Chemical Engineering Commons^™

Study Of Controlled Release Of Dapsone From Modified Montmorillonite And Polymer Matrices, Jia Fan

Theses

This thesis focuses on the controlled release system of Dapsone (DAP) as the Active Pharmaceutical Ingredient (API) intercalated into sodium montmorillonite (MMT-Na+) and their combination with an anionic copolymer (Eudragit® S100). The effects of the excipients on the API dissolution rate were studied from their release profile in simulated intestinal fluid (pH=7.4) at 37±0.5°C. In the first part of the research, ionizable Dapsone was intercalated in the interlayers of MMT-Na+ to produce a nanohybrid. In the second part of the research, the nanohybrid was melt dispersed in the polymer to produce ternary (API/ Clay/ Polymer) composites. For comparison, API-polymer solid …

The Use Of Two-Phase Molecular Dynamics Simulations To Determine The Phase Behavior And Critical Point Of Propane Molecular Models, Sonal Patel, W. Vincent Wilding, Richard L. Rowley

Faculty Publications

Molecular dynamics simulations were performed to determine two-phase configurations of model propane molecules below the critical point and in the near-critical, two-phase region. A postprocessor that uses a Monte Carlo method for determination of volumes attributable to each molecule was used to obtain density histograms of the particles from which the bulk coexisting equilibrium vapor and liquid densities were determined. This method of analyzing coexisting densities in a two-phase simulation is straightforward and can be easily implemented for complex, multisite models. Various degrees of internal flexibility in the propane models have little effect on the coexisting densities at temperatures 40 …

Anti-Neuroblastoma Activity Of Gold Nanorods Bound With Gd2 Monoclonal Antibody Under Near-Infrared Laser Irradiation, Ching-An Peng, Chung-Hao Wang

Michigan Tech Publications, Part 1

High-risk neuroblastoma is one of the most common deaths in pediatric oncology. Current treatment of this disease involves a coordinated sequence of chemotherapy, surgery, and radiation. Further advances in therapy will require the targeting of tumor cells in a more selective and efficient way so that survival can be improved without substantially increasing toxicity. To achieve tumor-selective delivery, disialoganglioside (GD2) expressed by almost all neuroblastoma tumors represents a potential molecular target that can be exploited for tumor-selective delivery. In this study, GD2 monoclonal antibody (anti-GD2) was conjugated to gold nanorods (GNRs) which are one of anisotropic nanomaterials that can absorb …

2011-2012 Che Newsletter, Department Of Chemical Engineering, Michigan Technological University

Department of Chemical Engineering Newsletters

Table of Contents

• Department
• Bioengineering Research
• Student News
• Alumni and Friends

Conference Program, Ted Knowlton

10th International Conference on Circulating Fluidized Beds and Fluidization Technology - CFB-10

No abstract provided.

Reflections On Mathematical Models And Simulation Of Gas-Particle Flows, Sankaran Sundaresan

10th International Conference on Circulating Fluidized Beds and Fluidization Technology - CFB-10

No abstract provided.

Gas Tracer Study In A Non Mechanical L-Valve, Mohammad-Mahdi Yazdanpanah, Ali Hoteit, Ann Forret, Thierry Gauthier, Arnaud Delebarre

10th International Conference on Circulating Fluidized Beds and Fluidization Technology - CFB-10

No abstract provided.

New System For The Continuous Removal Of Bio-Char From Bubbling Bed Pyrolyzers, Craig Mara, Lorenzo Ferrante, Franco Berruti, Cedric Briens

Bioenergy III: Present and New Perspectives on Biorefineries

No abstract provided.

Latest Developments On Application Of Heterogenous Basic Catalysts For An Efficient And Eco Friendly Synthesis Of Biodiesel: A Review, Yogesh C. Sharma, Bhaskar Singh, John Korstad

College of Science and Engineering Faculty Research and Scholarship

Heterogeneous catalysts are now being tried extensively for biodiesel synthesis. These catalysts are poised to play an important role and are perspective catalysts in future for biodiesel production at industrial level. The review deals with a comprehensive list of these heterogeneous catalysts which has been reported recently. The mechanisms of these catalysts in the transesterification reaction have been discussed. The conditions for the reaction and optimized parameters along with preparation of the catalyst, and their leaching aspects are discussed. The heterogeneous basic catalyst discussed in the review includes oxides of magnesium and calcium; hydrotalcite/layered double hydroxide; alumina; and zeolites. Yield …

Electrochemical Investigation Of Chromium Nanocarbide Coated Ti-6al-4v And Co-Cr-Mo Alloy Substrates, Viswanathan Swaminathan, Haitong Zeng, Daniel Lawrynowicz, Zongtao Zhang, Jeremy L. Gilbert

Biomedical and Chemical Engineering - All Scholarship

This study investigated the electrochemical behavior of chromium nano-carbide cermet coating applied on Ti–6Al–4V and Co–Cr–Mo alloys for potential application as wear and corrosion resistant bearing surfaces. The cermet coating consisted of a highly heterogeneous combination of carbides embedded in a metal matrix. The main factors studied were the effect of substrate (Ti–6Al–4V vs. Co–Cr–Mo), solution conditions (physiological vs. 1 M H₂O₂ of pH 2), time of immersion (1 vs. 24 h) and post coating treatments (passivation and gamma sterilization). The coatings were produced with high velocity oxygen fuel (HVOF) thermal spray technique at atmospheric conditions to …

Fluidized Bed Pyrolysis Of Lignin In A Bubbling Bed Reactor, Pietro Palmisano, Valentina Lago, Franco Berruti, Cedric Briens

Bioenergy III: Present and New Perspectives on Biorefineries

No abstract provided.

Meat And Bone Meal Pyrolysis Study In A Laboratory-Scale Bubbling Fluidized Bed Reactor, Federico M. Berruti, Lorenzo Ferrante, Cedric Briens, Franco Berruti

Bioenergy III: Present and New Perspectives on Biorefineries

No abstract provided.

Effects Of Biochar On Products Yields During Biomass Pyrolysis In A Bubbling Bed Reactor, Pietro Palmisano, Franco Berruti, Cedric Briens

Bioenergy III: Present and New Perspectives on Biorefineries

No abstract provided.

Advancements In Solid Acid Catalysts For Ecofriendly And Economically Viable Synthesis Of Biodiesel, Yogesh C. Sharma, Bhaskar Singh, John Korstad

College of Science and Engineering Faculty Research and Scholarship

Solid acid (heterogeneous) catalysts have a unique advantage in esterification and transesterification reactions which enhances the use of high acid value oil to be used as feedstock for synthesis of biodiesel. Various solid acid catalysts such as resins, tungstated and sulfated zirconia, polyaniline sulfate, heteropolyacid, metal complexes, sulfated tin oxide, zeolite, acidic ionic liquid, and others have been explored as potential heterogeneous catalysts. The activity of the catalyst differs slightly resulting in moderate to high conversion and yield. The reuse of the solid catalyst is governed by their deactivation, poisoning, and the extent of leaching in the reaction medium. The …

A Critical Review On Recent Methods Used For Economically Viable And Eco-Friendly Development Of Microalgae As A Potential Feedstock For Synthesis Of Biodiesel, Yogesh C. Sharma, Bhaskar Singh, John Korstad

College of Science and Engineering Faculty Research and Scholarship

Microalgae are being considered as a viable feedstock for large-scale production of biodiesel. However, though it may look simpler to obtain lipids from microalgae, the overall process of choosing an algal strain, cultivation, harvesting, dewatering, and extraction of oil is quite complicated and not economically prudent at this time. A thorough understanding of algae and the overall biodiesel production process discussed in this paper is vital so that focused research might lower the costs involved. Various diverse species of microalgae are currently being used as feedstocks for biofuel. Heterotrophic culture may be preferred over photoautotrophic cultivation. For cultivation, specially fabricated …

Modeling Diverse Physics Of Nanoparticle Self-Assembly In Pulsed Laser-Irradiated Metallic Films, Mikhail Khenner

Mathematics Faculty Publications

Presents physics behind dewetting of thin liquid films and mathematical/computational modeling tools (Educational/Research presentation for senior physics majors).

Stability Of A Strongly Anisotropic Thin Epitaxial Film In A Wetting Interaction With Elastic Substrate, Mikhail Khenner, Wondimu T. Tekalign, Margo S. Levine

Mathematics Faculty Publications

The linear dispersion relation for longwave surface perturbations, as derived by Levine et al. Phys. Rev. B 75, 205312 (2007) is extended to include a smooth surface energy anisotropy function with a variable anisotropy strength (from weak to strong, such that sharp corners and slightly curved facets occur on the corresponding Wulff shape). Through detailed parametric studies it is shown that a combination of a wetting interaction and strong anisotropy, and even a wetting interaction alone results in complicated linear stability characteristics of strained and unstrained films.

Stability Of A Strongly Anisotropic Thin Epitaxial Film In A Wetting Interaction With Elastic Substrate, Mikhail Khenner, Wondimu Tekalign, Margo Levine

Mathematics Faculty Publications

The linear dispersion relation for longwave surface perturbations, as derived by Levine et al. Phys. Rev. B 75, 205312 (2007) is extended to include a smooth surface energy anisotropy function with a variable anisotropy strength (from weak to strong, such that sharp corners and slightly curved facets occur on the corresponding Wulff shape). Through detailed parametric studies it is shown that a combination of a wetting interaction and strong anisotropy, and even a wetting interaction alone results in complicated linear stability characteristics of strained and unstrained films.

Computational Models Of Chemical Systems Inspired By Braess’ Paradox, Dante Lepore, Carl Barratt, Pauline Schwartz

Chemistry and Chemical Engineering Faculty Publications

Systems chemistry is a new discipline which investigates the interactions within a network of chemical reactions. We have studied several computational models of chemical systems inspired by mathematical paradoxes and have found that even simple systems may behave in a counterintuitive, non-linear manner depending upon various conditions. In the present study, we modeled a set of reactions inspired by one such paradox, Braess’ paradox, an interesting phenomenon whereby the introduction of additional capacity (e.g. pathways) in some simple network systems can lead to an unexpected reduction in the overall flow rate of “traffic” through the system. We devised several chemical …

Reinforced Chitosan-Based Heart Valve Scaffold And Utility Of Bone Marrow-Derived Mesenchymal Stem Cells For Cardiovascular Tissue Engineering, Mohammad Z. Albanna

Wayne State University Dissertations

Recent research has demonstrated a strong correlation between the differentiation profile of mesenchymal stem cells (MSCs) and scaffold stiffness. Chitosan is being widely studied for tissue engineering applications due to its biocompatibility and biodegradability. However, its use in load-bearing applications is limited due to moderate to low mechanical properties. In this study, we investigated the effectiveness of a fiber reinforcement method for enhancing the mechanical properties of chitosan scaffolds. Chitosan fibers were fabricated using a solution extrusion and neutralization method and incorporated into porous chitosan scaffolds. The effects of different fiber/scaffold mass ratios, fiber mechanical properties and fiber lengths on …