Biomedical Engineering and Bioengineering Commons^™

Existing Methods For Monitoring Power Autotransformers, Nurali Berdiyorovich Pyrmatov, Dilafruz Rustamjon Qizi Abdullabekova

Technical science and innovation

autotransformers, methods, diagnostics, efficiency, monitoring.Particular attention is given to analyzing the gas composition of transformer oil, which is a sensitive indicator of various defects such as thermal breakdown and heating. In addition, methods based on the measurement of external magnetic field strength are discussed. This technique provides a unique opportunity to detect magnetic anomalies associated with possible defects in the structural components of the transformer. The article emphasizes that successful monitoring requires an integrated approach, combining different techniques. The authors analyze the advantages and limitations of each method and offer practical recommendations for integrating these methods into maintenance systems. In …

Mathematical Modeling Of Fruit Drying And System Analysis Of The Process (On The Example Of Persimmon), Gani Dadayev, Jasur Safarov, Shakhnoza Sultanova, Qobiljon Muxiddinov

Technical science and innovation

Vegetable raw materials, as an object of drying, are characterized by a large amount of water and a low content of dry substances. Vegetable raw materials have a capillary-porous structure. Food products contain both bound and free moisture at the same time. The removal of moisture from the material during drying depends on the total moisture content and the form of connection of moisture with the material. Adsorption and osmotic - bound moisture is retained at the interface of colloidal particles with the environment. Food products contain both bound and free moisture at the same time. The quantitative ratio between …

Capacitive Electrode Based Moisture Measurement Converter Errors And How To Eliminate Them, Hamdam Jabborov, Temurbek Rashidov

Technical science and innovation

The article discusses the errors associated with the moisture measuring transducer that is based on the cylindrical electrode, along with their sources and calculation formulas for error elimination. The initial capacitance of the capacitive electrode humidity converter is dependent on its geometric parameters, such as the radii of the electrodes and their length. Accurate calculation of these geometric parameters enables the reduction of regular measurement errors in the input and switching circuit of the moisture converter to a minimum value, resulting in a significant increase in the informativeness and accuracy of the output signal. Consequently, some sources of measurement errors …

Influence Of Foil Stamping Parameters On Image Quality, Khalima Abishevna Babakhanova, Mukhlisa Ergashevna Khasanova, Aziz Azimjonovich Soadatov, Nigora Junaydullaevna Sadriddinova

Technical science and innovation

The paper evaluates the influence of technological process parameters, namely die temperature and pressure force, on the quality of foil stamping, which is one of the types of finishing having a wide range of applications due to giving unique decorative and protective elements to printed products. When evaluating the influence of process parameters on the linearity and coverability of the image, it was found that the pressure force has less influence on the result than the temperature. According to the data of the study, it can be concluded that the maximum percentage of completeness of covering is achieved at a …

Cancer Treatment By Targeting Hdac4 Translocation Induced By Microsecond Pulsed Electric Field Exposure: Mechanistic Insights Through Kinases And Phosphatases, Zahra Safaei

Theses and Dissertations

Epigenetic modifications, arising from sub-cellular shifts in histone deacetylase (HDAC) activity and localization, present promising strategies for diverse cancer treatments. HDACs, enzymes responsible for post-translational histone modifications, induce these epigenetic changes by removing acetyl groups from ε-N-acetyl-lysine residues on histones, thereby suppressing gene transcription. Within the HDAC group, class IIa HDACs are notable for their responsiveness to extracellular signals, bridging the gap between external stimuli, plasma membrane, and genome through nuclear-cytoplasmic translocation. This localization offers two significant mechanisms for cancer treatment: nuclear accumulation of HDACs represses oncogenic transcription factors, such as myocyte-specific enhancer factor 2C (MEF2C), triggering various cell death …

Development Of A Xenograft For Annular Repair Using Pulsed Electric Field Exposures For Enhanced Decellularization, Prince Mensah Kwaku Atsu

Theses and Dissertations

Severe back injuries and chronic pain necessitate surgical replacement of damaged intervertebral disc (IVD) cartilage in advanced disease stages. Bovine IVD tissue has been exposed to an upper threshold pulsed electric field (PEF) dose, causing cell death without thermal damage to the tissue. Subsequent PEF exposures at lower magnitudes have accelerated the removal of immunogenic biomolecules though electrokinetic extraction using optimized aqueous solutions. This approach yields a natural scaffold, ready for biocompatibility and mechanical strength assessment. The effects of microsecond pulsed electric fields (µsPEF) on primary bovine AF fibroblast-like cells have been characterized in vitro. PEFs of 10 and 100 …

One-Pot Assembly Of Drug-Eluting Silk Coatings With Applications For Nerve Regeneration, Tanner D. Fink, Jessica L. Funnell, Ryan J. Gilbert, R. Helen Zha

Chemical and Biochemical Engineering Faculty Research & Creative Works

Clinical use of polymeric scaffolds for tissue engineering often suffers from their inability to promote strong cellular interactions. Functionalization with biomolecules may improve outcomes; however, current functionalization approaches using covalent chemistry or physical adsorption can lead to loss of biomolecule bioactivity. Here, we demonstrate a novel bottom-up approach for enhancing the bioactivity of poly (l-lactic acid) electro spun scaffolds though interfacial coassembly of protein payloads with silk fibroin into nano thin coatings. In our approach, protein payloads are first added into an aqueous solution with Bombyx mori-derived silk fibroin. Phosphate anions are then added to trigger coassembly of the payload …

Development Of An Anisotropic Hyperelastic Material Model For Porcine Colorectal Tissues, Youssef Fahmy, Mohamed B. Trabia, Brian Ward, Lucas Gallup, Mary Froehlich

Mechanical Engineering Faculty Research

Many colonic surgeries include colorectal anastomoses whose leaks may be life-threatening, affecting thousands of patients annually. Various studies propose that mechanical interaction between the staples and neighboring tissues may play an important role in anastomotic leakage. Therefore, understanding the mechanical behavior of colorectal tissue is essential to characterizing the reasons for this type of failure. So far, experimental data characterizing the mechanical properties of colorectal tissue have been few and inconsistent, which has significantly limited understanding their behavior. This research proposes an approach to developing an anisotropic hyperelastic material model for colorectal tissues based on uniaxial testing of freshly harvested …

Machine Embroidery Of Light-Emitting Textiles With Multicolor Electroluminescent Threads, Seungse Cho, Taehoo Chang, Tianhao Yu, Sunland L. Gong, Chi Hwan Lee

Purdue University Libraries Open Access Publishing Fund

Advances in electroluminescent threads, suitable for weaving or knitting, have opened doors for the development of light-emitting textiles, driving growth in the market for flexible and wearable displays. Although direct embroidery of these textiles with custom designs and patterns could offer substantial benefits, the rigorous demands of machine embroidery challenge the integrity of these threads. Here, we present embroiderable multicolor electroluminescent threads—in blue, green, and yellow—that are compatible with standard embroidery machines. These threads can be used to stitch decorative designs onto various consumer fabrics without compromising their wear resistance or light-emitting capabilities. Demonstrations include illuminating specific messages or designs …

Assessing The Relationship Between Contralateral Limb Synergy And Rock Climbing Efficiency, Jeromy Miramontes

Theses, Dissertations and Capstones

Rock climbing is a total body sport testing the mental and physical capabilities of athletes. Efficiency of movement can improve the ability of climbers to perform at a higher capacity and reduce the risk of injury. Data on the relationship between the continuous relative phase (CRP) of contralateral joint rotations and time to completion of a bouldering move are ways to assess rock climbing. This study aimed to assess this relationship, as well as the geometric entropy (GE) of the center of mass displacement when completing the bouldering move, and the metabolic efficiency over 4 min of bouldering. The study …

An Automated On-The-Go Unloading System Reduces Harvest Operator Stress Relative To Manual Operation, Travis A. Burgers, Kusha Kamarei, Mukund Vora, Matthew Horne

Mechanical Engineering Faculty Publications

On-the-go unloading improves harvest operational efficiency, but it requires skilled labor because it is challenging and stressful to balance numerous concurrent tasks. Harvest automation reduces workload, stress, and fatigue. The objective of this study was to determine if using a commercially available, automated on-the-go unloading system (Raven Cart Automation TM , RCA, Raven Industries) would reduce operator stress com- pared to manual operation. Nine grain cart tractor operators and six combine operators participated in this study. Operators performed their typical harvest operation, except to alternate on-the-go unloading using RCA or operating manually. Skin conductance (elec- trodermal activity) was measured with …

Evaluation And Modulation Of The Circadian Clock In Human Keratinocytes And Epidermal Skin, William Harold Cvammen Iv

Browse all Theses and Dissertations

The circadian clock is a fundamental biological mechanism that regulates various physiological processes, including DNA repair, to synchronize with the day-night cycle. In human skin, exposure to ultraviolet (UV) light poses a significant challenge, inducing DNA damage that must be efficiently repaired to maintain genomic integrity and prevent carcinogenesis. This study delved into the complex interplay between the circadian clock, UV light exposure, DNA repair, and modulation of circadian transcriptional machinery in human skin. Initially, we examined the transcriptomic profile of the circadian clock in humans through in silico-based approaches and in vivo studies, revealing that core clock gene expression …

A 3d Dlt View Correction Tool For Manual Digitizing: A Cross-Platform Application For Correcting Shifted Image Coordinates Prior To Object Coordinate Reconstruction, William Moynihan

Theses, Dissertations and Capstones

While 3D direct linear transformation is a versatile motion capture method, care must be taken so that the cameras are not bumped or adjusted between the object space calibration phase and the end of video recording. Disturbing the cameras during this time will misalign the view, making the movement data invalid for the associated calibration. The purpose of this study was to design and validate a cross-platform software application for transforming image coordinates from a bumped camera to be compatible with the object space calibration and to determine the relationship between reconstruction error and changes to bumped camera views.

For …

Investigating The Role Of Anesthesia In Radiation Therapy, William Walter Daley

ENGS 88 Honors Thesis (AB Students)

Purpose:

Cancer claims 7.6 million lives worldwide annually, affecting millions more. Conventional (CONV) radiation therapy (RT) is a key weapon in the oncological arsenal. A novel mode of radiation delivery, utilizing ultra-high dose rates (UHDR), is associated with enhancing the RT therapeutic ratio by selectively sparing normal tissue without sparing tumor tissue. However, there are many roadblocks to the clinical implementation of UHDR RT —namely the lack of standardization of experimental conditions and the inconsistency of published and unpublished results. This thesis investigates variables that affect preclinical biological outcomes to radiation.

Materials/Methods:

Eight groups of 10 C57BL/6 mice were stratified …

Satisfaction And Absenteeism To Lectures:Cross-Sectionnel Study Of Dental Students, Manal El Hijazi, Soundouss Soulami, Ihsane Benyahya

Health Sciences

Introduction: Lectures are still the main pedagogical tool in universities. The aim of this study was to evaluate student satisfaction with lectures and to analyze the factors behind student absenteeism.

Methods: A descriptive cross-sectional study was carried out among dental student by a voluntary, anonymous self-administered questionnaire with open and closed question. Statistical analysis was performed by SPSS version 25 and the Chi2 test was used to compare percentages, with a significance level of p

Optimal Additive Fabrication Of Patient-Specific Bone Tissue Scaffolds Through Material Formulation, Computational Flow Simulation, And Material Deposition Monitoring, Ethan O’Malley

Theses, Dissertations and Capstones

The advancement of additive manufacturing technologies has opened new avenues for fabricating biocompatible and structurally functional bone tissue scaffolds, essential in treating osseous fractures, defects, and diseases. This research aims to develop mechanically strong, dimensionally precise, and patient-specific porous bone tissue scaffolds that provide both structural integrity and biological functionality. Through three interconnected studies, several key challenges in the fabrication of these structures using the PME additive manufacturing process are addressed. First, the influence of polysaccharide and hydroxyapatite concentrations on the compressive modulus of PME-printed porous scaffolds is investigated. By creating structures with varying hydroxyapatite and polysaccharide compositions, the study …

Inflammatory Protein Elicitation In Response To Whole-Body Vibration Exposure, Nicholas Miller

Theses, Dissertations and Capstones

This study aimed to assess the effects of whole-body vibration (WBV) on the brain through changes in blood protein concentrations, seat and head accelerations, and symptomatology over time. Subjects were assigned to control, 1-hour, or 8-hour vibration exposure groups. Glial fibrillary acidic protein (GFAP) and S100B concentrations were measured. Root mean square average weighted vibration (A_ws), vibration dose value (VDV), and seat-to-head transmissibility (STHT) were calculated. There were no differences in GFAP (p = 0.79) or S100B (p = 0.97) concentrations between 1-hour and 8-hour subjects (p = 0.79). Average weighted head acceleration (p …

Numerical Design, Fabrication, And Characterization Of Porous Tissue Scaffolds For Bone Regeneration, Brandon Coburn

Theses, Dissertations and Capstones

With the recent advancements within biomedical engineering of bone tissue scaffolds, there is still a need to develop mechanically robust and biocompatible with low immunogenicity for bone regeneration. Additionally, the evaluation of the fluid dynamics of the porous Triply Periodic Minimal Surfaces (TPMS) bone scaffold also shows the need for investigation due to the complex fluid interaction of hemodynamics that occurs with the scaffold internal and external domains. To aid in the development of treating bone fractures, defects, and diseases. Furthermore, with the induction of a wide variety of TPMS architecture that yields different topologies, the Convolutional Neural Network (CNN) …

Strain-Dependent Activity-Stability Relations In Ruo2 And Iro2 Oxygen Evolution Catalysts, Payal Chaudhary, Alexandra Zagalskaya, Herbert Over, Vitaly Alexandrov

Department of Chemical and Biomolecular Engineering: Faculty Publications

Strain engineering is an effective strategy in modulating activity of electrocatalysts, but the effect of strain on electrochemical stability of catalysts remains poorly understood. In this work, we combine ab initio thermodynamics and molecular dynamics simulations to examine the role of compressive and tensile strain in the interplay between activity and stability of metal oxides considering RuO₂ and IrO₂ as exemplary catalysts. We reveal that although compressive strain leads to improved activity via the adsorbate-evolving mechanism of the oxygen evolution reaction, even small strains should substantially destabilize these catalysts promoting dissolution of transition metals. In contrast, our results …

A Smart Energy-Efficient Hybrid Gait Monitoring System, Elsa Joy Harris

CGU Theses & Dissertations

Triboelectric nanogenerators are devices that harvest mechanical energy from the environment and turn it into electricity. By coupling the effect of contact electrification and electrostatic induction between two materials that come into contact and then separate they can convert the irregular, low frequency, waste biomechanical energy of human motion into useful electrical energy to run small body-worn electronics. This has shown promising results in multiple applications such as self-powered motion and haptic sensing, self-charging micro-storage devices, neuromorphic computing, and designing batteryless circuits to power small wearables. This work will investigate a smart energy-efficient hybrid gait monitoring system that is powered …