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Articles 1 - 30 of 416
Full-Text Articles in Medicine and Health Sciences
Predictors Of Full Functional Recovery In Endovascularly Treated Patients With Aneurysmalsubarachnoid Hemorrhage, Fati̇h Uzunkaya, Ayşegül İdi̇l Soylu
Predictors Of Full Functional Recovery In Endovascularly Treated Patients With Aneurysmalsubarachnoid Hemorrhage, Fati̇h Uzunkaya, Ayşegül İdi̇l Soylu
Turkish Journal of Medical Sciences
Background/aim: The knowledge of factors influencing functional outcomes after aneurysmal subarachnoid hemorrhage (ASH) has significantly increased in recent decades, still not enough. We aimed to identify the predictors of full functional recovery (FFR) in endovascularly treated patients with ASH. Materials and methods: A retrospective review was performed of adult patients who underwent endovascular treatment for ASH in a 5-year period. The association was evaluated of variables with FFR, defined as a modified Rankin Scale score of 0 or 1 at a 3-month follow-up. Results: This study included 204 patients with a percentage of FFR of 62.7%. On univariate analysis, the …
Volume And T2 Relaxation Time Measurements Of Quadriceps Femoris And Hamstringmuscles Are Reliable And Reproducible, Şeri̇fe Şeyma Torğutalp, Ömer Özkan, Şafak Parlak Sağol, Hati̇ce Kader Karli Oğuz, Feza Korkusuz
Volume And T2 Relaxation Time Measurements Of Quadriceps Femoris And Hamstringmuscles Are Reliable And Reproducible, Şeri̇fe Şeyma Torğutalp, Ömer Özkan, Şafak Parlak Sağol, Hati̇ce Kader Karli Oğuz, Feza Korkusuz
Turkish Journal of Medical Sciences
Background/aim: Volume and T2 relaxation time measurements of the skeletal muscle provide quantitative information. We aimed to evaluate the interobserver reliability and the intraobserver reproducibility of measurements of volumes and T2 relaxation times of the quadriceps femoris and the hamstring muscles. Materials and methods: A cross-sectional reliability study was conducted on ten recreational athletes. The images of the quadriceps and the hamstring muscles of both limbs were obtained using a 3.0 Tesla magnetic resonance imaging (MRI) scanner. Two sports medicine specialists measured muscle volumes from a total of 2560 images and T2 relaxation times from a total of 40 images, …
Wnt Signaling Pathway Activities May Be Altered In Primary Sjogren's Syndrome, Ahmet Karataş, Zühal Ömerci̇koğlu, Burak Öz, Adi̇le Ferda Dağli, Onur Çatak, Fazi̇let Erman, Kazim Şahi̇n, Nevzat Gözel, Süleyman Serdar Koca
Wnt Signaling Pathway Activities May Be Altered In Primary Sjogren's Syndrome, Ahmet Karataş, Zühal Ömerci̇koğlu, Burak Öz, Adi̇le Ferda Dağli, Onur Çatak, Fazi̇let Erman, Kazim Şahi̇n, Nevzat Gözel, Süleyman Serdar Koca
Turkish Journal of Medical Sciences
Background/aim: Sjögren's syndrome (SS) is an autoimmune disease and its pathogenesis is still not completely clear. The wingless (Wnt)/ß-catenin pathway has recently been shown to play an important role in inflammation. This study aims to determine the serum and saliva levels of Dickkopf (DKK)1 and sclerostin and to evaluate Wnt-1 and Wnt-3a expression in the salivary gland in patients with primary SS. Materials and methods: This study included 30 patients diagnosed with SS, 30 patients diagnosed with systemic lupus erythematosus (SLE), and 29 healthy controls. Serum and saliva levels of DKK1 and sclerostin were measured and the expressions of Wnt1 …
Increased Incidence Of Malignancy In Patients With Primary Hyperparathyroidism, Meli̇a Karaköse, Muhammet Kocabaş, Mustafa Can, Hati̇ce Çalişkan Burgucu, İlker Çordan, Mustafa Kulaksizoğlu, Feri̇dun Karakurt
Increased Incidence Of Malignancy In Patients With Primary Hyperparathyroidism, Meli̇a Karaköse, Muhammet Kocabaş, Mustafa Can, Hati̇ce Çalişkan Burgucu, İlker Çordan, Mustafa Kulaksizoğlu, Feri̇dun Karakurt
Turkish Journal of Medical Sciences
Background/aim: Primary hyperparathyroidism (PHPT) is a disease that is diagnosed more frequently and generally in the asymptomatic period, with widely available biochemical tests. Evidence suggesting an association between PHPT and malignancy risk is increasing. Clarification of this association will be useful in PHPT for malignancy screening and management of patients with PHPT. In this study, we aimed to investigate the frequency of cancer in PHPT patients. Materials and methods: A total of 775 PHPT patients were included in the retrospective study. Demographic, clinical and laboratory data of the patients were evaluated retrospectively. Results: Malignancy was detected in 128 (16.50%) of …
Transient Minimal Hydronephrosis On Contralateral Kidney In Infants With Unilateralhydronephrosis: Is It An Early Sign Of Worsening Of The Affected Kidney?, Mirzaman Huseynov, Rahşan Özcan, Şenol Emre, Nur Canpolat, Sebuh Kuruğoğlu, Haluk Burçak Sayman, Mehmet Eli̇çevi̇k, Yunus Söylet, Sabri̇ Nafi̇z Cenk Büyükünal, Haluk Emi̇r
Transient Minimal Hydronephrosis On Contralateral Kidney In Infants With Unilateralhydronephrosis: Is It An Early Sign Of Worsening Of The Affected Kidney?, Mirzaman Huseynov, Rahşan Özcan, Şenol Emre, Nur Canpolat, Sebuh Kuruğoğlu, Haluk Burçak Sayman, Mehmet Eli̇çevi̇k, Yunus Söylet, Sabri̇ Nafi̇z Cenk Büyükünal, Haluk Emi̇r
Turkish Journal of Medical Sciences
Background/aim: The criteria for surgical management of ureteropelvic junction obstruction are not well-defined, and there is a risk for loss of renal function before the operation. In this context, certain changes in contralateral kidney had been investigated in order to increase the sensitivity of diagnosis. In this study, we aimed to investigate whether contralateral transient minimal hydronephrosis (CTMH) can be considered as an "early alarm" sign for worsening of the affected kidney in infants with hydronephrosis. Materials and methods: A total of 182 infants (92 surgically treated and 90 conservatively followed-up) with unilateral hydronephrosis were retrospectively analyzed. Ultrasonography and renal …
Long Term Neurological Sequela Of Isolated Infarctions According To The Topographicareas Of Thalamus, Aygül Tanti̇k Pak, Zahi̇de Mai̇l Gürkan, Sebahat Nacar Doğan, Yildizhan Şengül
Long Term Neurological Sequela Of Isolated Infarctions According To The Topographicareas Of Thalamus, Aygül Tanti̇k Pak, Zahi̇de Mai̇l Gürkan, Sebahat Nacar Doğan, Yildizhan Şengül
Turkish Journal of Medical Sciences
Background/aim: Thalamus infarctions presented with various clinical findings are considered to be related to classical and variative infarction areas. In our study, we aimed to compare the sequela clinical findings of patients with isolated thalamus infarction according to anatomical areas. Materials and methods: Seventy patients diagnosed with isolated thalamus infarction in our clinic between 2010 and 2020 were included in the study. The infarction areas of the patients were divided into groups by the radiologist, including the variative areas to the classical areas using magnetic resonance imaging. Neurological examinations were performed and recorded. Sequela clinical findings of the groups were …
Determinants Of Remission In A Case Series Of Medullary Thyroid Carcinoma, Tuğçe Apaydin, Eren İmre, Di̇lek Yavuz
Determinants Of Remission In A Case Series Of Medullary Thyroid Carcinoma, Tuğçe Apaydin, Eren İmre, Di̇lek Yavuz
Turkish Journal of Medical Sciences
Background/aim: We aimed to present the clinical results of patients with medullary carcinoma under follow-up in our center and to determine parameters affecting remission and lymph node metastases. Material and methods: A retrospective analysis was performed of the medical records of 27 patients with MTC who were followed up between 2004 and 2020. Results: The mean age at diagnosis was 47.7 ± 14 years. The mean follow-up was 7.29 ± 4.9 years. Metastatic neck lymphadenopathy was detected in eight (29.6%) patients; none had distant metastasis at the time of diagnosis. The median tumor diameter was 1.50 (range: 0.4-6) cm. The …
Effect Of Decompressive Hemicraniectomy In Patients With Acute Middle Cerebral Arteryinfarction, Hali̇l İbrahi̇m Süner, Anil Tanburoğlu, Emre Durdağ, Soner Çi̇vi̇, Ayli̇n Güneşli̇ Yeti̇şken, Özgür Kardeş, Çağatay Andi̇ç, Kadi̇r Tufan
Effect Of Decompressive Hemicraniectomy In Patients With Acute Middle Cerebral Arteryinfarction, Hali̇l İbrahi̇m Süner, Anil Tanburoğlu, Emre Durdağ, Soner Çi̇vi̇, Ayli̇n Güneşli̇ Yeti̇şken, Özgür Kardeş, Çağatay Andi̇ç, Kadi̇r Tufan
Turkish Journal of Medical Sciences
Background/aim: We aimed to determine in which cases this procedure may be more effective based on the data of patients who underwent decompressive hemicraniectomy (DHC). Material and methods: Overall, 47 patients who underwent DHC due to acute middle cerebral artery (MCA) infarction between January 2014 and january 2019 were retrospectively investigated. These patients were divided into two groups: those who died after DHC (Group A) and those who survived DHC (Group B). The groups were compared in terms of various parameters. We investigated whether the patient's modified Rankin scale (mRS) status changed depending on age (> 60 and < 60 years). Results: The median age of all patients was 65 (37-80) years; groups A and B had median ages of 66.5 (37-80) and 61 (44-79) years (p = 0.111), respectively; 55.3% patients were male. The elapsed times until hospitalization after the onset of symptoms were 4.5 and 3 h in groups A and B, respectively (p = 0.014). The median GCS score at the time of admission was 7 (5-12) and 10 (8-14) in groups A and B, respectively (p = 0.0001). At the time of admission, 63.3% patients in group A had anisocoria, whereas no patient in group B had anisocoria (p = 0.0001). In postoperative period, 40% patients in group A and all patients in group B received AC/AA treatment. The survival of patients aged < 60 and > 60 years …
Outcomes Of The Conservative Management Of The Patients With Endometrialintraepithelial Neoplasia/Endometrial Cancer: Wait Or Treat!, Esra İşçi̇ Bostanci, Yasi̇n Durmuş, Si̇nem Ayşe Duru Çöteli̇, Fulya Kayikçioğlu, Nuretti̇n Boran
Outcomes Of The Conservative Management Of The Patients With Endometrialintraepithelial Neoplasia/Endometrial Cancer: Wait Or Treat!, Esra İşçi̇ Bostanci, Yasi̇n Durmuş, Si̇nem Ayşe Duru Çöteli̇, Fulya Kayikçioğlu, Nuretti̇n Boran
Turkish Journal of Medical Sciences
Background/aim: The objective of the study was to evaluate the response, relapse, reproductive results and demographic features of the patients with endometrioid adenocancer (EAC) and endometrial intraepithelial neoplasia (EIN) who were treated with conservative treatment. This is the largest study when we consider the single center studies in this field. Materials and methods: In the current retrospective study, 38 patients (6 EAC, 31 EIN, 1 synchronous tumors of ovary and endometrium) were recruited. They were treated with progesterone products for their fertility desire and comorbidity. Reproductive results, response rates, and recurrence rates were calculated and survival analyses were performed. Results: …
Dental And Temporomandibular Joint Alterations In Rheumatoid Arthritis Patients Andtheir Association With Salivary Oxidative Stress, Deni̇z Yaman, Duygu Göller Bulut, Gülbahar Ustaoğlu, Emre Avci, Murat Taşçi
Dental And Temporomandibular Joint Alterations In Rheumatoid Arthritis Patients Andtheir Association With Salivary Oxidative Stress, Deni̇z Yaman, Duygu Göller Bulut, Gülbahar Ustaoğlu, Emre Avci, Murat Taşçi
Turkish Journal of Medical Sciences
Background/aim: Rheumatoid arthritis (RA) is the most extensive inflammatory arthritis causing permanent deformities in the joint. Increasing evidence suggests that oxidative stress is a substantial factor in the pathogenesis of RA. This study aimed to examine the salivary oxidant-antioxidant status of RA and control groups and to compare these biomarkers by correlating them with disease activity, acute phase reactants, and clinical findings. Materials and methods: Age and sex-matched 60 participants including 30 patients with RA and 30 control (50 females, 10 males; mean age: 42.62 ± 10.89 years) were evaluated. RA disease activity and severity were evaluated by the disease …
Circulating Mir-29c-3p Is Downregulated In Patients With Acromegaly, Hakan Korkmaz, Kuyaş Heki̇mler Öztürk, Bora Torus
Circulating Mir-29c-3p Is Downregulated In Patients With Acromegaly, Hakan Korkmaz, Kuyaş Heki̇mler Öztürk, Bora Torus
Turkish Journal of Medical Sciences
Background/aim: miRNAs control various biological functions, such as cell proliferation, differentiation, signaling pathways, apoptosis and metabolism. Recently, it has been shown that there is a relationship between changes in miRNA expression and the development of acromegaly. Studies are needed to identify new disease-specific miRNAs. The aim of the current study is to evaluate plasma miR-29c-3p, miR-31-5p and miR-18a-5p steady-state levels in acromegaly. Another aim is to investigate whether there is a difference in the levels of these miRNAs in patients with inadequate control and controlled acromegaly with somatostatin analog (SSA) therapy. These miRNAs targeting the IGF-1 gene were determined by …
Can Treating Critically-Ill Haematological Malignancy Patients In A Separate Intensive Careunit Decrease Intensive Care Unit Mortality?, Şahender Gülbi̇n Aygencel Bikmaz, Nazlihan Boyaci Dündar, Melda Türkoğlu, Zeynep Arzu Yegi̇n, Zübeyde Nur Özkurt, Abdullah Münci̇ Yağci
Can Treating Critically-Ill Haematological Malignancy Patients In A Separate Intensive Careunit Decrease Intensive Care Unit Mortality?, Şahender Gülbi̇n Aygencel Bikmaz, Nazlihan Boyaci Dündar, Melda Türkoğlu, Zeynep Arzu Yegi̇n, Zübeyde Nur Özkurt, Abdullah Münci̇ Yağci
Turkish Journal of Medical Sciences
Background/aim: The aim of the study was to investigate whether treating haematological malignancy (HM) patients in a separate intensive care unit (ICU) would reduce ICU mortality. Materials and methods: HM patients treated by the same ICU team in a general medical ICU (GM-ICU) and a separate haematology ICU (H-ICU) were included in this study. Patients' demographic characteristics and ICU data were recorded retrospectively. Differences in the ICU course and prognosis between these two groups were determined. Results: A total of 251 patients (102 from GM-ICU, 149 from H-ICU) were included in this study. The disease severity and organ failure scores …
Two Different Methods Of Lidocaine Inhalation Before Diagnostic Flexible Bronchoscopy:Effects On Post-Bronchoscopy Respiratory Symptoms, Hasan Yüksel, Adem Yaşar, Arzu Açikel, İsmet Topçu, Özge Yilmaz
Two Different Methods Of Lidocaine Inhalation Before Diagnostic Flexible Bronchoscopy:Effects On Post-Bronchoscopy Respiratory Symptoms, Hasan Yüksel, Adem Yaşar, Arzu Açikel, İsmet Topçu, Özge Yilmaz
Turkish Journal of Medical Sciences
Background/aim: Use of topical anesthesia before flexible bronchoscopy for the evaluation of the upper airways prevents cough and stridor during and after the procedure while reducing the need for sedation. In practice, lidocaine is the medication of choice before bronchoscopy. There various types of nebulizers used for inhalation treatments. In this study, we compared the respiratory tract symptoms after flexible bronchoscopy between children who received pre-procedure topical lidocaine with mesh or jet nebulizers. Materials and methods: We enrolled 4-18 years old subjects that underwent flexible bronchoscopy due to treatment-resistant asthma in this retrospective case-control study. Twenty subjects received topical lidocaine …
The Study Of Tau And Phospho Tau Protein Levels In Attention Deficit And Hyperactivity, Hati̇ce Saraçoğlu, Eser Kiliç, Esra Demi̇rci̇
The Study Of Tau And Phospho Tau Protein Levels In Attention Deficit And Hyperactivity, Hati̇ce Saraçoğlu, Eser Kiliç, Esra Demi̇rci̇
Turkish Journal of Medical Sciences
Background/aim: Attention deficit and hyperactivity disorder (ADHD) is a widespread neurodevelopmental disorder that begins in childhood and has negative consequences throughout adult life. The etiology and pathogenesis of ADHD are still unclear. Tau protein is a soluble microtubule-related protein expressed by neurons and localized in the cytoplasm as well as axons. Tau protein provides stability of microtubule in two ways: phosphorylation and isoforms. The excessive phosphorylation of Tau separates the protein from the microtubule, thus making it unstable. In this study, we aimed to investigate whether there is a relationship between serum Tau protein and phospho Tau (p-Tau181) levels and …
Evaluation Of Proprioception In Patients Who Underwent Acl Reconstruction:Measurement In Functional Position, Si̇nem Suner Kekli̇k, Nevi̇n Aysel Güzel, Gamze Çobanoğlu, Ni̇han Kafa, Muhammet Baybars Ataoğlu, Zekeri̇ya Öztemür
Evaluation Of Proprioception In Patients Who Underwent Acl Reconstruction:Measurement In Functional Position, Si̇nem Suner Kekli̇k, Nevi̇n Aysel Güzel, Gamze Çobanoğlu, Ni̇han Kafa, Muhammet Baybars Ataoğlu, Zekeri̇ya Öztemür
Turkish Journal of Medical Sciences
Background/aim: Anterior cruciate ligament (ACL) injuries cause mechanoreceptor loss in the joint; therefore, proprioceptive deficits are observed after injury. In particular, proprioceptive measurements made in the functional position give more accurate results, and this is an area that requires further studies. This study aimed to evaluate proprioception in patients who had undergone ACL reconstruction (ACLR) in functional positions used in daily life (closed kinetic chain position), according to joint angles where ACL injuries occur more frequently, in comparison with healthy controls. Materials and methods: Thirty-four participants who underwent ACLR using a hamstring tendon graft (aged 29.18 ± 8.16 years; body …
An Alternative Supplemental Feeding Method For Preterm Infants: The Supplementalfeeding Tube Device, Müjde Çalikuşu İncekar, Seda Çağlar, Fatma Kaya Narter, Emri̇ye Tercan Tarakci, Emi̇ne Özpinar, Esra Demi̇rci̇ Ecevi̇t
An Alternative Supplemental Feeding Method For Preterm Infants: The Supplementalfeeding Tube Device, Müjde Çalikuşu İncekar, Seda Çağlar, Fatma Kaya Narter, Emri̇ye Tercan Tarakci, Emi̇ne Özpinar, Esra Demi̇rci̇ Ecevi̇t
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to determine the effects of the supplemental feeding tube device (SFTD) and bottle methods on weight gain, transition to full breastfeeding, breastfeeding success, and duration of discharge in preterm infants. Materials and methods: This randomized controlled trial was conducted with a total of 46 preterm infants including 23 infants in study (SFTD) and control (bottle) groups. An information form, an infant follow-up form for feeding, and LATCH breastfeeding assessment instrument were used to collect the data. Results: The gestation week of the infants in the study group was 31.22 ± 2.76, and in …
Is Conut Score A Prognostic Index In Patients With Diffuse Large Cell Lymphoma?, Gülsüm Akgün Çağliyan, Si̇bel Hacioğlu, Başak Ünver Koluman, Kadi̇r İlkkiliç, Ruki̇ye Nar, Mehmet Nuri̇ Başer, Asli Bozdemi̇r, Hande Şenol, Ni̇lay Şen Türk, Veysel Erol, Onurcan Yildirim, Ömer Çağliyan, Ni̇l Güler
Is Conut Score A Prognostic Index In Patients With Diffuse Large Cell Lymphoma?, Gülsüm Akgün Çağliyan, Si̇bel Hacioğlu, Başak Ünver Koluman, Kadi̇r İlkkiliç, Ruki̇ye Nar, Mehmet Nuri̇ Başer, Asli Bozdemi̇r, Hande Şenol, Ni̇lay Şen Türk, Veysel Erol, Onurcan Yildirim, Ömer Çağliyan, Ni̇l Güler
Turkish Journal of Medical Sciences
Background/aim: The aim of the study was to evaluate the effect of Controlling Nutritional Status (CONUT) score on the prognosis in patients with diffuse large B-cell lymphoma (DLBCL). Materials and methods: The present study was a retrospective study. The CONUT score was calculated based on serum albumin, total cholesterol and lymphocyte levels. This study included a total of 266 patients, 131 (49.2%) were female and 135 (50.8%) were male. The median follow-up period was 51 months (range: 1-190). Results: The median age was 64 years. The cut off CONUT was 1.5. There was a significant difference between patients with high …
Investigation Of The Effects Of Propofol/Ketamine Versus Propofol/Fentanyl On Nauseavomiting Administered For Sedation In Children Undergoing Magnetic Resonance Imaging:A Prospective Randomized Double-Blinded Study, Haci Semi̇h Gürcan, Ayşe Ülgey, Özlem Öz Gergi̇n, Si̇bel Seçki̇n Pehli̇van, Kara Mehmet Yildiz
Investigation Of The Effects Of Propofol/Ketamine Versus Propofol/Fentanyl On Nauseavomiting Administered For Sedation In Children Undergoing Magnetic Resonance Imaging:A Prospective Randomized Double-Blinded Study, Haci Semi̇h Gürcan, Ayşe Ülgey, Özlem Öz Gergi̇n, Si̇bel Seçki̇n Pehli̇van, Kara Mehmet Yildiz
Turkish Journal of Medical Sciences
Background/aim: In this study, we aimed to compare the effects of propofol-ketamine and propofol-fentanyl sedations on postprocedure nausea-vomiting in children undergoing magnetic resonance imaging (MRI). Materials and methods: This study included 100 pediatric patients (2-10 years old) who had propofol-ketamine and propofol-fentanyl for sedation to undergo MRI. The patients were divided into two groups, and sedation was performed through propofol-ketamine (Group K; n = 50) or propofol-fentanyl (Group F; n = 50). For sedation induction, intravenous (IV) bolus of 1.2 mg/kg propofol and 1 mg/kg ketamine were administered in Group K, IV bolus of 1.2 mg/kg propofol, and 1 µg/kg …
Extracorporeal Carbon Dioxide Removal (Ecco2r) In Copd And Ards Patients Withsevere Hypercapnic Respiratory Failure. A Retrospective Case-Control Study, Volkan İnal, Serdar Efe
Extracorporeal Carbon Dioxide Removal (Ecco2r) In Copd And Ards Patients Withsevere Hypercapnic Respiratory Failure. A Retrospective Case-Control Study, Volkan İnal, Serdar Efe
Turkish Journal of Medical Sciences
Background/aim: Treatment of severe hypercapnic respiratory failure (HRF) has some challenges in patients with chronic obstructive pulmonary disease (COPD) and acute respiratory distress syndrome (ARDS), especially when lung protective ventilation (LPV) strategies are required. Extracorporeal CO2 removal (ECCO2R) therapy is an emerging option to manage hypercapnia while allowing LPV in these cases. However, further data on ECCO2R use is still needed to make clear recommendations. Materials and methods: This study was conducted on patients admitted to intensive care unit (ICU) between January 1st, 2016 to December 31st, 2019. The medical records were retrospectively scanned in institutional software database. Patients who …
Flow Cytometric Analysis Of Platelet Surface Glycoproteins In The Diagnosis Of Thirty-Twoturkish Patients With Glanzmann Thrombasthenia: A Multicenter Experience, Berkay Saraymen, Sabahatti̇n Muhtaroğlu, Mustafa Yavuz Köker, Nazan Sarper, Emi̇ne Zengi̇n, Canan Albayrak, Davut Albayrak, Osman Bülent Zülfi̇kar, Sayi̇me Başak Koç Şenol, Esma Bentli̇, Semi̇h Yilmaz, Aysun Çeti̇n, Bülent Eser, Mustafa Çeti̇n
Flow Cytometric Analysis Of Platelet Surface Glycoproteins In The Diagnosis Of Thirty-Twoturkish Patients With Glanzmann Thrombasthenia: A Multicenter Experience, Berkay Saraymen, Sabahatti̇n Muhtaroğlu, Mustafa Yavuz Köker, Nazan Sarper, Emi̇ne Zengi̇n, Canan Albayrak, Davut Albayrak, Osman Bülent Zülfi̇kar, Sayi̇me Başak Koç Şenol, Esma Bentli̇, Semi̇h Yilmaz, Aysun Çeti̇n, Bülent Eser, Mustafa Çeti̇n
Turkish Journal of Medical Sciences
Background/aim: Glanzmann thrombasthenia (GT) is a rare autosomal recessively inherited bleeding disorder characterized by the quantitative (type 1 and type 2) or qualitative (type 3) deficiency in platelet membrane glycoprotein (GP) IIb/IIIa (CD41a/CD61) fibrinogen receptors. In type 1, 2, and 3, CD41a/CD61 expression is 5%, 5%-20% and above 20%, respectively. In this study, diagnosis of GT was confirmed and subgroups were identified in 32 Turkish patients by flow cytometry analysis. Materials and methods: CD41a/CD61 expression levels in platelet-rich plasma (PRP) obtained from peripheral venous EDTA blood samples were analyzed with a BD FACSCanto II flow cytometer (Becton Dickinson, Franklin Lakes, …
The Inhibition Of Src Kinase Suppresses The Production Of Matrix Metalloproteinases Infrom Synovial Fibroblasts And Inhibits Mapk And Stats Pathways, Demet Yalçin Kehri̇bar, Meti̇n Özgen, Servet Yolbaş, Ahmet Yildirim, Neşe Başak Türkmen, Ebru Önalan, Osman Çi̇ftçi̇, İbrahi̇m Hani̇fi̇ Özercan, Süleyman Serdar Koca
The Inhibition Of Src Kinase Suppresses The Production Of Matrix Metalloproteinases Infrom Synovial Fibroblasts And Inhibits Mapk And Stats Pathways, Demet Yalçin Kehri̇bar, Meti̇n Özgen, Servet Yolbaş, Ahmet Yildirim, Neşe Başak Türkmen, Ebru Önalan, Osman Çi̇ftçi̇, İbrahi̇m Hani̇fi̇ Özercan, Süleyman Serdar Koca
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to investigate the antiarthritic potentials of the inhibition of Src kinase in vivo and in vitro settings. Materials and methods: Arthritis was induced by intradermal injection of chicken type II collagen combined with incomplete Freund's adjuvant (collagen induced arthritis [CIA] model) in Wistar albino rats. One day after the onset of arthritis, dasatinib, a potent Src kinase inhibitor, (5 mg/kg/day) was given via oral gavage. Tissue Src, Fyn, MAPK and STAT mRNA expressions were determined by real-time polymerase chain reaction. On the other hand, fibroblast like synoviocytes (FLSs) were harvested patients with rheumatoid …
Synergistic Effect Of Vancomycin Combined With Cefotaxime, Imipenem, Or Meropenemagainst Staphylococcus Aureus With Reduced Susceptibility To Vancomycin, Arpasiri Srisrattakarn, Chonthicha Chaiyapoke, Sirikarn Booncharoen, Sujintana Wongthong, Aroonwadee Chanawong, Patcharaporn Tippayawat, Ratree Tavichakorntrakool, Aroonlug Lulitanond
Synergistic Effect Of Vancomycin Combined With Cefotaxime, Imipenem, Or Meropenemagainst Staphylococcus Aureus With Reduced Susceptibility To Vancomycin, Arpasiri Srisrattakarn, Chonthicha Chaiyapoke, Sirikarn Booncharoen, Sujintana Wongthong, Aroonwadee Chanawong, Patcharaporn Tippayawat, Ratree Tavichakorntrakool, Aroonlug Lulitanond
Turkish Journal of Medical Sciences
Background/aim: We investigated the synergistic effect between vancomycin and ß-lactams against vancomycin-susceptible (VSSA) and nonsusceptible MRSA isolates [heterogeneous vancomycin-intermediate S. aureus (hVISA) and VISA]. Materials and methods: A total of 29 MRSA, including 6 VISA, 14 hVISA, and 9 VSSA isolates, were subjected to a microbroth dilution-minimum inhibitory concentration (MIC) checkerboard using vancomycin combined with cefotaxime, imipenem, or meropenem. To confirm synergistic activity, the representative strains of VISA, hVISA, and VSSA were then selected for the time-kill curve method. Results: The combination of vancomycin with imipenem, meropenem, or cefotaxime exhibited synergistic effects against 17 (2 VISA, 9 hVISA, and 6 …
Effects Of Tacrolimus On C-Fos In Hippocampus And Memory Performances Instreptozotocin Model Of Alzheimer's Disease Of Rats, Ayşe Köylü, Berri̇n Zühal Altunkaynak, Burcu Deli̇baş
Effects Of Tacrolimus On C-Fos In Hippocampus And Memory Performances Instreptozotocin Model Of Alzheimer's Disease Of Rats, Ayşe Köylü, Berri̇n Zühal Altunkaynak, Burcu Deli̇baş
Turkish Journal of Medical Sciences
Background/aim: Calcineurin, an inhibitor of calcium dependent phosphatase is highly presented in a brain of an Alzheimer?s disease. Aging brain gets more sensitive to hyperactivation of calcineurin, and this event causes tau neurofibrillary plaque accumulation, which is one of the outcomes of this disease. The regions of hippocampus are much effected from the results of this process. Our hypothesis is that a calcineurin inhibitor, tacrolimus, could prevent the accumulation and the decrease of the neuronal cells. Therefore, this immunosuppressive drug could be a candidate for an early treatment of Alzheimer disease. Materials and methods: Fifteen male Wistar albino rats were …
Lutein/Zeaxanthin Isomers Regulate Neurotrophic Factors And Synaptic Plasticity Intrained Rats, Cemal Orhan, Füsun Erten, Beşi̇r Er, Mehmet Tuzcu, Nurhan Şahi̇n, Öznur Ece Durmaz Kurşun, Vijaya Juturu, Kazi̇m Şahi̇n
Lutein/Zeaxanthin Isomers Regulate Neurotrophic Factors And Synaptic Plasticity Intrained Rats, Cemal Orhan, Füsun Erten, Beşi̇r Er, Mehmet Tuzcu, Nurhan Şahi̇n, Öznur Ece Durmaz Kurşun, Vijaya Juturu, Kazi̇m Şahi̇n
Turkish Journal of Medical Sciences
Background/aim: This study was conducted to elucidate the effects of lutein/zeaxanthin isomers (L/Zi) on lipid metabolism, oxidative stress, NF-ΚB/Nrf2 pathways, and synaptic plasticity proteins in trained rats. Materials and methods: Wistar rats were distributed into four groups: 1) control, 2) L/Zi: rats received L/Zi at the dose of 100 mg/kg by oral gavage, 3) exercise, 4) exercise+L/Zi: rats exercised and received L/Zi (100 mg/kg) by oral gavage. The duration of the study was eight weeks. Results: Exercise combined with L/Zi reduced lipid peroxidation and improved antioxidant enzyme activities of muscle and cerebral cortex in rats (p < 0.001). In the Exercise + L/Zi group, muscle and cerebral cortex Nrf2 and HO-1 levels increased, while NF-ΚB levels decreased (p
Effects Of Intracerebroventricularly Administered Opioid Peptide Antagonistson Tissue Glycogen Levels In Rats After Exercise, Ayşe Şebnem İlhan, Şevi̇n Güney, Si̇bel Di̇ncer
Effects Of Intracerebroventricularly Administered Opioid Peptide Antagonistson Tissue Glycogen Levels In Rats After Exercise, Ayşe Şebnem İlhan, Şevi̇n Güney, Si̇bel Di̇ncer
Turkish Journal of Medical Sciences
Background/aim: Physical exercise is a state of physiological stress that requires adaptation of the organism to physical activity. Glycogen is an important and essential energy source for muscle contraction. Skeletal muscle and liver are two important glycogen stores, and the energy required to maintain exercise in rodents are provided by destruction of this glycogen depot. In this study, the effects of endogenous opioid peptide antagonism at the central nervous system level on tissue glycogen content after exhaustive exercise were investigated. Materials and methods: Rats had intracerebroventricularly (icv) received nonspecific opioid peptide receptor antagonist, naloxone (50 μ/10 μL in saline) and …
The Role Of Anakinra In The Modulation Of Intestinal Cell Apoptosis And Inflammatoryresponse During Ischemia/Reperfusion, Muhammed Kandemi̇r, Necdet Fati̇h Yaşar, Mete Özkurt, Rumeysa Özyurt, Nuri̇ye Ezgi̇ Bektur, Ni̇lüfer Erkasap
The Role Of Anakinra In The Modulation Of Intestinal Cell Apoptosis And Inflammatoryresponse During Ischemia/Reperfusion, Muhammed Kandemi̇r, Necdet Fati̇h Yaşar, Mete Özkurt, Rumeysa Özyurt, Nuri̇ye Ezgi̇ Bektur, Ni̇lüfer Erkasap
Turkish Journal of Medical Sciences
Background/aim: Even though interleukin-1 receptor antagonist, IL-1Ra, is used in certain inflammatory diseases, its effect on ischemia-reperfusion injury is a current research topic. We aimed to investigate the protective effects of anakinra, an IL-1Ra, on the I/R induced intestinal injury. Materials and methods: The rat model of intestinal ischemia-reperfusion was induced. Rats were randomized into 4 groups: (group 1) control group, (group 2) I/R group, (group 3 and 4) treatment groups (50 mg/kg and 100 mg/kg, respectively). Gene expressions of caspase-3, TNF-∝, IL-1∝, IL-6, and apoptotic cells in tissue samples were evaluated by PCR and TUNEL methods, respectively. Plasma levels …
Histopathological Effects Of Aloe Vera On Wound Healing Process In Penile Fracture Model:An Experimental Study, Kadi̇r Turgay Akgül, Engi̇n Doğanteki̇n, Eli̇f Özer, Mustafa Sirri Kotanoğlu, Yusuf Gökkurt, Sema Hücümenoğlu
Histopathological Effects Of Aloe Vera On Wound Healing Process In Penile Fracture Model:An Experimental Study, Kadi̇r Turgay Akgül, Engi̇n Doğanteki̇n, Eli̇f Özer, Mustafa Sirri Kotanoğlu, Yusuf Gökkurt, Sema Hücümenoğlu
Turkish Journal of Medical Sciences
Background/aim: This study assessed the histopathological effects of aloe vera (AV) on penile fractures (PF) formed experimentally in rat model. Materials and methods: Thirty-two Wistar adult male rats (220 to 250 g) were used. The PF model was created experimentally with a number 15 lancet. After the interventions, all of the rats were randomly and equally divided into 4 groups. In the first group, incision was not closed (group C). In the second group, AV was locally applied onto incision without suturing for 3 days (group AV). In the third group, the incision line was closed primarily (group PR). In …
Possible Antiapoptotic And Neuroprotective Effects Of Magnesium Sulphate On Retina In Apreterm Hypoxic-Ischemic Rat Model, Serhat İmamoğlu, Ebru Yalin İmamoğlu, Serkan Erdenöz, Alev Cumbul, Ünal Uslu, Şami̇l Aktaş, Hüsnü Fahri̇ Ovali
Possible Antiapoptotic And Neuroprotective Effects Of Magnesium Sulphate On Retina In Apreterm Hypoxic-Ischemic Rat Model, Serhat İmamoğlu, Ebru Yalin İmamoğlu, Serkan Erdenöz, Alev Cumbul, Ünal Uslu, Şami̇l Aktaş, Hüsnü Fahri̇ Ovali
Turkish Journal of Medical Sciences
Background/aim: The effects of systemic magnesium sulfate (MgSO4 ) on retina in preterm hypoxic-ischemic (HI) rat model are not known. Our aim was to investigate the effects of MgSO4 on retinal ganglion cell (RGC) count, retinal ganglion cell (RGC) apoptotic index, retinal vascular endothelial growth factor receptor-2 (VEGFR-2), and glial fibrillary acidic protein (GFAP) expressions in preterm HI rat model. Materials and methods: Fifteen, postnatal day (PND) 7 rat pups were divided into 3 groups: 1. Sham-operated group, 2. HI group, and 3. MgSO4 -treated HI group. The second and third groups underwent ischemia followed by exposure to hypoxia for …
Comparison Of The Effect Of Bipolar Coagulation And Fibrillar Structured Oxidizedcellulose On Formation Epidural Fibrosis In Rats, Eyüp Çeti̇n, Burak Eren, Feyza Karagöz Güzey, Azmi̇ Tufan, Abdurrahi̇m Taş, Mustafa Örnek, Bülent Uyanik, Tuğçe Çay
Comparison Of The Effect Of Bipolar Coagulation And Fibrillar Structured Oxidizedcellulose On Formation Epidural Fibrosis In Rats, Eyüp Çeti̇n, Burak Eren, Feyza Karagöz Güzey, Azmi̇ Tufan, Abdurrahi̇m Taş, Mustafa Örnek, Bülent Uyanik, Tuğçe Çay
Turkish Journal of Medical Sciences
Background/aim: Epidural fibrosis (EF) is a common cause of failed back surgery syndrome seen after spinal surgeries. The most frequent reason for the formation of EF is accumulated blood and its products in the operation zone. On the development of EF, the effect of bipolar coagulation and fibrillar oxidized cellulose, which are used frequently to control bleeding, was investigated. Materials and methods: In the study, 45 male Sprague Dawley rats were divided into three groups (control, fibrillar, and bipolar). Lumbar laminectomy was applied to all rats under sterile conditions. In the control group, the epidural area was washed with saline …
Effects Of Regular Whey Protein Consumption On Rat Thyroid Functions, Gökhan Akkurt, Bahar Kartal, Mustafa Ali̇moğullari, Sevi̇l Çayli, Ebru Ali̇moğullari
Effects Of Regular Whey Protein Consumption On Rat Thyroid Functions, Gökhan Akkurt, Bahar Kartal, Mustafa Ali̇moğullari, Sevi̇l Çayli, Ebru Ali̇moğullari
Turkish Journal of Medical Sciences
Background/aim: We aimed to investigate whether there was a significant difference in TSH, T3, T4 values and histopathologically evaluated thyroid tissues between rats that received ısole hydrolyzed whey protein (IHWP) at different doses regularly and rats fed with only standard feed. Material & methods: Total 24 rats were randomly divided into three groups with 8 rats in each group. First group were fed with standard feed for 12 weeks. Second group were given standard feed + daily 0.3 g/kg IHWP and rats in the third group standard feed + 0.5 g/kg IHWP for 12 weeks. Blood samples were collected from …