Biomedical Commons^™

Use Of Cosine Modulated Filter Bank To Quantify Human Muscle Fatigue Using Electromyography Signals Obtained During Isometric Voluntary Contractions, Liza Stephanie Rodriguez

Open Access Theses & Dissertations

As technology continues to advance, there continues to be an interest in applying engineering theories to solve medical problems. Technology has allowed researchers to investigate the properties and characteristics of the human body in hopes of emulating their complexities. The rising interest in the study of biopotentials for use in prosthetic limbs, exoskeletons and machine interfacing has led to a necessity to validate that the understanding of these signals is accurate. The study of biopotentials generated by muscles via a method known as electromyography (EMG) has improved the understanding of effects of rehabilitative treatments, assisted in diagnosing diseases, control of …

Direct Classification Of All American English Phonemes Using Signals From Functional Speech Motor Cortex, Emily M. Mugler, James L. Patton, Robert D. Flint, Zachary A. Wright, Stephan U. Schuele, Joshua Rosenow, Jerry J. Shih, Dean J. Krusienski, Marc W. Slutzky

Electrical & Computer Engineering Faculty Publications

Although brain-computer interfaces (BCIs) can be used in several different ways to restore communication, communicative BCI has not approached the rate or efficiency of natural human speech. Electrocorticography (ECoG) has precise spatiotemporal resolution that enables recording of brain activity distributed over a wide area of cortex, such as during speech production. In this study, we investigated words that span the entire set of phonemes in the General American accent using ECoG with 4 subjects. We classified phonemes with up to 36% accuracy when classifying all phonemes and up to 63% accuracy for a single phoneme. Further, misclassified phonemes follow articulation …

Reference Compensation For Localized Surface-Plasmon Resonance Sensors, Neha Nehru

Theses and Dissertations--Electrical and Computer Engineering

Noble metal nanoparticles supporting localized surface plasmon resonances (LSPR) have been extensively investigated for label free detection of various biological and chemical interactions. When compared to other optical sensing techniques, LSPR sensors offer label-free detection of biomolecular interactions in localized sensing volume solutions. However, these sensors also suffer from a major disadvantage – LSPR sensors remain highly susceptible to interference because they respond to both solution refractive index change and non-specific binding as well as specific binding of the target analyte. These interactions can severely compromise the measurement of the target analyte in a complex unknown media and hence limit …

Array Of Surface-Confined Glow Discharges In Atmospheric Pressure Helium: Modes And Dynamics, D. Li, D. X. Liu, Q. Y. Nie, H. P. Li, H. L. Chen, M. G. Kong

Bioelectrics Publications

Array of atmospheric pressure surface discharges confined by a two-dimensional hexagon electrode mesh is studied for its discharge modes and temporal evolution so as to a theoretical underpinning to their growing applications in medicine, aerodynamic control, and environmental remediation. Helium plasma surface-confined by one hexagon-shaped rim electrode is shown to evolve from a Townsend mode to a normal and abnormal glow mode, and its evolution develops from the rim electrodes as six individual microdischarges merging in the middle of the hexagon mesh element. Within one hexagon element, microdischarges remain largely static with the mesh electrode being the instantaneous cathode, but …

Numerical Study Of Lipid Translocation Driven By Nanoporation Due To Multiple High-Intensity, Ultrashort Electrical Pulses, Viswanadham Sridhara, Ravindra P. Joshi

Electrical & Computer Engineering Faculty Publications

The dynamical translocation of lipids from one leaflet to another due to membrane permeabilization driven by nanosecond, high-intensity (>100 kV/cm) electrical pulses has been probed. Our simulations show that lipid molecules can translocate by diffusion through water-filled nanopores which form following high voltage application. Our focus is on multiple pulsing, and such simulations are relevant to gauge the time duration over which nanopores might remain open, and facilitate continued lipid translocations and membrane transport. Our results are indicative of a N^1/2 scaling with pulse number for the pore radius. These results bode well for the use of pulse …

Laminar Flow Hood System Design, Sophie Schneider

Electrical Engineering

In 2011 health care costs for transplants were over 12 billion dollars in the United States for evaluation, procurement, facilities use, physicians, and post-transplant check-ups. In 2012 burns hospitalized 40,000 people and over 17,000 people received organ transplants. Sadly, the number of organ donors greatly lags the number of people on the transplant waiting list and the gap has widened over the decades. While preventative health care is extremely important, researching tissue engineering (TE) to treat patients in fatal condition provides alternatives for replacing or repairing a variety of damaged tissue. These alternative treatments can considerably reduce the supply-demand gap …

Development And Evaluation Of Chitosan Particle Based Antigen Delivery Systems For Enhanced Antigen Specific Immune Response, Bhanuprasanth Koppolu

Graduate Theses and Dissertations

Particle-based vaccine delivery systems are under exploration to enhance antigen-specific immunity against safe but poorly immunogenic polypeptide antigens. Chitosan is a promising biomaterial for antigen encapsulation and delivery due to its ability to form nano- and microparticles in mild aqueous conditions thus preserving the antigenicity of loaded polypeptides. The objective of this work is to develop a chitosan particle based antigen delivery system for enhanced vaccine response. Chitosan particle sizes, which ranged from 300 nm to 3 ìm, were influenced by chitosan concentration, chitosan molecular weight and addition rate of precipitant salt. The composition of precipitant salt played a significant …

A Quantitative Analysis Of A Paper-Based, Laser-Defined, Oxygen-Generating Platform For Chronic Wounds, Tiffany L. Huang, Babak Ziaie

The Summer Undergraduate Research Fellowship (SURF) Symposium

Chronic wounds affect 6.5 million patients a year while consuming US$25 billion in health care costs (Sen 2009 Wound Repair Regen.). Despite advances in wound management therapies, modern treatment for chronic wounds still requires continual professional attention and expensive equipment, posing serious practical and financial burdens for the regular patient. To provide an alternative solution, we are developing a low-cost smart bandage platform that integrates actuators and sensors to monitor and treat chronic wounds. One component of the integrated platform is an oxygen-generating module. It is a polydimethylsiloxane (PDMS) based microfluidic device fabricated on a parchment paper substrate that …

Altered Cholesterol Metabolism In Human Cancers Unraveled By Label-Free Spectroscopic Imaging, Shuhua Yue

Open Access Dissertations

Despite tremendous scientific achievements, cancer remains the second leading cause of death in the United States. Metabolic reprogramming has been increasingly recognized as a core hallmark of cancer. My dissertation work identified novel diagnostic markers and therapeutic targets for human cancers through the study of cholesterol in cancer cells.

Enabled by label-free Raman spectromicroscopy, we performed the first quantitative analysis of lipogenesis at single cell level in human patient cancerous tissues. Our imaging data revealed an unexpected, aberrant accumulation of esterified cholesterol in lipid droplets of high-grade prostate cancer and metastases, but not in normal prostate, benign prostatic hyperplasia, or …

Effects Of Dip-Coated Films On The Properties Of Implantable Intracortical Microelectrodes, Salah Sommakia

Open Access Dissertations

The successful clinical use of implantable intracortical microelectrodes (ICMs) to treat certain types of deafness, blindness, and paralysis is limited by a reactive tissue response (RTR) of the brain. This RTR culminates in the formation of a tight glial scar and a loss of neuronal density around implanted ICMs, and is accompanied by a decrease in signal to noise ratio and an increase in impedance. While no comprehensive mechanistic understanding of the underlying biology is currently agreed upon in the field, a general consensus exists around a highly volatile acute RTR phase. During this acute phase, the electrical properties of …

Developing A Drug Delivery System For Treatment Of Vocal Fold Scarring, Aaron Michael Kosinski

Open Access Dissertations

Vocal fold scarring is an affliction that results in the formation of a disorganized and stiff extracellular matrix (ECM) with abnormal ECM component densities & structures including a significant increase in collagen deposition. It is caused by improper healing post injury and results in profound changes in the biomechanical properties of the vocal folds impairing their ability to generate a normal mucosal wave during phonation.

Finding an effective treatment for vocal fold scarring has been elusive. Currently, treatments seek temporary solutions that correct glottal incompetence and reduce stiffness caused by the scar through the augmentation of the vocal folds using …

Numerical Techniques For The Noninvasive Assessment Of Material Properties And Stresses In Soft Biomaterials, Kent David Butz

Open Access Dissertations

The noninvasive measurement of finite displacements and strains in biomaterials by magnetic resonance imaging (MRI) may be shown to enable mathematical estimates of stress distributions and material properties within structures of the body such as articular cartilage or the intervertebral disc. Such methods will allow for non-contact and patient-specific modeling in a manner not currently possible with traditional mechanical testing or finite element techniques. Therefore, the objective of this thesis was to develop computational methods incorporating imaging-based measures of deformation, composition, and local microstructure to permit nondestructive analysis of a range of complex biomechanical systems.

Finite strain-based models were developed …

Effects Of Hearing Aid Amplification On Robust Neural Coding Of Speech, Jonathan Daniel Boley

Open Access Dissertations

Hearing aids are able to restore some hearing abilities for people with auditory impairments, but background noise remains a significant problem. Unfortunately, we know very little about how speech is encoded in the auditory system, particularly in impaired systems with prosthetic amplifiers. There is growing evidence that relative timing in the neural signals (known as spatiotemporal coding) is important for speech perception, but there is little research that relates spatiotemporal coding and hearing aid amplification.

This research uses a combination of computational modeling and physiological experiments to characterize how hearing aids affect vowel coding in noise at the level of …

A Novel Multiblock Immersed Boundary Method Enabling High Order Large Eddy Simulation Of Pathological And Medical Device Hemodynamics, Anupindi Kameswararao

Open Access Dissertations

Computational fluid dynamics (CFD) simulations are becoming a reliable tool in understanding disease progression, investigating blood flow patterns and evaluating medical device performance such as stent grafts and mechanical heart valves. Previous studies indicate the presence of highly disturbed, transitional and mildly turbulent flow in healthy and pathological arteries. Accurate simulation of the transitional flow requires high order numerics together with a scale resolving turbulence model such as large eddy simulation (LES). This in turn limits one to use a structured fluid flow solver on which complex, branching arterial domains that are typical in the human blood circulatory system could …

Developing Mhealth Solutions For Natural Family Planning, Md Miftah Uddin

Master's Theses (2009 -)

Natural Family Planning (NFP) is a method to help couples determine the fertile and infertile times of a woman’s menstrual cycle with natural indicators of fertility. NFP methods have advantages over other methods of family planning. Proper use of NFP methods also ensures high effectiveness (close to 98%) in helping couples avoid pregnancy. However, very few physicians prescribe NFP to their patients due to lack of credibility to the fertility methods and lack of access to NFP knowledge. The Marquette University College of Nursing Institute for Natural Family Planning has been researching for many years to increase knowledge and efficiency …

Footwear Antennas For Body Area Telemetry, Domenico Gaetano, Patrick Mcevoy, Max Ammann, Jacinta Browne, Louise Keating, Frances Horgan

Articles

Antennas designed to link footwear sensors within body centric networks are introduced with two small UWB antennas, one directional and another quasi-omnidirectional. The radiating characteristics are evaluated for three positions on a sample sports shoe using a detailed simulation model and measurements with a homogenous foot phantom. Antenna performance is assessed for resilience to close proximity loading by the footwear materials and the phantom foot.

Automated Channel Assessment For Single Chip Medradio Transceivers, Mark Alexander Hillig

Dissertations and Theses

Modern implantable and body worn medical devices leverage wireless telemetry to improve patient experience and expand therapeutic options. Wireless medical devices are subject to a unique set of regulations in which monitoring of the available frequency spectrum is a requirement. To this end, implants use software protocols to assess the in-band activity to determine which channel should be used. These software protocols take valuable processing time and possibly degrade the operational lifetime of the battery. Implantable medical devices often take advantage of a single chip transceiver as the physical layer for wireless communications. Embedding the channel assessment task in the …

Computational Modeling To Evaluate Helical Electrode Designs For Use In Vagus Nerve Stimulation, Anthony W. Cowley

Master's Theses

An estimated 0.5% of world’s population has been diagnosed with epilepsy. Of these patients 20-30% will be unable to achieve seizure control with anti-epileptic drugs. Vagus nerve stimulation (VNS) may be an appropriate treatment option for some patients with pharmaceutically refractory, partial-onset seizures.

VNS therapy uses a helical electrode to interface between the implantable pulse generator and the vagus nerve. While there have been several studies related to the mechanical and electrical safety of such electrodes, little work has been done toward understanding the effectiveness of the helical electrode in nerve stimulation. A better understanding of the voltage field and …

Applied Hw/Sw Co-Design: Using The Kendall Tau Algorithm For Adaptive Pacing, Kenneth W. Chee

Master's Theses

Microcontrollers, the brains of embedded systems, have found their way into every aspect of our lives including medical devices such as pacemakers. Pacemakers provide life supporting functions to people therefore it is critical for these devices to meet their timing constraints. This thesis examines the use of hardware co-processing to accelerate the calculation time associated with the critical tasks of a pacemaker. In particular, we use an FPGA to accelerate a microcontroller’s calculation time of the Kendall Tau Rank Correlation Coefficient algorithm. The Kendall Tau Rank Correlation Coefficient is a statistical measure that determines the pacemaker’s voltage level for heart …

Eye "R" Glasses: Development Of An Infrared Sensor System For Detecting The Human Body, Rick Wong

Master's Theses

Throughout the years, sensors have been an integral part of automation, alert, and medical systems. Many of these systems measure physiological characteristics of the human body to alert themselves of their current conditions. Drowsy driver systems, for instance, measure the eyes and facial movements with a camera to determine if the driver is falling asleep at the wheel. Electroencephalography (EEG), electrooculography (EOG), and electromyography (EMG) employ electrodes on the human body to measure electrical activity of a patient’s REM sleep cycle patterns. Pulse oximeters use optical light through a process called photoplethysmography (PPG) to measure heart rate.

As diverse as …