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Articles 1 - 30 of 175
Full-Text Articles in Medicine and Health Sciences
Insulin Resistance Impairs Response To Doxazosin Therapy In Men With Benign Prostatic Hyperplasia, Cevdet Serkan Gökkaya, Çeti̇n Volkan Özteki̇n, Cüneyt Özden, Emi̇n Öztürk, Bi̇nhan Kağan Aktaş, Ali̇ Memi̇ş
Insulin Resistance Impairs Response To Doxazosin Therapy In Men With Benign Prostatic Hyperplasia, Cevdet Serkan Gökkaya, Çeti̇n Volkan Özteki̇n, Cüneyt Özden, Emi̇n Öztürk, Bi̇nhan Kağan Aktaş, Ali̇ Memi̇ş
Turkish Journal of Medical Sciences
To evaluate the effects of insulin resistance (IR) on outcomes of doxazosin treatment for lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). Materials and methods: This prospective study included 64 patients with LUTS due to BPH. LUTS were evaluated using the international prostate symptom score (IPSS) and maximum flow rate (Qmax) in uroflowmetry. Diagnosis of IR was achieved using homeostasis model assessment (HOMA) score and patients were grouped with respect to absence (group 1, n = 44) or presence (group 2, n = 20) of IR. Patients were evaluated before and after 3 months of daily doxazosin …
Cytokeratin 18 And H-Fabp Levels In Intestinal Ischemia–Reperfusion Injury: Role Of Coenzyme Q10, Muaz Belvi̇ranli, Ni̇lsel Okudan, Hakki Gökbel, Aysel Kiyici, Mehmet Öz, Ayşe Kumak
Cytokeratin 18 And H-Fabp Levels In Intestinal Ischemia–Reperfusion Injury: Role Of Coenzyme Q10, Muaz Belvi̇ranli, Ni̇lsel Okudan, Hakki Gökbel, Aysel Kiyici, Mehmet Öz, Ayşe Kumak
Turkish Journal of Medical Sciences
The objective of this study was to investigate whether coenzyme Q10 (CoQ10) supplementation affects M30 and heart-type fatty acid binding protein (h-FABP) levels in intestinal ischemia-reperfusion injury-induced rats. Materials and methods: Thirty-two male Wistar rats were randomly divided into 4 groups. 1) Sham: Animals exposed to laparotomy without clamping the superior mesenteric artery (SMA); 2) ischemia-reperfusion (IR): rats exposed to laparotomy with occlusion of the SMA for 45 min, followed by 120 min of reperfusion period; 3) CoQ10 plus sham: 10 mg kg body weight^{-1} CoQ10 was administrated via intraperitoneal injection for 20 days, and thereafter animals were exposed to …
Molecular Characterization Of Acanthamoeba Isolated From Kayseri Well Water, Sali̇h Kuk, Süleyman Yazar, Süheyla Doğan, Ülfet Çeti̇nkaya, Çağri Şakalar
Molecular Characterization Of Acanthamoeba Isolated From Kayseri Well Water, Sali̇h Kuk, Süleyman Yazar, Süheyla Doğan, Ülfet Çeti̇nkaya, Çağri Şakalar
Turkish Journal of Medical Sciences
Potentially pathogenic free-living amoebae have a cosmopolitan distribution in soil, dust, air, and water. Generally, environmental free-living amoebae do not threaten human health. This study aimed to investigate the presence of Acanthamoeba in well waters drawn from different locations in Kayseri, Turkey, which are mainly used for drinking or irrigation by the residents in the region. Materials and methods: Twenty-nine samples, including 26 well water sediment samples and 3 tap water samples as the control, were collected from 3 different locations. Melting snow feeds 5, rain water 18, and tap water 3 of these wells. Results: Five of 26 well …
Amount Of Lateral Cortex Loss In The Femur While Inserting A Dhs-Plate, Mahmut Nedi̇m Ayteki̇n, Fati̇h Küçükdurmaz, Ali̇ Firat Esmer, Necdet Sağlam, Fuat Akpinar
Amount Of Lateral Cortex Loss In The Femur While Inserting A Dhs-Plate, Mahmut Nedi̇m Ayteki̇n, Fati̇h Küçükdurmaz, Ali̇ Firat Esmer, Necdet Sağlam, Fuat Akpinar
Turkish Journal of Medical Sciences
Although many anatomic, morphologic, and radiologic studies have been carried out for the femur as for all other bones of the skeletal system, we could not find any morphometric study to guide orthopedic surgeons on dynamic hip screw-plate (DHS-plate) applications of the proximal femur. Materials and methods: The lateral cortex width of 125 adult, dry, and grossly intact right and left cadaver femora was measured for the region of the femur in which the DHS-plate was applied, and the results were analyzed statistically. Results: The mean value of the proximal lateral cortex width of the femora was 27.63 mm. While …
Assessment Of Hearing Ability With Pure-Tone Audiometry And Otoacoustic Emission Methods In Patients Undergoing Spinal Anesthesia, Zi̇ya Kaya, Levent Gürbüzler, Mustafa Süren, Semi̇h Arici, Serkan Karaman
Assessment Of Hearing Ability With Pure-Tone Audiometry And Otoacoustic Emission Methods In Patients Undergoing Spinal Anesthesia, Zi̇ya Kaya, Levent Gürbüzler, Mustafa Süren, Semi̇h Arici, Serkan Karaman
Turkish Journal of Medical Sciences
To investigate the frequency of hearing loss after spinal anesthesia in patients undergoing spinal anesthesia using pure-tone audiometry and otoacoustic emission methods. Materials and methods: A total of 80 patients (40 females, 40 males, aged 18-65 years) were included in the study. For spinal anesthesia, a 27-gauge Quincke spinal needle was entered at the first attempt into the subarachnoidal space through the L4-L5 interval with the patient in the lateral decubitus position. The first day before spinal anesthesia, pure-tone audiometry, transient evoked otoacoustic emission, distortion product otoacoustic emission, and tympanometry were performed on all patients, and the same procedures were …
Expression Of Cyclin D1, P27, P21, Bcl-2, And P53 In Laryngeal Squamous Cell Carcinoma And An Investigation Of The Correlation With Conventional Prognostic Factors, Gülçi̇n Şi̇mşek, Ünsal Han, Bi̇nnur Önal, Fatma Fulya Köybaşioğlu, İstemi̇han Akin, Muharrem Dağli
Expression Of Cyclin D1, P27, P21, Bcl-2, And P53 In Laryngeal Squamous Cell Carcinoma And An Investigation Of The Correlation With Conventional Prognostic Factors, Gülçi̇n Şi̇mşek, Ünsal Han, Bi̇nnur Önal, Fatma Fulya Köybaşioğlu, İstemi̇han Akin, Muharrem Dağli
Turkish Journal of Medical Sciences
Because it is a multistep process, in carcinogenesis it is necessary to determine key genes such as cyclin D1, p27, p21, bcl-2, and p53 that are responsible for uncontrolled proliferation and other mechanisms. The aim of this study was to examine the correlation between the anomalous accumulation of these proteins and the prognosis of laryngeal carcinomas. Materials and methods: In our study, cyclin D1, p27, p21, bcl-2, and p53 expressions were analyzed immunohistochemically in laryngeal squamous cell carcinomas, and the findings were compared with conventional prognostic parameters such as patient age, sex, tumor localization and diameter, tumor differentiation, lymph node …
Invasive Device-Associated Hospital Infection Rates, Etiological Agents, And Their Antibiotic Susceptibilities In The Medical Intensive Care Unit Of A University Hospital In Turkey, Sali̇ha Çevi̇k, Vuslat Boşnak, Mustafa Namiduru, İlkay Karaoğlan, Ayşe Özlem Mete
Invasive Device-Associated Hospital Infection Rates, Etiological Agents, And Their Antibiotic Susceptibilities In The Medical Intensive Care Unit Of A University Hospital In Turkey, Sali̇ha Çevi̇k, Vuslat Boşnak, Mustafa Namiduru, İlkay Karaoğlan, Ayşe Özlem Mete
Turkish Journal of Medical Sciences
To determine the rate, etiological agents, antibiotic susceptibilities, and empirical treatment options of etiological agents of invasive device-associated hospital infections (IDAHIs) in the medical intensive care unit of a university hospital. Materials and methods: Between February 2007 and December 2009, 780 IDAHI cases were evaluated in 1650 patients. Results: Ventilator associated pneumonia, catheter-associated urinary tract infection, and central venous catheter-associated blood stream infection were observed in 415, 242, and 143 IDAHI cases, respectively. The most frequently isolated etiological agents were Acinetobacter spp. in ventilator-associated pneumonia, coagulase-negative staphylococci (CoNS) in central venous catheter-associated blood stream infection, and Candida spp. and E. …
Mean Platelet Volume As A Fibrosis Marker In Patients With Chronic Hepatitis C, Hati̇ce Karaman, Çi̇ğdem Karakükcü, Ahmet Karaman, Tuba Kayman, Samet Yalçin, Erdem Arzu Taşdemi̇r, Gökmen Zararsiz, Orhan Kürşat Poyrazoğlu
Mean Platelet Volume As A Fibrosis Marker In Patients With Chronic Hepatitis C, Hati̇ce Karaman, Çi̇ğdem Karakükcü, Ahmet Karaman, Tuba Kayman, Samet Yalçin, Erdem Arzu Taşdemi̇r, Gökmen Zararsiz, Orhan Kürşat Poyrazoğlu
Turkish Journal of Medical Sciences
We designed this study to evaluate the role of mean platelet volume (MPV) as a fibrosis marker in patients with chronic hepatitis C (CHC). Materials and methods: The study was designed at Kayseri Education and Research Hospital. Ninety-five patients with CHC were enrolled retrospectively into the study. The control group comprised 33 age- and sex-matched healthy individuals. Hepatitis C virus-RNA level, alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, prothrombin time (PT), platelet count (PC), serum albumin, histological activity index (HAI), liver fibrosis score (LFS), and MPV were obtained from the patients' files and a computerized database. Results: Statistically significant differences …
Right Ventricular Function And Its Relation With Timi Frame Count In The Coronary Slow Flow Phenomenon, Mustafa Yilmaz, Fatma Özlem Arican Özlük, Tezcan Peker, Adem Bekler, Kemal Karaağaç
Right Ventricular Function And Its Relation With Timi Frame Count In The Coronary Slow Flow Phenomenon, Mustafa Yilmaz, Fatma Özlem Arican Özlük, Tezcan Peker, Adem Bekler, Kemal Karaağaç
Turkish Journal of Medical Sciences
To investigate right ventricular function using conventional and tissue Doppler echocardiography in patients with coronary slow flow. Materials and methods: Twenty-two patients with slow coronary flow and 22 healthy subjects were included in the study. Right ventricular function was evaluated by conventional and tissue Doppler echocardiography. Additionally, right ventricular global function was assessed by myocardial performance index. Results: The tricuspid annulus peak early diastolic velocity (11.4 ± 2.2 cm/s, 13.9 ± 3 cm/s) and ratio of early to late diastolic velocity (0.70 ± 0.17 cm/s, 1.2 ± 0.38 cm/s) were lower in the patient group than in the controls (P …
The Effects Of Formaldehyde Intoxication On The Inducible Nitric Oxide Synthase Expression And Nitric Oxide Level In The Liver Tissue Of Rats, Ergün Uçmakli, Ferah Armutcu, Alaatti̇n Öztürk
The Effects Of Formaldehyde Intoxication On The Inducible Nitric Oxide Synthase Expression And Nitric Oxide Level In The Liver Tissue Of Rats, Ergün Uçmakli, Ferah Armutcu, Alaatti̇n Öztürk
Turkish Journal of Medical Sciences
To investigate inductive activity of formaldehyde (FA) on the expression of inducible nitric oxide synthase (iNOS) and level of nitric oxide (NO) in the liver of rats. Materials and methods: Sixteen male Wistar albino rats of the same age (3 months old) were divided into 2 experimental groups, with 8 rats as the control and 8 rats formaldehyde-treated (FAt). The FAt group received intraperitoneal injection of 10 mg/kg FA for 10 days. Activity of iNOS was shown with immunohistochemical stain kits, and the concentration of NO level was measured by spectrophotometric method in the liver tissue. Results: The FAt group …
The Effects Of Valsartan Treatment On Visfatin Levels And Lipid Profiles In Newly Diagnosed Hypertensives, İsmai̇l Atacan, Adem Parlak, Ümi̇t Aydoğan, Oktay Sari, Deni̇z Engi̇n Gök, Tuncer Çayci, Kenan Sağlam
The Effects Of Valsartan Treatment On Visfatin Levels And Lipid Profiles In Newly Diagnosed Hypertensives, İsmai̇l Atacan, Adem Parlak, Ümi̇t Aydoğan, Oktay Sari, Deni̇z Engi̇n Gök, Tuncer Çayci, Kenan Sağlam
Turkish Journal of Medical Sciences
In this study, the curative effect of valsartan on hypertension based on its effect on visfatin levels and lipid profiles was investigated. Materials and methods: Forty patients aged 38-60 with hypertension were included in the study. In order to determine initial visfatin levels and lipid profiles, blood samples were taken from the patients and all were started on 80-mg valsartan tablets. All patients were monitored for 12 weeks. Results: By using multivariate regression analysis, it was determined that visfatin levels affected systolic blood pressure (SBP) (P = 0.012, beta; -0.43, 95% CI: -0.092 to -0.012). After the patients received the …
Does Apnea-Hypopnea Index Alone Reflect Obstructive Sleep Apnea Severity?, Ömer Araz, Di̇dem Pulur, Eli̇f Yilmazel Uçar, Mehmet Meral, Ali̇ Meti̇n Görgüner, Meti̇n Akgün
Does Apnea-Hypopnea Index Alone Reflect Obstructive Sleep Apnea Severity?, Ömer Araz, Di̇dem Pulur, Eli̇f Yilmazel Uçar, Mehmet Meral, Ali̇ Meti̇n Görgüner, Meti̇n Akgün
Turkish Journal of Medical Sciences
We aimed to assess whether there was a correlation between the apnea-hypopnea index (AHI), desaturation time under 90% (DTU-90), and mean saturation (MS) levels and the parameters associated with tissue hypoxia. Materials and methods: A total of 144 subjects were included in the study. Blood C-reactive protein levels, blood uric acid levels, and urine microalbumin levels were measured and the urine uric acid/creatinine ratio and urine microalbumin/creatinine ratio were calculated. Results: Our study results suggest that MS and DTU-90, as well as the AHI, are correlated with the parameters reflecting hypoxemia and the other events secondary to hypoxia. Conclusion: MS …
Effect Of Hepatic Steatosis On Virological Response To Nucleos(T)Ide Analogs Therapy In Patients With Chronic Hepatitis B, Ahmet Karaman, Şebnem Gürsoy, Işin Soyuer, Hati̇ce Karaman, Muhammet Edi̇p Torun, Mustafa Alper Yurci̇, Mevlüt Başkol, Kadri̇ Güven, Ömer Özbakir, Mehmet Yücesoy
Effect Of Hepatic Steatosis On Virological Response To Nucleos(T)Ide Analogs Therapy In Patients With Chronic Hepatitis B, Ahmet Karaman, Şebnem Gürsoy, Işin Soyuer, Hati̇ce Karaman, Muhammet Edi̇p Torun, Mustafa Alper Yurci̇, Mevlüt Başkol, Kadri̇ Güven, Ömer Özbakir, Mehmet Yücesoy
Turkish Journal of Medical Sciences
To evaluate the impact of hepatic steatosis on the outcome of treatment in patients with chronic hepatitis B infection treated with oral antiviral therapy. Materials and methods: The study was designed in Erciyes University Medical Faculty Department of Gastroenterology. Patients who received oral antiviral therapy because of chronic hepatitis B were included in the study. Liver biopsy specimens were re-evaluated and classified according to Brunt’s steatosis classification. Virological response to oral antiviral therapy was compared between patients with and without steatosis. Results: One hundred and nineteen patients were included in the study, of which 36.1% had hepatic steatosis. Virological response …
A Small Outbreak Of Tularemia In A Rural Area, İbak Gönen
A Small Outbreak Of Tularemia In A Rural Area, İbak Gönen
Turkish Journal of Medical Sciences
To assess clinically and epidemiologically an outbreak of tularemia detected in a small village in Tokat Province in Turkey. Materials and methods: Recorded clinical and laboratory data of 15 serologically confirmed patients, who either presented to hospital or were diagnosed during family medicine visits to the village during the outbreak, were assessed. Forms including a questionnaire about the symptomatology and previously given treatments were filled out by the patients. In addition, the entire village was investigated to establish the origin of the outbreak. Results: Ages of the 15 individuals (9 females) ranged between 10 and 75, and the mean was …
A Comparison Of Tramadol, Sufentanil, Meperidine, And Lidocaine In Prevention Of Pain Due To Rocuronium Injection, Mehtap Honca, Belkiz Berna Külah, Tarik Purtuloğlu, Tevfi̇k Honca, Nuray Camgöz Eryilmaz, Uğur Özkan, Eyüp Horasanli
A Comparison Of Tramadol, Sufentanil, Meperidine, And Lidocaine In Prevention Of Pain Due To Rocuronium Injection, Mehtap Honca, Belkiz Berna Külah, Tarik Purtuloğlu, Tevfi̇k Honca, Nuray Camgöz Eryilmaz, Uğur Özkan, Eyüp Horasanli
Turkish Journal of Medical Sciences
Alleviation of the pain resulting from injection of rocuronium during anesthesia is still an unsolved problem. We aimed to compare the analgesic effects of sufentanil, tramadol, meperidine, and lidocaine on the pain from injection of rocuronium. Materials and methods: This prospective randomized double-blind study included 200 patients with ASA I-II. After a tourniquet was applied to the forearm, patients received 50 mg of tramadol (group T), 10 µg of sufentanil (group S), 40 mg of meperidine (group M), or 30 mg of lidocaine (group L). The tourniquet was released after 20 s and rocuronium was injected over 10 to 15 …
The Mr Imaging Features And The Analyses Of Quantitative Parameters In Cases With Surgically Repaired Tetralogy Of Fallot, Sali̇h Hamcan, Bülent Karaman, Bi̇lal Battal, Veysel Akgün, Kemal Kara, Tuncay Hazirolan, Uğur Bozlar
The Mr Imaging Features And The Analyses Of Quantitative Parameters In Cases With Surgically Repaired Tetralogy Of Fallot, Sali̇h Hamcan, Bülent Karaman, Bi̇lal Battal, Veysel Akgün, Kemal Kara, Tuncay Hazirolan, Uğur Bozlar
Turkish Journal of Medical Sciences
To present postoperative cardiac magnetic resonance (CMR) imaging features of cases of surgically repaired tetralogy of Fallot (TOF) and to evaluate the relationship among data used in follow-up procedures, such as right ventricular ejection fraction (RV-EF), pulmonary regurgitation fraction (PRF), and the degree of right ventricular (RV) dysfunction. Materials and methods: Fourteen patients (9 males and 5 females; mean age 11.9 ± 3.6 years) with surgically repaired TOF who were admitted to our clinic for follow-up CMR imaging between July 2008 and September 2011 were included in the study. A protocol that consisted of cine steady-state free precession (SSFP) and …
Intermittent Pneumatic Compression Pump In Upper Extremity Impairments Of Breast Cancer-Related Lymphedema, Hülya Uzkeser, Sali̇ha Karatay
Intermittent Pneumatic Compression Pump In Upper Extremity Impairments Of Breast Cancer-Related Lymphedema, Hülya Uzkeser, Sali̇ha Karatay
Turkish Journal of Medical Sciences
To investigate the effect of intermittent pneumatic compression (IPC) pumps on upper extremity impairments in breast cancer-related lymphedema. Materials and methods: Twenty-five patients with lymphedema were randomized into 2 groups. For 3 weeks, the pneumatic compression group (n = 12) underwent a treatment program including skin care, compression bandage, exercise therapy, manual lymph drainage (MLD), and IPC. The control group (n = 13) participated in the same program, but without IPC. The range of motion (ROM) of the upper extremities was measured with goniometry, and dysfunction of the shoulder was assessed with the Constant-Murley scale. Results: Significant improvements were observed …
Mmp-2, Timp-2, And Mmp-2/Timp-2 Complex Levels In Epidermoid Lung Cancer, Müfi̇de Öncel, Mehmet Aköz, Murat Öncel, Aysel Kiyici, Burhan Api̇li̇oğullari
Mmp-2, Timp-2, And Mmp-2/Timp-2 Complex Levels In Epidermoid Lung Cancer, Müfi̇de Öncel, Mehmet Aköz, Murat Öncel, Aysel Kiyici, Burhan Api̇li̇oğullari
Turkish Journal of Medical Sciences
To investigate serum levels of MMP-2, TIMP-2, and MMP-2/TIMP-2 complex in epidermoid lung cancer and determine whether one of these markers or any combination of them can be used as a prognostic factor and in the management of this disease. Materials and methods: Twenty-eight patients with non-small cell lung cancer and 21 healthy, age-matched individuals participated in this study. MMP-2, TIMP-2, and MMP-2/TIMP-2 complex levels were measured in the sera of the patients and controls with the ELISA technique. Results: MMP-2, TIMP-2, and MMP-2/TIMP-2 complex levels were significantly elevated in patients with non-small cell lung cancer compared to the controls …
Neurocognitive Functioning In Young High-Risk Offspring Having A Parent With Bipolar I Disorder, Erdem Deveci̇, Erol Ozan, İsmet Kirpinar, Meltem Oral, Ali̇ Gökhan Daloğlu, Nazan Aydin, Ahmet Öztürk
Neurocognitive Functioning In Young High-Risk Offspring Having A Parent With Bipolar I Disorder, Erdem Deveci̇, Erol Ozan, İsmet Kirpinar, Meltem Oral, Ali̇ Gökhan Daloğlu, Nazan Aydin, Ahmet Öztürk
Turkish Journal of Medical Sciences
To investigate attention, memory, verbal-linguistic ability, and executive functions in symptom-free young offspring having a parent with bipolar I disorder (BD1O) in comparison with healthy controls (CO). Materials and methods: Thirty symptom-free BD1O and 37 CO were recruited. The groups (both all participants and those >=11 years of age) were well-matched for age, sex, IQ, and years of education. The neurocognitive battery included the Rey Auditory Verbal Learning and Memory Test, Controlled Word Association Test, Digit Span Test, Trail Making Test, Auditory Consonant Trigram Test, Wisconsin Card Sorting Test, Stroop Test, and Test of Variables of Attention. Results: The BD1O …
Assessment Of Left-Ventricular Diastolic Function In Diabetic Patients: The Role Of Cardiac Mr Imaging, İhsan Yüce, İbrahi̇m Hali̇l Tanboğa, Ümmügülsüm Bayraktutan, Enbi̇ya Aksakal, Hayri̇ Oğul, Ahmet Yalçin, Yeşi̇m Kizrak, Abdulmeci̇t Kantarci
Assessment Of Left-Ventricular Diastolic Function In Diabetic Patients: The Role Of Cardiac Mr Imaging, İhsan Yüce, İbrahi̇m Hali̇l Tanboğa, Ümmügülsüm Bayraktutan, Enbi̇ya Aksakal, Hayri̇ Oğul, Ahmet Yalçin, Yeşi̇m Kizrak, Abdulmeci̇t Kantarci
Turkish Journal of Medical Sciences
To evaluate the reliability of cardiac magnetic resonance (CMR) imaging in diabetic patients with clinically suspected cardiomyopathy and to compare the consistency of CMR imaging with 2-dimensional echocardiography (2DE). Materials and methods: Twenty-one diabetic patients with clinically suspected cardiomyopathy were evaluated with CMR imaging and 2DE. Two observers for each modality performed the evaluation. Quantitative data (the ejection fraction, end-systolic volume, end-diastolic volume, left-ventricular mass index, and left-atrial volume index) were acquired from both observers. The data were compared for statistical agreement using the Bland-Altman test between the modalities. Results: The CMR examination and 2DE results were consistent with each …
Aeg-1 Expression In Invasive Ductal And Lobular Breast Cancers And Its Relationship With Prognostic Parameters, Havva Erdem, Murat Oktay, Ali̇ Kemal Uzunlar, Ümran Yildirim, Handan Ankarali, Mehmet Yaşar
Aeg-1 Expression In Invasive Ductal And Lobular Breast Cancers And Its Relationship With Prognostic Parameters, Havva Erdem, Murat Oktay, Ali̇ Kemal Uzunlar, Ümran Yildirim, Handan Ankarali, Mehmet Yaşar
Turkish Journal of Medical Sciences
The astrocyte-elevated gene-1 (AEG-1, also known as metadherin) is associated with various aspects of tumour malignancy; however, little knowledge is available related to the role of AEG-1 in ductal and lobular carcinomas. The aim of this study was to investigate the relationship of AEG-1 with the prognostic parameters in invasive ductal and lobular carcinomas. Materials and methods: This study was conducted on a total of 72 paraffin-embedded breast tumour samples. They consisted of 61 ductal and 11 lobular carcinomas. Breast tumour samples were stained for AEG-1. The prognostic parameters were compared with the results of AEG-1 stains. Results: We observed …
Investigations Of Als1 And Hwp1 Genes In Clinical Isolates Of Candida Albicans, Melek İnci̇, Mustafa Altay Atalay, Burçi̇n Özer, Ömer Evi̇rgen, Ni̇zami̇ Duran, Vi̇cdan Köksaldi Motor, Ayşe Nedret Koç, Yüsüf Önlen, Çeti̇n Kilinç, Süleyman Durmaz
Investigations Of Als1 And Hwp1 Genes In Clinical Isolates Of Candida Albicans, Melek İnci̇, Mustafa Altay Atalay, Burçi̇n Özer, Ömer Evi̇rgen, Ni̇zami̇ Duran, Vi̇cdan Köksaldi Motor, Ayşe Nedret Koç, Yüsüf Önlen, Çeti̇n Kilinç, Süleyman Durmaz
Turkish Journal of Medical Sciences
To explore the presence of ALS1 and HWP1 genes by multiplex polymerase chain reaction (PCR) in Candida albicans strains. Materials and methods: By using the multiplex PCR method, the presence of agglutinin-like sequence 1 (ALS1) and hyphal wall protein 1 (HWP1) genes were investigated in 206 C. albicans strains that were isolated from various clinical samples. Phenotypic identification of slime formation by microplate and tube adherence tests was performed. Results: The presence of the ALS1 gene was detected in 53.9% of all strains, while the HWP1 gene was present in 5.3%. Slime formation was phenotypically detected in the 62.2% of …
The Effects Of Antioxidants On Testicular Apoptosis And Oxidative Stress Produced By Cell Phones, Aki̇f Koç, Doğan Ünal, Ersi̇n Çi̇mentepe, Ömer Bayrak, Ömer Faruk Karataş, Mehmet Erol Yildirim, Reyhan Bayrak, Murat Aydin
The Effects Of Antioxidants On Testicular Apoptosis And Oxidative Stress Produced By Cell Phones, Aki̇f Koç, Doğan Ünal, Ersi̇n Çi̇mentepe, Ömer Bayrak, Ömer Faruk Karataş, Mehmet Erol Yildirim, Reyhan Bayrak, Murat Aydin
Turkish Journal of Medical Sciences
The aim of this study was to determine the probable effects of cellular phone usage on apoptosis and oxidative/antioxidative balance in testicular tissue, and the probable protective role of vitamin C and E on these processes. Materials and methods: Forty-two male rats were divided into 6 groups: control, antioxidant, calling, stand-by, calling plus antioxidant, and stand-by plus antioxidant. Oxidant and antioxidant parameters and apoptotic indexes were studied. Two identical cell phones were used in the calling and stand-by groups. Results: Cell phone usage significantly increased apoptosis in call, but not in the stand-by position, in testicular tissue. Apoptosis produced in …
Effects Of Obstructive Sleep Apnea Syndrome On Temperament And Character, Fatma Fi̇dan, Ömer Özbulut, Apdullah Ayçi̇çek, Ahmet Hakki Aşik, Mehmet Ünlü
Effects Of Obstructive Sleep Apnea Syndrome On Temperament And Character, Fatma Fi̇dan, Ömer Özbulut, Apdullah Ayçi̇çek, Ahmet Hakki Aşik, Mehmet Ünlü
Turkish Journal of Medical Sciences
There are few studies that have evaluated personality characteristics in patients with obstructive sleep apnea syndrome (OSAS). We aimed to evaluate 2 groups, OSAS patients and controls, using a temperament and character inventory (TCI) questionnaire. Materials and methods: Patients with OSAS symptoms and who underwent polysomnography in the sleep laboratory were included in the study. A TCI questionnaire was given to 52 patients. Those whose apnea-hypoapnea index (AHI) was >=10 were included as the OSAS group and those whose score was
Effectiveness Of Hp-Hmg Versus R-Fsh In Patients Undergoing Ivf/Icsi Cycles With Moderate Male-Factor Infertility, Ni̇lgün Turhan, Aslihan Pekel, Ayli̇n Ayrim, Burcu Kasap, Ömer Bayrak
Effectiveness Of Hp-Hmg Versus R-Fsh In Patients Undergoing Ivf/Icsi Cycles With Moderate Male-Factor Infertility, Ni̇lgün Turhan, Aslihan Pekel, Ayli̇n Ayrim, Burcu Kasap, Ömer Bayrak
Turkish Journal of Medical Sciences
The aim of this case-control study was to compare the efficacy of highly purified human menopausal gonadotropin (HP-hMG) versus recombinant follicle stimulating hormone (r-FSH) treatments following gonadotropin-releasing hormone (GnRH) agonist suppression in patients undergoing intracytoplasmic sperm injection (ICSI) with moderate male-factor infertility in terms of oocyte and embryo quality and clinical pregnancy outcomes. Materials and methods: A total of 240 infertile women were treated with HP-hMG (HP-hMG group, n = 120 patients) or r-FSH (r-FSH group, n = 120 patients) following GnRH agonist suppression (long regimen). Inclusion criteria for the study groups were infertility due to moderate oligoasthenoteratospermia with no …
Can Plasma-Free Dna Concentration Be A Diagnostic Tool In Critically Ill Septic Patients?, Başak Ceyda Meço, Fatma Handan Cuhruk, Melek Tulunay, Mehmet Oral, Mustafa Necmetti̇n Ünal
Can Plasma-Free Dna Concentration Be A Diagnostic Tool In Critically Ill Septic Patients?, Başak Ceyda Meço, Fatma Handan Cuhruk, Melek Tulunay, Mehmet Oral, Mustafa Necmetti̇n Ünal
Turkish Journal of Medical Sciences
To investigate the diagnostic value of plasma-free DNA concentration (PF-DNA) in septic patients compared to nonseptic patients and to correlate it with clinical outcome. Materials and methods: Forty-two mechanically ventilated consecutive patients (11 septic, 31 nonseptic) admitted to the intensive care unit (ICU) were recruited. On admission, besides PF-DNA concentration, APACHE II and SOFA scores and serum C-reactive protein (CRP), procalcitonin (PCT), and serum lipid concentrations, together with clinical outcome, were assessed. Plasma samples from 11 volunteers were also collected. Appropriate statistics were used for analysis. Results: Median PF-DNA concentrations on admission were significantly higher in septic patients compared to …
Preliminary Data From A Surveillance Study On Surgical Site Infections And Assessment Of Risk Factors In A University Hospital, Mustafa Namiduru, İlkay Karaoğlan, Riza Çam, Vuslat Boşnak, Ayşe Özlem Mete
Preliminary Data From A Surveillance Study On Surgical Site Infections And Assessment Of Risk Factors In A University Hospital, Mustafa Namiduru, İlkay Karaoğlan, Riza Çam, Vuslat Boşnak, Ayşe Özlem Mete
Turkish Journal of Medical Sciences
Surgical site infections (SSIs) lead to substantial mortality, morbidity, and socioeconomic loss. To explore the rate of infections and risk factors for the development of infection in surgical units. Materials and methods: All patients (n = 1397) who underwent a surgical intervention and were hospitalized for >48 h in surgical units (except the ophthalmology unit) of Gaziantep University Medical Faculty Hospital between 17 March 2008 and 15 July 2008 were included in the study. The Center for Disease Control and Prevention criteria were used for identifying and diagnosing SSIs. Rate of SSI was calculated as the number of SSIs observed …
Pyrazinamide Monoresistance In Clinical Isolates, Nezaket Kalir, Ayşe Aydan Özkütük, Nuran Esen, Nuri̇ Özkütük
Pyrazinamide Monoresistance In Clinical Isolates, Nezaket Kalir, Ayşe Aydan Özkütük, Nuran Esen, Nuri̇ Özkütük
Turkish Journal of Medical Sciences
To determine pyrazinamide (PZA) monoresistance in clinical isolates of Mycobacterium tuberculosis complex (MTBC) isolated in hospitals in and around İzmir. Materials and methods: The study was performed between 2004 and 2009 with 150 streptomycin, isoniazid, rifampicin, and ethambutol susceptible MTBC clinical strains isolated in the university hospitals of İzmir and Manisa. The PZA susceptibility of the isolates was determined by the BACTEC 460 TB test. Results: The results indicated that resistance to PZA was present in 5 (3.3%) of the 150 MTBC isolates susceptible to all primary drugs except PZA. Conclusion: It is not essential to perform PZA susceptibility tests …
Investigation Of The Protective Effects Of L-Carnitine And L-Arginine On Cardiovascular Changes Induced By Acth And Dexamethasone In Rabbits, Bi̇rkan Topçu, Metehan Uzun
Investigation Of The Protective Effects Of L-Carnitine And L-Arginine On Cardiovascular Changes Induced By Acth And Dexamethasone In Rabbits, Bi̇rkan Topçu, Metehan Uzun
Turkish Journal of Medical Sciences
To determine the protective effects of L-carnitine on cardiovascular changes that may occur in rabbits treated with adrenocorticotropic hormone (ACTH) and dexamethasone (DEX). Materials and methods: Rabbits of equal weight were divided into 7 groups with 6 animals in each. Blood samples were collected from all groups on days 1, 7, and 14, and blood pressure values and ECG monitoring were recorded. Nitric oxide (NO), creatine kinase MB (CK-MB), and troponin I (TnI) levels were determined in blood samples. Heart rate, QT, and corrected QT (QTc) values were calculated from ECG records. Results: The QT and QTc times were prolonged …
The Effects Of An Adaptive Directional Beam Microphone On The Mismatch Negativity Responses Of Cochlear Implant Users In Noise, Asuman Erdoğan, Ferda Akdaş
The Effects Of An Adaptive Directional Beam Microphone On The Mismatch Negativity Responses Of Cochlear Implant Users In Noise, Asuman Erdoğan, Ferda Akdaş
Turkish Journal of Medical Sciences
To investigate the effects of noise on mismatch negativity (MMN) responses and the possible benefits of an adaptive directional BEAM microphone in noise during MMN recordings, and to compare the cochlear implant-evoked potential results with normal hearing subjects. Materials and methods: /da/ and /di/ speech stimuli were used to elicit MMN responses in 11 Freedom cochlear implant users and in 11 normal hearing subjects. Speech noise was delivered at 80 dB sound pressure level (-10 dB signal-to-noise ratio). All subjects were tested in quiet and noisy conditions. To compare the microphone effects, MMN responses for the cochlear implant group were …