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Full-Text Articles in Medicine and Health Sciences

Factors Influencing Turnover Intention Among Registered Nurses In Thailand: A Preliminary Study, Vachira Posai, Associate Professor Chanokporn Jitpanya, Rn, Ms, Ph.D., Assistant Professor Wisarut Srisinthorn, Md, Associate Professor Paramee Thongsuksaid, Md Nov 2025

Factors Influencing Turnover Intention Among Registered Nurses In Thailand: A Preliminary Study, Vachira Posai, Associate Professor Chanokporn Jitpanya, Rn, Ms, Ph.D., Assistant Professor Wisarut Srisinthorn, Md, Associate Professor Paramee Thongsuksaid, Md

Chulalongkorn Medical Journal

Background: The global nursing shortage impacts healthcare systems. Understanding factors influencing nurses' turnover intentions is essential for developing effective retention strategies.

Objective: To identify predictors of turnover intention among nurses, focusing on variables such as age, number of children, years of nursing experience, monthly personal income, burnout, emotional labor, job stress (assessed through effort, reward, and overcommitment), nurse-practice environment, work-family conflict, and work engagement.

Methods: A secondary data analysis was conducted using data from a multicenter, longitudinal study involving 1,005 nurses from two public hospitals in Thailand. Data collection instruments included a demographic questionnaire, the Burnout Assessment Tool, the Emotional …


Knowledge, Attitude And Practice Of Butchers Regarding Crimean Congo Hemorrhagic Fever In An Endemic Area Of Iran, Mohammad Amin Gorouhi, Abbas Aghaei Afshar, Najmeh Mansoori, Parya Jangipour Afshar, Leila Shirani-Bidabadi, Ismaeil Alizadeh, Nariman Shahhosseini Nov 2025

Knowledge, Attitude And Practice Of Butchers Regarding Crimean Congo Hemorrhagic Fever In An Endemic Area Of Iran, Mohammad Amin Gorouhi, Abbas Aghaei Afshar, Najmeh Mansoori, Parya Jangipour Afshar, Leila Shirani-Bidabadi, Ismaeil Alizadeh, Nariman Shahhosseini

Chulalongkorn Medical Journal

Background: In endemic countries, Crimean-Congo hemorrhagic fever (CCHF) is an important zoonotic disease with significant public health implications. Previous studies in Iran suggests that CCHF poses a significant health risk to slaughterhouse workers and butchers. The main objecive of this study was to investigate the knowledge, attitude, and practice of butchers regarding CCHF at their workplace in an endemic area in southeastern Iran.

Methods: A descriptive cross-sectional study was conducted from January to March 2022 in Zarand city. In total, 60 butchers were included in the city. Statistical analysis was performed using SPSS version 22.

Results: The average scores of …


Impact Of The Rs1050757 C>T Variant In The 3'Utr Of The G6pd Gene On Mrna Structure And Mirna Binding In G6pd Deficiency: A Nanopore Minion Sequencing Study, Lawrence Billy Vasco Djama, Vorthon Sawaswong Ph.D., Prangwalai Chanchaem, Punchalee Mungkalasut Ph.D., Thanaporn Pimpakan, Poonlarp Cheepsunthorn Ph.D., Sunchai Payungporn Ph.D., Chalisa L. Cheepsunthorn Ph.D. Nov 2025

Impact Of The Rs1050757 C>T Variant In The 3'Utr Of The G6pd Gene On Mrna Structure And Mirna Binding In G6pd Deficiency: A Nanopore Minion Sequencing Study, Lawrence Billy Vasco Djama, Vorthon Sawaswong Ph.D., Prangwalai Chanchaem, Punchalee Mungkalasut Ph.D., Thanaporn Pimpakan, Poonlarp Cheepsunthorn Ph.D., Sunchai Payungporn Ph.D., Chalisa L. Cheepsunthorn Ph.D.

Chulalongkorn Medical Journal

Background: Glucose 6-phosphate dehydrogenase (G6PD) deficiency is a genetic disorder caused by impaired enzyme function or instability due to mutations in the G6PD gene, resulting in reduced enzyme activity. This study aimed to investigate mutations in the regulatory regions of the G6PD gene using Nanopore MinION sequencing to explore the potential impact of non-coding variants on G6PD activity.

Methods: Blood samples from 19 males (13 adults, 6 neonates) with G6PD deficiency or intermediate enzyme activity but unidentified coding sequence mutations were analysed. Genomic DNA was amplified using degenerate oligonucleotide-primed PCR (DOP-PCR) and sequenced with the Oxford Nanopore MinION platform. Bioinformatic …


Effect Of Feeding A Saccharomyces Cerevisiae Fermentationderived Postbiotics On Growth Performance And Intestinal Health In The Crossbred Broiler Chickens Under A Low Biosecurity Production System, Ho Thi Dung, Pham Hoang Son Hung, Le Duc Thao, Nguyen Van Chao, Bui Thi Hien, Nguyen Thi Hoa, Le Thi Thu Hang, Anjan Mondal, Victor Nsereko, Le Dinh Phung Nov 2025

Effect Of Feeding A Saccharomyces Cerevisiae Fermentationderived Postbiotics On Growth Performance And Intestinal Health In The Crossbred Broiler Chickens Under A Low Biosecurity Production System, Ho Thi Dung, Pham Hoang Son Hung, Le Duc Thao, Nguyen Van Chao, Bui Thi Hien, Nguyen Thi Hoa, Le Thi Thu Hang, Anjan Mondal, Victor Nsereko, Le Dinh Phung

The Thai Journal of Veterinary Medicine

Open farming systems with low biosecurity conditions are very common in developing countries. In the context that many countries in the world have issued regulations prohibiting the use of antibiotics for disease prevention, finding effective alternatives becomes more important, especially for farms with low biosecurity. This study aimed to explore the effects of a Saccharomyces cerevisiae fermentation-derived postbiotics (SCFP) on growth performance and intestinal health of crossbred broiler chickens raised in a low bio-security production system. One hundred ninety-two 1-day-old chickens were assigned to 2 treatments. Dietary treatments were: 1) a standard basal diet and 2) a standard basal diet …


Seroprevalence Of Small Ruminant Lentiviruses (Srlvs) And Peste Des Petits Ruminants Virus (Pprv) In Nonvaccinated Sheep And Goats In Sarawak, Malaysia, Bura Thlama Paul, Ali Saidu, Maria Eva Barudi, Faez Firdaus Abdullah Jesse, Juriah Kamaludeen, Suhaili Mustafa, Masnindah Malahubban, Ali Hanafiah Hakim, Krishnan Nair Balakrishnan, Mohd Azmi Mohd Lila Oct 2025

Seroprevalence Of Small Ruminant Lentiviruses (Srlvs) And Peste Des Petits Ruminants Virus (Pprv) In Nonvaccinated Sheep And Goats In Sarawak, Malaysia, Bura Thlama Paul, Ali Saidu, Maria Eva Barudi, Faez Firdaus Abdullah Jesse, Juriah Kamaludeen, Suhaili Mustafa, Masnindah Malahubban, Ali Hanafiah Hakim, Krishnan Nair Balakrishnan, Mohd Azmi Mohd Lila

The Thai Journal of Veterinary Medicine

Small ruminant lentiviruses (SRLVs) and Peste des Petits Ruminants virus (PPRV) are economically important viral diseases that threaten small ruminant production globally. While previous studies have reported their serological status in Peninsular Malaysia, there is limited epidemiological information on their occurrence in East Malaysia. This study aimed to determine the seroprevalence and risk factors of SRLVs and PPRV among nonvaccinated sheep and goats from selected smallholder farms in Sarawak. A total of 245 serum samples collected from sheep (n = 117) and goat (n = 128) were screened using commercial ID Screen® PPR competition (PPRC ver. 0821) and MVV/CAEV …


Biofilm Formation Of A Strain Of Bovine Escherichia Coli And Analysis Of Its Influencing Factors, Xin Zhang, Yunjiao Chen, Weijuan Jia, Zhilin Liu, Zelin Jia, Jiayu Cui, Huisheng Xiong, Yuhang Zhang, Xueli Wang Oct 2025

Biofilm Formation Of A Strain Of Bovine Escherichia Coli And Analysis Of Its Influencing Factors, Xin Zhang, Yunjiao Chen, Weijuan Jia, Zhilin Liu, Zelin Jia, Jiayu Cui, Huisheng Xiong, Yuhang Zhang, Xueli Wang

The Thai Journal of Veterinary Medicine

This study investigated the biofilm (BF) formation of a bovine-derived Escherichia coli (E. coli) strain (designated DL1907) and analyzed the factors influencing its formation. The BF-forming capacity, optimal formation time and temperature, as well as the effects of different culture media, pH levels, NaCl concentrations, and glucose concentrations, were assessed using the crystal violet method. The results demonstrated that the strain had a strong BF-forming capacity, achieving the most intact BF structure after 36 h of culture at 37°C. Trypticase Soy Broth (TSB) medium promoted the strongest BF formation compared to Luria-Bertani (LB) and Müller-Hinton Broth (MH) media. …


Molecular Identification Of Cryptosporidium Spp. Isolated From Dairy Calves In The Northern Region Of Algeria, Dadda Anes, Abdellah Mohamed Cherif, Aoun Leila, Chatanun Eamudomkarn, Khelef Djamel, Keeseon S Eom, Dongmin Lee, Barakaeli Abdieli Ndosi, Mohammed Mebarek Bia Oct 2025

Molecular Identification Of Cryptosporidium Spp. Isolated From Dairy Calves In The Northern Region Of Algeria, Dadda Anes, Abdellah Mohamed Cherif, Aoun Leila, Chatanun Eamudomkarn, Khelef Djamel, Keeseon S Eom, Dongmin Lee, Barakaeli Abdieli Ndosi, Mohammed Mebarek Bia

The Thai Journal of Veterinary Medicine

Cryptosporidium spp. is the most frequent agent in Algeria that causes neonatal diarrhea in calves, with high symptomatic diarrhea in pre-weaned dairy calves. The study aims to measure the prevalence, distribution, and genotype of Cryptosporidium-infected calves in one of Algeria's high milk production areas (North Central and Northeast). From 35 dairy cattle farms were selected 172 (77 with diarrheic and 95 without diarrheic symptoms) calves aged less than 60 days. Twenty-three farms (65.71%) were detected with cryptosporidiosis using a modified Ziehl-Neelsen stain, whereby 68 calves (39.53%) were obtained positive. The Copro-ELISA test gave an individual prevalence of (37.66%, 22.11%) …


Successful Therapeutic Response Of Intravenous Immunoglobulin In Guillain-Barre Syndrome With Onset More Than Two Weeks: A Case Report, Ezra Immanuelly Pribadi, Fauna Herawati, Valentinus Besin, Marisca Evalina Gondokesumo Oct 2025

Successful Therapeutic Response Of Intravenous Immunoglobulin In Guillain-Barre Syndrome With Onset More Than Two Weeks: A Case Report, Ezra Immanuelly Pribadi, Fauna Herawati, Valentinus Besin, Marisca Evalina Gondokesumo

Chulalongkorn Medical Journal

Guillain-Barré Syndrome (GBS), with a global incidence of 1–2 cases per 100,000 population annually, remains the most common cause of acute flaccid paralysis. Standard treatment includes plasma exchange within 4 weeks or intravenous immunoglobulin (IVIg) within 2 weeks of symptom onset. However, IVIg may still benefit selected late-presenting cases. Here, we report a case a 17-year-old male presented with progressive bilateral limb weakness and paresthesia that began approximately 3 weeks before admission. He also experienced a brief syncope episode and defecation syncope, indicating possible autonomic involvement. On hospital day 3, after shared decision-making, the family opted for IVIg over plasma …


A Rare Variation In The Branching Pattern Of The Axillary Artery, Preethi Umanath, Sutha Selvaraj Oct 2025

A Rare Variation In The Branching Pattern Of The Axillary Artery, Preethi Umanath, Sutha Selvaraj

Chulalongkorn Medical Journal

ABSTRACT:

BACKGROUND: This study aims to elucidate a previously unreported rare variation in the branching pattern of the third part of the axillary artery.

Results and discussion: During the routine dissection of a male cadaver, it was observed that the third part branches of the left axillary artery, specifically the anterior and posterior circumflex humeral arteries, were completely absent. To compensate for the missing branches, an unusual ascending branch emerged from the arteria profunda brachii (a branch of the brachial artery). This branch later divided into two: the deltoid branch, which accompanied the axillary nerve, entered in to …


Morphological And Biological Properties Of Platelet Rich Fibrin Membrane Producing From Different Centrifugation Protocols, Vannarut Satitpitakul Md, Sarisa Tangkhunchaisaeng Oct 2025

Morphological And Biological Properties Of Platelet Rich Fibrin Membrane Producing From Different Centrifugation Protocols, Vannarut Satitpitakul Md, Sarisa Tangkhunchaisaeng

Chulalongkorn Medical Journal

Background: Platelet-rich fibrin (PRF) membranes represent a promising tool for corneal epithelial disease treatment, though a standardized protocol remains unestablished. Objective: This study aimed to evaluate the morphological and biological properties of Platelet-Rich Fibrin (PRF) membranes producing from different centrifugation protocols Methods: Four distinct low speed centrifugation protocols (100g/5min, 200g/5min, 100g/10min, and 200g/10min) were established for PRF production from 3 healthy volunteers. We assessed fibrin and membrane dimensions, white blood cell and platelet concentrations, kinetic release of growth factors (TGF-, PDGF-BB, VEGF, IGF-1), and inflammatory cytokines (IL-6, IL-1, TNF-). In vitro degradation and bacterial contamination were also examined. Results: All …


The Impact Of G6pd Deficiency On Liver Damage And Disease Progression In Hepatocellular Carcinoma: A Cross-Sectional Study In Thailand, Watcharapong Jugnam-Ang, Phatchayanat Tansakul, Makamas Chanda, Poonlarp Cheepsunthorn, Pisit Tangkijvanich, Chalisa L. Cheepsunthorn Ph.D. Oct 2025

The Impact Of G6pd Deficiency On Liver Damage And Disease Progression In Hepatocellular Carcinoma: A Cross-Sectional Study In Thailand, Watcharapong Jugnam-Ang, Phatchayanat Tansakul, Makamas Chanda, Poonlarp Cheepsunthorn, Pisit Tangkijvanich, Chalisa L. Cheepsunthorn Ph.D.

Chulalongkorn Medical Journal

Background. Glucose 6-phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway, producing reduced nicotinamide adenine dinucleotide phosphate (NADPH) to support redox homeostasis and cancer cell proliferation. While G6PD deficiency has been linked to reduced cancer risk, its impact on hepatocellular carcinoma (HCC) remains unclear.

Objectives. This study investigates the prevalence of G6PD deficiency in HCC patients and its association with clinical parameters across disease stages.

Methods. A cross-sectional study analyzed G6PD activity and clinical data from 174 HCC patients, 100 hepatitis B virus (HBV)-infected patients, and 154 healthy controls. Peripheral blood G6PD activity was measured, and …


Investigating The Organs At Risk (Oar) Received Dose During Prostate Cancer Therapy Using Intensity Modulated Radiation Therapy (Imrt) And 3d Conformal Radiotherapy (3dcrt): A Comparison Study, Talib Abdulwahid, Hussein Mraity, Mustafa Al-Aseebee, Zeyad Al-Dulaimi, Ali Abid Abojassim Oct 2025

Investigating The Organs At Risk (Oar) Received Dose During Prostate Cancer Therapy Using Intensity Modulated Radiation Therapy (Imrt) And 3d Conformal Radiotherapy (3dcrt): A Comparison Study, Talib Abdulwahid, Hussein Mraity, Mustafa Al-Aseebee, Zeyad Al-Dulaimi, Ali Abid Abojassim

Chulalongkorn Medical Journal

Radiotherapy domain is known to impose undesired risk of radiation to normal tissue surrounding the tumor. So, the treatment planning systems are developing with time to introduce a perfect treatment. Organs at risks surrounding prostate tumors are sensitive to high doses of radiation. This study is aimed at comparing the efficiency of the three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiation therapy (IMRT) techniques during the treatment of prostate cancer. A cross-sectional study was performed in Middel Euphrate Csancer Center, Najaf , Iraq. A 25 patients with prostate tumor were enrolled. They underwent CT scans from imaging then treated with x-ray …


Effectiveness Of Vitamin D3 In Facilitating The Therapeutic Progression Of Healing Diabetic Foot Ulcers, Fatemeh Nouri, Sara Aghaei, Gülüzar Özbolat, Yusuf Döğüş, Mahdi Mirhamidi, Reza Rahimi Barghani, Amin Daemi Oct 2025

Effectiveness Of Vitamin D3 In Facilitating The Therapeutic Progression Of Healing Diabetic Foot Ulcers, Fatemeh Nouri, Sara Aghaei, Gülüzar Özbolat, Yusuf Döğüş, Mahdi Mirhamidi, Reza Rahimi Barghani, Amin Daemi

Chulalongkorn Medical Journal

Background: Today’s, diabetes and its complications have afflicted a large population all over the world, so that it is estimated that its prevalence in all age groups will reach from 2.8% in 2000 to 4.4% in 2030. It is well known that vitamin D may cause rapid wound healing and anti-inflammatory.

Objective: Regarding the importance of the quality of life of diabetic patients and the improvement of chronic diabetic foot ulcers, this paper aims to investigate the efficacy of vitamin D3 on the healing of diabetic foot ulcers. The present research is conducted as a randomized controlled trial.

Methods: …


Non-Invasive Way For Detection Of Neonatal Jaundice Using Gbr, Priti V. Bhagat, Mukesh Raghuwanshi, Ashutosh D. Bagde Oct 2025

Non-Invasive Way For Detection Of Neonatal Jaundice Using Gbr, Priti V. Bhagat, Mukesh Raghuwanshi, Ashutosh D. Bagde

Chulalongkorn Medical Journal

Background: Neonatal jaundice is a common condition in newborns due to excess levels of bilirubin. The traditional method for bilirubin testing is invasive, i.e., through blood tests only, which is painful to infants. Therefore, this study uses machine learning algorithms to develop a non-invasive way to detect neonatal jaundice.

Objectives: Design a computer-aided support system to detect neonatal jaundice using machine learning algorithm.

Methods: The gradient-boosting regression model is used to predict the bilirubin level. Gradient Boosting is a robust boosting algorithm that combines several weak learners into strong learners, in which each new model is trained to minimize the …


The Comparison Of Radiation Attenuation Correction Techniques For Relative Renal Function In Renal Cortical Scintigraphy, Benchamat Phromphao, Sorasak Wanitchanan, Trai Chairat, Thunyaluk Sawatnatee, Tanawat Sontrapornpol Oct 2025

The Comparison Of Radiation Attenuation Correction Techniques For Relative Renal Function In Renal Cortical Scintigraphy, Benchamat Phromphao, Sorasak Wanitchanan, Trai Chairat, Thunyaluk Sawatnatee, Tanawat Sontrapornpol

Chulalongkorn Medical Journal

Background: Renal cortical scintigraphy using Tc-99m Dimercaptosuccinic acid (Tc-99m DMSA) is the detection of cortical abnormalities. In addition, relative renal function (RRF) is performed by DMSA scintigraphy and estimated from the radiopharmaceutical uptake in both kidneys with radiation attenuation correction. Generally, attenuation correction is calculated from mathematic methods with kidney depth correction for an accurate renal function value.

Objective: The purpose of this research was to study the correlation of the RRF with radiation attenuation correction by geometric mean (GM) method and kidney depth correction by Beer-Lambert law equation.

Methods: Researchers studied in the spherical phantom, kidney phantom and patient’s …


Periodontal Status In Patients With Chronic Skin Diseases: A Pilot Study, Hao Nguyen, Thuy Nguyen, Thuy Vo, Huong Duong, Hoa Ho, Nhi Pham, Nguyen Pham, Nam Huynh Oct 2025

Periodontal Status In Patients With Chronic Skin Diseases: A Pilot Study, Hao Nguyen, Thuy Nguyen, Thuy Vo, Huong Duong, Hoa Ho, Nhi Pham, Nguyen Pham, Nam Huynh

Chulalongkorn Medical Journal

Background: Many skin diseases, especially those that also involve the oral mucosa lesions might play an important role in the etiopathogenesis of oral health and mucocutaneous inflammation. The presence of these oral sores may make it more difficult to maintain good oral hygiene, which increases plaque accumulation and raises the risk of developing periodontal disease.

Objectives: This study aimed to evaluate and compare the periodontal status of chronic skin disease (CSD) patients with healthy controls.

Methods: 109 patients and 37 healthy subjects were included in this study. Parameters evaluated included bleeding on probing index (BOP), periodontal pocket depths (PPD), clinical …


Biocompatibility And Anti-Inflammatory Effects Of Thai Cannabidiol-Containing Topical Anesthetic Gel Prototype In A Dermal Irritation Test, Pasutha Thunyakitpisal, Supattarayan Thongjit, Apitchaya Pruksametanan, Wijit Banlunara Assoc. Prof. Oct 2025

Biocompatibility And Anti-Inflammatory Effects Of Thai Cannabidiol-Containing Topical Anesthetic Gel Prototype In A Dermal Irritation Test, Pasutha Thunyakitpisal, Supattarayan Thongjit, Apitchaya Pruksametanan, Wijit Banlunara Assoc. Prof.

The Thai Journal of Veterinary Medicine

The objective of this study is to investigate and compare the effect of cannabidiol (CBD)-containing and non-CBD topical anesthetic gel prototypes on skin irritation in rabbits at 24, 48, and 72 h post-application. Topical anesthetic gel prototypes containing 0.1% CBD and without CBD were developed. Six rabbits (Oryctolagus cuniculus) were used for skin irritation testing according to ISO 10993-23: 2021. The animals were randomly and equally divided into two groups (CBD and non-CBD gel groups). The gels were applied to the animals’ skin at the dorsal area of the flank with good contact for 4 h. Distilled water …


High Occurrence Of Long Bone Nonunion : Assessing Significant Biological Risk Factors And Management Results, Bimo Sasono, Aldy Dion Oct 2025

High Occurrence Of Long Bone Nonunion : Assessing Significant Biological Risk Factors And Management Results, Bimo Sasono, Aldy Dion

Journal of Health Research

Background: A comprehensive study evaluated the risk of nonunion per fracture in a population of over four million adults and determined that rates vary depending on patients' risk factors, nonunion rates can reach in excess of 10%. This study aims to address the issue by scrutinizing the demographic characteristics of patients, pinpointing the biological risk factors for long bone nonunion and evaluating the nonunion management effectiveness.

Methods: This analytical, observational retrospective cohort study used medical record data from a regional hospital in Surabaya, Indonesia (2020–2023), involving 147 eligible patients. Data were analyzed using logistic regression with a significance level of …


Exploring Workplace Mental Health And Counseling Needs In Open University Staff: A Mixed-Methods Study, Pathanin Sangaroon, Oranuch Kanjanaprakorn, Araya Prasertchai, Worrawit Nakpan Sep 2025

Exploring Workplace Mental Health And Counseling Needs In Open University Staff: A Mixed-Methods Study, Pathanin Sangaroon, Oranuch Kanjanaprakorn, Araya Prasertchai, Worrawit Nakpan

Journal of Health Research

Background: Workplace mental health is a growing concern in higher education, especially in open and distance learning (ODL) settings, where staff face unique stressors. This study examines the mental health and counseling needs of academic and support staff at Sukhothai Thammathirat Open University (STOU), Thailand, using a biopsychosocial lens.

Methods: An explanatory sequential mixed-methods design was used. In the quantitative phase, 332 staff completed a questionnaire on mental health and biopsychosocial factors. Twelve participants then took part in interviews to explore their experiences and counseling preferences. Quantitative data were analyzed using stepwise regression, and qualitative data through thematic analysis. …


Dermatological Primary Health Care Services For Older Adults In Thailand, Chinmanat Lekhavat, Jiruth Sriratanaban Sep 2025

Dermatological Primary Health Care Services For Older Adults In Thailand, Chinmanat Lekhavat, Jiruth Sriratanaban

Journal of Health Research

Background: The increasing population aging worldwide poses challenges to accessibility to dermatological care, especially in rural areas with limited dermatologist availability. Establishing dermatological primary health care (PHC) services for older adults is crucial for improving access, efficiency, and equity. However, no study has systematically explored such a system.

Method: This mixed-methods study employed a participatory action research (PAR) model to identify structural and procedural requirements, patient journeys, health needs, and expectations. Data were collected through focus groups, in-depth interviews, and surveys. Design thinking workshops, guided by PAR principles, were used to develop dermatological PHC services. A survey was conducted across …


Efficiency And Clinical Outcomes Of Platelet-Rich Plasma Therapy On Canine Coxofemoral Osteoarthritis, Patama Arunrattanakul, Kumpanart Soontornvipart Sep 2025

Efficiency And Clinical Outcomes Of Platelet-Rich Plasma Therapy On Canine Coxofemoral Osteoarthritis, Patama Arunrattanakul, Kumpanart Soontornvipart

The Thai Journal of Veterinary Medicine

The purpose of this study was to find out the optimal technique to prepare plasma with the highest platelet concentration in platelet rich plasma (PRP), as well as determine the result of autologous PRP from the dogs with osteoarthritis (OA) condition. It was shown that the PRP could reduce inflammation, cell regeneration and enhance angiogenesis to support the injured tissue. This study was composed of two phases; the first phase aimed to find the best centrifugation speed and time that could be able to produce the plasma with the highest platelet concentration by conducting the experiment from a total of …


Antiplatelet Effects Of Angelica Dahurica Root Extract Without Gastric Lesion Formation In Rats, Pitiphat Srisom, Kasem Rattanapinyopituk, Uthai Sotanaphun, Rataya Luechapudiporn Sep 2025

Antiplatelet Effects Of Angelica Dahurica Root Extract Without Gastric Lesion Formation In Rats, Pitiphat Srisom, Kasem Rattanapinyopituk, Uthai Sotanaphun, Rataya Luechapudiporn

The Thai Journal of Pharmaceutical Sciences

Background: Platelet aggregation plays a crucial role in hemostasis; however, excessive platelet activation can lead to thrombus formation, contributing to cardiovascular diseases. While aspirin (acetylsalicylic acid [ASA]) is commonly used as an antiplatelet agent, its longterm use is associated with gastrointestinal side effects. Angelica dahurica (AD), a traditional herbal remedy, has shown in vitro antiplatelet activity and cyclooxygenase enzyme inhibition. However, its in vivo effects on platelet aggregation and gastric safety remain unclear.

Objectives: This study aimed to investigate whether Angelica dahurica root extract (ADE) could inhibit platelet aggregation and prevent aspirin-induced gastric lesions.

Materials and Methods: AD was extracted …


Bone-Sparing Effects Of Pueraria Mirifica Extract On Bone Loss In Androgen-Deficient Cynomolgus Macaques (Macaca Fascicularis), Thaweechai Saetae, Taratorn Kemthong, Sukanya Jaroenporn, Suchinda Malaivijitnond Sep 2025

Bone-Sparing Effects Of Pueraria Mirifica Extract On Bone Loss In Androgen-Deficient Cynomolgus Macaques (Macaca Fascicularis), Thaweechai Saetae, Taratorn Kemthong, Sukanya Jaroenporn, Suchinda Malaivijitnond

The Thai Journal of Pharmaceutical Sciences

Background: Synthetic estrogens provide remarkable benefits for bone health in men; however, they also present several drawbacks after long-term use. Pueraria mirifica, a phytoestrogen-rich herb, has garnered attention due to its positive effects and minimal adverse side effects on bone in females. Most research on bone health has been conducted on rodents; however, bone architecture and remodeling in rodents differ from those in humans, making it challenging to apply the results to clinical trials.
Objectives: Thus, this study assessed the bonesparing effects of P. mirifica extract (PME) in androgen-deficient male cynomolgus macaques.

Materials and Methods: Adult male macaques were divided …


Quality By Design Approach To Method Development And Validation For Quantitative Estimation Of Dapagliflozin And Linagliptin In Pharmaceutical Tablet Dosage Forms, Prechha Shrestha, Ashwinee Kumar Shrestha, Rajan Shrestha, Barsha Thapa Sep 2025

Quality By Design Approach To Method Development And Validation For Quantitative Estimation Of Dapagliflozin And Linagliptin In Pharmaceutical Tablet Dosage Forms, Prechha Shrestha, Ashwinee Kumar Shrestha, Rajan Shrestha, Barsha Thapa

The Thai Journal of Pharmaceutical Sciences

Objectives: The present study utilizes a quality by design approach to develop a simple, robust, and stability-indicating high-performance liquid chromatography method for quantifying dapagliflozin (DAPA) and linagliptin (LINA) in a fixed-dose combination and validate it according to the ICH-Q2 (R1) guidelines.

Materials and Methods: The effect of critical method parameters (CMPs), namely percentage of acetonitrile (ACN), pH of the buffer, and flow rate, on critical quality attributes (CQAs) such as retention time, area, tailing factor, and theoretical plates was studied using Box–Behnken design (BBD). Response optimizer was utilized to optimize the experimental conditions. The mobile phase (MP) consisted of ACN …


Continuous Glucose Monitoring Versus Self-Monitoring For Patients With Type 1 Diabetes: A Systematic Review And Meta-Analysis, Prayuth Poowaruttanawiwit, Kwanchai Rattanamanee, Nonnachanok Chaiyot, Saranpreeya Srisinroongruang Sep 2025

Continuous Glucose Monitoring Versus Self-Monitoring For Patients With Type 1 Diabetes: A Systematic Review And Meta-Analysis, Prayuth Poowaruttanawiwit, Kwanchai Rattanamanee, Nonnachanok Chaiyot, Saranpreeya Srisinroongruang

The Thai Journal of Pharmaceutical Sciences

Background: Patients with type 1 diabetes mellitus (T1DM) require intensive glucose monitoring to achieve optimal glycemic control and prevent complications. While self-monitoring of blood glucose (SMBG) has long been the standard approach, continuous glucose monitoring (CGM) offers real-time data and trend analysis that may enhance clinical decision-making.

Objective: This study aimed to evaluate whether CGM provides superior glycemic outcomes compared with SMBG in individuals with T1DM.

Materials and Methods: A systematic review and meta-analysis were conducted following preferred reporting items for systematic reviews and meta-analyses guidelines. Four randomized controlled trials involving T1DM patients using either CGM or SMBG were included. …


Screening And Evaluation Of Thai Herbal Plants As Multifunctional Agents For Targeting Amyloid Β Pathogenesis In Alzheimer's Disease, Ruedeemars Yubolphan, Suchinda Malaivijitnond, Sukanya Jaroenporn Sep 2025

Screening And Evaluation Of Thai Herbal Plants As Multifunctional Agents For Targeting Amyloid Β Pathogenesis In Alzheimer's Disease, Ruedeemars Yubolphan, Suchinda Malaivijitnond, Sukanya Jaroenporn

The Thai Journal of Pharmaceutical Sciences

Background: Alzheimer's disease (AD) is a neurodegenerative disorder driven by complex pathophysiological processes. Current therapeutic strategies emphasize the development of multifunctional agents, particularly those derived from natural sources, to target multiple stages of the amyloid β (Aβ) cascade, a central contributor to AD pathology.

Objectives: This study aimed to investigate the anti-Aβ activity of nine Thai herbs and evaluate their potential as multifunctional agents for AD treatment.

Methods: Nine Thai herbs—Caesalpinia sappan (CS), Thunbergia laurifolia (TL), Rhinacanthus nasutus (RN), Tabernaemontana divaricata (TD), Cyperus rotundus (CR), Terminalia chebula (TC), Azadirachta indica (AI), Piper retrofractum (PR), and Asparagus racemosus (AR)—were screened …


Hematologic And Serum Biochemical Reference Intervals For Formosan Sika Deer (Cervus Nippon Taiouanus) From A Semi-Free-Ranging Population In Taiwan, Chen-Wei Wang, Ke-Lun Chen, Hung-Yi Wu, Chia-Ying Lin Sep 2025

Hematologic And Serum Biochemical Reference Intervals For Formosan Sika Deer (Cervus Nippon Taiouanus) From A Semi-Free-Ranging Population In Taiwan, Chen-Wei Wang, Ke-Lun Chen, Hung-Yi Wu, Chia-Ying Lin

The Thai Journal of Veterinary Medicine

The Formosan sika deer (Cervus nippon taiouanus), an endemic Taiwanese subspecies, holds a pivotal role in local conservation. This study addresses a significant knowledge gap by establishing population-specific reference intervals (RIs) for this species, as existing RIs are based on limited captive populations and may not accurately reflect the health of semi-free-ranging cohorts. We analyzed 632 sampling events from 232 healthy adult deer within Kenting National Park over 12 years (2013–2024). This study adhered to ASVCP guidelines, establishing instrument-specific RIs and employing linear mixed-effects models (LMMs) to evaluate the complex interactions among analytical instruments, sex, and body weight. …


Innovative Glycerin Impregnation Of Female Livestock Genital Organs And Satisfaction Assessment For Veterinary Anatomy Education In Thailand, Paisan Tienthai, Jantima Intarapanya, Pawana Chuesiri Sep 2025

Innovative Glycerin Impregnation Of Female Livestock Genital Organs And Satisfaction Assessment For Veterinary Anatomy Education In Thailand, Paisan Tienthai, Jantima Intarapanya, Pawana Chuesiri

The Thai Journal of Veterinary Medicine

Veterinary anatomy education faces several challenges, including increasing student enrollment, regulatory restrictions on animal use, and limitations of traditional preservation methods. Formalin preservation poses health risks, while plastination is costly and lacks flexibility. The conventional and modified Elnady Techniques present a safer and more cost-effective alternative, offering soft and flexible specimens; however, the adverse features still appear, and some steps require expensive equipment. This study aims to refine these Elnady Techniques, called ‘innovative glycerin impregnation’ for preserving female reproductive organs by reducing costs and simplifying the process using basic equipment. Additionally, veterinary students' satisfaction with glycerin-preserved specimens was compared to …


Blood Glucose Concentration In Highly Prolific Sows Before Farrowing: Its Relationship With Parity And Litter Size, Preechaphon Taechamaeteekul, Silvia Comencini, Fabio De Rensis, Roberta Saleri, Padet Tummaruk Sep 2025

Blood Glucose Concentration In Highly Prolific Sows Before Farrowing: Its Relationship With Parity And Litter Size, Preechaphon Taechamaeteekul, Silvia Comencini, Fabio De Rensis, Roberta Saleri, Padet Tummaruk

The Thai Journal of Veterinary Medicine

Farrowing is an energy-demanding period for prolific sows, with blood glucose levels serving as key indicators affecting farrowing outcomes and piglet survival. This study aimed to evaluate blood glucose levels in prolific sows prior to farrowing, assess the prevalence of hypoglycemia in late gestation, and investigate the relationship between blood glucose levels, parity, and litter size under tropical conditions. A total of 67 Danish Landrace × Yorkshire sows were grouped based on litter size (6–14, 15–17, or ≥18 piglets) and parity (2–4 and 5–6). To determine glucose levels, blood samples were collected at 115.8 ± 1.6 days of gestation, at …


Bacterial Identification And Antibiotic Sensitivity Profiles From Captive Birds At Taipei Zoo, Younjung Chang, I-Li Liu, Jane-Fang Yu, Lih-Chiann Wang Aug 2025

Bacterial Identification And Antibiotic Sensitivity Profiles From Captive Birds At Taipei Zoo, Younjung Chang, I-Li Liu, Jane-Fang Yu, Lih-Chiann Wang

The Thai Journal of Veterinary Medicine

Bacterial infections are common in zoo birds. They may be caused by pathogenic bacteria or opportunistic bacteria due to trauma or stress-induced immune compromise. Improper use of antibiotics contributes to the development of resistant bacteria, making treatment complicated or ineffective. However, comprehensive clinical investigations into bacterial prevalence and antibiotic susceptibility in zoo-captive birds remain limited. This study identified the bacterial species present in captive diseased birds at the zoo and conducted a 12-year analysis of their antibiotic susceptibility profiles. The specimens from 48 birds at Taipei Zoo from 2006 to 2017 were submitted to a commercial reference laboratory for bacterial …