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Full-Text Articles in Dentistry

Evaluation Of A No-Code Ai Model For Detecting Periapical Radiolucencies: Impact Of Anatomical Region On Diagnostic Performance, Manal Hamdan, Kevin W. Yu, Marguerite Miller, Stephanie J. Sidow, Zaid Badr, Sergio E. Uribe Dec 2026

Evaluation Of A No-Code Ai Model For Detecting Periapical Radiolucencies: Impact Of Anatomical Region On Diagnostic Performance, Manal Hamdan, Kevin W. Yu, Marguerite Miller, Stephanie J. Sidow, Zaid Badr, Sergio E. Uribe

School of Dentistry Faculty Research and Publications

Background

To develop a no-code artificial intelligence (AI) model for the detection of apical radiolucent lesions and to assess how lesion location influences the model’s diagnostic performance.

Methods

312 periapical radiographs were retrospectively collected, each accompanied by a corresponding cone-beam computed tomography (CBCT) scan obtained within six months and a radiology report authored by board-certified oral and maxillofacial radiologists. These reports served as the reference standard, and all findings were cross-verified by the primary investigator through CBCT review. The dataset included 181 images with at least one apical radiolucent lesion and 131 lesion-free controls. Using the no-code AI platform LandingLens …


Long-Term Effect Of Ammonia- And Water-Based Silver Fluoride On Dentin Collagen Matrix, Merve Uctasli, Roda Seseogullari-Dirihan, Thiago Henrique Scarabello Stape, Mustafa Murat Mutluay, Arzu Tezvergil-Mutluay Apr 2026

Long-Term Effect Of Ammonia- And Water-Based Silver Fluoride On Dentin Collagen Matrix, Merve Uctasli, Roda Seseogullari-Dirihan, Thiago Henrique Scarabello Stape, Mustafa Murat Mutluay, Arzu Tezvergil-Mutluay

School of Dentistry Faculty Research and Publications

Objective

To evaluate the long-term effect of ammonia- and water-based silver fluoride treatments on the degradation of the dentin collagen matrix.

Methods

Dentin beams (0.3x3x7mm) were demineralized (10 % H3PO4), rinsed and randomly distributed into six groups. Groups (n = 10 beams/group) were treated with (1) ammonia-based silver fluoride = SDF; (2) SDF + potassium iodide = KI (3) water-based silver fluoride = SF (4) SF + KI (5) KI (6) untreated demineralized dentin beams served as control. Following treatments, dry mass, modulus of elasticity and enzymatic activity were assessed. Dentin beams were incubated in calcium- …


Three-Dimensional Displacement Of Upper Cervical Vertebrae In Severe Mandibular Deviation Caused By Condylar Hyperplasia: A Tomographic Segmentation Study, Claudia Milena Ramírez, Rodrigo Cárdenas-Perilla, Luis Eduardo Almeida, Diego Fernando López Feb 2026

Three-Dimensional Displacement Of Upper Cervical Vertebrae In Severe Mandibular Deviation Caused By Condylar Hyperplasia: A Tomographic Segmentation Study, Claudia Milena Ramírez, Rodrigo Cárdenas-Perilla, Luis Eduardo Almeida, Diego Fernando López

School of Dentistry Faculty Research and Publications

Objective: To evaluate the three-dimensional (3D) angular displacement (Roll, Yaw, and Pitch) of the upper cervical vertebrae (C1, C2, and C3) in patients with severe mandibular deviation (MD) due to condylar hyperplasia (CH), utilizing a computed tomography (CT)-based segmentation approach. Methods: This retrospective cross-sectional study included 50 patients with MD ≥ 6 mm caused by hemimandibular elongation (HE) or a hybrid form (HF) of CH. The skull, mandible, and cervical vertebrae (C1–C3) were segmented using 3D Slicer software. Angular deviations (Pitch, Yaw, Roll) were measured relative to the Frankfurt plane. Patients were categorized by the side of CH (right or …


Cytotoxicity Of Ammonia- And Water-Based Silver Fluoride Treatments, Merve Uctasli, Roda Seseogullari-Dirihan, Mustafa Murat Mutluay, Arzu Tezvergil-Mutluay Feb 2026

Cytotoxicity Of Ammonia- And Water-Based Silver Fluoride Treatments, Merve Uctasli, Roda Seseogullari-Dirihan, Mustafa Murat Mutluay, Arzu Tezvergil-Mutluay

School of Dentistry Faculty Research and Publications

This study aims to investigate the trans-dentinal and direct cell viability of ammonia- and water-based silver fluoride treatments. Deep dentin discs were prepared, balanced for permeability and autoclaved. Three-dimensional cultures of odontoblast-like cells were transferred to the pulpal aspect of the dentin slices inside perfusion split chambers designed for dentin-barrier cytotoxicity test, following ISO 7405. An experimental resin-based glass ionomer cement and a polyvinylsiloxane impression material served as positive and negative controls, respectively. The experimental treatments included: (i) ammonia-based silver fluoride = SDF, (ii) SDF + potassium iodide = KI, (iii) water-based silver fluoride = SF, and (iv) SF + …


Impacts Of Artificial Intelligence On Computed Tomography In Endodontics: An Integrative Review, Camila Da Silva Fagundes, Ana Ligya Monteiro Soares, Fabiofederal University Of Paraíba Luiz Cunha D'Assuncao, Elsbeth Kalenderian, Claudia Batista Melo Feb 2026

Impacts Of Artificial Intelligence On Computed Tomography In Endodontics: An Integrative Review, Camila Da Silva Fagundes, Ana Ligya Monteiro Soares, Fabiofederal University Of Paraíba Luiz Cunha D'Assuncao, Elsbeth Kalenderian, Claudia Batista Melo

School of Dentistry Faculty Research and Publications

Background. Artificial Intelligence (AI), defined as systems capable of replicating human tasks aimed at performing complex tasks and supporting decision-making, is entering the field of Dentistry, standing out with its application in research and clinical practices, such as diagnosis using Cone Beam Computed Tomography. The objective of this study is to identify and organize scientific evidence related to the use of Artificial Intelligence in computed tomography as an advanced resource in Endodontics.

Materials and methods. This study is an integrative review, structured in well-defined steps, namely: formulation of the guiding question, selection of inclusion and exclusion criteria, identification of descriptors …


Effect Of Different Implant Abutment Materials On Optical Properties Of Translucent Monolithic Zirconia Crowns, Nisha Patel, Geoffrey A. Thompson, Carl Drago, Mohamed Elshewy, David W. Berzins, Hongseok An Oct 2025

Effect Of Different Implant Abutment Materials On Optical Properties Of Translucent Monolithic Zirconia Crowns, Nisha Patel, Geoffrey A. Thompson, Carl Drago, Mohamed Elshewy, David W. Berzins, Hongseok An

School of Dentistry Faculty Research and Publications

Purpose

The use of translucent monolithic zirconia crowns in implant dentistry raises concerns about the underlying abutment color affecting esthetic outcomes. While abutment effects are documented for traditional ceramics, data are limited for modern monolithic zirconia. The purpose of this investigation is to evaluate how abutment material and zirconia brand influence the final color of translucent monolithic zirconia crowns.

Materials and Methods

Eighty monolithic zirconia crowns (four brands; n = 20 each) were fabricated in shade A2 and cemented onto five abutment types: titanium (Ti), gold-hued Ti, pink-hued Ti, zirconia, and a natural dentin-shaded control. Crowns were placed on abutments …


Structure-Activity Relationships Of A–And B-Type Proanthocyanidins In Long-Term Dentin Biomodification And Biocompatibility, Yvette Alania, Mariana Reis-Havlat, Shu-Xi Jing, Fahimeh Tabatabaei, James B. Mcalpine, Shao-Nong Chen, Guido F. Pauli, Ana K. Bedran-Russo Oct 2025

Structure-Activity Relationships Of A–And B-Type Proanthocyanidins In Long-Term Dentin Biomodification And Biocompatibility, Yvette Alania, Mariana Reis-Havlat, Shu-Xi Jing, Fahimeh Tabatabaei, James B. Mcalpine, Shao-Nong Chen, Guido F. Pauli, Ana K. Bedran-Russo

School of Dentistry Faculty Research and Publications

Objective

To explore the structure-activity relationships of plant-based proanthocyanidins (PACs) with dental pulp stem cells (DPSCs) and the long-term biomechanical stability of PAC-modified dentin extracellular matrix (ECM).

Methods

Mid-coronal dentin ECM (n= 8) was treated with eight PAC tetramers and trimers with varying A-/B-type linkages. Chemo-mechanical analyses included dynamic mechanical analysis and ATR-FTIR spectroscopy. Viscoelastic components were calculated after PAC biomodification, 18-month incubation, and protein destabilization. Collagen structure was assessed via IR amide absorbance ratios. DPSCs were cultured with PACs at different concentrations (100, 10, and 1 μg/mL) to measure proliferation. ANOVA and post-hoc tests were used for …


Color Change In Commercial Resin Composites With Different Photoinitiators, Feng Gao, David W. Berzins Sep 2025

Color Change In Commercial Resin Composites With Different Photoinitiators, Feng Gao, David W. Berzins

School of Dentistry Faculty Research and Publications

The yellowing effect of camphorquinone (CQ) has led manufacturers to add alternative initiators into resin composites (RCs) to reduce the amount of CQ used. The aim of this study was to investigate the color change in commercial RCs with alternative photoinitiators besides CQ. Color change upon polymerization and aging in air and artificial saliva for up to 3 months was tested for seven commercial RCs (traditional and bulk-fill) with either CQ only or CQ and additional photoinitiators (CQ+). Color measurements were obtained with a spectrophotometer. Color change (ΔE) was calculated using the CIELab and CIEDE2000 formulae. ANOVA and a post …


Dental Care For Patients With Congenital Bleeding Disorder: A Systematic Review, Afsary Jahan Khan, Sydur Rahaman Riyadh, Mohammed Gh Abd Ali Al-Naser, Norjehan Yahaya, Mas Suryalis Ahmad, Aminda Faizura Omar, Altaf H. Shah Sep 2025

Dental Care For Patients With Congenital Bleeding Disorder: A Systematic Review, Afsary Jahan Khan, Sydur Rahaman Riyadh, Mohammed Gh Abd Ali Al-Naser, Norjehan Yahaya, Mas Suryalis Ahmad, Aminda Faizura Omar, Altaf H. Shah

School of Dentistry Faculty Research and Publications

Introduction

Dental management in patients with congenital bleeding disorder (CBD) can be complex, as even minor oral surgery may precipitate prolonged bleeding. Effective treatment requires a thorough medical and dental history evaluation, including pre-, intra-, and post-operative planning. This systematic review (SR) aims to analyze data on CBD patients, including age, treatment techniques, outcomes, and recommendations for minimizing bleeding risks.

Materials and Methods

A comprehensive electronic search was conducted across five databases—PubMed via MEDLINE, Embase, Cochrane Library, Scopus, and Web of Science—using expert-validated keywords. Manual searches complemented the selection process, covering studies from first January 2009, to December 31, 2024. …


Evaluating Dental Ai Research Papers: Key Considerations For Editors And Reviewers, Sergio E. Uribe, Manal H. Hamdan, Nicola Alberto Valente, Satoshi Yamaguchi, Fahad Umer, Antonin Tichy, Ruben Pauwels, Falk Schwendicke Sep 2025

Evaluating Dental Ai Research Papers: Key Considerations For Editors And Reviewers, Sergio E. Uribe, Manal H. Hamdan, Nicola Alberto Valente, Satoshi Yamaguchi, Fahad Umer, Antonin Tichy, Ruben Pauwels, Falk Schwendicke

School of Dentistry Faculty Research and Publications

Objective

Artificial intelligence (AI) is increasingly used in dental research for diagnosis, treatment planning, and disease prediction. However, many dental AI studies lack methodological rigor, transparency, or reproducibility, and no dedicated peer-review guidance exists for this field.

Methods

Editors and reviewers from the ITU/WHO/WIPO AI for Health – Dentistrygroup participated in a structured survey and group discussions to identify key elements for reviewing AI dental research. A draft of the recommendations was circulated for feedback and consensus.

Results

The consensus from editors and reviewers identified four key indicators of high-quality AI dental research: (1) relevance to a real clinical …


Corrigendum To “A Compound Of Concentrated Growth Factor And Periodontal Ligament Stem Cell-Derived Conditioned Medium” [Tissue Cell 65 (2020) 101373], Z. Aghamohammadi, M. Kadkhodazadeh, M. Torshabi, Fahimeh Tabatabaei Sep 2025

Corrigendum To “A Compound Of Concentrated Growth Factor And Periodontal Ligament Stem Cell-Derived Conditioned Medium” [Tissue Cell 65 (2020) 101373], Z. Aghamohammadi, M. Kadkhodazadeh, M. Torshabi, Fahimeh Tabatabaei

School of Dentistry Faculty Research and Publications

No abstract provided.


Quality Of Life Outcomes Following Total Temporomandibular Joint Replacement: A Systematic Review Of Long-Term Efficacy, Functional Improvements, And Complication Rates Across Prosthesis Types, Luis Eduardo Almeida, Samuel Zammuto, Louis G. Mercuri Jul 2025

Quality Of Life Outcomes Following Total Temporomandibular Joint Replacement: A Systematic Review Of Long-Term Efficacy, Functional Improvements, And Complication Rates Across Prosthesis Types, Luis Eduardo Almeida, Samuel Zammuto, Louis G. Mercuri

School of Dentistry Faculty Research and Publications

Introduction:

Total temporomandibular joint replacement (TMJR) is a well-established surgical solution for patients with severe TMJ disorders. It aims to relieve chronic pain, restore jaw mobility, and significantly enhance quality of life. This systematic review evaluates QoL outcomes following TMJR, analyzes complication profiles, compares custom versus stock prostheses, explores pediatric applications, and highlights technological innovations shaping the future of TMJ reconstruction.

Methods:

A systematic search of PubMed, Embase, and the Cochrane Library was conducted throughout April 2025 in accordance with PRISMA 2020 guidelines. Sixty-four studies were included, comprising 2387 patients. Results: Primary outcomes assessed were QoL improvement, pain reduction, and …


Periodontal Diseases In Africa, Mojisola Olujitan, Patricia O. Ayanbadejo, Kehinde Umeizudike, Afolabi Oyapero, Christopher Okunseri, Azeez Butali Jun 2025

Periodontal Diseases In Africa, Mojisola Olujitan, Patricia O. Ayanbadejo, Kehinde Umeizudike, Afolabi Oyapero, Christopher Okunseri, Azeez Butali

School of Dentistry Faculty Research and Publications

Periodontal diseases, a group of complex conditions marked by an excessive immune response and periodontal tissue destruction, are a global health concern. Since 1990, the incidence of these diseases has doubled, with Western sub-Saharan Africa experiencing the highest burden. Accurate diagnosis and case identification are crucial for understanding the etiology, features of disease, research, treatment and prevention. Modern perspectives on periodontal disease classification are based on commonality among those affected. However, current literature is often plagued by methodological inconsistencies and focused on disease mechanisms in European populations. Health inequalities in low- and middle-income countries (LMICs) are exacerbated by these challenges, …


Evaluating Artificial Intelligence Chatbots For Patient Education In Oral And Maxillofacial Radiology, Dilek Helvacioglu-Yigit, Husniye Demirturk, Kamran Ali, Dania Tamimi, Lisa J. Koenig, Abeer Almashraqi Jun 2025

Evaluating Artificial Intelligence Chatbots For Patient Education In Oral And Maxillofacial Radiology, Dilek Helvacioglu-Yigit, Husniye Demirturk, Kamran Ali, Dania Tamimi, Lisa J. Koenig, Abeer Almashraqi

School of Dentistry Faculty Research and Publications

Objective

This study aimed to compare the quality and readability of the responses generated by 3 publicly available artificial intelligence (AI) chatbots in answering frequently asked questions (FAQs) related to Oral and Maxillofacial Radiology (OMR) to assess their suitability for patient education.

Study Design

Fifteen OMR-related questions were selected from professional patient information websites. These questions were posed to ChatGPT-3.5 by OpenAI, Gemini 1.5 Pro by Google, and Copilot by Microsoft to generate responses. Three board-certified OMR specialists evaluated the responses regarding scientific adequacy, ease of understanding, and overall reader satisfaction. Readability was assessed using the Flesch-Kincaid Grade Level (FKGL) …


Ensuring Integrity In Dental Education: Developing A Novel Ai Model For Consistent And Traceable Image Analysis In Preclinical Endodontic Procedures, Mohamed Ibrahim, Meisam Omidi, Arndt Guentsch, Joseph Gaffney, Jennifer Talley Jun 2025

Ensuring Integrity In Dental Education: Developing A Novel Ai Model For Consistent And Traceable Image Analysis In Preclinical Endodontic Procedures, Mohamed Ibrahim, Meisam Omidi, Arndt Guentsch, Joseph Gaffney, Jennifer Talley

School of Dentistry Faculty Research and Publications

Aim

Academic integrity is crucial in dental education, especially during practical exams assessing competencies. Traditional oversight may not detect sophisticated academic dishonesty methods like radiograph substitution or tampering. This study aimed to develop and evaluate a novel artificial intelligence (AI) model utilizing a Siamese neural network to detect inconsistencies in radiographic images taken for root canal treatment (RCT) procedures in preclinical endodontic courses, thereby enhancing educational integrity.

Methododology

A Siamese neural network was designed to compare radiographs from different RCT procedures. The model was trained on 3390 radiographs, with data augmentation applied to improve generalizability. The dataset was split into …


Long-Term Assessment Of Skeletal And Dental Asymmetry After Conventional And Mini-Implant-Assisted Rapid Palatal Expansion, Brett Barton, Shea Jamieson, Marinho Del Santo Jr, Manuel Lagravere Vich, Dawei Liu, Sumit Yadav, Shivam Yogesh Mehta Apr 2025

Long-Term Assessment Of Skeletal And Dental Asymmetry After Conventional And Mini-Implant-Assisted Rapid Palatal Expansion, Brett Barton, Shea Jamieson, Marinho Del Santo Jr, Manuel Lagravere Vich, Dawei Liu, Sumit Yadav, Shivam Yogesh Mehta

School of Dentistry Faculty Research and Publications

Introduction

This study aimed to evaluate the short-term and long-term skeletal and dental asymmetry with miniscrew-assisted rapid palatal expansion (MARPE), rapid palatal expansion (RPE), and control group using cone-beam computed tomography (CBCT) analysis.

Methods

A total of 180 CBCT scans were analyzed for 60 patients divided into 3 groups: MARPE (mean age 13.7 ± 1.74 years), RPE (mean age 13.9 ± 1.14 years), and control (mean age 13.3 ± 1.49 years). CBCT scans were recorded at 3 points: pretreatment (T1), postexpansion (T2), and posttreatment (T3). The anterior nasal spine, posterior nasal spine, zygomaticomaxillary point, anterior nasal cavity width, posterior nasal …


Effect Of Surface Conditioning On The Adhesive Bond Strength Of 3d-Printed Resins Used In Permanent Fixed Dental Prostheses, Marco Dederichs, Zaid Badr, Stephanie Viebranz, Sandor Nietzsche, Ulrike Schulze-Spate, Anne-Sophie Schmelzer, Thomas Lehmann, Arndt Guentsch Apr 2025

Effect Of Surface Conditioning On The Adhesive Bond Strength Of 3d-Printed Resins Used In Permanent Fixed Dental Prostheses, Marco Dederichs, Zaid Badr, Stephanie Viebranz, Sandor Nietzsche, Ulrike Schulze-Spate, Anne-Sophie Schmelzer, Thomas Lehmann, Arndt Guentsch

School of Dentistry Faculty Research and Publications

Objectives

Although pre-treatment parameters for subtractive computer-aided design/computer-aided manufacturing (CAD/CAM) materials have been thoroughly investigated, data regarding additive restorative materials designed for permanent use in the oral cavity are scarce. This study investigated the effects of abrasive materials and blasting pressure on the bond strength of 3D-printed resins used in permanent restorations.

Methods

A total of n = 44 test specimens additively manufactured from Formlabs’ `Permanent Crown Resin' were prepared. Three groups with n = 11 specimens were airborne-particle abraded with 50 µm aluminium oxide at 1 bar, 2 bar or 3 bar. The control group did not receive any …


Dental Anxiety And Oral Health In American Indian And Alaska Natives, Tamanna Tiwari, Casey D. Wright, Lisa J. Heaton, Morgan Santoro, Eric P. Tranby Apr 2025

Dental Anxiety And Oral Health In American Indian And Alaska Natives, Tamanna Tiwari, Casey D. Wright, Lisa J. Heaton, Morgan Santoro, Eric P. Tranby

School of Dentistry Faculty Research and Publications

Objective

American Indian and Alaska native (AI/AN) individuals report distrust of the healthcare system. This study explored associations between having either high levels of dental distrust or high levels of dental care-related fear and anxiety (“dental anxiety”) and oral health outcomes in AI/AN adults.

Methods

The 2022 State of Oral Health Equity in America survey included the Modified Dental Anxiety Scale and asked to what extent respondents agreed with the statement, “At my last oral health visit, I trusted the oral health provider I saw”, and asked about self-rated oral health and presence of a dental home.

Results

AI/AN individuals …


Does Social Media Increase Perioperative Anxiety In Patients Undergoing Impacted Third Molar Surgery?, Ufuk Tatli, Tahayasin Kalkan Mar 2025

Does Social Media Increase Perioperative Anxiety In Patients Undergoing Impacted Third Molar Surgery?, Ufuk Tatli, Tahayasin Kalkan

School of Dentistry Faculty Research and Publications

Background

In anticipation of third molar surgery, patients may experience increased anxiety. Patients frequently access social media platforms and view content about surgical treatments.

Purpose

The study purpose was to measure the level of perioperative anxiety of patients scheduled for third molar surgery exposed to social media and identify factors associated with patient anxiety.

Study Design, Setting, Sample

This is a prospective cohort study of patients undergoing impacted mandibular third molar surgery from September 2021 to August 2022 at the outpatient clinic of Cukurova University School of Dentistry.

Predictor Variable

The predictor variable was level of exposure to viewing third …


Implant Placement-Associated Tissue Swelling: A Digital Three-Dimensional And Patient-Based Assessment, Vrisiis Kofina, Juan Valencia Rincon, Swati Y. Rawal, Andrew R. Dentino, Shengtong Han, Dimitris N. Tatakis Mar 2025

Implant Placement-Associated Tissue Swelling: A Digital Three-Dimensional And Patient-Based Assessment, Vrisiis Kofina, Juan Valencia Rincon, Swati Y. Rawal, Andrew R. Dentino, Shengtong Han, Dimitris N. Tatakis

School of Dentistry Faculty Research and Publications

Objectives

There is scarce evidence on immediate soft tissue and patient-reported outcome measures (PROMs) following implant surgery. This prospective study aimed to quantify post-implant placement intraoral swelling and to correlate it with PROMs.

Materials and methods

Twenty-six patients undergoing standardized single implant placement (two-stage protocol) were recruited. Soft tissue swelling was recorded by intraoral scans immediately pre-surgery (PS) and post-operatively (IP), and at 2 (2d), 7 (7d) and 14 days (14d) and 2 months (2 m). Ridge width, height, and volume changes from IP were recorded. PROMs (pain, swelling, difficulty of mouth opening, and OHIP-14) were recorded pre- and post-operatively. …


Bilateral Condylar Hyperplasia: Importance Of Its Diagnosis In The Treatment And Long-Term Stability Of Skeletal Class Iii Correction, Diego Fernando Lopez, Martin Fernando Orozco, Sofia Ochoa Gomez, Santiago Herrera Guardiola, Luis Eduardo Almeida Mar 2025

Bilateral Condylar Hyperplasia: Importance Of Its Diagnosis In The Treatment And Long-Term Stability Of Skeletal Class Iii Correction, Diego Fernando Lopez, Martin Fernando Orozco, Sofia Ochoa Gomez, Santiago Herrera Guardiola, Luis Eduardo Almeida

School of Dentistry Faculty Research and Publications

Background: Condylar hyperplasia (CH) leads to mandibular overgrowth with anatomical, aesthetic, and functional consequences, particularly affecting facial harmony. It is characterized by severe mandibular prognathism (MP) in bilateral cases. This study aims to propose a therapeutic algorithm for diagnosing and treating bilateral condylar hyperplasia (BCH) based on demographic, clinical, craniofacial growth, and clivus ratio uptake conditions. Methods: Ten patients with severe skeletal Class III by MP, whose alteration was clinically associated with BCH, were consecutively evaluated in a specialized dentofacial deformity center between the period of 2019 and 2024. A detailed protocol was followed to gather clinical history, assess anatomical …


A Personalized Periodontitis Risk Based On Nonimage Electronic Dental Records By Machine Learning, Laura Swinckels, Ander De Keijzer, Bruno G. Loos, Reuben Joseph Applegate, Krishna Kumar Kookal, Elsbeth Kalenderian, Harmen Bijwaard, Josef Bruers Feb 2025

A Personalized Periodontitis Risk Based On Nonimage Electronic Dental Records By Machine Learning, Laura Swinckels, Ander De Keijzer, Bruno G. Loos, Reuben Joseph Applegate, Krishna Kumar Kookal, Elsbeth Kalenderian, Harmen Bijwaard, Josef Bruers

School of Dentistry Faculty Research and Publications

Objective: This study aimed to develop a machine-learning (ML) model to predict the risk for Periodontal Disease (PD) based on nonimage electronic dental records (EDRs).

Methods: By using EDRs collected in the BigMouth repository, dental patients from the US were included. Patients were labeled as cases or controls, based on PD diagnosis, treatment and pocketing. By learning from their data, a model was trained. The ability of the developed model to predict PD was evaluated by the accuracy, sensitivity, specificity and area under the curve (AUROC) and the most important features were determined. The best-performing model was applied …


Efficacy Of 3d-Printed Chitosan-Cerium Oxide Dressings Coated With Vancomycin-Loaded Alginate For Chronic Wounds Management, Sharareh Shahroudi, Amir Parvinnasab, Erfan Salahinejad, Shaghayegh Abdi, Sarah Rajabi, Lobat Tayebi Feb 2025

Efficacy Of 3d-Printed Chitosan-Cerium Oxide Dressings Coated With Vancomycin-Loaded Alginate For Chronic Wounds Management, Sharareh Shahroudi, Amir Parvinnasab, Erfan Salahinejad, Shaghayegh Abdi, Sarah Rajabi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Multifunctional wound dressings with antibacterial and antioxidant properties hold significant promise for treating chronic wounds; however, achieving a balance of these characteristics while maintaining biocompatibility is challenging. To enhance this balance, this study focuses on the design and development of 3D-printed chitosan-matrix composite scaffolds, which are incorporated with varying amounts of cerium oxide nanoparticles (0, 1, 3, 5, and 7 wt%) and subsequently coated with a vancomycin-loaded alginate layer. The structure, antibiotic drug delivery kinetics, biodegradation, swelling, biocompatibility, antibacterial, antioxidant, and cell migration behaviors of the fabricated dressings were evaluated in-vitro. The findings reveal that all of the formulations …


The Influence Of A Deep Learning Tool On The Performance Of Oral And Maxillofacial Radiologists In The Detection Of Apical Radiolucencies, Manal Hamdan, Sergio E. Uribe, Lyudmila Tuzova, Dmitry Tuzoff, Zaid Badr, Andre Mol, Donald A. Tyndall Feb 2025

The Influence Of A Deep Learning Tool On The Performance Of Oral And Maxillofacial Radiologists In The Detection Of Apical Radiolucencies, Manal Hamdan, Sergio E. Uribe, Lyudmila Tuzova, Dmitry Tuzoff, Zaid Badr, Andre Mol, Donald A. Tyndall

School of Dentistry Faculty Research and Publications

Objectives

This study aimed to assess the impact of a deep learning model on oral radiologists’ ability to detect periapical radiolucencies on periapical radiographs. The secondary objective was to conduct a regression analysis to evaluate the effects of years of experience, time to diagnose, and specialty.

Methods

This study used an annotated dataset and a beta version of a deep learning model (Denti.AI). The testing subset comprised 68 intraoral periapical radiographs confirmed with cone-beam computed tomography for the presence/absence of apical radiolucencies. Four oral radiologists participated in a cross-over reading scenario, analysing the radiographs under 2 conditions: initially without AI …


Promoting Angiogenesis/Osteogenesis By A New Copper/Magnesium Hydroxide Hybrid Nanoparticle: In Vitro And In Vivo Investigation, Parsa Khalkhali, Meisam Omidi, Daniela S. Masson-Meyers, Babak Akbari, Mohammad Mehdi Dehghan, Hossein Aminianfar, Saeed Farzad-Mohajeri, Van Mansouri, Lobat Tayebi Jan 2025

Promoting Angiogenesis/Osteogenesis By A New Copper/Magnesium Hydroxide Hybrid Nanoparticle: In Vitro And In Vivo Investigation, Parsa Khalkhali, Meisam Omidi, Daniela S. Masson-Meyers, Babak Akbari, Mohammad Mehdi Dehghan, Hossein Aminianfar, Saeed Farzad-Mohajeri, Van Mansouri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

In this study, a new hybrid nanoparticle composed of magnesium hydroxide and copper oxide (Mg(OH)2/CuO) with an optimized ratio of magnesium (Mg) to copper (Cu) was designed and incorporated into a 3D-printed scaffold made of polycaprolactone (PCL) and gelatin. These hybrid nanostructures (MCNs) were prepared using a green, solvent-free method. Their topography, surface morphology, and structural properties were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The fabricated 3D-printed PCL/Gelatin/MCN scaffolds were investigated in vitro and in vivo. Cell viability tests on murine calvarial preosteoblasts (MC3T3-E1) and human umbilical vein …


Ectopic Dental Canal: A Case Report Highlighting A Unique Bifid Mandibular Canal Variant, Kevin W. Yu, Manal Hamdan, Stephanie J. Sidow Dec 2024

Ectopic Dental Canal: A Case Report Highlighting A Unique Bifid Mandibular Canal Variant, Kevin W. Yu, Manal Hamdan, Stephanie J. Sidow

School of Dentistry Faculty Research and Publications

Bifid mandibular canals are common anatomical findings with variations based on direction and location of branching, which carry significant clinical implications for endodontic and surgical dental procedures. This case report describes a previously unreported ectopic dental canal that branches off the superior border of the mandibular canal, enters the apex of a mandibular second molar, traverses through the root, anastomoses with the root canal system, and subsequently exits through the lingual aspect of the root. The anastomosis of this ectopic dental canal with the mesial lingual canal led to significant bleeding during rotary instrumentation. This unique anatomical variation demonstrates the …


Mesoporous Silica Administration As A New Strategy In The Management Of Warfarin Toxicity: An In-Vitro And In-Vivo Study, Fatemeh Farjadian, Fatemeh Parsi, Reza Heidari, Khatereh Zarkesh, Hamid Reza Mohammadi, Soliman Mohammadi-Samani, Lobat Tayebi Dec 2024

Mesoporous Silica Administration As A New Strategy In The Management Of Warfarin Toxicity: An In-Vitro And In-Vivo Study, Fatemeh Farjadian, Fatemeh Parsi, Reza Heidari, Khatereh Zarkesh, Hamid Reza Mohammadi, Soliman Mohammadi-Samani, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Purpose:

Warfarin is one of the most widely used anticoagulants that functions by inhibiting vitamin K epoxide reductase. Warfarin overdose, whether intentional or unintentional, can cause life-threatening bleeding. Here, we present a novel warfarin adsorbent based on mesoporous silica that could serve as an antidote to warfarin toxicity.

Methods:

Amino-functionalized mesoporous silica (MS-NH2) was synthesized based on the co-condensation method through a soft template technique followed by template removal. The prepared structure and functional group were studied by Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) checked the morphology. The …


Impact Of Obstructive Sleep Apnea On Masticatory Muscle Function, Diana Russo, Luis Eduardo Almeida, Vincenzo Ronsivalle, Marco Cicciù, Gabriele Cervino, Maria Maddalena Marrapodi, Giuseppe Minervini Nov 2024

Impact Of Obstructive Sleep Apnea On Masticatory Muscle Function, Diana Russo, Luis Eduardo Almeida, Vincenzo Ronsivalle, Marco Cicciù, Gabriele Cervino, Maria Maddalena Marrapodi, Giuseppe Minervini

School of Dentistry Faculty Research and Publications

Obstructive sleep apnea (OSA) is a common and potentially serious sleep disorder characterized by repetitive episodes of complete or partial upper airway obstruction during sleep. These obstructions result in a reduction or cessation of airflow, leading to oxygen desaturation, and disruptions in sleep patterns.1,2 Common symptoms of OSA include loud snoring, gasping or choking during sleep, excessive daytime sleepiness, morning headaches, and irritability. Obstructive sleep apnea is often associated with other medical conditions, such as obesity, hypertension, cardiovascular disease, and diabetes. Diagnosis typically involves polysomnography to assess the frequency and severity of apneic episodes.


Comparison Of Accuracy Of Different Dental Age Estimation Methods In Finnish And Turkish Populations, Aysima Darici, Merih Seval Olmez, H. Cem Güngör, Paivi Rajavaara, Annina Sipola, Vuokko Anttonen, Jari Pakkila Nov 2024

Comparison Of Accuracy Of Different Dental Age Estimation Methods In Finnish And Turkish Populations, Aysima Darici, Merih Seval Olmez, H. Cem Güngör, Paivi Rajavaara, Annina Sipola, Vuokko Anttonen, Jari Pakkila

School of Dentistry Faculty Research and Publications

Objective: The aims of this study were to assess the accuracy of Cameriere’s and Demirjian’s methods in Finnish children, and compare the findings with those of the Turkish children according to dental age.

Material and methods: Dental panoramic tomography (DPT) of children (482 Finnish, 423 Turkish) aged between 5 and 15 years were evaluated. Comparison of mean difference between estimated and chronological age was evaluated. The difference between two means was analysed using paired t-test at 95% confidence interval (CI). Pearson correlation coefficients were used to estimate the correlation between chronological and estimated ages.

Results: Demirjian’s method resulted in …


Short- And Long-Term Effects Of Conventional And Miniscrew-Assisted Rapid Palatal Expansion On Hard Tissues Using Voxel-Based Superimposition Of Serial Cone-Beam Computed Tomography Scans, Isaac R. Empson, Marinho Del Santo Jr., Chia-Ling Kuo, Manuel Lagravere Vich, Dawei Liu, Sumit Yadav, Shivam Yogesh Mehta Nov 2024

Short- And Long-Term Effects Of Conventional And Miniscrew-Assisted Rapid Palatal Expansion On Hard Tissues Using Voxel-Based Superimposition Of Serial Cone-Beam Computed Tomography Scans, Isaac R. Empson, Marinho Del Santo Jr., Chia-Ling Kuo, Manuel Lagravere Vich, Dawei Liu, Sumit Yadav, Shivam Yogesh Mehta

School of Dentistry Faculty Research and Publications

Introduction

The objective of this study was to evaluate the short-term and long-term hard-tissue changes with miniscrew-assisted rapid palatal expansion (MARPE) and rapid palatal expansion (RPE) compared with a matched control group with voxel-based superimposition using 3-dimensional cone-beam computed tomography (CBCT) scans.

Methods

A total of 180 CBCT scans were analyzed for 60 patients with a mean age of 13.9 years at 3 time points: pretreatment (T1), postexpansion (T2), and posttreatment (T3). Patients were divided into 3 groups: MARPE, RPE, and controls. Voxel-based superimposition was performed for CBCTs from T1 to T2 and T1 to T3 using the anterior cranial …