Chemical Engineering Commons^™

Characterization Of Antibody Repertoires Developed From Naive And Recall Responses, Nicholas C. Curtis

Dartmouth College Ph.D Dissertations

Adaptive immunity, comprised in part by the antibody repertoire, is the cornerstone of our ability to remain healthy amongst the plethora of pathogenic challenges we encounter daily. Despite the importance of understanding antibody repertoire development, much remains unknown about the composition and evolution of circulating antibodies in response to viral challenges. To better understand antibody repertoire development, we profiled the serum antibody repertoire using a combination of next-generation sequencing and serum antibody proteomics in the predominantly naïve response against SARS-CoV-2 spike and the recalled response to influenza hemagglutinin. The response to SARS-CoV-2 spike in four convalescent individuals was diverse (consisting …

Schaeffler Icvd Coating Machine, Louis Mcgrath

Williams Honors College, Honors Research Projects

Chemical Vapor Deposition (CVD) is mutual technology used to deposit thin film through a gaseous phase by vaporizing the solid materials. This conventional process usually requires high thermal stability of the materials, which is not applicable for most of the polymeric materials. Therefore, a novel process, initiated Chemical Vapor Deposition (iCVD) is developed by introducing the gaseous monument and initiator to form the thin film in-situ. By adjusting the free-radical polymerization in the vapor phase, a variety of thin and uniform polymer films can be achieved. Depending on the chemistry, iCVD has many categories. This report explains the design …

Causational Analysis And Rectification Of Issues Concerning Scale Formation On Hot-Rolled Straight Bar Product And Its Effects On Ultrasonic Testing, Riley Mattix

Williams Honors College, Honors Research Projects

At Charter Steel's NDT Processing Plant located in Cleveland, Ohio, a concern has arisen regarding the recently implemented bar straightening and UT (Ultrasonic Testing) equipment. A substantial amount of mill scale, which is typically removed during the straightening process, is persisting on the bar’s surface throughout most of the NDT procedure. This lingering scale has been observed to flake off once inside the UT equipment, introducing unwanted noise and phantom peaks into the UT readings. Additionally, thick mill scale has been identified as a source of background interference in the received data. In contrast, bars that have been subjected to …

Determination Of Spore Viability In Concrete Across Several Factors Using Most Probable Number, Samuel Boyer

Williams Honors College, Honors Research Projects

To determine the lowest concentration of spore added to polyurethane-cement composite (PUCCO) particles that can still germinate after curing in concrete. This research project is a small addition to the larger research project being undertaken by Mirza Mohammed Rashiduzzaman for his Masters. The larger project involves the use of fungal spores added in concrete to act as a self-healing component when cracks form in the concrete structure over time. These spores are suspended in a protective oil and loaded into small, hardened sponge-like PUCCO cubes to act as growth points when water and air can reach the PUCCO in the …

Electrostatic Sorting Of Lunar Regolith Simulants For Sustainable Resource Utilization: Modeling And Characterization Of Particle Size Distribution, Abdullah Al Moinee, Peter Bachle, Kyle Newport, William Schonberg, David Bayless, Jeffrey Smith, Daoru Han, Fateme Rezaei

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

In pursuit of sustainable resource utilization on the Moon, this paper delves into modeling and characterization of particle size distribution (PSD) of lunar regolith simulants in an electrostatic system. A prototype electrostatic sieve was built and tested with four sample simulants mirroring properties of lunar mare and highland regolith. An alternating four-phase (90 degrees, 180 degrees, 270 degrees, 360 degrees) traveling square-wave was utilized for particle-directed transport to model the diverse trajectories of the particles. Numerically, we scrutinized how the distribution functions of the particles are manifested as the electrostatic field propagates, with a focus on three distinct particle ranges …

State Estimation And Economic Analysis For Electrochemical Sensor-Based Corrosion Monitoring, Chandra Sekhar Somayajula

Graduate Theses, Dissertations, and Problem Reports (ETD)

Coal is currently the third-largest source of electricity production in the U.S. However, renewables are projected to be the primary source of electricity production in the future. Though coal-fired power plants (CFPPs) are rapidly retiring in the U.S., many CFPPs worldwide are expected to stay operational for a while due to factors like easy and cheap access to comparatively inexpensive coal. Therefore, non-renewable sources like coal are still expected to be prevalent and be used to ensure the stability of the electric grid in the foreseeable future. The existing coal-fired power plants generally designed to operate at base-loaded conditions are …

Design And Development Of Biocompatible Mofs And Silica-Based Nanocarriers With Controlled Pharmacokinetics For Drug Delivery Applications, Neila Pederneira

Doctoral Dissertations

"In the past decade, a big interest has drawn into nanoporous metal-organic frameworks (MOFs) and silica-based materials as nanocarriers for drug delivery applications, owing to their exceptionally high surface area and highly structured porous network. The overall goal of this research was to optimize the pharmacokinetic behavior of several highly porous biocompatible drug carriers that have the potential to carry Ibuprofen, 5-Fluorouracil, and Curcumin to the desired tissue without creating a burst effect and minimizing the amount of dosage and size that conventional capsules require. The specific objectives of this study are to (i) assess the effect of drug solubility …

Effect Of Various Irrigation Protocols And Antioxidant Application On Bonding Performance Of Two Adhesive Systems To Coronal Dentin, Nada Omar, Haidy N. Salem, Ahmed Abdou, Lamiaa M. Moharam

Chemical and Biochemical Engineering Faculty Research & Creative Works

Background: The aim was to evaluate the effect of different irrigation protocols and antioxidants application on the shear bond strength (SBS) of two different adhesive systems to deep coronal dentin at different temperature. Material and Methods: One hundred and twenty human premolar teeth were cut longitudinally in two halves, then the prepared specimens were allocated into four main groups according to the irrigation protocols; Distilled water (control), Sodium hypochlorite (NaOCl) + Ethylenediamine Tetra-acetic Acid (EDTA), and NaOCl + Editronate (HEDP), two subgroups according to irrigation solutions temperature; 4°C and 37°C, two divisions according to grape seed extract (GSE) application (with …

The Comprehensive Study Of High Viscosity Friction Reducers In High-Tds And High-Temperature Environments, Xiaojing Ge

Doctoral Dissertations

"High viscosity friction reducers (HVFRs) have been recently gaining more attention and increasing in use, not only as friction-reducing agents but also as proppant carriers. Reusing of produced water has also been driven by both environmental and economic benefits. Currently, most friction reducers on the market are anionic friction reducers, which are fully compatible with most produced water with low to medium level of Total Dissolved Solids (TDS) but show a significant drop at high TDS conditions in term of their friction reduction performance in most cases. On the contrary, cationic friction reducers are believed to have better TDS tolerance …

Investigating The Potential Of Blended Feedstocks For Biofuel Production Via Pyrolysis Process: Experimental And Aspen Simulation Approach, Hasan Jawad Hammood Al-Abedi

Doctoral Dissertations

"The development of renewable energy sources has become increasingly urgent considering the climate crisis and the need to reduce greenhouse gas emissions. Pyrolysis, which is decomposition of an organic feedstock without oxygen, is a thermo-chemical process that has garnered significant attention as a promising technology for sustainable energy production, capable of converting biomass and waste materials into biofuels.

The primary objective of this study is to investigate the pyrolysis and co-pyrolysis behaviors of corn stover (CS), refuse-derived fuel (RDF), and oil shale (OS) in equal mass ratios. Utilizing a thermogravimetric analyzer and differential scanning calorimetry (DSC), the co-pyrolysis process is …

Lithospheric Drip And Mantle Thermal Upwelling Beneath Central Asia And The Southern Great Plains Of North America: Evidence From Receiver Function Imaging, Yangyang Liao

Doctoral Dissertations

"Investigating the depth of mantle transition zone (MTZ) discontinuities provides insights into mantle dynamics, including regional-scale downwelling of mantle lithosphere (i.e., lithospheric drip) and upwelling of thermal materials (i.e., mantle plume). In our study, we employ receiver functions to image the 410 km (d410) and 660 km (d660) mantle discontinuities and to ascertain thickness of the MTZ beneath Central Asia and the Great Plains in United States. The findings unveil a significantly thickened transition zone, exhibiting an average thickness of 284 km beneath East Sayan. When considered alongside geochemical observations, our results indicate that the descent of the lithosphere is …

Sustainable Cementitious Materials For Building And Sorption Applications, Sukanta Kumar Mondal

Doctoral Dissertations

"Ordinary Portland Cement (OPC) is the most widely used cement material, but it contributes over 8% of the global CO₂ emission and the process is energy intensive. Moreover, OPC faces durability challenges, particularly in aggressive environments. Hence, there is rapidly increasing interest in sustainable alternative cements with lower carbon footprint, lower energy consumption, and those that offer superior properties that are beneficial for specific applications. Two sustainable cementitious materials that are frequently researched as an alternative to OPC are calcium sulfoaluminate (CSA) cement and alkali-activated materials (AAMs). CSA cement lowers CO₂ emission by over 40% compared to OPC, …

Investigation Of Asphaltene Instability Under Gas Injection In Unconventional Reservoirs And Its Impact On Oil Recovery Performance, Mukhtar Elturki

Doctoral Dissertations

"Unconventional reservoirs, such as shale gas and tight oil formations, have become an important source of energy in recent years. However, these reservoirs often contain high levels of asphaltenes, which can lead to deposition and blockages in production wells and reduce the flow of hydrocarbons during gas enhanced oil recovery (GEOR) techniques. This study aims to experimentally evaluate the impact of miscible and immiscible carbon dioxide (CO₂) and nitrogen (N₂) on asphaltene deposition and its impact on oil recovery performance in unconventional shale reservoirs.

This research began with a comprehensive literature review and data analysis of GEOR methods in unconventional …

The Effects Of Uv-Radiation On The Removal Of Microplastics In Water Using Agglomeration-Micro-Flotation, Palot Srichonphaisarn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Microplastics, plastic particles with diameter 1 micrometer to 5 millimeters, can disturb marine ecosystems due to their small size and surface properties which can be a carrier for hazardous matters. While wastewater treatment plants could remove some microplastics but some of them remain. Among the various removal techniques, flotation is a potential method due to the hydrophobic nature of microplastics. This study investigates the effects of ultraviolet radiation on the surface wettability of microplastics and removal efficiency of microplastics. The 6 types of microplastics were prepared from plastic boards. After the ultraviolet radiation, the results showed that ultraviolet radiation could …

Effect Of Zeolite Support Of Nickel-Copper Catalyst On Conversion Of Palm Oil To Sustainable Aviation Fuel, Natnicha Ritmun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Sustainable aviation fuel (SAF) is increasingly recognized as a critical alternative for reducing the environmental impact of the aviation industry, which is a significant source of global greenhouse gas emissions. SAF production primarily utilizes vegetable oils as feedstock rather than biomass, due to their low functional group content and chemical structure that closely resembles that of fossil fuels. This research focuses on the development of bimetallic catalysts made from nickel, with copper as promoters, supported on various zeolites including SAPO-11, Zeolite Y, and Zeolite ZSM-5. The chemical and physical properties of these catalysts were analyzed using several techniques, including X-ray …

Methanol Production Via Co2 Hydrogenation In Gas Phase With 1-Propanol Assisted In Fixed Bed Reactor, Narakorn Ninkaew

Chulalongkorn University Theses and Dissertations (Chula ETD)

The methanol synthesis from CO2 hydrogenation reaction using 1-propanol alcohol was selected to solvent involved in the new reaction pathway with CO2 and H2 as reactants in a gas phase fixed bed reactor. To study the effect of temperature at 160-230 °C, space velocity (GHSV) at 60-592 h-1, the mole ratio of 1 propanol to CO2 at 0-1.25, H2 to CO2 mole ratio of 5 and a pressure of 30 bar. From the experiment, the mole ratio of 1 propanol to CO2 at 1, the temperature of 170 °C and the space velocity of 420 h-1. It was found that …

การผลิตเมทานอลจากปฏิกิริยาไฮโดรจีเนชันของแก๊สคาร์บอนไดออกไซด์ที่มีเอทานอลในสภาวะแก๊สที่เครื่องปฏิกรณ์แบบเบดนิ่ง, ชนาภัทร บุญประคม

Chulalongkorn University Theses and Dissertations (Chula ETD)

เมทานอลเป็นวัตถุดิบเคมีตั้งต้นที่สำคัญสำหรับอุตสาหกรรมเคมี อุตสาหกรรมยา อุตสาหกรรมเครื่องใช้ไฟฟ้า ในวิทยานิพนธ์นี้จึงมีความสนใจในการศึกษาผลของเอทานอลในการผลิตเมทานอลจากปฏิกิริยาไฮโดรจีเนชันของแก๊สคาร์บอนไดออกไซด์ที่มีเอทานอลในสภาวะแก๊สที่เครื่องปฏิกรณ์แบบเบดนิ่ง สำหรับการศึกษาผลของเอทานอล แบ่งการศึกษาออกเป็น 3 ขั้นตอนหลัก ได้แก่ การศึกษาเส้นทางการเกิดปฏิกิริยา การตรวจสอบปัจจัยที่มีผลต่อการผลิตเมทานอล และการคำนวณที่สภาวะสมดุลด้วยโปรแกรม Aspen Plus การศึกษาภายใต้สมมติฐานว่า การเพิ่มเอทานอลในการผลิตเมทานอลจากปฏิกิริยาไฮโดรจีเนชันของแก๊สคาร์บอนไดออกไซด์ จะสามารถทำให้ผลิตเมทานอลได้ดีที่อุณหภูมิต่ำ ผลการศึกษาพบว่า การเพิ่มเอทานอลในกระบวนการเปลี่ยนเส้นทางปฏิกิริยา ทำให้เกิดเอทธิลฟอร์เมทเป็นตัวกลางในการสร้างเมทานอล การศึกษาอุณหภูมิ พบว่า การลดอุณหภูมิช่วยให้ปฏิกิริยาไฮโดรจีเนชันของคาร์บอนไดออกไซด์เป็นเอทิลฟอร์เมตและปฏิกิริยาไฮโดรจีเนชันของเอทิลฟอร์เมตเป็นเมทานอลและเอทานอลมีประสิทธิภาพมากขึ้น อีกทั้งยังสามารถช่วยลดการเกิดปฏิกิริยาข้างเคียง ทั้งนี้ สันนิษฐานได้ว่าเอทานอลที่ถูกเติมเข้ามามีผลในการแย่งจับตำแหน่งออกฤทธิ์ (active site) บนตัวเร่งปฏิกิริยา ทำให้การเกิดปฏิกิริยาไฮโดรจีเนชันของคาร์บอนมอนอกไซด์ที่อุณหภูมิ 200 และ 230 องศาเซลเซียสไม่สามารถทำได้อย่างมีประสิทธิภาพ นอกจากนี้ การศึกษาของการเพิ่มความเร็วเชิงพื้นที่พบว่า ค่าร้อยละการเปลี่ยนแปลงคาร์บอนไดออกไซด์และค่าร้อยละผลผลิตของเมทานอลลดลง เนื่องจากลดเวลาสัมผัสระหว่างสารตั้งต้นกับตำแหน่งที่เกิดปฏิกิริยาของตัวเร่งปฏิกิริยา ส่งผลให้สารตั้งต้นสัมผัสกับตัวเร่งปฏิกิริยาน้อยลงทำให้ไม่มีเวลามากพอที่จะเกิดปฏิกิริยาอย่างสมบูรณ์ อีกทั้งพบเอทิลฟอร์เมตน้อย สันนิษฐานได้ว่าปฏิกิริยาไฮโดรจีเนชันของเอทิลฟอร์เมตเป็นเมทานอลและเอทานอลนั้นเกิดขึ้นอย่างรวดเร็วในช่วงค่าความเร็วเชิงพื้นที่ที่กำหนด อีกทั้งพบว่าการลดความเร็วเชิงพื้นที่ ที่อุณหภูมิ 200 และ 230 องศาเซลเซียส ทำให้ปฏิกิริยาไฮโดรจีเนชันของคาร์บอนมอนอกไซด์เกิดขึ้นอย่างมีประสิทธิภาพมากยิ่งขึ้น ผลการศึกษาการเพิ่มอัตราส่วนโมลของเอทานอลต่อคาร์บอนไดออกไซด์ โดยคาดว่าจะช่วยให้เพิ่มค่าการเปลี่ยนแปลงคาร์บอนไดออกไซด์และผลผลิตของเมทานอล ผลการทดลองที่ความเร็วเชิงพื้นที่ 296 ชม.-1 ปฏิกิริยาไฮโดรจีเนชันของคาร์บอนไดออกไซด์และการไฮโดรจีเนชันของเอทิลฟอร์เมต พบว่า การเพิ่มเอทานอลในปฏิกิริยาจะช่วยเพิ่มเอทิลฟอร์เมต อย่างไรก็ตาม หากเพิ่มสัดส่วนเอทานอลที่มากเกินไปจะไปจำกัดการผลิตเมทานอล จากผลการศึกษาการเปลี่ยนแปลงอัตราส่วนโมลเอทานอลต่อคาร์บอนไดออกไซด์ภายใต้การเปลี่ยนความเข้มข้นของสารตั้งต้น พบว่า การเพิ่มความเข้มข้นของคาร์บอนไดออกไซด์และไฮโดรเจนในกรณีที่ไม่มีเอทานอล มีค่าร้อยละการเปลี่ยนแปลงคาร์บอนไดออกไซด์และค่าร้อยละผลผลิตของเมทานอลน้อยกว่ากรณีที่มีเอทานอล แสดงให้เห็นถึงอัตราการเกิดปฏิกิริยาที่ช้ากว่ากรณีที่มีเอทานอล จากผลการศึกษานี้ทำให้เอทานอลทำหน้าที่คล้ายกับตัวทำละลายเชิงเร่งปฏิกิริยา (catalytic solvent)

Oxidative Cleavage Of Oleic Acid At High Temperature Under Autogenous Pressure, Nichkamon Suwannit

Chulalongkorn University Theses and Dissertations (Chula ETD)

The oxidative cleavage of oleic acid to produce azelaic acid and nonanoic acid, both of which are high-value chemicals and essential precursors in the pharmaceutical and plastic industries, was investigated. The objectives of this study were to examine the influence of temperature on reaction mechanisms, product formation, and reaction efficiency, as well as to optimize the reaction conditions for potential industrial applications. The research utilized hydrogen peroxide (H2O2) as the oxidizing agent, tungsten oxide (WO3) as the catalyst, and tert-butanol as a co-solvent under self-generated autogenous pressure conditions. The temperature range studied was 80 to 160°C, aiming to evaluate the …

Uv-Enhanced Catalytic Oxidative Cleavage Of Oleic Acid., Trinnasit Wittayakullertsin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Oleic acid, a key component of plant oils such as palm oil, is a versatile feedstock for producing high-value bio-based chemicals. Utilizing its potential aligns with Thailand's objective of promoting sustainability as a premier palm oil producer. The conventional oxidative cleavage of oleic acid typically requires extreme conditions, including high temperatures, and ozone, which are expensive and harmful to the environment. This research provides an innovative method for utilizing ultraviolet (UV) radiation to increase oxidative cleavage at low temperatures (below 80°C). It employs hydrogen peroxide (H2O2) as an oxidizing agent and tungsten trioxide (WO3) as a catalyst to generate hydroxyl …

Ultrafine Fully Vulcanized Natural Rubber Modified By Grafting With Methyl Methacrylate Monomer As Toughening Modifiers For Polylactic Acid, Panyawutthi Rimdusit

Chulalongkorn University Theses and Dissertations (Chula ETD)

This work focused on toughening polylactic acid (PLA) with an abundant and sustainable bio-based filler from natural rubber. Deproteinized natural rubber (DPNR) was modified by grafting with methyl methacrylate monomer (MMA) and further crosslinked via e-beam irradiation and spray drying to achieve ultrafine fully vulcanized powdered natural rubber grafted with polymethylmethacrylate (UFPNR-g-PMMA) to solves in the challenges of incompatibility between the DPNR and PLA. Interestingly, UFPNR-g-PMMA showed no agglomeration between rubber particles compared to that of neat UFPNR which showed partial agglomeration after irradiation crosslinking. The flexural toughness shows a significant improvement (351%) to 11280 ± 1522 kJ/m3 compared to …