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Articles 1 - 30 of 73
Full-Text Articles in Medicine and Health Sciences
Measurement Of Urine Albumin Levels With A Monoclonal Antibody Based In-House Elisa, Cemaletti̇n Aybay, Resul Karakuş
Measurement Of Urine Albumin Levels With A Monoclonal Antibody Based In-House Elisa, Cemaletti̇n Aybay, Resul Karakuş
Turkish Journal of Medical Sciences
Microalbuminuria is considered to be an early indicator of diabetic nephropathy. We have previously reported the establishment of A-HAlb/98 hybridoma secreting monoclonal antibody that specifically recognizes human serum albumin (HSA). In this report, an in-house enzyme-linked immunosorbent assay (ELISA) was developed using this antibody for the measurement of urinary albumin (UA) and UA was examined in 24 different samples. A-HAlb/98 was used as the capture antibody by immobilizing onto microtitre plates in ELISA format. HSA-specific polyclonal rabbit immunoglobulin was labelled with biotin and then used as the tracer antibody. The dynamic assay range of ELISA for albumin was established to …
Antimicrobial Activity And Characteristics Of Bacteriocins Produced By Vaginal Lactobacilli, Şengül Alpay Karaoğlu, Faruk Aydi̇n, S. Sirri Kiliç, Ali̇ O. Kiliç
Antimicrobial Activity And Characteristics Of Bacteriocins Produced By Vaginal Lactobacilli, Şengül Alpay Karaoğlu, Faruk Aydi̇n, S. Sirri Kiliç, Ali̇ O. Kiliç
Turkish Journal of Medical Sciences
The aim of this study is to test the production of bacteriocin in vaginal Lactobacilli and determining the characterization and antibacterial activity of this bacteriocin. For this reason 100 Lactobacillus strains were isolated and identified from vaginal swab samples of 75 women who attended obstetric and gynecology clinics. It was determined that six of 100 Lactobacillus strains produced bacteriocin. The antibacterial activity of bacteriocins was examined and found to be effective on vaginal L. gasseri, L. acidophilus, Gardnerella vaginalis ATCC 14018 and Pseudomonas aeroginosa ATCC 10145. We also found that bacteriocins were sensitive to proteinase enzymes and alkalinity, but resistant …
Diagnostic Value Of Ki-67li In Hepatocellular Carcinoma Ki-67 Antigen Expression In Hepatocellular Carcinoma, Metastatic Adenocarcinoma And Normal Hepatocytes, Işin Soyuer, Cemi̇l Eki̇nci̇, Muhsi̇n Kaya, Yasemi̇n Genç, Kadi̇r Bahar
Diagnostic Value Of Ki-67li In Hepatocellular Carcinoma Ki-67 Antigen Expression In Hepatocellular Carcinoma, Metastatic Adenocarcinoma And Normal Hepatocytes, Işin Soyuer, Cemi̇l Eki̇nci̇, Muhsi̇n Kaya, Yasemi̇n Genç, Kadi̇r Bahar
Turkish Journal of Medical Sciences
One hundred liver fine-needle aspiration cytology (FNAC) specimens obtained from 42 patients with hepatocellular carcinomas (HCC), 38 patients with metastatic adenocarcinomas (MAC) and 20 patients with non-malignant liver disease (control group) were studied. Liver specimens were stained with an immunoperoxidase method using a monoclonal antibody to Ki-67 (MIB1). Ki-67 antigen was visualised in cold acetone, and a fresh liver needle aspiration cytology specimen using antibodies was used to identify proliferating hepatocytes. In this study it was examined that; if there is a difference between the groups in terms of Ki-67 positivity and degree of differentiation of tumor and the relationship …
Quantification Of The Fli1 Gene Expression By Real-Time Quantitative Rt-Pcr, Hakan Savli, Sema Sirma, Uğur Özbek
Quantification Of The Fli1 Gene Expression By Real-Time Quantitative Rt-Pcr, Hakan Savli, Sema Sirma, Uğur Özbek
Turkish Journal of Medical Sciences
In this study, quantification levels were investigated to define alterations in the expression of the FLI1 gene on acute promyelocytic leukemia (APL), which is characterized by a reciprocal t(15,17) translocation of fusing the PML gene to the retinoic acid receptor alpha (RAR alpha) gene. The FLI1 gene plays an important role in several signal transduction pathways, and is involved in the normal regulation of myeloid hematopoiesis and leukomogenesis. We used the real-time quantitative RT-PCR (LightCycler) with SYBR Green I dye method for the labeling and analysis of the quantification of FLI1 gene RT-PCR products. Ribosomal protein S9 (RPS9) was used …
An Assessment Of Femur Growth Parameters In Human Fetuses And Their Relationship To Gestational Age, Taner Zi̇ylan, Khalil Awadh Murshed
An Assessment Of Femur Growth Parameters In Human Fetuses And Their Relationship To Gestational Age, Taner Zi̇ylan, Khalil Awadh Murshed
Turkish Journal of Medical Sciences
Fetal femur length assessment has been the subject of numerous investigations. Skeletal growth disturbances, estimation of fetal gestational age, developmental abnormality and detection of certain fetal congenital anomalies, and determination of population growth characteristics have been the objectives of different investigators' studies. The purpose of this study was to evaluate the relationships between the crown-rump length (CRL) and fetal femur growth parameters and the gestational age during the second and third trimesters. Thirty dead normal immature and premature fetuses were selected from the fetal collection at the Anatomy Department of the Medical School, Selçuk University. Depending on the fetal CRL …
Prevalence Of Oral Precancerous Lesions In A Selected Turkish Population, Çağri Deli̇lbaşi, Hakan Akman, Eni̇s Redzep, Ümi̇t K. Akal
Prevalence Of Oral Precancerous Lesions In A Selected Turkish Population, Çağri Deli̇lbaşi, Hakan Akman, Eni̇s Redzep, Ümi̇t K. Akal
Turkish Journal of Medical Sciences
Oral cancers are malignancies that have high metastasis potential and thus survival rate of the patients is low. Today, epidemiological studies are being widely conducted on precancerous lesions, defined as predecessor lesions. In order to investigate the prevalence of oral precancerous lesions among Turkish people, 2000 consecutive outpatients who referred to our clinic for routine dental treatment, were examined. The proportion of lesions with potential to transform into cancer was 4.0%. It was concluded that leukoplakia and lichen planus were the most commonly observed precancerous lesions. All lesions had male propensity and the most affected site was the buccal mucosa. …
Suicide In The Province Of Eskişehir, Turkey: The Approach Of Forensic Medicine, Yasemi̇n Günay Balci, Emre Albek
Suicide In The Province Of Eskişehir, Turkey: The Approach Of Forensic Medicine, Yasemi̇n Günay Balci, Emre Albek
Turkish Journal of Medical Sciences
In the present study, a retrospective evaluation of suicides in the province of Eskişehir in 1997-1999 is made. Investigation reports of the Central Prosecutor's Office were obtained and the demographic data of the victims as well as the judicial criteria for the classification as "suicide" were evaluated. There were 94 cases of suicide and 65 of them (69.1%) involved males. Age distribution showed a predominance in the age group of 15-34 years. Suicide in males over 55 years of age occurred more frequently than in females (p < 0.05). Causes of death in suicides included hanging in 68.0% of cases, firearm wounding in 16.0%, jumping from heights in 7.4%, drug intake in 5.3%, railway suicides in 2.2% and butane inhalation in 1.1%; 79.8% of suicides occurred in residences. In 93.6% of the cases, scene investigation reports and drawings were obtainable, while photographs of the scene or of the victim were present in 53.2% of cases. A forensic medicine specialist's inquest had been performed in all cases whilst a medico-legal autopsy had been carried out in only 29.8% of cases. Death certificates were issued following an inquest and scene investigation in 66 cases. Medico-legal autopsies were performed in 73.3% of the cases of firearm wounding, 25.0% of the cases of hanging and 6.7% of suicides committed by other means. In conclusion, we emphasize the importance of a medico-legal autopsy in all suicide cases.
Anti-Hev Antibody Prevalence In Three Distinct Regions Of Turkey And Its Relationship With Age, Gender, Education And Abortions, Di̇lek Olcay, Can Polat Eyi̇gün, Şükrü Volkan Özgüven, İsmai̇l Yaşar Avci, Ahmet Bülent Beşi̇rbelli̇oğlu, Selma Yegane Tosun, Alaaddi̇n Pahsa
Anti-Hev Antibody Prevalence In Three Distinct Regions Of Turkey And Its Relationship With Age, Gender, Education And Abortions, Di̇lek Olcay, Can Polat Eyi̇gün, Şükrü Volkan Özgüven, İsmai̇l Yaşar Avci, Ahmet Bülent Beşi̇rbelli̇oğlu, Selma Yegane Tosun, Alaaddi̇n Pahsa
Turkish Journal of Medical Sciences
Hepatitis E virus (HEV) causes epidemics in developing countries such as India, Burma, Indonesia, Chad and China, but it causes sporadic cases in developed countries such as the U.S.A., Canada and the U.K. Turkey represents a bridge between HEV endemic and non-endemic areas, and HEV may cause epidemics in Turkey. In this study, the prevalence of HEV in three distinct regions of Turkey and its relationship with age, gender, education and abortions was investigated. Nine hundred ten randomly selected cases from three cities in three geographic regions of Turkey (Manisa from the Aegean region, Elmadağ/Ankara from Central Anatolia and Diyarbakır …
Are The Sequence And Level Of The Branches Of The Popliteal Artery Different In The Fetus Than In The Adult?: Two Fetuses With Popliteal Arterial Variation, Zeli̇ha Kurtoğlu, Mustafa Akteki̇n, Ahmet Hakan Öztürk, Cem Kara
Are The Sequence And Level Of The Branches Of The Popliteal Artery Different In The Fetus Than In The Adult?: Two Fetuses With Popliteal Arterial Variation, Zeli̇ha Kurtoğlu, Mustafa Akteki̇n, Ahmet Hakan Öztürk, Cem Kara
Turkish Journal of Medical Sciences
URTOĞLU Mustafa AKTEKİN Ahmet Hakan ÖZTÜRK Cem KARA Department of Anatomy Faculty of Medicine, Mersin University, Mersin - Turkey
Abdominal Actinomycosis Appearing As An Intraabdominal Tumoral Mass, Ömer Şakrak, İpek Müderri̇soğlu, Abdulkadi̇r Bedi̇rli̇, Özhan İnce, Özlem Canöz
Abdominal Actinomycosis Appearing As An Intraabdominal Tumoral Mass, Ömer Şakrak, İpek Müderri̇soğlu, Abdulkadi̇r Bedi̇rli̇, Özhan İnce, Özlem Canöz
Turkish Journal of Medical Sciences
RAK^1 İpek MÜDERRİSOĞLU^2 Abdulkadir BEDİRLİ^1 Özhan İNCE^1 Özlem CANÖZ^3 Departments of ^1General Surgery, ^2Obstetrics and Gynecology, ^3Pathology, Faculty of Medicine, Erciyes University, Kayseri - Turkey
A Cerebral Hydatid Cyst Case First Presenting With Gerstmann's Syndrome: A Case Report And Literature Review, Mehmet Dumlu Aydin, Nazan Aydin
A Cerebral Hydatid Cyst Case First Presenting With Gerstmann's Syndrome: A Case Report And Literature Review, Mehmet Dumlu Aydin, Nazan Aydin
Turkish Journal of Medical Sciences
umlu AYDIN^1 Nazan AYDIN^2 Departments of ^1Neurosurgery , ^2Psychiatry, Faculty of Medicine, Atatürk University, Erzurum - Turkey
Immunization Of Mice With Plasmid Dna Encoding Hepatitis B Virus Core Antigen (Hbcag), Yasemi̇n Bulut, Hakan Bulut, Mehmet Zi̇ya Doymaz
Immunization Of Mice With Plasmid Dna Encoding Hepatitis B Virus Core Antigen (Hbcag), Yasemi̇n Bulut, Hakan Bulut, Mehmet Zi̇ya Doymaz
Turkish Journal of Medical Sciences
The aim of this study was to investigate the antibody response following immunization with plasmid vector DNA containing the hepatitis B virus core antigen (HBcAg) gene of a hepatitis B virus (HBV) isolated from a patient in Turkey. A HBcAg gene fragment was cloned into a pcDNA 3 eukaryotic expression vector. After confirmation of the cloning of the HBcAg gene, the expressing vector based HBcAg was used in DNA immunization experiments. Four-to 6-week-old Balb/c mice were immunized with HBcAg expressing plasmids and the anti-HBcAg antibody responses of the mice were evaluated by enzyme immunoassay (EIA). The results of this study …
Evaluation Of Phagocytic Function Of The Spleen After Splenic Artery Ligation In Secondary Hypersplenism, Celaletti̇n Vatansev, Şaki̇r Teki̇n, Mustafa Şahi̇n, Mustafa Serdengeçti̇, Mustafa C. Avunduk
Evaluation Of Phagocytic Function Of The Spleen After Splenic Artery Ligation In Secondary Hypersplenism, Celaletti̇n Vatansev, Şaki̇r Teki̇n, Mustafa Şahi̇n, Mustafa Serdengeçti̇, Mustafa C. Avunduk
Turkish Journal of Medical Sciences
The aim of this study was to investigate the effects of splenic artery ligation on the phagocytic functions and morphology of the spleen in rabbits in which secondary hypersplenism was induced by splenic vein ligation (SVL). Thirty New Zealand-type rabbits were included in this study. The rabbits were separated into three groups of 10 subjects each. The first group underwent laparotomy, and the second and third groups underwent laparotomy + splenic vein ligation. At the end of the fourth week, the first and second groups underwent laparotomy while the third group underwent laparotomy + splenic artery ligation. At the end …
A Modified Method For The Determination Of Plasma Total Homocysteine By High Performance Liquid Chromatography, Serhat Tokgöz, Cumhur Bi̇lgi̇, Erdi̇nç Çakir, M. Kemal Erbi̇l, Türker Kutluay
A Modified Method For The Determination Of Plasma Total Homocysteine By High Performance Liquid Chromatography, Serhat Tokgöz, Cumhur Bi̇lgi̇, Erdi̇nç Çakir, M. Kemal Erbi̇l, Türker Kutluay
Turkish Journal of Medical Sciences
We have modified a high-performance liquid chromatography (HPLC) procedure for homocysteine assay using 7-fluoro-2, 1, 3-benzoxadiazole-4-sulfonamide (ABD-F) pre-column derivatization. In this study, the thiol compounds were liberated from plasma proteins by reduction with 2-mercaptoethanol (BME) and derivatized with a thiol-specific fluoregenic marker, ABD-F. The derivatives were separated by reversed-phase HPLC on a Hypersil C 18 column (4.6 x 150 mm; 5 µ) using isocratic elution with 0.1 M phosphate buffer pH 6.0 containing 8% methanol and fluorescence detection. Excitation and emission wavelengths were 386 and 516 nm. The peak of homocysteine was eluted at 413 ± 25 s. Mean within-day …
Problems In Urinary Iodine Determination Methods And An Automated Kinetic Assay As A Solution, Mustafa Gültepe, Ömer Özcan, Osman Meti̇n İpçi̇oğlu, Kadi̇r Avşar
Problems In Urinary Iodine Determination Methods And An Automated Kinetic Assay As A Solution, Mustafa Gültepe, Ömer Özcan, Osman Meti̇n İpçi̇oğlu, Kadi̇r Avşar
Turkish Journal of Medical Sciences
Accurate, fast and economical urinary iodine measurement is very important in diagnosing iodine deficiency disorders. The urinary iodine determination method using ammonium persulfate digestion based on the Sandell-Kolthoff reaction was optimized and modified to kinetic and automated assay. Ammonium persulfate digestion was performed at +95 ºC in a water-bath to ± 0.1 ºC precision. The performance of both the Sandell-Kolthoff reaction at 37 ºC and its kinetic measurement at 340 nm was tested in a random access automated analyzer. For method comparison, urinary iodine concentrations were measured using both the conventional chloric acid digestion method and the kinetic automated method …
Pcr Analysis Of Hsv-Negative Erythema Multiforme For The Expression Of Other Herpesviruses, Mukadder Koçak, Emel Erkek, Özgül Kisa, Çakir Güney, Ahu Bi̇rol
Pcr Analysis Of Hsv-Negative Erythema Multiforme For The Expression Of Other Herpesviruses, Mukadder Koçak, Emel Erkek, Özgül Kisa, Çakir Güney, Ahu Bi̇rol
Turkish Journal of Medical Sciences
Background: Herpes simplex virus (HSV) is the primary herpesvirus implicated to have a causal role in erythema multiforme (EM), both in cases with an antecedent herpetic infection and in idiopathic EM. However, the association of EM with several other viral infections has been clearly documented. Objective: The aim of the present study was to investigate a hypothetical role for the remaining members of the herpesvirus family in HSV-negative cases of EM. Methods: Fresh, unfixed lesional skin biopsies from 25 patients with HSV-negative EM were studied for the presence of Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus-6 (HHV-6) and human herpesvirus-7 …
Lipid Peroxidation, Nitrate And Nitrite Levels In Eclamptic And Intrauterine Growth Retarded Pregnancies, Hati̇ce Paşaoğlu, Nesli̇han Bukan, Gülsen Bulduk, Şevki̇ Çelen
Lipid Peroxidation, Nitrate And Nitrite Levels In Eclamptic And Intrauterine Growth Retarded Pregnancies, Hati̇ce Paşaoğlu, Nesli̇han Bukan, Gülsen Bulduk, Şevki̇ Çelen
Turkish Journal of Medical Sciences
In this study we investigated nitric oxide metabolites nitrate+nitrite and lipid peroxidation product (malonyldialdehyde: MDA) related to the pathogenesis of eclampsia and intrauterine growth retarded (IUGR) pregnancy. Plasma nitrate+nitrite levels were higher in the eclamptic (31.6 ± 16.7 µmol/L p < 0.001) and IUGR (24.3 ± 9.5 µmol/L p < 0.005) groups than in the control group (18.8 ± 6.9 µmol /L). Plasma MDA levels were higher in the eclamptic group (5.5 ± 2.5 nmol/ml (p < 0.05) but not significantly different in the IUGR (3.4 ± 2.4 nmol/ml p > 0.05) group than control group (3.0 ± 1.3 nmol/ml). In addition, the plasma nitrite+nitrate and MDA levels in the eclamptic group were higher than in the IUGR group (p < 0.05). These variations could play different roles in the pathogenesis of eclampsia and IUGR pregnancy.
Lecithin:Cholesterol Acyltransferase Activity And Cholesteryl Ester Transfer Rate In Patients With Diabetes Mellitus, Melahat Di̇ri̇can, Zehra Serdar, Emre Sarandöl, Esma Sürmen Gür
Lecithin:Cholesterol Acyltransferase Activity And Cholesteryl Ester Transfer Rate In Patients With Diabetes Mellitus, Melahat Di̇ri̇can, Zehra Serdar, Emre Sarandöl, Esma Sürmen Gür
Turkish Journal of Medical Sciences
Several factors may be responsible for the high prevalence of atherosclerosis in diabetes mellitus, including alterations in reverse cholesterol transport. In the present study, the activity of plasma lecithin:cholesterol acyltransferase (LCAT) and the cholesteryl ester transfer rate, and concentrations of lipids and lipoproteins were measured in 11 patients with insulin-dependent diabetes mellitus (type 1), 42 patients with noninsulin-dependent diabetes mellitus (type 2) and compared with those in age-matched control groups (Control I, n = 14; and Control II, n = 29, respectively). No statistically significant differences were observed in plasma total cholesterol, triglyceride, ester cholesterol or very low density lipoprotein …
Comparison Of Indirect Methods For Lactose Malabsorption, İsmai̇l Kurt, Mohammed Wael Abou Ghoush, Adnan Haşi̇mi̇, A. Muhi̇tti̇n Serdar, Türker Kutluay
Comparison Of Indirect Methods For Lactose Malabsorption, İsmai̇l Kurt, Mohammed Wael Abou Ghoush, Adnan Haşi̇mi̇, A. Muhi̇tti̇n Serdar, Türker Kutluay
Turkish Journal of Medical Sciences
Although direct determination of the lactase activity of the small intestinal mucosa is considered a "gold standard" for the diagnosis of hypolactasia leading to lactose malabsorption, less invasive and simpler indirect techniques like the "plasma glucose response test" and "breath hydrogen test" are preferred in daily practice to diagnose the disorder. The aim of this study was to compare the different indirect diagnostic methods for lactose malabsorption. The following tests were performed in 54 adults: plasma glucose response test, breath hydrogen test and urine galactose/creatinine ratio. The diagnostic variables were as follows: increased plasma glucose £ 20 mg/dl; increased exhalation …
Subtalar Dislocations: A Report Of Two Cases, Özcan Pehli̇van, Can Solakoğlu, İbrahi̇m Akmaz
Subtalar Dislocations: A Report Of Two Cases, Özcan Pehli̇van, Can Solakoğlu, İbrahi̇m Akmaz
Turkish Journal of Medical Sciences
HLİVAN Can SOLAKOĞLU İbrahim AKMAZ Department of Orthopedics and Traumatology, Gülhane Military Medical Academy, Haydarpaşa Training Hospital, İstanbul - Turkey
Bilateral Intratesticular Varicocele In A Patient With A History Of Bilateral Cryptorchidism, Nuri̇ Erdoğan, Oğuz Ekmekçi̇oğlu, Murat Baykara
Bilateral Intratesticular Varicocele In A Patient With A History Of Bilateral Cryptorchidism, Nuri̇ Erdoğan, Oğuz Ekmekçi̇oğlu, Murat Baykara
Turkish Journal of Medical Sciences
OĞAN^1 Oğuz EKMEKCİOĞLU^2 Murat BAYKARA^1 Departments of ^1Radiology, ^2Urology, Faculty of Medicine, Erciyes University, Kayseri, Turkey
Paratesticular Solitary Fibrous Tumour: Case Report And Review Of The Literature, Nusret Akpolat, Arslan Ardiçoğlu, Seyfetti̇n Yahşi̇, A.Rahmi̇ Onur
Paratesticular Solitary Fibrous Tumour: Case Report And Review Of The Literature, Nusret Akpolat, Arslan Ardiçoğlu, Seyfetti̇n Yahşi̇, A.Rahmi̇ Onur
Turkish Journal of Medical Sciences
KPOLAT^1 Arslan ARDIÇOĞLU^2 Seyfettin YAHŞİ^1 A. Rahmi ONUR^2 Departments of ^1Pathology and ^2Urology, Faculty of Medicine, Fırat University, Elazığ - TURKEY
Echinococcus Infestation Of Quadriceps Femoris Muscle Misdiagnosed As A Soft Tissue Tumor (A Case Report), Kaan Erler, Mahmut Kömürcü, M.Taner Özdemi̇r, Uğur Bariş Özkal, Mustafa Başbozkurt, Ömer Günhan
Echinococcus Infestation Of Quadriceps Femoris Muscle Misdiagnosed As A Soft Tissue Tumor (A Case Report), Kaan Erler, Mahmut Kömürcü, M.Taner Özdemi̇r, Uğur Bariş Özkal, Mustafa Başbozkurt, Ömer Günhan
Turkish Journal of Medical Sciences
ER^1 Mahmut KÖMÜRCÜ^1 M.Taner ÖZDEMİR^1 U. Barış ÖZKAL^1 Mustafa BAŞBOZKURT^1 Ömer GÜNHAN^2 Departments of ^1Orthopedics and Traumatology, ^2Pathology Gülhane Military Medical Academy, Etlik, Ankara - TURKEY
Peritoneal Defense Mechanisms, Toni̇ Hau
Peritoneal Defense Mechanisms, Toni̇ Hau
Turkish Journal of Medical Sciences
No abstract provided.
Bacterial Translocation After Partial Hepatic Resection Under Ischemia And Reperfusion In Rats: Incidence And Time Course, Abdulkadi̇r Bedi̇rli̇, Selma Gökahmetoğlu, Kadi̇r Can Küçük, Işin Soyuer, İlkay Güler, Ömer Şakrak
Bacterial Translocation After Partial Hepatic Resection Under Ischemia And Reperfusion In Rats: Incidence And Time Course, Abdulkadi̇r Bedi̇rli̇, Selma Gökahmetoğlu, Kadi̇r Can Küçük, Işin Soyuer, İlkay Güler, Ömer Şakrak
Turkish Journal of Medical Sciences
Infectious complications are major causes of morbidity and mortality following major hepatic resection. We investigated in rats the incidence and time course of bacterial translocation after partial hepatectomy during ischemia and reperfusion. Forty-eight male Wistar rats weighing 230 to 280 g were studied. Partial liver warm ischemia was performed for 15 min followed by reperfusion for 15 min. During a second 15 min of ischemia, 70% hepatectomy was performed. The animals were divided into six groups of eight animals each. Animals were sacrificed 8, 16, 24, 48, 72, and 120 h after the hepatectomy. At each time point blood was …
Histological Changes In The Rat Thoracic Aorta After Chronic Nitric Oxide Synthase Inhibition, Ni̇gar Vardi, Feral Öztürk, Ersi̇n Fadillioğlu, Ali̇ Otlu, Murat Yağmurca
Histological Changes In The Rat Thoracic Aorta After Chronic Nitric Oxide Synthase Inhibition, Ni̇gar Vardi, Feral Öztürk, Ersi̇n Fadillioğlu, Ali̇ Otlu, Murat Yağmurca
Turkish Journal of Medical Sciences
The objective of this study was to determine the morphological effects of chronic nitric oxide (NO) inhibition on the thoracic aorta of Wistar rats. Fifteen male Wistar Albino rats were divided into three groups. Group I rats (control group, n = 5) received tap water, group II rats (n = 5) recieved 100 mg/kg L-NAME (moderate NO inhibiton) and group III rats (n = 5) received 500 mg/kg L-NAME, in drinking water (severe NO inhibition) for 15 days. At the end of 15 days, the carotid arteries of the rats were cannulated and their blood pressure was measured. The rats …
A Preliminary Study Of Dna Damage In Peripheral Lymphocytes From Lung Cancer Patients And Healthy Subjects, Arthur See King Sham, Yim Tong Szeto, Iris Frances Foster Benzie, Kian Cheng Tan-Un
A Preliminary Study Of Dna Damage In Peripheral Lymphocytes From Lung Cancer Patients And Healthy Subjects, Arthur See King Sham, Yim Tong Szeto, Iris Frances Foster Benzie, Kian Cheng Tan-Un
Turkish Journal of Medical Sciences
A pilot study was undertaken to investigate the differences in oxidative DNA damage and 2-h DNA repair in peripheral lymphocytes between lung cancer patients and healthy subjects. Twenty-four lung cancer patients and 23 normal controls were recruited from the Queen Mary Hospital, Hong Kong SAR, China. Single cell gel electrophoresis (comet assay) was performed to measure the oxidative damage, repair and baseline of peripheral lymphocytes in the subjects. There were no significant differences in baseline DNA damage and oxidative stress damage and DNA repair at 2 h among the two groups of lung cancer patients who had blood taken before …
Tissue Plasminogen Activator Mass Concentration In Ischemic Acute Stroke Patients, Cavi̇t Boz, Abdurrahman Akbaş, Zekeri̇ya Ali̇oğlu, Mehmet Özmenoğlu
Tissue Plasminogen Activator Mass Concentration In Ischemic Acute Stroke Patients, Cavi̇t Boz, Abdurrahman Akbaş, Zekeri̇ya Ali̇oğlu, Mehmet Özmenoğlu
Turkish Journal of Medical Sciences
The role of endogenous fibrinolysis in cerebral infarction has been investigated, but with conflicting results. In this study, variations of tissue-type plasminogen activator (t-PA) antigen concentrations over time after stroke were examined at the acute and subacute phases of ischemic stroke in a group of patients and in a control group. The relationships between t-PA levels and stroke severity, lesion volume and clinical status were also investigated. This study was carried out in 45 patients with acute ischemic stroke and 21 control subjects who had similar characteristics. Levels of t-PA mass concentration were measured via the ELISA, while Student's t, …
Fasting And Post-Methionine Load Plasma Homocysteine Levels In Patients With Angiographically Defined Coronary Artery Disease, Mustafa Özkan, M. Kemal Erbi̇l, Münzer Al Rashed, Emi̇n Özgür Akgül, Tuncer Çayci, Cumhur Bi̇lgi̇, Gürkan Meti̇nyurt, Şeri̇f Akman, Türker Kutluay
Fasting And Post-Methionine Load Plasma Homocysteine Levels In Patients With Angiographically Defined Coronary Artery Disease, Mustafa Özkan, M. Kemal Erbi̇l, Münzer Al Rashed, Emi̇n Özgür Akgül, Tuncer Çayci, Cumhur Bi̇lgi̇, Gürkan Meti̇nyurt, Şeri̇f Akman, Türker Kutluay
Turkish Journal of Medical Sciences
Elevated plasma homocysteine concentration either in fasting state or after methionine loading is an independent risk factor for vascular disease. The aim of this study was to evaluate the relationship between fasting total homocysteine (tHcy) and post-methionine load tHcy in healthy control subjects and in patients with angiographically defined coronary artery disease (CAD). Methionine loading has been used to investigate impaired methionine metabolism, especially of the trans-sulphuration pathway. We investigated the effect of methionine excess on total plasma homocysteine in 65 control subjects (44 men and 21 women) who attended a polyclinic of Gülhane Military Medical Academy (GMMA) in Ankara. …
Hemodynamic Changes After Aortopulmonary Separation, Ersi̇n Fadillioğlu, M. Kemal Irmak, Murat Yağmurca, Hasan Erdoğan
Hemodynamic Changes After Aortopulmonary Separation, Ersi̇n Fadillioğlu, M. Kemal Irmak, Murat Yağmurca, Hasan Erdoğan
Turkish Journal of Medical Sciences
The neural crest origin of the aortopulmonary septum has led us to investigate the septum. We designed the present study to assess the hemodynamic changes following aortopulmonary separation in the rat. We freed the ascending aorta from the pulmonary artery by blunt dissection and placed aluminium foil between them in anesthetized, ventilated, open-chest animals and found that the procedure resulted in a slight but significant increase in systolic and diastolic blood pressure and in an insignificant elevation of the heart rate. The hemodynamic deterioration observed after the separation process might be a result of a possible function of the aortopulmonary …