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Articles 1 - 30 of 196
Full-Text Articles in Medicine and Health Sciences
Is The Management Of Rh-Rh Incompatibility With Noninvasive Fetal Rh Genotypingfor Targeted Prophylaxis Cost-Effective In The Turkish Population?, Emi̇ne Demi̇rel, Sefa Kelekçi̇, Emre Ekmekci̇, Mustafa Şengül, Razi̇ye İri̇, Melahat Atasever
Is The Management Of Rh-Rh Incompatibility With Noninvasive Fetal Rh Genotypingfor Targeted Prophylaxis Cost-Effective In The Turkish Population?, Emi̇ne Demi̇rel, Sefa Kelekçi̇, Emre Ekmekci̇, Mustafa Şengül, Razi̇ye İri̇, Melahat Atasever
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to assess unnecessary immunization rates and compare the cost-effectiveness of targeted prophylaxis with fetal Rh genotyping with that of traditional management of Rh-Rh incompatibility in a virtual economic model. Materials and methods: This retrospective data analysis was conducted at two tertiary centers between 2011 and 2015. The data of 1135 pregnant women were analyzed. The main outcome measure was to determine the unnecessary immunization rate among the whole Rh-Rh incompatibility group. The second outcome measure was to compare the cost-effectiveness of universal immunization with that of targeted prophylaxis with fetal Rh genotyping in …
The Effect Of Obstructive Sleep Apnea Syndrome On The Central Auditory System, Ayşe İri̇z, Mehmet Düzlü, Oğuz Köktürk, Yusuf Kemal Kemaloğlu, Faki̇h Ci̇hat Eravci, Işik Si̇bel Küçükünal, Recep Karamert
The Effect Of Obstructive Sleep Apnea Syndrome On The Central Auditory System, Ayşe İri̇z, Mehmet Düzlü, Oğuz Köktürk, Yusuf Kemal Kemaloğlu, Faki̇h Ci̇hat Eravci, Işik Si̇bel Küçükünal, Recep Karamert
Turkish Journal of Medical Sciences
Background/aim: Obstructive sleep apnea syndrome (OSAS) is a disease characterized by repeated hypoxia attacks during sleep. The effect of hypoxia on the central nervous system is a well-known entity. In this study we aimed to investigate the effect of OSAS on the central auditory system. Materials and methods: Twenty-one OSAS patients diagnosed by polysomnography (PSG) and 10 control subjects were included in the study. After a thorough otorhinolaryngology examination, all subjects underwent pure tone audiometry (250 to 8000 Hz frequency). The subjects with normal otoscopic examination and hearing threshold were included in the study. All participants underwent speech discrimination analyses …
An Analysis Of The Relationship Between Autoantibodies Andclinical Findings In Patients With Systemic Sclerosis, Müçteba Enes Yayla, Ufuk İlgen, Nurşen Düzgün
An Analysis Of The Relationship Between Autoantibodies Andclinical Findings In Patients With Systemic Sclerosis, Müçteba Enes Yayla, Ufuk İlgen, Nurşen Düzgün
Turkish Journal of Medical Sciences
Background/aim: We aimed to investigate the prevalence of anti-RNA polymerase (RNAP) III and other autoantibodies in a group of Turkish patients with systemic sclerosis (SSc) and their relation with clinical features. Materials and methods: The prevalence of anti-RNAP III and other autoantibodies was analyzed in 93 patients with SSc and control groups including 86 patients with systemic lupus erythematosus (SLE) and 65 healthy subjects, respectively. Their relationship with diseases findings was assessed in a cross-sectional manner. Results: Prevalences of anti-RNAP III were 2/93 (2.2%) in SSc, 1/86 (1.2%) in SLE, and 1/65 (1.5%) in the healthy group and there was …
Advantages Of B-Mode Ultrasound Combined With Strain Elastography In Differentiation Of Idiopathic Granulomatous Mastitis From Malignant Breast Lesions, Serdar Arslan, Fati̇h Öncü, M. Ali̇ Eryilmaz, Mehmet Sedat Durmaz, Ayşegül Altunkeser, Yaşar Ünlü
Advantages Of B-Mode Ultrasound Combined With Strain Elastography In Differentiation Of Idiopathic Granulomatous Mastitis From Malignant Breast Lesions, Serdar Arslan, Fati̇h Öncü, M. Ali̇ Eryilmaz, Mehmet Sedat Durmaz, Ayşegül Altunkeser, Yaşar Ünlü
Turkish Journal of Medical Sciences
Background/aim: To evaluate the diagnostic performance of strain elastography (SE) combined with B-mode ultrasound in distinguishing between idiopathic granulomatous mastitis (IGM) and malignant breast lesions. Materials and methods: Seventy-seven malignant breast lesions and 36 IGM were assessed using B-mode ultrasound and SE. Ultrasonographic findings for all the breast lesions were classified based on the 2013 American College of Radiology Breast Imaging Reporting and Data System (BI-RADS-US), and the SE findings were evaluated based on the strain ratio and a five-point scale. The diagnostic performances of B-mode ultrasonography, SE, and the combination of both methods were compared. Results: Significant differences in …
Cpr-Related Thoracic Injuries: Comparison Of Cpr Guidelines Between 2010 And 2015, Kaan Yusufoğlu, Mehmet Özgür Erdoğan, İsmai̇l Tayfur, Mustafa Ahmet Afacan, Şahi̇n Çolak
Cpr-Related Thoracic Injuries: Comparison Of Cpr Guidelines Between 2010 And 2015, Kaan Yusufoğlu, Mehmet Özgür Erdoğan, İsmai̇l Tayfur, Mustafa Ahmet Afacan, Şahi̇n Çolak
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate traumatic thorax complications in post-CPR patients and to investigate whether or not there has been a decrease in these complications since the adoption of current chest compression recommendations. Materials and methods: Post-CPR patients with return of spontaneous circulation (ROSC) were admitted between January 2014 and January 2016 were analyzed retrospectively. Patients admitted to the ED in 2014 were resuscitated according to 2010 AHA CPR guidelines, while those admitted to the ED in 2015 were resuscitated according to current ERC CPR guidelines. Results: The study population comprised 48 male and 35 female patients. Of the …
Is The Extent Of Surgical Resection Important In Patient Outcome In Benign And Borderline Phyllodes Tumors Of The Breast?, Ali̇ İbrahi̇m Sevi̇nç, Süleyman Özkan Aksoy, Meri̇h Güray Durak, Pinar Balci
Is The Extent Of Surgical Resection Important In Patient Outcome In Benign And Borderline Phyllodes Tumors Of The Breast?, Ali̇ İbrahi̇m Sevi̇nç, Süleyman Özkan Aksoy, Meri̇h Güray Durak, Pinar Balci
Turkish Journal of Medical Sciences
Background/aim: Phyllodes tumors (PTs) of the breast are rare, and their diagnosis and treatment remain controversial. This retrospective study aims to examine the clinical outcome of benign and borderline PTs, according to the surgical margins. Materials and methods: We examined the medical records of 122 patients in our clinic, who had histologically confirmed benign and borderline PTs between 1994 and 2017. Results: The mean age of the patients was 40.6 years (range 18.0-81.0, ±12.1 standard deviation [SD]) and the mean tumor size was 25.8 mm (range 9-65, ±10.3 SD). All patients underwent a breast-conserving procedure and the median follow-up was …
Efficacy Of Adhesive Strips To Reduce Postoperative Periorbital Edema And Ecchymosis Following Rhinoplasty, Sedat Tatar, Mehmet Hakan Bulam, Selahatti̇n Özmen
Efficacy Of Adhesive Strips To Reduce Postoperative Periorbital Edema And Ecchymosis Following Rhinoplasty, Sedat Tatar, Mehmet Hakan Bulam, Selahatti̇n Özmen
Turkish Journal of Medical Sciences
Background/aim: Periorbital edema and ecchymosis may develop following rhinoplasty. The aim of this study was to assess the efficacy of adhesive strip application on the upper and lower eyelids to reduce postoperative edema and ecchymosis following rhinoplasty. Materials and methods: The eyelids of one side were randomly selected, and an adhesive strip of standard size and number was applied at the end of the operation. The strips were removed at postoperative day 3; photos of the eyes were taken at days 3 and 7. Edema and ecchymosis were graded on a scale from 1 to 4. The ecchymosis areas on …
Correlation Between Epicardial Adipose Tissue Thickness And The Degree Of Coronary Artery Atherosclerosis, Arthur Atilla Keresztesi, Gabriela Asofie, Mihai Adrian Simion, Harald Jung
Correlation Between Epicardial Adipose Tissue Thickness And The Degree Of Coronary Artery Atherosclerosis, Arthur Atilla Keresztesi, Gabriela Asofie, Mihai Adrian Simion, Harald Jung
Turkish Journal of Medical Sciences
Background/aim: The purpose of the current study was to evaluate the thickness of the epicardial adipose tissue and its association with the degree of coronary artery disease in a group of autopsied cases. Materials and methods: A number of 79 cases were included in the study. Five preestablished incisions of the epicardial adipose tissue (EAT) were made on each of the hearts. These five points were next to/on the path of the major coronary vessels. The degree of coronary atherosclerosis was evaluated during the autopsy. Results: The results revealed the greatest thickness of the EAT on the incision made on …
Hiv Infection And Poor Renal Outcomes Following Noncardiac Surgery, Yoshan Moodley
Hiv Infection And Poor Renal Outcomes Following Noncardiac Surgery, Yoshan Moodley
Turkish Journal of Medical Sciences
Background/aim: The relevance of HIV infection in perioperative renal risk stratification remains unclear. This research sought to investigate the impact of HIV infection, as well as other established preoperative risk factors for poor perioperative renal outcome (PPRO), in a population of 565,225 adult noncardiac surgery patients whose data were obtained from the 2009-2011 California State Inpatient Database. Materials and methods: HIV status, established preoperative risk factors, and the study outcome (PPRO) were determined with the Clinical Classification Software codes recorded for each patient. Data were analyzed using univariate (Mann-Whitney U test, chi-square, and Fisher′s exact test) and multivariate (binary logistic …
Relationship Between Pk2 And Number Of Kupffer Cells Duringthe Progression Of Liver Fibrosis In Patients With Hbv, Xiao-Qin Liu, Rong-Rong Wei, Cheng-Cheng Wang, Li-Yu Chen, Cong Liu, Kai Liu
Relationship Between Pk2 And Number Of Kupffer Cells Duringthe Progression Of Liver Fibrosis In Patients With Hbv, Xiao-Qin Liu, Rong-Rong Wei, Cheng-Cheng Wang, Li-Yu Chen, Cong Liu, Kai Liu
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the potential regulatory role of prokineticin 2 (PK2) in modulation of the number and function of Kupffer cells (KCs) during the progression of liver fibrosis in patients with hepatitis B virus (HBV). Materials and methods: We obtained liver tissue sections from 200 patients with HBV undergoing surgical resection in our hospital between January 2013 and July 2016. Of these 200 tissue sections, 150 were fibrosis tissues and 50 were hepatocellular carcinoma tissues. Immunohistochemical evaluations were performed to assess the expression levels of CD68 and PK2 in the sections. The clinical parameters of these 200 …
Comparison Of Standard Agglutination Tests, Enzyme Immunoassay, And Coombs Gel Test Used In Laboratory Diagnosis Of Human Brucellosis, Emi̇ne Emel Koçman, Memnune Selda Erensoy, Meltem Taşbakan, Meltem Çi̇çekli̇oğlu
Comparison Of Standard Agglutination Tests, Enzyme Immunoassay, And Coombs Gel Test Used In Laboratory Diagnosis Of Human Brucellosis, Emi̇ne Emel Koçman, Memnune Selda Erensoy, Meltem Taşbakan, Meltem Çi̇çekli̇oğlu
Turkish Journal of Medical Sciences
Background/aim: It was aimed to evaluate the results of Rose Bengal (RB), ELISA total tests (IgM and IgG), and the Brucella Coombs gel test (BCGT), which are used as screening tests, with the combined results of a tube agglutination test (standard Wright test: SWT) and a tube agglutination test with antihuman globulin (AHG TAT). Materials and methods: Samples from 97 patients prediagnosed with brucellosis (age ≥18 years) were screened with RB, ELISA, and BCGT. SWT < 160 samples and RB-negative but ELISA- or BCGT-positive samples were tested by AHG TAT. SWT ≥ 160 or AHG TAT ≥ 160 was taken as reference. Results: Thirty-two of 56 RB-positive samples and one RB-negative but ELISA- and BCGT-positive sample were found to be ≥160 with SWT or AHG TAT. Sensitivity, specificity, accuracy, and agreement (kappa) values according to SWT ≥ 160 or AHG TAT ≥ 160 positivity were as follows, respectively: RB 96.9%, 62.5%, 74.2%, and 0.509; ELISA total 100%, 60.9%, 74.2%, and 0.515; BCGT test 97%, 70.3%, 79.4%, and 0.594. Conclusion: Sensitivities of the screening tests are similar, but positivities should be confirmed by more specific tests. Positive samples from screening tests should be tested with AHG if the SWT value is
Carfilzomib Experience In Relapsed/Refractory Multiplemyeloma: A Single-Center Experience, Ayşe Uysal, Nur Akad Soyer, Melda Özkan, Fahri̇ Şahi̇n, Fi̇li̇z Vural, Mahmut Töbü, Murat Tombuloğlu, Güray Saydam
Carfilzomib Experience In Relapsed/Refractory Multiplemyeloma: A Single-Center Experience, Ayşe Uysal, Nur Akad Soyer, Melda Özkan, Fahri̇ Şahi̇n, Fi̇li̇z Vural, Mahmut Töbü, Murat Tombuloğlu, Güray Saydam
Turkish Journal of Medical Sciences
Background/aim: Carfilzomib (CFZ) is a new-generation proteasome inhibitor with significant activity in relapsed or refractory multiple myeloma (R/R-MM). We have retrospectively evaluated R/R-MM patients who were treated with CFZ plus dexamethasone. Materials and methods: Twenty-one R/R-MM patients who were treated with CFZ plus dexamethasone between October 2013 and January 2016 were screened. The patients were followed until March 2016 after CFZ treatment. Results: Ten (47.6%) of the patients were female and 11 (52.4%) of them were male. The median age was 62 (47-76) years. The median number of prior treatment lines was 3 (2-7). The median number of administered cycles …
Neuroendocrine Tumors Detected In Appendectomy Specimens: Ten-Year Single-Center Experience, Fatma Şenel, Hati̇ce Karaman, Hacer Demi̇r
Neuroendocrine Tumors Detected In Appendectomy Specimens: Ten-Year Single-Center Experience, Fatma Şenel, Hati̇ce Karaman, Hacer Demi̇r
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate neuroendocrine tumors (NETs) detected in appendectomy specimens and the incidence and clinicopathologic characteristics of these tumors in our center. Materials and methods: A total of 13,863 patients were evaluated retrospectively. All underwent appendectomy operation in the Kayseri Training and Research Hospital and had a histopathological examination at the Pathology Clinic between January 2007 and March 2017. Age, sex, preoperative clinical findings, operation procedure, and histopathological examination results of the cases reported to be NET are presented. Results: NET was detected in 29 cases (0.2%) in the histopathological examination of 13,863 appendectomy …
Appraisal Of The ″Pediatric Ards: Consensus Recommendations From The Pediatric Acute Lung Injury Consensus Conference″ With The Agree Ii Instrument, Orkun Tolunay, İlknur Tolunay, Riza Di̇nçer Yildizdaş, Tamer Çeli̇k, Ümi̇t Çeli̇k
Appraisal Of The ″Pediatric Ards: Consensus Recommendations From The Pediatric Acute Lung Injury Consensus Conference″ With The Agree Ii Instrument, Orkun Tolunay, İlknur Tolunay, Riza Di̇nçer Yildizdaş, Tamer Çeli̇k, Ümi̇t Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: The ″Pediatric Acute Lung Injury Consensus Conference″ (PALICC) was convened in order to develop a taxonomy to define pediatric acute respiratory distress syndrome (ARDS). The Appraisal of Guidelines for Research and Evaluation (AGREE) assesses the quality of guidelines. The aim of this study is to evaluate the new pediatric ARDS guideline using the AGREE II instrument. To the best of our knowledge, this is the first assessment of the new pediatric ARDS clinical practice guideline in the English literature. Materials and methods: Four appraisers assessed the new pediatric ARDS guideline with the AGREE II instrument. At the end of …
Validity And Reliability Of The Turkish Version Of The Dsm-5 Generalized Anxiety Disorder Severity Scale For Children Aged 11-17 Years, Şermi̇n Yalin Sapmaz, Handan Özek Erkuran, Di̇lek Ergi̇n, Masum Öztürk, Nesri̇n Şen Celasi̇n, Duygu Karaarslan, Ömer Aydemi̇r
Validity And Reliability Of The Turkish Version Of The Dsm-5 Generalized Anxiety Disorder Severity Scale For Children Aged 11-17 Years, Şermi̇n Yalin Sapmaz, Handan Özek Erkuran, Di̇lek Ergi̇n, Masum Öztürk, Nesri̇n Şen Celasi̇n, Duygu Karaarslan, Ömer Aydemi̇r
Turkish Journal of Medical Sciences
Background/aim: This study aimed to assess the validity and reliability of the Turkish version of the DSM-5 Generalized Anxiety Disorder Severity Scale - Child Form. Materials and methods: The study sample consisted of 32 patients treated in a child psychiatry unit and diagnosed with generalized anxiety disorder and 98 healthy volunteers who were attending middle or high school during the study period. For the assessment, the Screen for Child Anxiety and Related Emotional Disorders (SCARED) was also used along with the DSM-5 Generalized Anxiety Disorder Severity Scale - Child Form. Results: Regarding reliability analyses, the Cronbach alpha internal consistency coefficient …
Soft Spot: The Important Zone At The Standard Posterior Portal Of Shoulder Arthroscopy, Burcu Erçakmak, Ceren Günenç Beşer, Mehmet Hakan Özsoy, Mehmet Deni̇z Demi̇ryürek, Alp Bayramoğlu, Kadi̇r Mutlu Hayran
Soft Spot: The Important Zone At The Standard Posterior Portal Of Shoulder Arthroscopy, Burcu Erçakmak, Ceren Günenç Beşer, Mehmet Hakan Özsoy, Mehmet Deni̇z Demi̇ryürek, Alp Bayramoğlu, Kadi̇r Mutlu Hayran
Turkish Journal of Medical Sciences
Background/aim: The localization of the standard posterior portal of shoulder arthroscopy and landmarks mentioned in the literature are unclear. The purpose of this prospective cadaveric study was to determine the localization of the standard posterior portal and its distance to the neural structures. Materials and methods: One fresh frozen and 10 formalin-fixed adult cadaveric shoulders were dissected. In the beach chair position, a 5-mm trocar was placed anteroposteriorly from the superior edge of the subscapularis muscle, superior to the tip of the coracoid process and tangent to the glenoid. The relevant distances of the posterior exit point were measured. Results: …
Bedside Measurement Of The Optic Nerve Sheath Diameterwith Ultrasound In Cerebrovascular Disorders, Yücel Yüzbaşioğlu, Sema Yüzbaşioğlu, Selçuk Coşkun, Ferhat İçme, Tolga Öz, Refi̇k Kunt, Si̇nan Becel, Emi̇ne Akçay, Havva Şahi̇n Kavakli
Bedside Measurement Of The Optic Nerve Sheath Diameterwith Ultrasound In Cerebrovascular Disorders, Yücel Yüzbaşioğlu, Sema Yüzbaşioğlu, Selçuk Coşkun, Ferhat İçme, Tolga Öz, Refi̇k Kunt, Si̇nan Becel, Emi̇ne Akçay, Havva Şahi̇n Kavakli
Turkish Journal of Medical Sciences
Background/aim: We aimed to show the role of determination of optic nerve sheath diameter (ONSD) by bedside ultrasonography in an emergency department in the diagnosis of cerebrovascular disorders and its correlation with the clinical picture. Materials and methods: This prospective cross-sectional study included 55 patients with cerebrovascular disorders and 53 controls. Age, sex, ONSD, comorbid disease status, and multidetector computed tomography results of all subjects and application periods and National Institutes of Health Stroke Scale (NIHSS) scores of the patient group were evaluated. Results: The ONSD of the patient and control groups was determined as a median of 5.7 mm …
Evaluation Of Urinary Incontinence And Quality Of Life In Marriedwomen Aged Between 20 And 49 Years (Sakarya, Turkey), Kevser İlçi̇oğlu, Sevi̇l Şahi̇n, Nebahat Özerdoğan, Alaetti̇n Ünsal
Evaluation Of Urinary Incontinence And Quality Of Life In Marriedwomen Aged Between 20 And 49 Years (Sakarya, Turkey), Kevser İlçi̇oğlu, Sevi̇l Şahi̇n, Nebahat Özerdoğan, Alaetti̇n Ünsal
Turkish Journal of Medical Sciences
Background/aim: This study aimed to determine the prevalence of urinary incontinence and to evaluate the relationship between urinary incontinence and quality of life in married women. Materials and methods: This is a cross-sectional study conducted among married women aged 20-49 years living in the vicinity of the Çökekler Community Clinic (Family Health Center) in Sakarya, Turkey, from 1 November 2011 to 15 April 2012. The study group consisted of 1161 women. Results: The frequency of urinary incontinence was 71.5% (n = 830). Out of a total of 830 patients with symptoms of urinary incontinence, mixed was the most frequently determined …
Diagnostic Utility Of The Sonographic Median To Ulnar Nervecross-Sectional Area Ratio In Carpal Tunnel Syndrome, Tuğba Atan, Zafer Günendi̇
Diagnostic Utility Of The Sonographic Median To Ulnar Nervecross-Sectional Area Ratio In Carpal Tunnel Syndrome, Tuğba Atan, Zafer Günendi̇
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to assess the diagnostic utility of the ultrasonographic ratio of median nerve cross-sectional area (m-CSA) to ulnar nerve cross-sectional area (u-CSA), the m-CSA/u-CSA ratio, in carpal tunnel syndrome (CTS). Materials and methods: Fifty patients with positive symptoms and electromyography results of CTS and 50 healthy matched control subjects were evaluated. Ultrasonographic m-CSA and u-CSA measurements of each participant were made at the level of the pisiform bone and the m-CSA/u-CSA ratio was calculated. Results: Using the m-CSA cut-off value of 11.95 mm2 showed a sensitivity of 80% and a specificity of 80% while …
Prognostic Value Of Interferon-Gamma, Interleukin-6, And Tumor Necrosis Factor-Alpha In The Radiation Response Of Patients Diagnosed With Locally Advanced Non-Small-Cell Lung Cancer And Glioblastoma Multiforme, Çi̇ğdem Damla Deni̇z, Mehmet Gürbi̇lek, Mehmet Koç
Prognostic Value Of Interferon-Gamma, Interleukin-6, And Tumor Necrosis Factor-Alpha In The Radiation Response Of Patients Diagnosed With Locally Advanced Non-Small-Cell Lung Cancer And Glioblastoma Multiforme, Çi̇ğdem Damla Deni̇z, Mehmet Gürbi̇lek, Mehmet Koç
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the effect of chemoradiotherapy (CRT) on interferon-gamma (IFN-γ), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), which are critical markers of the clinical radiation response of patients with locally advanced non-small-cell lung cancer (NSCLC) and glioblastoma multiforme (GBM). Materials and methods: Thirty patients who were treated with CRT and 20 healthy controls were prospectively evaluated. Circulating levels of cytokines were measured by enzyme-linked immunosorbent assay procedure. Post-CRT and pre-CRT levels were compared. Results: Post-CRT, TNF-α and IFN-γ levels were significantly lower than pre-CRT levels in the NSCLC and GBM groups, respectively. The statistical analysis did …
Cross-Cultural Adaptation, Reliability, And Validity Of The Turkish Version Of The Cancer Fatigue Scale In Patients With Breast Cancer, Sedef Şahi̇n, Meral Huri̇, Orkun Tahi̇r Aran, Mi̇ne Uyanik
Cross-Cultural Adaptation, Reliability, And Validity Of The Turkish Version Of The Cancer Fatigue Scale In Patients With Breast Cancer, Sedef Şahi̇n, Meral Huri̇, Orkun Tahi̇r Aran, Mi̇ne Uyanik
Turkish Journal of Medical Sciences
Background/aim: The Cancer Fatigue Scale (CFS) was developed to evaluate the severity of fatigue in patients with breast cancer. The aim of this study is to translate and culturally adapt a Turkish version and investigate the validity and reliability of the CFS in Turkish patients with fatigue symptoms. Materials and methods: Eighty participants completed the Turkish version of the CFS for breast cancer and the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire ″Core 30″ (EORTC QLQ-C30). Test-retest reliability was evaluated by repeating the CFS with a 7-day interval. Results: The CFS demonstrated high test-retest …
Retinopathy Of Prematurity In Extremely Premature Infants: Multiplebirths Versus Single Births, İkbal Seza Petri̇çli̇, Caner Kara, Ni̇hal Demi̇rel, Di̇lek Ulubaş Işik, Ahmet Yağmur Baş
Retinopathy Of Prematurity In Extremely Premature Infants: Multiplebirths Versus Single Births, İkbal Seza Petri̇çli̇, Caner Kara, Ni̇hal Demi̇rel, Di̇lek Ulubaş Işik, Ahmet Yağmur Baş
Turkish Journal of Medical Sciences
Background/aim: This study aimed to compare the incidence of any stage of retinopathy of prematurity (ROP) and type 1 ROP between extremely preterm multiple- and single-birth infants. Materials and methods: In this retrospective study, we included extremely preterm infants who were ≤27 weeks of gestational age at birth. The screened infants were divided into two groups: single and multiple births. The incidence of any stage of ROP and type 1 ROP was compared between the groups. Results: This study included 301 infants; 225 were in the single-birth group and 76 were in multiple-birth group. The incidences of any stage of …
Bservational Study Of Dermatological Manifestations In Patients Admitted To Atertiary Poison Center In Iran, Haleh Talaie, Soheila Nasiri, Mehdi Gheisari, Sahar Dadkhahfar, Soma Ahmadi
Bservational Study Of Dermatological Manifestations In Patients Admitted To Atertiary Poison Center In Iran, Haleh Talaie, Soheila Nasiri, Mehdi Gheisari, Sahar Dadkhahfar, Soma Ahmadi
Turkish Journal of Medical Sciences
Background/aim: Acute unintentional and deliberate poisoning by medications and chemicals is a frequent emergency, especially in Iran. This study aimed to evaluate the frequency and character of skin findings occurring in patients with acute intentional and aunintentional poisoning. Materials and methods: This prospective observational study was performed at the Loghman Hakim Hospital Poison Center over a period of 6 months from April 2016 to September 2016. Data including patient demographics, cause of poisoning, and level of consciousness were collected. Pediatric patients (under the age of 13) and patients who died in the first hours of admission were excluded from the …
Effects Of Nefopam With Fentanyl In Intravenous Patient-Controlled Analgesia After Arthroscopic Orthopedic Surgery: A Prospective Double-Blind Randomized Trial, You Na Oh, Kyu Nam Kim, Mi Ae Jeong, Dong Won Kim, Ji Yoon Kim, Hyun Seo Ki
Effects Of Nefopam With Fentanyl In Intravenous Patient-Controlled Analgesia After Arthroscopic Orthopedic Surgery: A Prospective Double-Blind Randomized Trial, You Na Oh, Kyu Nam Kim, Mi Ae Jeong, Dong Won Kim, Ji Yoon Kim, Hyun Seo Ki
Turkish Journal of Medical Sciences
Background/aim: We performed this prospective randomized double-blind study to compare the effects of nefopam versus ketorolac in intravenous fentanyl-based patient-controlled analgesia (PCA) after shoulder arthroscopic orthopedic surgery. Materials and methods: Ninety-two patients were randomly divided into two groups to receive intravenous PCA. Patients were assigned to either the nefopam group (nefopam 120 mg and fentanyl 20 µg/kg) or the ketorolac group (ketorolac 2 mg/kg and fentanyl 20 µg/kg). Pain was assessed on a visual analogue scale (VAS) and a numeric rating scale (NRS). Additionally, patient satisfaction, adverse events, and vital signs were monitored. Results: There were no significant differences in …
Translocation Breakpoints Of Chromosome 3 In Male Carriers: A Report Oftwelve Cases And A Review Of The Literature, Hongguo Zhang, Ruixue Wang, Linlin Li, Haibo Zhu, Hao Zhang, Ruizhi Liu
Translocation Breakpoints Of Chromosome 3 In Male Carriers: A Report Oftwelve Cases And A Review Of The Literature, Hongguo Zhang, Ruixue Wang, Linlin Li, Haibo Zhu, Hao Zhang, Ruizhi Liu
Turkish Journal of Medical Sciences
Background/aim: This study aimed to explore the breakpoints in chromosome 3 translocation and the clinical features present in male carriers to enable informed genetic counseling of these patients. Materials and methods: A total of 5235 men who were infertile or receiving counseling for infertility were recruited. Cytogenetic analyses were performed using G-banding. A search for translocations on chromosome 3 involved in male infertility was performed using PubMed, Google Scholar, and CNKI. The relationships of translocation breakpoints with male infertility and recurrent pregnancy loss were also analyzed. Results: Among the 82 patients with balanced reciprocal translocations among 5235 male patients, 12 …
Neutrophil-To-Lymphocyte Ratio And Microvascular Complications In Subjects With Type 2 Diabetes: Pakistan′S Perspective, Asher Fawwad, Anum Mehmood Butt, Iftikhar Ahmed Siddiqui, Maria Khalid, Rubina Sabir, Abdul Basit
Neutrophil-To-Lymphocyte Ratio And Microvascular Complications In Subjects With Type 2 Diabetes: Pakistan′S Perspective, Asher Fawwad, Anum Mehmood Butt, Iftikhar Ahmed Siddiqui, Maria Khalid, Rubina Sabir, Abdul Basit
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to find the association between diabetic microvascular complications and the neutrophil-to-lymphocyte ratio (NLR) in subjects with type 2 diabetes. Materials and methods: This was a retrospective study based on hospital data records from January 2005 to May 2016 at the Baqai Institute of Diabetology and Endocrinology. The eligibility criteria included subjects with type 2 diabetes with their latest complete blood count while subjects with conditions such as chronic inflammation, cancer, heart failure, and end-stage renal disease were not eligible for inclusion. Subjects were divided into two groups: one with any microvascular complications and …
Biofilm Formation In Uropathogenic Escherichia Coli: Association With Adhesion Factor Genes, Hojjatolah Zamani, Ali Salehzadeh
Biofilm Formation In Uropathogenic Escherichia Coli: Association With Adhesion Factor Genes, Hojjatolah Zamani, Ali Salehzadeh
Turkish Journal of Medical Sciences
Background/aim: Biofilm formation is a major determinant factor in the development of urinary tract infections (UTIs) by uropathogenic Escherichia coli (UPEC). Several adhesion factors are involved in attachment of bacterial cells to the urinary tract and biofilm development. Materials and methods: The possible relationship between different adhesion factor genes (AFGs) and biofilm formation among UPEC isolates was investigated. Prevalence of different AFGs including fimA, fimH, papAH, papC, papEF, sfa-S, foc/G, and bmaE and their association to biofilm formation were investigated. Phenotypic expression of type 1 and P fimbriae was also investigated. Results: Our results showed that 84% of UPEC were …
Effects Of Cinnamic Acid On Complications Of Diabetes, Hati̇ce Gül Anlar, Merve Bacanli, Tuğbagül Çal, Sevtap Aydin, Nuray Ari, Ülkü Ündeğer Bucurgat, Ari̇f Ahmet Başaran, Ayşe Nurşen Başaran
Effects Of Cinnamic Acid On Complications Of Diabetes, Hati̇ce Gül Anlar, Merve Bacanli, Tuğbagül Çal, Sevtap Aydin, Nuray Ari, Ülkü Ündeğer Bucurgat, Ari̇f Ahmet Başaran, Ayşe Nurşen Başaran
Turkish Journal of Medical Sciences
Background/aim: Diabetes mellitus (DM) is a major health problem worldwide. Cinnamic acid (CA) and its derivatives are synthesized in plants and increasing attention has been given to them in recent years due to the high number of beneficial health properties attributed to their consumption. The aim of this study was to investigate the effects of CA on streptozotocin-induced diabetes in Wistar albino rats. Materials and methods: DNA damage was evaluated in the blood, liver, and kidney cells of rats by the alkaline comet assay. Oxidative stress parameters such as catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase, and glutathione peroxidase activities and …
Protective Effect Of Erdosteine On Erythrocyte Deformabilityin A Rat Model Of Lower Limb Ischemia/Reperfusion Injury, Abdullah Özer, Hüseyi̇n Demi̇rtaş, Faruk Meti̇n Çomu, Di̇lek Erer, Yi̇ği̇t Kiliç, Bariş Mardi̇n, Mustafa Arslan, Ayşegül Küçük, Gürsel Levent Oktar
Protective Effect Of Erdosteine On Erythrocyte Deformabilityin A Rat Model Of Lower Limb Ischemia/Reperfusion Injury, Abdullah Özer, Hüseyi̇n Demi̇rtaş, Faruk Meti̇n Çomu, Di̇lek Erer, Yi̇ği̇t Kiliç, Bariş Mardi̇n, Mustafa Arslan, Ayşegül Küçük, Gürsel Levent Oktar
Turkish Journal of Medical Sciences
Background/aim: The protective effect of erdosteine on local and distant organ injury due to ischemia/reperfusion has been well documented but its effect on erythrocyte deformability needs further investigation. Our aim was to investigate the effect of erdosteine on erythrocyte deformability in the infrarenal aorta of rats undergoing ischemia/reperfusion. Materials and methods: Our study was conducted with 18 Wistar albino rats. Rats were divided into 3 groups: a randomized control group (group 'control', n = 6), an ischemia/reperfusion group without erdosteine (group 'ischemia/reperfusion', n = 6), and an ischemia/reperfusion group with erdosteine at 150 mg kg$^{-1}$, intraperitoneally (group 'ischemia/reperfusion - erdosteine', …
In Vivo Attenuation Of Angiogenesis In Hepatocellular Carcinoma By Nigella Sativa, Moustafa Fathy, Toshio Nikaido
In Vivo Attenuation Of Angiogenesis In Hepatocellular Carcinoma By Nigella Sativa, Moustafa Fathy, Toshio Nikaido
Turkish Journal of Medical Sciences
Background/aim: Angiogenesis is imperative in malignant tumor growth. Hepatocellular carcinoma is a typical hypervascular tumor that relies on angiogenesis. The aim of this study is to investigate the in vivo molecular mechanism underlying the antitumor properties of Nigella sativa ethanolic extract (NSEE) through its antiangiogenic effect against diethyl nitrosamine (DENA)-induced hepatocarcinogenesis. Materials and methods: Male Wistar rats were divided into 4 groups: normal, NSEE, DENA, and NSEE-DENA groups. Final body weight, hepatosomatic indices, serum AFP, serum vascular endothelial growth factor (VEGF) levels, and liver tissue hepatocyte growth factor ß (HGFß) protein expression were estimated. Liver sections were stained for histological …