial and ethnic minorities are underrepresented in healthcare, and the barriers to persistence and success. Little research exists explaining why men are underrepresented in the …


Enhancing Adherence To Best Practice Guidelines Related To Pressure Injury Prevention In The Operating Room At A Children's Hospital During Comprehensive Dental Procedures., Alyce Bailey Seaver Aug 2023

Enhancing Adherence To Best Practice Guidelines Related To Pressure Injury Prevention In The Operating Room At A Children's Hospital During Comprehensive Dental Procedures., Alyce Bailey Seaver

Doctor of Nursing Practice Papers

Background: 1,600,000 patients develop a hospital-acquired pressure injury every year, and 23% of these originate during surgery. Research has demonstrated that the incidence of hospital-acquired pressure injuries developing during surgery has risen over the past 5 years. This rise has been attributed to nurse circulators exhibiting poor knowledge regarding best practices for intraoperative patient positioning and intraoperative documentation that does not follow standards of care.

Purpose: This quality improvement project aimed to enhance circulator knowledge on best practices for intraoperative patient positioning and improve documentation of intraoperative patient positioning in the electronic medical record to comply with standards of …


Dental Care Utilization Among U.S. Children Participating In Early Head Start Programs, Ahlam Ibraheem Joufi Aug 2023

Dental Care Utilization Among U.S. Children Participating In Early Head Start Programs, Ahlam Ibraheem Joufi

Health Services Research Dissertations

Early childhood caries (ECC) remains one of the most common preventable diseases among children under the age of 6 years. Several national stakeholders recommend establishing a continuous collaboration of individuals involved with receiving oral health services (dental home) and routine dental care for the child by 12 months. Despite this recommendation, disparities exist among young, low-income children in preventive dental service utilization. The Early Head Start (EHS) program serves low-income children aged 0-3 years and their families and promotes oral health practices and service utilization within the program. This study aims to examine predictors of dental care utilization among children …


Alveolar Bone Remodeling In Response To Orthodontic Tooth Movement, Matthew Raymond Mcgrady Jul 2023

Alveolar Bone Remodeling In Response To Orthodontic Tooth Movement, Matthew Raymond Mcgrady

Master's Theses (2009 -)

Objective: Dental protrusion and retrusion are common malocclusions in clinical orthodontics. When teeth are moved orthodontically, the alveolar bone surrounding the teeth remodels. In the past, incisor retraction-associated alveolar bone remodeling has been studied. However, less is known about the alveolar bone remodeling after incisors are proclined. This study aimed to assess the changes in alveolar bone thickness after proclination of maxillary incisors. The null hypothesis was that there is no difference in the surrounding alveolar bone thickness after orthodontic tooth movement. Materials and Methods: Patients were selected under the inclusion criteria of moderate-to-severe bimaxillary dental retrusion (U1-SN < 97°, L1-MP < 88.0°), absence of craniofacial anomalies, non-extraction, absence of missing teeth, with quality pre-and post-treatment lateral cephalometric images. Nineteen patients (10 males, 9 females; mean age 14.7 years) were selected, and their pre-treatment and post-treatment lateral cephalograms were digitally traced using a customized cephalometric analysis to compare changes in labial and lingual alveolar bone thickness (ABT) after orthodontic treatment. A two-sample t-test with R statistical software version 4.1.2 was used to measure the differences between the pre- and post-treatment cephalometric measurements. A p value less than 0.05 was considered statistically significant. Results: According to the SN-7° measurement method, ABT increased at the labial(b) SN-7 (0.27mm ± 0.70; p<0.05) and U1 labial(c) SN-7 (0.79mm ± 1.56; p<0.05) levels; however, ABT decreased at the U1 lingual (c) SN-7 (1.13mm ± 1.35; p<0.05) level. According to the perpendicular of the long axis of U1 root measurement method, ABT increased at the U1 labial(c) ⊥U1 (0.55mm ± 1.35; p<0.05) level while ABT decreased at the U1 lingual (b) ⊥U1 (0.79mm ± 1.03; p<0.05) and U1 lingual (c) ⊥U1 (1.61mm ±1.39; p<0.05) levels. Statistically significant changes were also found in post-treatment incisor angulation U1-SN° (8.05° ± 8.25; p<0.05), U1 – NA° (7.44° ± 8.08; p < 0.05) and post-treatment incisor position U1 – NA (mm) (1.64mm ± 2.63; p<0.05). Conclusion:The null hypothesis was rejected based on our results. There are statistically significant changes to the labial and lingual alveolar bone (ABT) after proclination of the maxillary incisors. Our data support previous findings in orthodontics literature. Further studies should be conducted that can employ larger sample sizes with imaging methods that overcome the limitations of conventional two-dimensional imaging.


Maxillary And Mandibular Incisor And Molar Dentoalveolar Heights In Untreated Subjects Presenting Class I And Class Ii Malocclusion, Samantha Zavada Cardinal Jul 2023

Maxillary And Mandibular Incisor And Molar Dentoalveolar Heights In Untreated Subjects Presenting Class I And Class Ii Malocclusion, Samantha Zavada Cardinal

Master's Theses (2009 -)

Objective : Class II malocclusion has been extensively studied, however there are many unanswered questions. This study analyzed the difference in incisor and molar dentoalveolar heights of untreated subjects presenting with Class I and Class II malocclusion. Dentialveolar heights are an aspect of the craniofacial complex that changes with growth and development and are manipulated by orthodontists. These changes hold important clinical implications for the development, maintenance and treatment of malocclusions. Methods : A sample of 96 untreated Class I and Class II subjects, with a total of 611 cephalograms was drawn from the archives of the University of Michigan …


Model Minority Myth And Oral Health Disparities In Asian Americans Of Multnomah County In Oregon, Taylor Kang Jun 2023

Model Minority Myth And Oral Health Disparities In Asian Americans Of Multnomah County In Oregon, Taylor Kang

University Honors Theses

This thesis explores the concept of the Model Minority Myth (MMM) and its impact on minority groups such as Asian American communities. It discusses how the MMM is one of the many reasons why health disparities such as oral health disparities, may exist for these groups, particularly in the context of White-majority places like the city of Portland and Multnomah County in Oregon. These disparities, as a result, prevent communities from achieving racial equity in areas such as employment, education, occupation, and income, to name a few. At first glance, the MMM seems to shed an optimistic light with its …


Oral Health Literacy: A Tool To Reduce Oral Health Disparities Among Californians, Rubina Bukhari May 2023

Oral Health Literacy: A Tool To Reduce Oral Health Disparities Among Californians, Rubina Bukhari

Master's Projects and Capstones

Oral health is the health of the mouth, cheeks, teeth, and their supporting structure within the oral cavity. It helps in performing day-to-day routine functions such as swallowing, tasting, chewing, talking, and making a wide array of complex facial expressions. Apart from performing everyday functions, oral health is a crucial contributor to the overall state of well-being and good quality of life. It is measured by oral conditions such as tooth decay, gum disease (Periodontal), and oral cancers. Tooth decay and cavity formations are the most prevalent oral health conditions which affect people of all age groups. However, children are …


Women In Dentistry At The University Of Mississippi: Increasing The Confidence And Skills Of Future Women Dentists, Lakin Cramer May 2023

Women In Dentistry At The University Of Mississippi: Increasing The Confidence And Skills Of Future Women Dentists, Lakin Cramer

Honors Theses

Women in Dentistry became a registered student organization in February 2022. The purpose of the organization is to encourage and promote the professional and personal success of women in dentistry on the University of Mississippi Oxford campus. The historical and current literature of Women in Dentistry serve to provide a framework for the importance of uplifting women as they prepare for a career in dentistry. During my time as Founder and President of Women in Dentistry, my goal was to establish the organization, provide mentorship to prospective female dental school applicants, and increase the confidence and skills of future women …


Aging An Ancient Maya Population From Actuncan, Belize Using Dental X-Rays, Kaitlyn Nicole Cash May 2023

Aging An Ancient Maya Population From Actuncan, Belize Using Dental X-Rays, Kaitlyn Nicole Cash

Honors Theses

My goal is to determine an accurate age at death estimation of an ancient Maya population from the archaeological site of Actuncan, Belize. This was done by measuring the lengths of the coronal pulp cavities in the individuals’ teeth. I used X-Ray images to measure the coronal pulp cavities of the teeth and estimated age using multiple regression formulae for premolars, molars, and incisors to make age estimations. The formulae came from two studies, Ikeda et al. (1985) and Drusini (2008), that form the basis of my research. Ikeda et al. (1985) was the first to use this aging method, …


Impact Of Financial And Demographic Factors On Severity Of Treatment Procedure, Vanessa Gunderson May 2023

Impact Of Financial And Demographic Factors On Severity Of Treatment Procedure, Vanessa Gunderson

Theses/Capstones/Creative Projects

Indirect pulp caps (IPCs) and pulpotomies are forms of vital pulp therapy. These procedures are performed on young patients who have deep cavities due to bacterial biofilm damage; however, the two are performed and utilized differently. The less severe of the two procedures is an IPC. This is when decayed dentin is covered with biocompatible material to avoid pulp exposure. The more severe procedure, the pulpotomy, is when the inflamed coronal pulp tissue is removed either partially or fully to save any remaining pulp tissue. In this study, all IPCs and pulpotomies performed by Dr. Ben Reimer throughout ~4.5-years of …


The Emerging Oral Pathogen, Filifactor Alocis, Modulates Antimicrobial Responses In Primed Human Neutrophils., Ian J. Snider May 2023

The Emerging Oral Pathogen, Filifactor Alocis, Modulates Antimicrobial Responses In Primed Human Neutrophils., Ian J. Snider

College of Arts & Sciences Senior Honors Theses

Periodontitis is an irreversible, chronic inflammatory, infectious disease of the oral cavity that affects approximately half of all adults 30 years or older in the USA. The oral cavity is under high immune surveillance because of its constant exposure to microbes in the environment. The primary immune cell responsible for this surveillance is the neutrophil. Pathogens associated with periodontitis possess virulence factors and have evolved strategies to evade neutrophil antimicrobial responses to survive. One such pathogen is Filifactor alocis, whose presence is associated with the progression of periodontitis. F. alocis manipulates several neutrophil antimicrobial functional responses to avoid killing, an …


Chemotherapeutic Drug Resistance Associated With Differential Mirna Expression Of Mir-375 And Mir-27 Among Oral Cancer Cell Lines, Kieran Huni May 2023

Chemotherapeutic Drug Resistance Associated With Differential Mirna Expression Of Mir-375 And Mir-27 Among Oral Cancer Cell Lines, Kieran Huni

UNLV Theses, Dissertations, Professional Papers, and Capstones

Objective: Although progress has been made towards the identification of molecular profiles that influence oral cancer growth and metastasis, recent advances have suggested that non-coding microRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of chemotherapeutic responsiveness. Based upon the paucity of information regarding this phenomenon, this project will determine whether these specific microRNAs are correlated with oral cancer responsiveness to chemotherapies, including Paclitaxel, Cisplatin and Fluorouracil (5FU).Methods: Commercially available and well-characterized oral squamous cell carcinoma cell lines (SCC4, SCC9, SCC15, SCC25 and CAL27) were used for this study. Experimental 96-well assays …