Dentistry Commons^™

A Retrospective Analysis Of The Role Of Age And Sex In Outcomes Of Non-Surgical Periodontal Therapy At A Single Academic Dental Center, Nikola Angelov, Nikolaos Soldatos, Effie Ioannidou, Tonia C Carter, Neel Shimpi, Joseph Applegate, Krishna Kumar Kookal, Karo Parsegian

Faculty, Staff and Student Publications

The present study examined the role of age and sex in the outcomes of non-surgical periodontal therapy (NSPT). De-identified demographic and periodontal characteristics of patients who presented for baseline periodontal evaluation, NSPT, and periodontal re-evaluation were abstracted from electronic health records. Independent associations of age and sex with severe periodontitis defined as ≥ 5 mm clinical attachment loss (CAL) and ≥ 6 mm probing depth (PD) were determined using multinomial logistic regression. The null hypothesis was rejected at α <  0.05. A total of 2866 eligible subjects were included in the analysis. Significantly lower odds of CAL ≤ 4 mm than CAL ≥ 5 mm (reference) were observed in adults aged 35-64 (odds ratio, OR, 0.19; 95% confidence interval, CI 0.13, 0.29) and ≥ 65 years (OR 0.13; 95% CI 0.07, 0.25) compared to those aged 18-34 years. Odds of PD <  4 mm versus PD ≥ 6 mm (reference) were lower in adults aged 35-64 years than those aged 18-34 years (OR 0.71; 95% CI 0.55, 0.90) and higher in females compared to males (OR 1.67; 95% CI 1.14, 2.44). These results suggest more compromised post-NSPT outcomes in older adults and males compared to the respective populations and highlight the need for personalized therapeutic strategies in these populations.

Mathematical Modeling For Dental Decay Prevention In Children And Adolescents, Mahdiyeh Soltaninejad

Dissertations

The high prevalence of dental caries among children and adolescents, especially those from lower socio-economic backgrounds, is a significant nationwide health concern. Early prevention, such as dental sealants and fluoride varnish (FV), is essential, but access to this care remains limited and disparate. In this research, a national dataset is utilized to assess sealants' reach and effectiveness in preventing tooth decay, particularly focusing on 2nd molars that emerge during early adolescence, a current gap in the knowledge base. FV is recommended to be delivered during medical well-child visits to children who are not seeing a dentist. Challenges and facilitators in …

Barriers To Dental Utilization Among Medicaid-Enrolled Young Children From Primary Care Practices In Northeast Ohio, David Selvaraj, Neel Agarwal, Jeffrey M. Albert, Suchitra Nelson

Faculty Scholarship

Objectives: To evaluate the individual and community factors that contribute to dental utilization among young children on Medicaid utilizing the Anderson Model and the Socio-Ecological Framework. Methods: This observational cross-sectional study was conducted using baseline data (socio-demographics, clinical dental need) from a cluster-randomized hybrid effectiveness-implementation trial among 1021 child–parent dyads recruited from primary care practices across northeast Ohio. The baseline data were then linked to dental Medicaid claims data (categorized as any dental visit, volume, and type in the past 12 months) and ICD-10 codes from the child's EHR data (individual-level) together with Dental Health Provider Shortage Area (HPSA) status …

Stimulator Of Interferon Genes Pathway Activation Through The Controlled Release Of Stingel Mediates Analgesia And Anti-Cancer Effects In Oral Squamous Cell Carcinoma, Minh Phuong Dong, Neeraja Dharmaraj, Estela Kaminagakura, Jianfei Xue, David G Leach, Jeffrey D Hartgerink, Michael Zhang, Hana-Joy Hanks, Yi Ye, Bradley E Aouizerat, Kyle Vining, Carissa M Thomas, Sinisa Dovat, Simon Young, Chi T Viet

Faculty, Staff and Student Publications

Oral squamous cell carcinoma (OSCC) presents significant treatment challenges due to its poor survival and intense pain at the primary cancer site. Cancer pain is debilitating, contributes to diminished quality of life, and causes opioid tolerance. The stimulator of interferon genes (STING) agonism has been investigated as an anti-cancer strategy. We have developed STINGel, an extended-release formulation that prolongs the availability of STING agonists, which has demonstrated an enhanced anti-tumor effect in OSCC compared to STING agonist injection. This study investigates the impact of intra-tumoral STINGel on OSCC-induced pain using two separate OSCC models and nociceptive behavioral assays. Intra-tumoral STINGel …

Recent Advances In Nanomaterial-Based Biosensor For Periodontitis Detection, Mohammad Hosseini Hooshiar, Masoud Amiri Moghaddam, Mohammad Kiarashi, Athraa Y Al-Hijazi, Abbas Fadel Hussein, Hareth A Alrikabi, Sara Salari, Samar Esmaelian, Hassan Mesgari, Saman Yasamineh

Faculty, Staff and Student Publications

Periodontitis, a chronic inflammatory condition caused by bacteria, often causes gradual destruction of the components that support teeth, such as the alveolar bone, cementum, periodontal ligament, and gingiva. This ultimately results in teeth becoming loose and eventually falling out. Timely identification has a crucial role in preventing and controlling its progression. Clinical measures are used to diagnose periodontitis. However, now, there is a hunt for alternative diagnostic and monitoring methods due to the progress of technology. Various biomarkers have been assessed using multiple bodily fluids as sample sources. Furthermore, conventional periodontal categorization factors do not provide significant insights into the …

Dental Therapists: Arizona Dentists’ Perceptions And Attitudes Towards The Workforce Model, Autumn Butler

Dental Hygiene ETDs

Dental therapists have emerged as a solution to improve access to dental care. Understanding Arizona dentists' attitudes towards dental therapists is crucial in the successful integration into the dental workforce and its potential to be a viable solution. Licensed dentists in Arizona were invited to participate in an anonymous study. Participants were asked questions regarding the scope of practice, current educational standards, and quality of treatment to determine the attitudes of dentists towards dental therapists. Eight dentists licensed in Arizona participated in the survey (N=8). The study found concerns among Arizona dentists regarding the treatment quality and educational standards (N=3; …

Association Of F. Alocis And D. Pneumosintes With Periodontitis Disease Severity And Red Complex Bacteria, Hawaabi F.M. Shaikh, Pratima U. Oswal, Manohar Suresh Kugaji, Sandeep S. Katti, Kishore Gajanan Bhat, Eswar Kandaswamy, Vinayak M. Joshi

School of Dentistry Faculty Publications

Oral biofilms are considered the principal etiological agent in the development of periodontitis. Novel species that may contribute to periodontitis and dysbiosis have been identified recently. The study aims to evaluate the presence of F. alocis and D. pneumosintes in healthy and diseased patients and their association with clinical parameters and with red complex bacteria. The study included 60 subjects, with 30 patients each in the healthy and periodontitis groups. The clinical parameters were noted, and samples were subjected to DNA extraction followed by a polymerase chain reaction. Statistical analysis was performed using the Graph Pad Prism software. Results: F. …

Charting The Cellular Biogeography In Colitis Reveals Fibroblast Trajectories And Coordinated Spatial Remodeling, Paolo Cadinu, Kisha N Sivanathan, Aditya Misra, Rosalind J Xu, Davide Mangani, Evan Yang, Joseph M Rone, Katherine Tooley, Yoon-Chul Kye, Lloyd Bod, Ludwig Geistlinger, Tyrone Lee, Randall T Mertens, Noriaki Ono, Gang Wang, Liliana Sanmarco, Francisco J Quintana, Ana C Anderson, Vijay K Kuchroo, Jeffrey R Moffitt, Roni Nowarski

Faculty, Staff and Student Publications

Gut inflammation involves contributions from immune and non-immune cells, whose interactions are shaped by the spatial organization of the healthy gut and its remodeling during inflammation. The crosstalk between fibroblasts and immune cells is an important axis in this process, but our understanding has been challenged by incomplete cell-type definition and biogeography. To address this challenge, we used multiplexed error-robust fluorescence in situ hybridization (MERFISH) to profile the expression of 940 genes in 1.35 million cells imaged across the onset and recovery from a mouse colitis model. We identified diverse cell populations, charted their spatial organization, and revealed their polarization …

The Fight For Fluoridation In Stl, Noor Yousaf

Undergraduate Research Symposium

Fluoridation is the addition of fluoride to a source of drinking water. In St. Louis’s public water supply, the amount of fluoride remains the same since 1953 at 5ppm. Dr. Ralph Rosen and his team of dentists and researchers advocated for the fluoridation of the water because it reduced the frequency of dental caries occurring in children and adults alike, but the public had opinions on the sudden addition of chemicals to their water. This includes how the public’s health will be affected, how consumer products would change, and also how effective this addition of fluoride would be. This debate …

The Role Of School-Based Dental Sealing Programs And Fluoride Varnish In Preventing Caries, Gyuri Park

SACAD: Scholarly Activities

To examine the effectiveness of school-based dental sealant programs and fluoride varnish applied to the teeth, we analyzed existing research on both methods. We also reviewed data from past research to reason the need for state funds, a sealant metric, and the elimination of prior exam rules for hygienists to increase dental sealant programs in the United States. Both dental sealants and fluoride varnish applied to the molar were found to be effective in caries prevention in existing dental research.

Ada News - 04/08/2024, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Deepdof-Se: Affordable Deep-Learning Microscopy Platform For Slide-Free Histology, Lingbo Jin, Yubo Tang, Jackson B Coole, Melody T Tan, Xuan Zhao, Hawraa Badaoui, Jacob T Robinson, Michelle D Williams, Nadarajah Vigneswaran, Ann M Gillenwater, Rebecca R Richards-Kortum, Ashok Veeraraghavan

Faculty, Staff and Student Publications

Histopathology plays a critical role in the diagnosis and surgical management of cancer. However, access to histopathology services, especially frozen section pathology during surgery, is limited in resource-constrained settings because preparing slides from resected tissue is time-consuming, labor-intensive, and requires expensive infrastructure. Here, we report a deep-learning-enabled microscope, named DeepDOF-SE, to rapidly scan intact tissue at cellular resolution without the need for physical sectioning. Three key features jointly make DeepDOF-SE practical. First, tissue specimens are stained directly with inexpensive vital fluorescent dyes and optically sectioned with ultra-violet excitation that localizes fluorescent emission to a thin surface layer. Second, a deep-learning …

Time, Talent, And Treasure

Journal of the Macomb Dental Society

This article features a monthly column from the Macomb Dental Society Executive Director, Dr. Christopher Gorecki.

Trident - Spring 2024, Dugoni School Of Dentistry

Trident

The alumni newsletter of the Orthodontics program at University of the Pacific, Arthur A. Dugoni School of Dentistry

Caries Management For The Modern Era

Journal of the Macomb Dental Society

This month's Meeting lecture reviewed non-restorative versus restorative management of caries based on science, evidence based research and leading expert guidelines with Dr. Margherita Fontana. Dr. Fontana stressed that caries risk assessments done with patients give insights but that should not be the end of the conversation.

Macomb Dental Society Journal Spring 2024

Journal of the Macomb Dental Society

In the Spring 2024 issue, the reader will find the following feature articles:

• Reporting from the Macomb Legislative Event
• Caries Management for the Modern Era
• Membership: Thinking Outside the (Sudoku) Box

Also included are regular columns from the President, Executive Director and Editor, as well as news shorts and information on upcoming events.

Contact Point Spring 2024, Arthur A. Dugoni School Of Dentistry

Contact Point

No abstract provided.

Genetic Analysis Of Hereditary Gingival Fibromatosis Associated Sos1 Missense Variants Of Uncertain Significance In Caenorhabditis Elegans, Himani Patel

Theses

Hereditary gingival fibromatosis (HGF) is a disease that can present as benign overgrowth of gingival tissue in the mouth. The overgrowth can enclose the entire mouth and teeth in severe cases or present itself in a concentrated area. Researchers have identified that mutations in the SOS1 gene can be responsible for HGF. This disease can impair basic functions related to the mouth. Eating, smiling, speaking can all be affected. Additionally, excess inflammation can cause periodontal disease because of the difficulty in maintaining proper oral health. Periodontal disease can lead to severe bone loss which can lead to complete loss of …

Sepsis Is Serious. Recognize The Signs, Stuart L. Segelnick Dds, Ms, Cde

The New York State Dental Journal

Untreated or poorly managed periodontal disease, caries, endodontic and dental alveolar lesions can lead to sepsis. Case reports published in dental literature highlight the morbidity and mortality of dental disease complications.

J Mich Dent Assoc April 2024

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association provides news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. It stands as the primary publication reaching Michigan dentists.

In the April 2024 issue, the Journal focuses on the landscape of practicing in rural settings. Original content includes:

• A cover story highlighting Michigan’s Donated Dental Service Program
• A feature on Michigan’s Revised Kindergarten Oral Health Assessment Law
• A feature article on the origins, future, and use of the CDT Code
• Profiles of the 2024-25 MDA Officer, Trustee and ADA Delegation candidate
• An …

Ada Report: Ada Board Discusses New Services, Ce Changes, And Dental School Issues, Michele Tulak-Gorecki Dds

The Journal of the Michigan Dental Association

Michele Gulak-Gorecki, DDS, 9th District Trustee for the ADA, highlights discussions from the winter ADA Board meeting. Key points include the emphasis on ADA values, expansion of member services such as financial offerings, updates on revenue and membership models, collaboration with new dentists, improvements in continuing education programs, and insights from dental school deans on reducing education costs.

Mda At Your Service: What Is The Beneficial Ownership Information Report?, Kristin Johnson Dds

The Journal of the Michigan Dental Association

MDA Staff, with input from Kristin Johnson, DDS, explains the Beneficial Ownership Information Report required by the Corporate Transparency Act. Dental practices with fewer than 20 full-time employees and <$5M in annual sales must file by Jan. 1, 2025. They also address MIOSHA regulations, dental assistant duties, and access to MDA resources like the Delegation of Duties Chart and educational videos on infant oral health.

Effect Of Layer Thickness, Inner Structure, And Implant Angulation On The Accuracy Of 3d Printed Models With Implant Analogs, Omar Elsergany

Dentistry

Objective: This study evaluated the effect of layer thickness, model inner structure, and im- plant angulation on the accuracy of 3D printed models with repositional analogs.

Materials and methods: 126 models designed to receive all-on-4 implant retained fixed den- tal prosthesis were 3D printed. Models were divided into 2 groups (n=63) according to posterior implant angulation (Group 1; 30 ̊ and group 2;45 ̊). The models were then divided into three sub- groups (n=21) according to the printing layer thickness (Group a; 50 μm, group b; 100 μm, and group c; 150 μm). Each subgroup was later subdivided into 3 …

Color Stability And Marginal Adaptation Of Ceramic Veneers Cemented Using Different Composite Resins, Basma Refaat Fayad, Maged Zohdy, Engy Adel Farag, Ghada Hussein

Dentistry

BACKGROUND: The purpose of this study was to compare the color stability and marginal adaption of lithium disilicate veneers before and after thermocycling using various resin composite materials employed as cement. METHODS: Laminate veneer preparation was done on an acrylic tooth according to standardized procedures. The veneer preparations were duplicated into twenty-one dies. The veneers were fabricated from lithium disilicate using the CEREC in Lab system. According to the cement type, the twenty-one die specimens were randomly divided into three equal groups: group I, with light cured adhesive resin cement (N.=7), group II, with owable light cured composite, and group …

Impact Of Learning-Style-Based Education On Student Performance And Perception In Preclinical Endodontics: Part Ii, Rebecca Flaugher

Master's Theses (2009 -)

Objectives: This study aimed to investigate if providing supplemental learning materials aligned to students’ learning modes is equally beneficial among all modes both subjectively and objectively. Methods: IRB approval was obtained (Approval #HR-3746). Second-year dental students (n=92) enrolled in Preclinical Endodontics took Kolb Experiential Learning Profile (KELP) questionnaire to determine their learning mode: Abstract Conceptualization (AC), Active Experimentation (AE), Reflective Observation (RO), or Concrete Experience (CE). Students were assigned into groups corresponding to their learning mode. Students performed non-surgical root canal treatment (NSRCT) on a #9 typodont tooth and were graded to determine baseline performance (Project 1). Students were then …

Performance And Preference Of Rotary Files By Pre-Doctoral Dental Students At Marquette School Of Dentistry, Morgan Elizabeth Mccall

Master's Theses (2009 -)

Introduction: The aim of this study was twofold: 1) objectively evaluate root canal shaping and procedural mishaps using different NiTi rotary systems in the hands of unexperienced pre-doctoral dental students; 2) to gain an understanding of which rotary file system students subjectively prefer. Methods: Second year dental students (n=94) enrolled in preclinical endodontics received instructional videos and didactic lectures on the use of three different rotary filing systems: Vortex Blue, EndoSequence, and ProTaper Universal. Students completed root canal treatment using each file system on 3D printed premolars. The quantitative evaluation was completed after each project by two calibrated examiners using …

A Computational Fluid Dynamics Analysis Comparing Irrigation Within Complex Root Canal Anatomy, Madeleinne Fern

Master's Theses (2009 -)

Objectives: The aim of this study was to compare fluid dynamics in complex root canal systems shaped with minimally invasive versus progressively tapered file systems using single and double side-vented irrigation tips at different flowrates. Methods: Two identical, plastic mandibular molars were instrumented with minimally invasive and progressive file systems and scanned via micro-computed tomography. A computational fluid dynamics model was generated and enhanced with accessory canals and isthmus in the distal and mesial roots, respectively. The model replicated irrigation within complex canal anatomy using both a single and double side-vented, 30-gauge irrigation tip at four flowrates: 0.05, 0.10, 0.15 …

Sleeveless Guides Are More Accurate Than Sleeved Guides: An In Vitro Study, Jenna Hang

Master's Theses (2009 -)

BACKGROUND: Esthetic and functional results of an implant and its final prosthesis depend largely on the accuracy of implant placement. Fully-guided surgeries have been proven to be more accurate than non-guided implant placement. Surgical guides with metal keys are often used during guided surgery, but add tolerance to the guides. Sleeveless guides may improve accuracy of implant placement. OBJECTIVE: This study aims to examine the difference between surgical guides with (S) and without sleeves (SL) in terms of trueness and precision. A secondary aim was to assess the impact of the distance of the guide to the implant platform. METHODS: …

Preemptive Analgesia And Pain After Periodontal And Implant- Related Procedures: A Systematic Review And Meta-Analysis, Christos Gousias

Master's Theses (2009 -)

Objective: The purpose of this systematic review and meta-analysis is to document the effect of preemptive analgesia on patient-reported pain following periodontal and implant-related surgical procedures. Methods: A comprehensive search of the literature was conducted in PubMed, Cochrane, and Web of Science (PROSPERO ID: CRD42023471166). Randomized placebo-controlled clinical trials on adults undergoing periodontal and implant-related surgeries were included. A meta-analysis was performed comparing pain data at postoperative hours 1, 3, 6, 8, 24 and 72 between pre-emptive medication versus placebo groups. Results: Two independent reviewers screened 1,044 titles and included 15 studies (open flap debridement 6/12; flap and osseous surgery …

In Vitro Comparison Of Cellular Cytoxicity Of Conventional Vs. Cad/Cam Denture Base Materials, Zainab Hill Albasry

Master's Theses (2009 -)

Aim: Adverse reactions and local irritation of the oral mucosa to prostheses constructed from PMMA include allergic response, erythema, and a burning sensation of the tongue and mucosal tissues. Evidence on the cytotoxic effects of digitally manufactured denture base materials remains scarce. The aim of this study was to evaluate and compare the cytotoxic effects of CAD/CAM fabricated denture bases versus conventionally heat-cured acrylic resin materials. Materials and Methods: In total, 75 disks of five different denture resin materials – 15 disks per group were prepared: Ivocap (group 1; control), Ivotion denture base (group 2), Lucitone 3D denture base (group …