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Articles 1 - 30 of 4486
Full-Text Articles in Medicine and Health Sciences
Relationship Between C-Reactive Protein/Albumin Ratio And Mucocutaneous Symptom Frequency And Disease Severity In Behçet’S Disease, Erdal Pala, Mustafa Bayraktar
Relationship Between C-Reactive Protein/Albumin Ratio And Mucocutaneous Symptom Frequency And Disease Severity In Behçet’S Disease, Erdal Pala, Mustafa Bayraktar
Turkish Journal of Medical Sciences
Background/aim: There is no specific marker that can be applied to determine the severity of Behçet’s disease. The aim of this study is to investigate the potential of C-reactive protein (CRP)/albumin (CAR) ratio as a tool for assessing the severity of Behçet’s disease.Materials and methods: A retrospective crosssectional study was conducted by examining hospital archives. The CRP and albumin levels of Behçet’s disease patients who presented to our dermatology clinic over a three-year period from February 2020 to February 2022 were included, along with the identical laboratory parameters in the control group. The CAR ratio was calculated and statistically compared …
The Outcome In Pediatric Acute Myeloblastic Leukemia; Results Of The First-Line Treatment And Contribution Of Hematopoietic Stem Cell Transplantation To Survival Of Relapsed Patients, Nazan Sarper, Intzi Tachzin, Sema Aylan Gelen, Emine Zengi̇n
The Outcome In Pediatric Acute Myeloblastic Leukemia; Results Of The First-Line Treatment And Contribution Of Hematopoietic Stem Cell Transplantation To Survival Of Relapsed Patients, Nazan Sarper, Intzi Tachzin, Sema Aylan Gelen, Emine Zengi̇n
Turkish Journal of Medical Sciences
Background/aim: To analyze the long-term outcome of pediatric patients with acute myeloblastic leukemia.Materials and methods: Data from 69 patients 0–18 years of age diagnosed between December 2001 and October 2019 were analyzed in April 2023. Patients received MRC-AML10 chemotherapy (2ADE+MACE+MidAC). No maintenance chemotherapy or preventive cranial radiotherapy was administered. Twelve patients with Down syndrome and 15 patients with promyelocytic leukemia were in the cohort. Patients with Down syndrome received reduced chemotherapy (cumulative anthracycline 420 mg/m2, cytarabine 3.4 g/m2, etoposide 1400 mg/m2). ATRA was added to chemotherapy in promyelocytic leukemia.Results: Four patients (5.8%) died in the induction (two typhlitis, one intracranial …
Evaluation Of Smoking Cessation Counseling Practices Of Physicians Working In Primary Health Care Institutions, Fatma Nur Karaçorlu, Edibe Pi̇ri̇nçci̇
Evaluation Of Smoking Cessation Counseling Practices Of Physicians Working In Primary Health Care Institutions, Fatma Nur Karaçorlu, Edibe Pi̇ri̇nçci̇
Turkish Journal of Medical Sciences
Background/aim: In this study, we aimed to evaluate the self-reported practice of physicians working in primary health care institutions in Elazığ Province about smoking cessation counseling.Materials and methods: The population of this cross-sectional study consisted of 262 physicians working in primary health care institutions in Elazığ. We aimed to reach the entire population without using the sample selection method and we successfully reached 95.42% (250 people) of the population. A questionnaire form was used for data collection. The data obtained were evaluated by frequency, percentage, mean ± standard deviation, median and minimum–maximum, and binary logistic regression analysis.Results: The mean age …
Internal Mucosal Resection And Llc Suspension: A New Method To Establish A Stable Tip Rotation Angle And Reduce The Nasal Bridge Length, Mehmet Dadaci, Moath Zuhour, Bilsev İnce, Zeynep Altuntaş
Internal Mucosal Resection And Llc Suspension: A New Method To Establish A Stable Tip Rotation Angle And Reduce The Nasal Bridge Length, Mehmet Dadaci, Moath Zuhour, Bilsev İnce, Zeynep Altuntaş
Turkish Journal of Medical Sciences
Background/aim: Herein, we describe a new technique to obtain both the appropriate degree of rotation angle and the ideal nasal bridge length. The aim of this study is to investigate the long-term results of this new technique with regard to these two variables.Materials and methods: A total of 76 (27 males, 49 females) patients were operated in accordance with the presented technique. Internal caudal mucosal excision and lower lateral cartilage (LLC) suspension were applied to all the patients included in this prospective study. Preoperative, immediate postoperative, and postoperative 1st-year photographs were taken. NOSE scores were obtained in the postoperative 1st …
Displaced Sigmoid Notch Fracture And Higher Patient Age Are Associated With Distal Radioulnar Joint Subluxation, Saygın Kamaci, Melih Oral, Engin Türkay Yilmaz, Taha Aksoy, Barış Kafa, Mazhar Tokgözoğlu
Displaced Sigmoid Notch Fracture And Higher Patient Age Are Associated With Distal Radioulnar Joint Subluxation, Saygın Kamaci, Melih Oral, Engin Türkay Yilmaz, Taha Aksoy, Barış Kafa, Mazhar Tokgözoğlu
Turkish Journal of Medical Sciences
Background/aim : Distal radius fractures (DRFs) are frequently associated with distal radioulnar joint (DRUJ) instability. The purpose of this study is to evaluate the effect of the sigmoid notch and ulna styloid fracture types on DRUJ subluxation following closed reduction and casting of DRFs via calculating radioulnar ratio (RUR) on post-reduction computed tomography (CT) images. Materials and methods: In our study, post-reduction CT images of 202 patients with distal radius fractures was evaluated retrospectively. CT images were evaluated for RUR, sigmoid notch fracture, and ulna styloid types. Sigmoid notch fractures were classified as non-displaced in the sigmoid notch fractures (NDS) …
Clinical, Radiological, And Surgical Outcomes Of 431 Patients With Adrenal Incidentalomas: Retrospective Study Of A 10-Year Single-Center Experience, Nari̇n Nasiroğlu İmga, Yılmaz Aslan, Merve Çatak, İbrahim Can Aykanat, Altuğ Tuncel, Dilek Berker
Clinical, Radiological, And Surgical Outcomes Of 431 Patients With Adrenal Incidentalomas: Retrospective Study Of A 10-Year Single-Center Experience, Nari̇n Nasiroğlu İmga, Yılmaz Aslan, Merve Çatak, İbrahim Can Aykanat, Altuğ Tuncel, Dilek Berker
Turkish Journal of Medical Sciences
Background/aim: The incidence of adrenal tumors is increasing due to the widespread utilization of radiographic imaging techniques. Factors such as tumor size, radiological characteristics, and functionality of adrenal adenomas play crucial roles in diagnosis and subsequent management. In this retrospective study, we investigated the clinical, radiological, and surgical features of patients with adrenal incidentalomas (AIs) and evaluated their follow-up results.Materials and methods: We analyzed data from 431 patients diagnosed with AIs (130 males, 301 females) who underwent adrenal hormone evaluation at our center. We compared nonfunctioning and functioning AIs in terms of radiological features. We also compared baseline and follow-up …
Serum And Urine Interferon-Inducible Protein 10, Galectin-9, And Siglec-1 As Biomarkers Of Disease Activity In Systemic Lupus Erythematosus, Şafak Mi̇ri̇oğlu, Suzan Çinar, Ömer Uludağ, Erdem Gürel, Sibel Varelci̇, Yasemin Özlük, Işın Kiliçaslan, Yasemin Yalçinkaya, Halil Yazici, Ahmet Gül, Murat İnanç, Bahar Artim Esen
Serum And Urine Interferon-Inducible Protein 10, Galectin-9, And Siglec-1 As Biomarkers Of Disease Activity In Systemic Lupus Erythematosus, Şafak Mi̇ri̇oğlu, Suzan Çinar, Ömer Uludağ, Erdem Gürel, Sibel Varelci̇, Yasemin Özlük, Işın Kiliçaslan, Yasemin Yalçinkaya, Halil Yazici, Ahmet Gül, Murat İnanç, Bahar Artim Esen
Turkish Journal of Medical Sciences
Background/aim: In this prospective study, we aimed to investigate the association of serum (s) and urine (u) IP-10, galectin-9, and SIGLEC-1 with disease activity in patients with systemic lupus erythematosus (SLE).Materials and methods: Sixty-three patients with active SLE (31 renal, 32 extrarenal) were included. Thirty patients with inactive SLE (15 renal, 15 extrarenal), 17 with renal active AAV, and 32 healthy volunteers were selected as control groups. Serum and urine IP-10, galectin-9, and SIGLEC-1 were tested using ELISA.Results: Levels of sIP-10 (p = 0.046), uIP-10 (p < 0.001), sGalectin-9 (p = 0.03), and uSIGLEC-1 (p = 0.006) were significantly higher in active SLE group compared to the inactive SLE; however, no differences were detected in the comparison of uGalectin-9 (p = 0.18) and sSIGLEC-1 (p = 0.69) between two groups. None of the biomarkers discriminated patients with active renal SLE from active extrarenal SLE. ROC analyses revealed an AUC of 0.63 (0.52–0.73) for sIP-10, 0.78 (0.68–0.86) for uIP-10, 0.64 (0.53–0.74) for sGalectin-9, and 0.68 (0.57–0.77) for uSIGLEC-1 in discriminating disease activity in SLE, which did not outperform C3 (0.75, 0.64–0.84) and C4 (0.72, 0.61–0.82). sIP-10 (p = 0.001), uIP-10 (p = 0.042), and uGalectin-9 (p = 0.009) were significantly increased in patients with active renal SLE compared to active renal AAV. sGalectin-9 (p < 0.001) and sIP-10 levels (p = 0.06) were decreased after 8 (5–22.5) months of treatment.Conclusion: sIP-10, uIP-10, sGalectin-9, and uSIGLEC-1 reflect global disease activity in SLE but do not outperform C3 and C4. sIP-10 and uIP-10 may be specific for active SLE compared to active AAV. sIP-10 and sGalectin-9 might be valuable in monitoring response after treatment.
Antiobesity And Antidyslipidemic Properties Of Clitoria Ternatea Petals Aqueous Extract Against Rats Induced By High-Fat Diet, I Gede Aswin Parisya Sasmana, Desak Made Wihandani, I Gede Krisna Arim Sadeva, Wilson Halim, Putu Putri Agustini, Lalita Samala, I Gusti Ngurah Agung Surya Pratama, Lidiya Nuraliza Rachmawati, Aizar Vesa Prasetyo, Ni Komang Ayu Amanda Setiari Jaya
Antiobesity And Antidyslipidemic Properties Of Clitoria Ternatea Petals Aqueous Extract Against Rats Induced By High-Fat Diet, I Gede Aswin Parisya Sasmana, Desak Made Wihandani, I Gede Krisna Arim Sadeva, Wilson Halim, Putu Putri Agustini, Lalita Samala, I Gusti Ngurah Agung Surya Pratama, Lidiya Nuraliza Rachmawati, Aizar Vesa Prasetyo, Ni Komang Ayu Amanda Setiari Jaya
Turkish Journal of Medical Sciences
Background/aim: Obesity is a chronic metabolic disease involving dysregulation of fat metabolism that affects 13% of the world’s population. Obesity has been linked to dyslipidemia with a lot of complication, including stroke, chronic kidney disease, fatty liver disease, and so on. One of the natural resources that have several potential effects including anticholesterol, antiobesity, and antidyslipidemia is the butterfly pea (Clitoria ternatea/CT). CT’s petal has been found to contain high levels of anthocyanins and tannins that can inhibit the biosynthesis of cholesterol and lipid. This study aims to investigate the antiobesity and antidyslipidemic effects of Clitoria ternatea extract (CTE).Materials and …
Small Airway Resistance In Obese And Nonobese Patients With Obstructive Sleep Apnea Syndrome Using Impulse Oscillometry, Nejdiye Güngördü, Aytan İsmayi̇lova, Nigar Ali̇yeva, Tamer A M Alhelou, Ayşenur Özdi̇l Eser, Ilgım Vardaloğlu Koyuncu, Nihal Enşen, Ersan Atahan, Şermin Börekçi̇, Bilun Gemi̇ci̇oğlu
Small Airway Resistance In Obese And Nonobese Patients With Obstructive Sleep Apnea Syndrome Using Impulse Oscillometry, Nejdiye Güngördü, Aytan İsmayi̇lova, Nigar Ali̇yeva, Tamer A M Alhelou, Ayşenur Özdi̇l Eser, Ilgım Vardaloğlu Koyuncu, Nihal Enşen, Ersan Atahan, Şermin Börekçi̇, Bilun Gemi̇ci̇oğlu
Turkish Journal of Medical Sciences
Background/aim: There is limited information on the pathologic changes in the small airways among obese and nonobese patients with obstructive sleep apnea syndrome (OSAS). Impulse oscillometry (IOS) measures airway resistance and reactance independently of patient effort. This study aimed to compare airway resistance in small airways using IOS between obese and nonobese patients with OSAS.Materials and methods: In this real-life cross-sectional study, demographic information was collected from obese and nonobese subjects diagnosed with moderate and severe OSAS without any other underlying diseases. Spirometry and IOS measurements were conducted, and the values of both groups were statistically analyzed.Results: The nonobese group …
Developing Patient Safety Scale For Hospitals, Metin Di̇nçer, Esra Karataş Okyay, Yunus Emre Karataş, Erol Göral
Developing Patient Safety Scale For Hospitals, Metin Di̇nçer, Esra Karataş Okyay, Yunus Emre Karataş, Erol Göral
Turkish Journal of Medical Sciences
Background/aim: The study aimed to contribute to the literature with a reliable and valid scale for hospitals to be used in determining the current patient safety culture and following up on its development.Materials and methods: The study was conducted with the participation of 1137 healthcare professionals selected using the convenience sampling method in 3 secondary-care state hospitals and three research and training hospitals, one of which was affiliated with a medical faculty, and two were affiliated with the Health Sciences University. To begin with, to discover the latent structure of the items on the scale, an Exploratory Factor Analysis (EFA) …
Preoperative Parent Education And Postoperative Nurse-Led Care For Boys Versus Routine Hospital Care For Urethroplasty For Hypospadias In Western China: A Retrospective Study, Lisi Wang, Zhengdong Wang, Xiaohui Mao, Yingjun Fu, Qian Lei, Qin Liao
Preoperative Parent Education And Postoperative Nurse-Led Care For Boys Versus Routine Hospital Care For Urethroplasty For Hypospadias In Western China: A Retrospective Study, Lisi Wang, Zhengdong Wang, Xiaohui Mao, Yingjun Fu, Qian Lei, Qin Liao
Turkish Journal of Medical Sciences
Background/aim: Urethroplasty is the preferred treatment for hypospadias but is affected by the severity of anomalies, making it a complex procedure with potential postoperative complications. Following surgery, parents receive instructions and recommendations, whether from nurses or physicians, regardless of complication rates. However, nurses play a crucial role in educating caregivers before surgery and providing postoperative care during follow-up. The study aims to assess parents’ knowledge and practices, as well as the frequency of complications in boys who underwent urethroplasty for hypospadias and received postoperative nurse-led care and whose parents received preoperative education against those of boys who underwent urethroplasty under …
The Effect Of Human Recombinant Epidermal Growth Factor On Neovascularization And Pedicle Division Time In A Rat Interpolation Flap Model, Aziz Parspanci, Yavuz Keçeci̇, Peyker Temi̇z
The Effect Of Human Recombinant Epidermal Growth Factor On Neovascularization And Pedicle Division Time In A Rat Interpolation Flap Model, Aziz Parspanci, Yavuz Keçeci̇, Peyker Temi̇z
Turkish Journal of Medical Sciences
Background/aim: In practice, waiting 2–3 weeks for interpolation flaps pedicle division result in certain morbidities and discomfort for patient. The division time of flap pedicle depends on neovascularization from the recipient bed and includes wound healing stages. We aimed to investigate the effect of recombinant human epidermal growth factor (rhEGF) on the flap viability during early pedicle division.Materials and methods: Thirty-six rats were allocated to two main groups as control and study. A cranial based flap measuring 5 × 5 cm was elevated from the back, including all layers of the skin. While the cranial half of the defect was …
Determination Of The Embryotoxic Effects Of Propofol Injected Into Eggs On The Cerebellum And Spinal Cord Using Histologic Methods: An Animal Study, Murat İzgi̇, Emrah Sur
Determination Of The Embryotoxic Effects Of Propofol Injected Into Eggs On The Cerebellum And Spinal Cord Using Histologic Methods: An Animal Study, Murat İzgi̇, Emrah Sur
Turkish Journal of Medical Sciences
This study aims to determine the possible embryotoxic effects of propofol on the cerebellum and spinal cord using fertile chicken eggs. Materials and methods: A total of 430 fertile eggs were divided into 5 groups: control, saline, 2.5 mg.kg–1, 12.5 mg.kg–1, and 37.5 mg.kg–1 propofol. Injections were made immediately before incubation via the air chamber. On the 15th, 18th, and 21st day of incubation, 6 embryos from each group were evaluated. Serial paraffin sections taken from the cerebellum and spinal cord were stained with hematoxylin–eosin, Kluver–Barrera, toluidine blue, and periodic acid-Schiff ’s reaction. The outer granular layer and total cortex …
Tracking The Footsteps Of Burkholderia Mallei: Determination Of The Molecular Differences And Potential Resistance Genes, Dilek Dülger, Seda Eki̇ci̇, Mehmet Demi̇rci̇, Akın Yi̇ği̇n, Orkun Babacan
Tracking The Footsteps Of Burkholderia Mallei: Determination Of The Molecular Differences And Potential Resistance Genes, Dilek Dülger, Seda Eki̇ci̇, Mehmet Demi̇rci̇, Akın Yi̇ği̇n, Orkun Babacan
Turkish Journal of Medical Sciences
Chemical biological radiological nuclear threats are at an important point in the agenda of world health today, as theycan cause mass deaths. B. mallei attracts attention as a potential biological warfare agent due to its features such as multidrug resistance,a rapid transmission mechanism via aerosol, the absence of a complete treatment protocol for the infection it causes, and the absence ofan approved vaccine for protection against the bacteria. B. mallei suspect samples must be studied by experienced personnel in biosafetylevel III laboratories. B mallei is a difficult and troublesome pathogen to diagnose and many unknowns about B. mallei today. Therefore,the …
The Potential Mechanism Of Treating Ic/Bps With Hyperbaric Oxygen By Reducing Vascular Endothelial Growth Inhibitor And Hypoxia-Inducible Factor-1Α, Jing Zhang, Jiarui Kang, Liyang Wu
The Potential Mechanism Of Treating Ic/Bps With Hyperbaric Oxygen By Reducing Vascular Endothelial Growth Inhibitor And Hypoxia-Inducible Factor-1Α, Jing Zhang, Jiarui Kang, Liyang Wu
Turkish Journal of Medical Sciences
To investigate the roles of vascular endothelial growth inhibitor (VEGI) and hypoxia-inducible factor-1α (HIF-1α) in the treatment of refractory interstitial cystitis/bladder pain syndrome (IC/BPS) with hyperbaric oxygen (HBO).Materials and methods: A total of 38 patients were included. They were assessed before and 6 months after HBO treatment. Three- day voiding diaries were recorded, and O’leary-Sant scores, visual analog scale (VAS) scores, quality of life (QoL) scores, pelvic pain, and urgency/frequency (PUF) scores were evaluated. Bladder capacity was assessed by cystoscopy. Bladder mucosa was collected for Western blot, qRT-PCR, and immunofluorescence staining to compare the expression of VEGI and HIF-1α before …
Leaky Gut And Inflammatory Biomarkers In A Medication Overuse Headache Model In Male Rats, Doğa Vuralli, Hale Gök Dağidir, Elif Abbasoğlu Topa, Hayrunnisa Bolay Belen
Leaky Gut And Inflammatory Biomarkers In A Medication Overuse Headache Model In Male Rats, Doğa Vuralli, Hale Gök Dağidir, Elif Abbasoğlu Topa, Hayrunnisa Bolay Belen
Turkish Journal of Medical Sciences
Medication overuse is common among chronic migraine patients and nonsteroidal antiinflammatory drugs (NSAIDs)are the most frequently overused drugs. The pathophysiological mechanisms underlying medication overuse headache (MOH) are notcompletely understood. Intestinal hyperpermeability and leaky gut are reported in patients using NSAIDs. The aim of the study is toinvestigate the role of leaky gut and inflammation in an MOH model MOH model in male rats.Methods: The study was conducted in male Sprague Dawley rats. There were two experimental groups. The first group was the chronicNSAID group in which the rats received mefenamic acid (n = 8) for four weeks intraperitoneally (ip) and …
Evaluation Of Eye And Serum Findings In Different Waters In Rabbits By Drowning And Submersion Modeling, Aziz Yilmaz, Erdem Hösükler, Abdulgani Kaymaz, Ahmet Yücel Üçgül, Zehra Zerrin Erkol
Evaluation Of Eye And Serum Findings In Different Waters In Rabbits By Drowning And Submersion Modeling, Aziz Yilmaz, Erdem Hösükler, Abdulgani Kaymaz, Ahmet Yücel Üçgül, Zehra Zerrin Erkol
Turkish Journal of Medical Sciences
This study investigated serum, vitreous, and anterior chamber fluid electrolyte changes, corneal thickness (CT),corneal volume (CV), anterior chamber volume (ACV), and anterior chamber depth (ACD) as an auxiliary diagnostic method in theidentification of drowning in fresh or salt water.Materials and methods: The study used 35 healthy, adult, male, white New Zealand rabbits, seperated into five groups (control, saltwaterdrowning (SWD), saltwater immersion (SWI), freshwater drowning (FWD), freshwater immersion (FWI)). CT, CV, ACV, and ACDmeasurements were made with Pentacam topography at 0, 2, and 4 h in all groups. Magnesium (mg), sodium (Na), and chlorine (Cl)were measured in the blood at 0 …
Effect Of Humic Acid On Oxidative Stress And Neuroprotection In Traumatic Spinal Cord Injury: An Experimental Study, Burak Kinali, Nail Özdemi̇r, Ali Karadağ, Özge Kaya Korkmaz, Ayşe Gülden Di̇ni̇z, Fatma Demet Arslan
Effect Of Humic Acid On Oxidative Stress And Neuroprotection In Traumatic Spinal Cord Injury: An Experimental Study, Burak Kinali, Nail Özdemi̇r, Ali Karadağ, Özge Kaya Korkmaz, Ayşe Gülden Di̇ni̇z, Fatma Demet Arslan
Turkish Journal of Medical Sciences
Traumatic spinal cord injury (TSCI) is an important health problem, especially in developing countries withadditional socioeconomic loss. Humic acid (HA) usually has antioxidant, antiinflammatory, blood circulating, and antiviral effects.Hence, it was aimed herein to show the effect of HA on neuroprotection in a TSCI model.Materials and method: A TSCI model was used, in which 24 Wistar albino rats were divided into 4 groups: control group: subjectedto only laminectomy; sham group: subjected to laminectomy + TSCI; HA 5 mg/kg group: subjected to laminectomy + TSCI +intraperitoneal (IP) injection of 5 mg/kg of HA; and HA 10 mg/kg group: subjected to laminectomy …
Effects Of Glutamine And Omega-3 Fatty Acids On Intestinal Neomucosa Formation On Colon Serosa In Rats, Mehmet Köstek, Uygar Demi̇r, Ramazan Uçak, Burak Yasin Avci, Aydın Ünal, Osman Bilgin Gülçi̇çek, Ozan Çalişkan, Bülent Çi̇tgez, Erdinç Seri̇n, Sıtkı Gürkan Yetki̇n, Mehmet Mi̇hmanli, Mehmet Uludağ
Effects Of Glutamine And Omega-3 Fatty Acids On Intestinal Neomucosa Formation On Colon Serosa In Rats, Mehmet Köstek, Uygar Demi̇r, Ramazan Uçak, Burak Yasin Avci, Aydın Ünal, Osman Bilgin Gülçi̇çek, Ozan Çalişkan, Bülent Çi̇tgez, Erdinç Seri̇n, Sıtkı Gürkan Yetki̇n, Mehmet Mi̇hmanli, Mehmet Uludağ
Turkish Journal of Medical Sciences
Intestinal neomucosa formation is a technique defined for the treatment of short bowel syndrome. This study evaluates the effect of glutamine and omega-3 fatty acids on the growth of intestinal neomucosa on the colonic serosal surface has been evaluated.Materials and methods: Thirty-two adult male Sprague-Dawley rats were randomly divided into 4 groups: sham, control, glutamine, and omega-3. Laparotomy was performed on all groups. For rats other than the sham group, a 1-cm full-thickness incision was made 4 cm proximal to the ileocecal valve, and colonic serosal surface was sutured as a serosal patch over these openings. By using the oral …
Evaluation Of Baseline F-18 Fdg Positron Emission Tomography In The Diagnosis And Assessment Of Giant Cell Arteritis, Burak İnce, Emine Göknur Işik, Zeynep Gözde Özkan, Yasemin Yalçinkaya, Bahar Artım Esen, Ahmet Gül, Murat İnanç
Evaluation Of Baseline F-18 Fdg Positron Emission Tomography In The Diagnosis And Assessment Of Giant Cell Arteritis, Burak İnce, Emine Göknur Işik, Zeynep Gözde Özkan, Yasemin Yalçinkaya, Bahar Artım Esen, Ahmet Gül, Murat İnanç
Turkish Journal of Medical Sciences
The aim of this study is to evaluate the baseline F18-FDG PET/CT findings of individuals diagnosed with giant cellarteritis (GCA) and to explore its association with clinical findings and classification criteria.Materials and methods: We analysed data from patients who underwent F18-FDG PET/CT scans to investigate large vessel (LV)involvement between 2010 and 2019. Only patients with a clinical diagnosis of GCA and at least 6 months of follow-up were included.We compared initial clinical features and laboratory findings based on the presence of LV vasculitis on PET/CT and the maximumstandard uptake value (SUVmax) of vascular territories.Results: Twenty-nine patients (median age at diagnosis: …
Clinical Characteristics And Disease Course Before And After Sars-Cov-2 Infection In A Large Cohort Of Systemic Sclerosis Patients, Aslıhan Avanoğlu Güler, Büşra Özçi̇men, Mesude Seda Aydoğdu, Alper Sari, Aliyeva Numune, Nazife Tüzün Ersan, Seda Çolak, Hazan Karadeni̇z, İbrahim Vasi̇, Hamit Küçük, Yasemin Yalçinkaya, Abdulsamet Erden, Mehmet Kayaalp, Mehmet Akif Öztürk, Berna Göker, Ahmet Omma, Sedat Yilmaz, Süleyman Serdar Koca, Murat İnanç, Ali Akdoğan, Abdurrahman Tufan
Clinical Characteristics And Disease Course Before And After Sars-Cov-2 Infection In A Large Cohort Of Systemic Sclerosis Patients, Aslıhan Avanoğlu Güler, Büşra Özçi̇men, Mesude Seda Aydoğdu, Alper Sari, Aliyeva Numune, Nazife Tüzün Ersan, Seda Çolak, Hazan Karadeni̇z, İbrahim Vasi̇, Hamit Küçük, Yasemin Yalçinkaya, Abdulsamet Erden, Mehmet Kayaalp, Mehmet Akif Öztürk, Berna Göker, Ahmet Omma, Sedat Yilmaz, Süleyman Serdar Koca, Murat İnanç, Ali Akdoğan, Abdurrahman Tufan
Turkish Journal of Medical Sciences
The objective of this study is to evaluate the clinical presentations and adverse outcomes of Coronavirus Disease 2019 (COVID-19) in patients with systemic sclerosis (SSc) and assess the impact of SSc features on the clinical course of COVID-19.Materials and methods: In this multicenter, retrospective study, SSc patients with COVID-19 were included. Clinical features of SSc, along with detailed COVID-19 data, were extracted from medical records and patient interviews.Results: The study included 112 patients (mean age 51.4 ± 12.8 years; 90.2% female). SSc-associated interstitial lung disease (ILD) was evident in 57.1% of the patients. The findings revealed hospitalization in 25.5%, respiratory …
A Retrospective Study On The Clinical And Molecular Outcomes Of Calpainopathy In A Turkish Patient Cohort, İzem Olcay Şahi̇n, Emine Karataş, Mikail Demi̇r, Büşra Tan, Hüseyin Per, Yusuf Özkul, Munis Dündar
A Retrospective Study On The Clinical And Molecular Outcomes Of Calpainopathy In A Turkish Patient Cohort, İzem Olcay Şahi̇n, Emine Karataş, Mikail Demi̇r, Büşra Tan, Hüseyin Per, Yusuf Özkul, Munis Dündar
Turkish Journal of Medical Sciences
Calpainopathy, also known as limb-girdle muscular dystrophy recessive type 1, is a progressive muscle disorder that impacts the muscles around the hips and shoulders. The disease is caused by defects in the CAPN3 gene and can be inherited in both recessive and dominant forms. In this retrospective study, we aimed to evaluate the clinical and molecular results of our patients with calpainopathy and to examine the CAPN3 variants in Turkish and global populations.Materials and methods: Molecular analyses were performed using the next-generation sequencing (NGS) method. CAPN3 variants were identified through the examination of various databases.Results: In this retrospective study, the …
The Effects Of On-Pump And Off-Pump Coronary Artery Bypass Surgery On Oxidative Stress And Cerebral Oxygenation: A Prospective Observational Study, Ökkeş Hakan Mi̇ni̇ksar, Sameh Alagha, Ferit Çi̇çekçi̇oğlu, Mehtap Honca, Ayşe Yeşim Göçmen
The Effects Of On-Pump And Off-Pump Coronary Artery Bypass Surgery On Oxidative Stress And Cerebral Oxygenation: A Prospective Observational Study, Ökkeş Hakan Mi̇ni̇ksar, Sameh Alagha, Ferit Çi̇çekçi̇oğlu, Mehtap Honca, Ayşe Yeşim Göçmen
Turkish Journal of Medical Sciences
In this prospective observational study, our goal was to investigate the relationship between serum levels of oxidative stress (OS) parameters and regional cerebral oxygen saturation (rSO2) in addition to evaluating postoperative clinical outcomes among patients undergoing coronary artery bypass graft surgery (CABG).Materials and methods: This study comprised 64 adult patients undergoing elective CABG (on-pump [n = 48] and off-pump [n = 16]) procedures. Serum OS levels and rSO2 values were measured intraoperatively at three specific time points: T1 (after induction), T2 (15 min before aortic cross-clamp removal or the final distal anastomosis), and T3 (15 min after aortic cross-clamp removal …
Does The Pleth Variability Index Have Any Predictive Value For Intraoperative Respiratory Problems In Bariatric Surgery?, Esra Özayar, Mehmet Şahap, Handan Güleç, Aysun Kurtay, Adem Selvi̇, Hakan Buluş, Özlem Ari
Does The Pleth Variability Index Have Any Predictive Value For Intraoperative Respiratory Problems In Bariatric Surgery?, Esra Özayar, Mehmet Şahap, Handan Güleç, Aysun Kurtay, Adem Selvi̇, Hakan Buluş, Özlem Ari
Turkish Journal of Medical Sciences
We aimed to search the relationship between the preoperative PVI (pleth variability index) and intraoperative respiratory parameters to reveal whether PVI can be used as a prediction tool in bariatric surgery.Materials and methods: Forty patients undergoing bariatric surgery were included. Noninvasive pleth variability index measured via finger probe before induction of general anesthesia. Following intubation each patient was ventilated in controlled mode. Intraoperative blood pressure, peak airway pressure, end-tidal CO2, SpO2, PEEP, and FiO2 were recorded every 5 min for the first 10 min and then every 10 min until extubation. Steroid and bronchodilator requirements were recorded.Results: The systolic pressure-PVI, …
The Effect Of Erector Spinae Plane Block On Postoperative Extubation Time And Laboratory Parameters In Open Heart Surgery: A Retrospective Study, Feyza Çalişir, Yavuz Orak, Ömer Faruk Boran, Metin Ege, Mehmet Emin Karabeki̇roğlu, Hilal Bi̇radli, Adem Doğaner
The Effect Of Erector Spinae Plane Block On Postoperative Extubation Time And Laboratory Parameters In Open Heart Surgery: A Retrospective Study, Feyza Çalişir, Yavuz Orak, Ömer Faruk Boran, Metin Ege, Mehmet Emin Karabeki̇roğlu, Hilal Bi̇radli, Adem Doğaner
Turkish Journal of Medical Sciences
In open heart surgery, sternotomy causes inflammation in tissues, and inflammation causes postoperative pain. This study aims to examine the effects of bilateral erector spinae plane (ESP) blocks on postoperative extubation time and laboratory parameters in open heart surgery.Materials and methods: The study was managed using retrospective data from 85 patients who underwent open-heart surgery. Patients who received intravenous analgesia and were transferred to the intensive care unit with intubation were included in the study. Two groups were formed: those who received preoperative bilateral ESP block (ESB) and those nonblock (NB). Statistical significance was investigated between ESB and NB in …
Survival Benefit Of Resin Cartridge Extracorporeal Blood Purification Therapy In Patients With Septic Shock, Serdar Efe, Pervin Hanci, Volkan İnal
Survival Benefit Of Resin Cartridge Extracorporeal Blood Purification Therapy In Patients With Septic Shock, Serdar Efe, Pervin Hanci, Volkan İnal
Turkish Journal of Medical Sciences
Extracorporeal blood purification (EBP) therapies have shown promise as potential rescue treatments for patientswith septic shock. However, precise evidence regarding their effectiveness is lacking. This case-control study aimed to evaluate the 28-day survival benefit of a resin cartridge-based EBP therapy compared to conventional therapies in patients with septic shock.Materials and methods: The study sample was collected retrospectively from the medical records of patients admitted to the intensivecare unit (ICU) between 2015 and 2020. The study included patients with septic shock aged ≥18 years who had ICU stays >96 h andexcluded those lost to follow-up by 28 days or readmitted. First, …
Reliability And Validity Of New Isokinetic Strength Assessment For Rotator Cuff Muscles In A Muscle Architecture-Based Position, Çağlar Soylu, Mustafa Ertuğrul Yaşa, Pervin Demi̇r, Ahmet Mustafa Ada, Tüzün Firat, Necmiye Ün Yildirim
Reliability And Validity Of New Isokinetic Strength Assessment For Rotator Cuff Muscles In A Muscle Architecture-Based Position, Çağlar Soylu, Mustafa Ertuğrul Yaşa, Pervin Demi̇r, Ahmet Mustafa Ada, Tüzün Firat, Necmiye Ün Yildirim
Turkish Journal of Medical Sciences
Isokinetic strength assessment of the rotator cuff muscle is frequently applied in a variety of shoulder postures, butnone of these consider muscular architecture, which is one of the most important aspects of improving strength development. This studyaimed to examine the test and retest reliability and validity of the muscle architecture-based position (MABP), which is 25° abductionand 20° external rotation, in healthy subjects to be able to select a better isokinetic assessment position for shoulder rotator cuff muscles.Materials and methods: A total of 54 healthy males with a mean age of 21.0 ± 1.2 years and mean body mass index of …
Acute Responses Of Strength-Related Gene Expressions To Maximum Strength And Force Sense Acuity, Muammer Altun, Erdal Balcan, Sevinç Batir, Mehmet Hilmi Gökmen, Şule Özgüneş, Zübeyde Öztel
Acute Responses Of Strength-Related Gene Expressions To Maximum Strength And Force Sense Acuity, Muammer Altun, Erdal Balcan, Sevinç Batir, Mehmet Hilmi Gökmen, Şule Özgüneş, Zübeyde Öztel
Turkish Journal of Medical Sciences
Although high muscle strength worsens the sense of force, it is unknown whether there is a relationship betweenthis deterioration and the underlying molecular mechanisms. This study examined the relationship between decreased force sense (FS)acuity and strength-related gene expressions.Materials and methods: Maximal voluntary isometric contraction (MVIC) and FS (50% MVIC) tests were performed on the kneejoints of twenty-two subjects. The expression analyses were evaluated by qRT-PCR in blood samples taken before, after MVIC, after 50%MVIC, and 15 min after the test.Results: MVIC and FS error values were significantly correlated with each other (r = .659, p = .001). The qRT-PCR analyses …
Rehabilitation Therapy Versus Drug-Only Therapy In Patients With Multiple Sclerosis, Florin Mihai Marcu, Doriana Ciobanu, Ioan Cosmin Boca, Elena Sirbu, Paul Alexandru Deme, Nicolae Catalin Hreniuc, Dorina Ianc
Rehabilitation Therapy Versus Drug-Only Therapy In Patients With Multiple Sclerosis, Florin Mihai Marcu, Doriana Ciobanu, Ioan Cosmin Boca, Elena Sirbu, Paul Alexandru Deme, Nicolae Catalin Hreniuc, Dorina Ianc
Turkish Journal of Medical Sciences
The treatment for multiple sclerosis (MS) does not cure the disease, but it is intended to reduce the intensity, duration, and frequency of symptoms. Rehabilitation therapy (RT), including an individualized physical therapy program (PTP) and adapted occupational therapy (OT), has benefits in terms of aerobic capacity, muscle strength, coordination, and ability to perform activities of daily living (ADL). The primary objective of this study was to examine the efficacy of RT comprising PTP, OT, and drug treatment (DT) versus DT alone in patients with MS. Another objective was to highlight the importance of continuing the PT and OT at home, …
The Effect Of Video-Assisted Training On Upper Extremity Problems And Functions After Rotator Cuff Repair: A Randomized Controlled Trial, Canan Kanat, Gülay Altun Uğraş, Recep Ünal, Servet Can Dönmez, Bahar Taşdelen, Fehmi Volkan Öztuna
The Effect Of Video-Assisted Training On Upper Extremity Problems And Functions After Rotator Cuff Repair: A Randomized Controlled Trial, Canan Kanat, Gülay Altun Uğraş, Recep Ünal, Servet Can Dönmez, Bahar Taşdelen, Fehmi Volkan Öztuna
Turkish Journal of Medical Sciences
The shoulder is the most mobile joint in the body, and is frequently exposed to injuries. The applied surgical treatments, protection of the shoulder after surgery, care in the use of the shoulder in activities of daily living (ADLs) and gradual exercise programs are all vital to the recovery process. The present study investigates the effect of video-assisted training (VAT) on upper extremity complications and functions after rotator cuff repair (RCR).Materials and method: Included in this prospective, parallel two-armed, randomized controlled study were an experimental group (n: 24) that received VAT detailing early postoperative care for RCR and instructions on …