Chemical Engineering Commons^™

Engineering At-Home Dilution And Filtration Methods To Enable Paper-Based Colorimetric Biosensing In Human Blood With Cell-Free Protein Synthesis, Tyler J. Free, Ryan W. Tucker, Katelyn M. Simonson, Sydney A. Smith, Caleb M. Lindgren, William G. Pitt, Bradley C. Bundy

Faculty Publications

Diagnostic blood tests can guide the administration of healthcare to save and improve lives. Most clinical biosensing blood tests require a trained technician and specialized equipment to process samples and interpret results, which greatly limits test accessibility. Colorimetric paper-based diagnostics have an equipment-free readout, but raw blood obscures a colorimetric response which has motivated diverse efforts to develop blood sample processing techniques. This work uses inexpensive readily-available materials to engineer user-friendly dilution and filtration methods for blood sample collection and processing to enable a proof-of-concept colorimetric biosensor that is responsive to glutamine in 50 µL blood drop samples in less …

The Effect Of Process Parameters On The Properties Of Elastic Melt Blown Nonwovens: Air Pressure And Dcd, Li Change, Yanfen Zhou, Stephen Jerrams, Jianwei Ma, Shaojuan Chen

Articles

An elastic masterbatch and elastic melt blown nonwovens are prepared based successively on styrene-ethylene/butylene-styrene (SEBS) and polypropylene (PP) blend. The phase separation morphology, rheological properties and crystal structure of the elastic masterbatch are investigated. The results show that a compatible and stable structure is obtained in molten SEBS and PP blend with excellent mobility in the temperature range of 210–230C. The crystallization of PP slows down resulting in a finer structure due to the restriction of the SEBS network structure with rarely change of crystalline structure. The relationship between process parameters and properties of the elastic nonwoven is also studied …

Using Computational Fluid Dynamics And Optical Sensor Technology To Scale Cell Culture Platforms, Mandar Makwana

KGI Theses and Dissertations

Different cell culture vessels ranging from micro scale to laboratory scale to commercial scale play critical role in upstream process development for biologics manufacturing. Based on the mode of operation, cell culture vessels have different hydrodynamic environments, making it challenging to scale. Integrated approaches using computational tools supported by experimental studies can overcome these challenges. Computational Fluid Dynamics (CFD) is one such tool that can simulate hydrodynamics within the cell culture vessels and can provide insights at macro and micro-scale. Accuracy of a CFD model significantly depends on the fluid model and assumptions. Traditionally, simple two-equation fluid models were developed …

Concentration Field Based Micropore Flow Rate Measurements, Matia P. Edwards, Samuel F. D. J. Gómez, Michael S. H. Boutilier

Chemical and Biochemical Engineering Publications

Demand is growing for a larger catalogue of experimental techniques to measure flow rates through micro-/nanoscale systems for both fundamental research and device development. Flow emerging from a hole in a plane wall is a common system of interest in such work for its relevance to membrane separation. In this paper, we consider the possibility of measuring volume flow rates through small scale orifice plates from images of dye dispersions downstream. Based on approximate analytical solutions to the advection–diffusion equation, we show that, at low Reynolds numbers, the concentration in the nearly hemispherical plume that forms increases linearly with inverse …

Experimental Study: Investigating The Anions And Cations' Effects On The Elasticity Of The Anionic And Cationic High Viscosity Friction Reducers, Xiaojing Ge, Ghith Biheri, Abdulmohsin Imqam, Baojun Bai, Yuwei Zhang

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

High viscosity friction reducers (HVFRs) are widely used as friction-reducing agents and proppant carriers during hydraulic fracturing. The reuse of produced water has gained popularity due to environmental and economic benefits. Currently, the field's most commonly used friction reducers are anionic and cationic HVFRs. Anionic HVFRs are typically pumped with freshwater, while cationic HVFRs are used with high Total Dissolved Solids (TDS) produced water. Cationic friction reducers are believed to have better TDS tolerance, friction reduction performance, and proppant transport capabilities compared to anionic friction reducers under high TDS conditions due to their superior viscoelastic properties. In addition, the impact …

Finite Line Relief Well System Design For Dams And Levees, Andrew M. Keffer, Erich D. Guy, Katherine R. Grote

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

An Analytical Method is Commonly Used to Design Relief Well Systems by Assuming the Well Line Extends an Infinite Distance Parallel to the Dam or Levee. This Assumption May Be Met in Some Cases, But When a Well Line is of Finite Length, This Can Severely Underestimate Excess Heads. Although These Consequences Have Been Historically Recognized, a Practical Graph-Based Analytical Approach for Finite Well Line Design Has Not Been Developed. Finite Well Lines Exist and Continue to Be Installed at Many Locations, So This Study Developed a Practical Design Method for Such Systems. Analytical Solutions and Numerical Models Were Used …

Oil Recovery Performance And Asphaltene Deposition Evaluation Of Miscible And Immiscible Carbon Dioxide Or Nitrogen Huff-N-Puff Processes In Shale Reservoirs, Mukhtar Elturki, Abdulmohsin Imqam, Shari Dunn-Norman, Hasan Shaglouf, Ahmed Kablan

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

The utilization of gas enhanced oil recovery to extract oil from unconventional reservoirs has become a widely discussed topic, as it has proven to be effective in significantly boosting oil recovery rates. Among various enhanced oil recovery methods, Gas Enhanced Oil Recovery (GEOR) is a frequently implemented approach. However, a significant challenge encountered during the process of injecting Carbon Dioxide (CO₂) or Nitrogen (N₂) to displace oil is the occurrence of asphaltene precipitation and deposition, which can impede production. This work is an experimental study to examine the effects of cyclic (huff-n-puff) CO₂ or N …

The Taphonomic Character, Occurrence, And Persistence Of Upper Permian–Lower Triassic Plant Assemblages In The Mid-Paleolatitudes, Bogda Mountains, Western China, Robert A. Gastaldo, Mingli Wan, Wan Yang

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

The Bogda Mountains, Xianjiang Uygur Autonomous Region, Western China, Expose an Uppermost Permian–Lower Triassic Succession of Fully Continental Strata Deposited Across Three Graben (Half Graben) Structures in the Mid-Paleolatitudes of Pangea. a Cyclostratigraphy Scheme Developed for the Succession is Subdivided into Three Low-Order Cycles (Wutonggou, Jiucaiyuan, Shaofanggou). Low-Order Cycles Are Partitioned into 1838 High-Order Cycles based on Repetitive Environmental Changes, and their Plant Taphonomic Character is Assessed in . 4700 M of High-Resolution, Measured Sections Distributed Across ~ 100 Km. Four Taphonomic Assemblages Are Represented By: Permineralized Wood (Both Autochthonous and Allochthonous), Megafloral Adpressions (?parautochthonous and Allochthonous) Identifiable to Systematic …

Comparing Weathering Effects Of Ultraviolet And Xenon Arc Accelerated Aging On Polyvinyl Chloride, Collin Mcinnes

Williams Honors College, Honors Research Projects

As the ubiquitousness of polymers increases and begins seeing use in outdoor settings, the need to fully understand how these materials degrade is also necessary. This study aims to compare two known accelerated aging methods, namely an ultraviolet light chamber and a xenon arc light chamber, to understand what differences, if any, manifest in the mechanical, chemical, and cosmetic deterioration of polyvinyl chloride (PVC) after long-term exposure. The study utilizes Fourier-transform infrared spectroscopy, dynamic mechanical analysis, thermogravimetric analysis, and colorimetry analysis to determine the extent of degradation and potential discrepancies between the aging methods.

3d Cfd Simulation Of A Bubble Column With Internals: Validation Of Interfacial Forces And Internal Effects For Local Gas Holdup Predictions, Hayder Al-Naseri, Joshua P. Schlegel, Muthanna H. Al-Dahhan

Nuclear Engineering and Radiation Science Faculty Research & Creative Works

CFD Models (Turbulent Models and Interfacial Forces) Incorporated with the Population Balance Model (PBM) Have Been Validated, Azimuthally, with the Gamma-Ray-Computed Tomography (CT) Results to Address the Effect of the Presence of Internals with Different Arrangements and Diameters. the Superficial Gas Velocity Applied Was Varied from 0.05 to 0.45 M/s. the Results Exhibit the Capability to Predict the Hydrodynamics of the Bubble Column, Further Incorporating the Population Balance Model and Promoting the Prediction of Simulation in High Superficial Gas Velocity. the Effect of Internals Revealed that the Gas Holdup Was Significantly Enhanced in the Bubble Column's Wall Region, While the …

Prediction Of Single Proppant Terminal Settling Velocity In High Viscosity Friction Reducers By Using Artificial Neural Networks And Xgboost, Xiaojing Ge, Rong Lu, Ghith Biheri, Abdulmohsin Imqam, Baojun Bai

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

High viscosity friction reducers (HVFRs) have been recently gaining more attention and increasing in use, not only as friction-reducing agents but also as proppant carriers. The settling velocity of the proppant is one of the key outputs to describe their proppant transport capability. However, it is influenced by many factors such as fluid properties, proppant properties, and fracture properties. Many empirical/physics-based models and correlations to predict particle settling velocity have been developed. However, they are usually based on certain assumptions and have applicable limits. In contrast, machine learning models can be considered as a black box. The objective of this …

Recovery Of Valuable Metals From Electronic Waste Using A Novel Ammonia-Based Hydrometallurgical Process, Peijia Lin

Theses and Dissertations--Mining Engineering

The growing quantity of waste electrical and electronic equipment (WEEE), also known as electronic waste (E-waste), has been an area of growing public concern. The abundance of valuable metals contained in waste printed circuit boards (WPCBs) has made it a promising secondary resource, especially for Cu and Au. Although the recovery of metals from WPCBs via hydrometallurgical routes has been studied extensively over the past 20 years, most of the research has been limited in the laboratory. In current hydrometallurgical processes, strong acids and expensive oxidizers are often used to ensure a high recovery of metals without considering the sustainability …

A Process Intensification Approach To Improve Volatile Fatty Acids Production, Extraction, And Valorization, Can Liu

Theses and Dissertations--Biosystems and Agricultural Engineering

Anaerobic digestion (AD) is a widely used biowaste conversion method. Recent studies have explored arrested methanogenesis as an alternative approach to leverage existing AD facilities and produce volatile fatty acids (VFAs) instead of biogas. VFAs have been recognized as precursors for a range of value-added chemicals and bioproducts. Arrested methanogenesis involves inducing acidic fermentation by halting the AD process before methanogenesis. It has been found that higher organic loading and thermophilic conditions enhance VFA accumulation and stabilize the acidic fermentation (AF) system.

Brewer's spent grain (BSG), a significant by-product of the brewing industry, was employed as the feedstock for VFA …

Magnetic Inversion Approach For Modeling Data Acquired Across Faults: Various Environmental Cases Studies, Khalid S. Essa, Eid R. Abo-Ezz, Neil Lennart Anderson, Omar A. Gomaa, Mahmoud Elhussein

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

An effective extension to the particle swarm optimizer scheme has been developed to visualize and modelize robustly magnetic data acquired across vertical or dipping faults. This method can be applied to magnetic data sets that support various investigations, including mining, fault hazards assessment, and hydrocarbon exploration. The inversion algorithm is established depending on the second horizontal derivative technique and the particle swarm optimizer algorithm and was utilized for multi-source models. Herein, the inversion method is applied to three synthetic models (a dipping fault model contaminated without and with different Gaussian noises levels, a dipping fault model affected by regional anomaly, …

The Influence Of Tropical Atlantic Sea-Surface Temperatures And The North Atlantic Subtropical High During The Maya Droughts, Derek K. Gibson, Jonathan Obrist-Farner, Brooke A. Birkett, Jason H. Curtis, Melissa A. Berke, Peter M.J. Douglas, Prudence M. Rice, Jeremy Maurer

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

The frequency and duration of Late-Holocene hydrologic extremes in northern Guatemala were investigated using multiple sedimentological and geochemical proxies preserved in a sediment core collected from Lake Petén Itzá. A general trend of increasing aridity in the Maya Lowlands during the past 2000 years was punctuated by several multidecadal- to centennial-scale drought events recorded in the Petén Itzá sediments. In particular, the period spanning the Maya Terminal Classic Period and the Medieval Climate Anomaly (MCA), between 800 and 1300 CE, was marked by several extreme droughts and included the driest conditions of the past 2000 years between 950 and 1100 …

Drainage And Sedimentary Response Of The Northern Andes And The Pebas System To Miocene Strike-Slip Tectonics: A Source To Sink Study Of The Magdalena Basin, S. Zapata, L. Calderon-Diaz, C. Jaramillo, Francisca Oboh-Ikuenobe, J. C. Piedrahita, M. Rodríguez-Cuevas, A. Cardona, E. R. Sobel, M. Parra, V. Valencia, A. Patiño, J. S. Jaramillo-Rios, M. Flores, J. Glodny

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Miocene strike-slip tectonics was responsible for creating and closing short-lived (ca. 6 Ma) passages and the emergence of isolated topography in the Northern Andes. These geological events likely influenced the migration and/or isolation of biological populations. To better understand the paleogeography of the Miocene hinterland and foreland regions in the Northern Andes, we conducted a source-to-sink approach in the Magdalena Basin. This basin is located between the Central and Eastern Cordilleras of Colombia and contains an ample Miocene record, which includes Lower Miocene fine-grained strata and Middle Miocene to Pliocene coarsening-up strata. Our study presents a new data set that …

Study Of Legionella Pneumophila Treatment With Copper In Drinking Water By Single Cell-Icp-Ms, Lei Xu, Austin Sigler, Anna Chernatynskaya, Lindsey Rasmussen, Jingrang Lu, Endalkachew Sahle-Demessie, David J. Westenberg, Hu Yang, Honglan Shi

Biological Sciences Faculty Research & Creative Works

Legionella pneumophila is a persistent opportunistic pathogen that poses a significant threat to domestic water systems. Previous studies suggest that copper (Cu) is an effective antimicrobial in water systems. A rapid and sensitive quantification method is desired to optimize the conditions of L. pneumophila treatment by Cu and to better understand the interaction mechanisms between Cu and cells. In this study, we developed a highly sensitive single cell (SC)-ICP-MS method to monitor L. pneumophila cell concentration and track their uptake of Cu. The SC-ICP-MS method showed excellent sensitivity (with a cell concentration detection limit of 1000 cells/mL), accuracy (good agreement …

Cyberphysical Systems And Energy: A Discussion With Reference To An Enhanced Geothermal Process, Keshav Kasturi Rangan, Henrique Oyama, Ilham Azali Assoumani, Helen Durand, K.Y. Simon Ng

Chemical Engineering and Materials Science Faculty Research Publications

As cyberphysical systems research advances, energy systems will be able to benefit from the developments. In this section, we discuss several points in two newer areas for cyberphysical systems research in chemical engineering: 1) cybersecurity of process control systems; and 2) quantum computation of control actions. The discussion is presented in a general manner, with relevance to flow systems or under traditional control laws (e.g., proportional control). However, to showcase energy systems relevance, we will provide links, at intervals, between the developments discussed and enhanced geothermal systems with energy production through the Organic Rankine Cycle (ORC).

Descriptive Systematics Of Upper Palaeocene–Lower Eocene Pollen And Spores From The Northern Niger Delta, South-Eastern Nigeria, Luke Mander, Carlos Jaramillo, Francisca Oboh-Ikuenobe

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Fossil pollen and spores are a vital source of information on the geological history of tropical vegetation including reconstructions of vegetation diversity and composition. However, such work relies on a sound taxonomic framework, and this is challenging to achieve because of the large number of pollen and spore morphotypes that are encountered in palynological preparations from tropical sediments. In tropical West Africa, for example, extensive taxonomic work on Cretaceous–Paleogene pollen and spores was undertaken in the later part of the twentieth century, but more recent palynological work has focused on stratigraphy and basin evolution, and there is a need for …

Assessment Of The Dimensionless Groups-Based Scale-Up Of Gas–Solid Fluidized Beds, Faraj M. Zaid, Haider Al-Rubaye, Thaar M. Aljuwaya, Muthanna H. Al-Dahhan

Chemical and Biochemical Engineering Faculty Research & Creative Works

The most common scale-up approach for gas–solids fluidized beds is based on matching the governing dimensionless parameters. In the literature, this approach has been validated only by means of measuring global parameters between different sizes of fluidized beds. However, such global measurements are not sufficient to depict all the interplaying hydrodynamic phenomena and hence verify the scale-up relationships. Therefore, to assess this approach, an advanced gas–solids optical probe and pressure transducer measurement techniques have been applied to quantify local hydrodynamic parameters in two different sized fluidized beds. Four different sets of experimental conditions were designed and conducted to examine the …