Department Of Biological Systems Engineering Newsletter, Spring 2015,
2015
University of Nebraska - Lincoln
Department Of Biological Systems Engineering Newsletter, Spring 2015
BSE Department Magazine
No abstract provided.
Magnetic Manipulation And Multimodal Imaging For Single Cell Direct Mechanosensing,
2015
Purdue University
Magnetic Manipulation And Multimodal Imaging For Single Cell Direct Mechanosensing, Robert L. Wilson
Open Access Theses
The study of internal mechanics of single cells is paramount to understand mechanisms of mechanoregulation. External loading and cell-mediated force generation result in changes in cell shape, rheology, and the deformation of subcellular structures such as the nucleus. Moreover, alterations in the processes that regulate these responses have been further correlated to specific pathologies. Cellular deformation is often studied through application of forces in the environment of the cell, relying on strain and stress transfer through focal adhesions and the cytoskeletal system. However, the transfer of these external forces to internal mechanics can introduce uncertainties in the interpretation of subcellular …
Synthesis And Characterization Of A Lubricin Mimic (Mlub) To Reduce Friction On The Articular Cartilage Surface,
2015
Purdue University
Synthesis And Characterization Of A Lubricin Mimic (Mlub) To Reduce Friction On The Articular Cartilage Surface, Alexandra May Lawrence
Open Access Theses
The lubricating proteoglycan, lubricin, facilitates the remarkable low friction and wear properties of articular cartilage in the synovial joints of the body. Lubricin lines the joint surfaces and plays a protective role as a boundary lubricant in sliding contact; down-regulation of lubricin is associated with cartilage degradation and the pathogenesis of osteoarthritis. An unmet need for early osteoarthritis treatment is the development of therapeutic molecules that mimic lubricin function and yet are also resistant to enzymatic degradation common in the damaged joint. Here, we engineered a lubricin mimic (mLub) that resists enzymatic degradation and binds to the articular surface to …
Multimodal Sensory Integration For Perception And Action In High Functioning Children With Autism Spectrum Disorder,
2015
Marquette University
Multimodal Sensory Integration For Perception And Action In High Functioning Children With Autism Spectrum Disorder, Nicole Marie Gregor Salowitz
Dissertations (1934 -)
Movement disorders are the earliest observed features of autism spectrum disorder (ASD) present in infancy. Yet we do not understand the neural basis for impaired goal-directed movements in this population. To reach for an object, it is necessary to perceive the state of the arm and the object using multiple sensory modalities (e.g. vision, proprioception), to integrate those sensations into a motor plan, to execute the plan, and to update the plan based on the sensory consequences of action. In this dissertation, I present three studies in which I recorded hand paths of children with ASD and typically developing (TD) …
Identification And Retraining Of Sensorimotor Deficits To Reduce Intention Tremor In Multiple Sclerosis,
2015
Marquette University
Identification And Retraining Of Sensorimotor Deficits To Reduce Intention Tremor In Multiple Sclerosis, Megan Heenan
Dissertations (1934 -)
Multiple sclerosis (MS) affects approximately 1 in 1000 Americans and is a significant cause of disability in the United States. One significant contributor to disability in MS is intention tremor, which manifests as an oscillation about the endpoint of a goal-directed movement. A major challenge of treating intention tremor is that the underlying causes of tremor in MS are unknown. In this study, we describe a systems-level computational model and an experimental technique that parameterizes subject-specific deficits in sensory feedback control during goal-directed movements. We used this approach to characterize sensorimotor control and examine how sensory and motor processes are …
Nebulized Solvent Ablation Of Aligned Plla Fibers For The Study Of Neurite Response To Anisotropic-To-Isotropic Fiber/Film Transition (Afft) Boundaries In Astrocyte-Neuron Co-Cultures,
2015
Missouri University of Science and Technology
Nebulized Solvent Ablation Of Aligned Plla Fibers For The Study Of Neurite Response To Anisotropic-To-Isotropic Fiber/Film Transition (Afft) Boundaries In Astrocyte-Neuron Co-Cultures, Jonathan M. Zuidema, Gregory P. Desmond, Christopher J. Rivet, Kathryn R. Kearns, Deanna M. Thompson, Ryan J. Gilbert
Chemical and Biochemical Engineering Faculty Research & Creative Works
Developing robust invitro models of in vivo environments has the potential to reduce costs and bring new therapies from the bench top to the clinic more efficiently. This study aimed to develop a biomaterial platform capable of modeling isotropic-to-anisotropic cellular transitions observed in vivo, specifically focusing on changes in cellular organization following spinal cord injury. In order to accomplish this goal, nebulized solvent patterning of aligned, electro spun poly-. l-lactic acid (PLLA) fiber substrates were developed. This method produced a clear topographic transitional boundary between aligned PLLA fibers and an isotropic PLLA film region. Astrocytes were then seeded on these …
Surface Modification Of Biodegradable Porous Mg Bone Scaffold Using Polycaprolactone/Bioactive Glass Composite,
2015
Missouri University of Science and Technology
Surface Modification Of Biodegradable Porous Mg Bone Scaffold Using Polycaprolactone/Bioactive Glass Composite, Mostafa Yazdimamaghani, Mehdi Razavi, Daryoosh Vashaee, Lobat Tayebi
Chemical and Biochemical Engineering Faculty Research & Creative Works
A reduction in the degradation rate of magnesium (Mg) and its alloys is in high demand to enable these materials to be used in orthopedic applications. For this purpose, in this paper, a biocompatible polymeric layer reinforced with a bioactive ceramic made of polycaprolactone (PCL) and bioactive glass (BG) was applied on the surface of Mg scaffolds using dip-coating technique under low vacuum. The results indicated that the PCL-BG coated Mg scaffolds exhibited noticeably enhanced bioactivity compared to the uncoated scaffold. Moreover, the mechanical integrity of the Mg scaffolds was improved using the PCL-BG coating on the surface. The stable …
Software Tools And Analysis Methods For The Use Of Electromagnetic Articulography Data In Speech Research,
2015
Marquette University
Software Tools And Analysis Methods For The Use Of Electromagnetic Articulography Data In Speech Research, Andrew Kolb
Master's Theses (2009 -)
Recent work with Electromagnetic Articulography (EMA) has shown it to be an excellent tool for characterizing speech kinematics. By tracking the position and orientation of sensors placed on the jaws, lips, teeth and tongue as they move in an electromagnetic field, information about movement and coordination of the articulators can be obtained with great time resolution. This technique has far-reaching applications for advancing fields related to speech articulation, including recognition, synthesis, motor learning, and clinical assessments. As more EMA data becomes widely available, a growing need exists for software that performs basic processing and analysis functions. The objective of this …
Development Of A Practical Visual-Evoked Potential-Based Brain-Computer Interface,
2015
Old Dominion University
Development Of A Practical Visual-Evoked Potential-Based Brain-Computer Interface, Nicholas R. Waytowich
Biomedical Engineering Theses & Dissertations
There are many different neuromuscular disorders that disrupt the normal communication pathways between the brain and the rest of the body. These diseases often leave patients in a `locked-in" state, rendering them unable to communicate with their environment despite having cognitively normal brain function. Brain-computer interfaces (BCIs) are augmentative communication devices that establish a direct link between the brain and a computer. Visual evoked potential (VEP)- based BCIs, which are dependent upon the use of salient visual stimuli, are amongst the fastest BCIs available and provide the highest communication rates compared to other BCI modalities. However. the majority of research …
In Vivo Near Ir Fluorescent Imaging Of Hollow Polymeric Nanocapsules,
2015
Old Dominion University
In Vivo Near Ir Fluorescent Imaging Of Hollow Polymeric Nanocapsules, Venkata Suresh Patthipati
Biological Sciences Theses & Dissertations
Medical Imaging has been an integral component in medical diagnosis and therapeutics. It is frequently used in conjunction with other treatment modalities and has been used for developing applications that range from cancer management to clinical practice. Nanotechnology and its applications are foreseen to have a profound impact on life sciences. Nanomaterial based imaging has a significant potential in addressing medical challenges such as tumor localization, targeted delivery of drugs and real time diagnosis and management of circulation pathology. In particular, polymer based nanoparticles are increasingly being developed as they can be customized according to the diagnostic and/or therapeutic requirements. …
Cerebrovascular Reactivity Alterations Due To Subconcussive Repetitive Head Trauma In Asymptomatic High School Football Players,
2015
Purdue University
Cerebrovascular Reactivity Alterations Due To Subconcussive Repetitive Head Trauma In Asymptomatic High School Football Players, Chetas Joshi
Open Access Theses
Chronic neurological damage as a result of chronic repetitive head trauma is a major concern for football athletes today. Repetitive concussions have been linked to many neurological disorders. Recently, it has been reported that repetitive subconcussive events can contribute to long-term neurodegeneration. For these reasons, it is important to understand the effect repetitive subconcussive head trauma has on brain health in young athletes. Past research has demonstrated that cerebrovascular reactivity (CVR), an important mediator of cerebrovascular regulation, is impaired following mild traumatic brain injury (mTBI). This impairment increases susceptibility to secondary injury following mTBI. In this study, Breath-Hold (BH) task …
Development Of A Neuromusculoskeletal Computer Model In A Chondrodystrophic Dog.,
2015
University of Louisville
Development Of A Neuromusculoskeletal Computer Model In A Chondrodystrophic Dog., Gregory Russo States
Electronic Theses and Dissertations
Intervertebral disc disease (IVDD) is a naturally occurring disease in dogs that produces a spontaneous injury to the spinal cord. IVDD is characterized by mineralization of the intervertebral disc nucleus pulposus, which reduces its load bearing capacity and results in high rates of intervertebral disc herniation (IVDH). IVDH is disproportionately present in Dachshunds compared to other breeds, affecting an estimated 1 in 5 Dachshunds during their lifetime (Levine, J. M. et al., 2011). Assessment of injury severity and recovery in animal models is generally performed using a point scale, where subjects are graded according to metrics such as pain perception, …
Characterization And Evaluation Of Head Impact Sensors And Varsity Football Helmets,
2015
Purdue University
Characterization And Evaluation Of Head Impact Sensors And Varsity Football Helmets, Brian R. Cummiskey
Open Access Theses
An increased understanding of the effects of brain injury in recent years has led to greater attention being given to the topic. A desire to investigate the causal agents of these injuries in athletes has led to the development and use of several devices that track head impacts as well as improving helmet technology to protect players from said impacts. In order to determine which devices are able to best measure head impacts, a Hybrid III headform was used to quantify the accuracy for translational and angular accelerations. Testing was performed by means of administering impacts to a helmet on …
High Density Collagen Fibril Constructs With Tunable Mechano-Biology In Acellular And Cellular Configurations,
2015
Purdue University
High Density Collagen Fibril Constructs With Tunable Mechano-Biology In Acellular And Cellular Configurations, Kevin Blum
Open Access Theses
Collagen has long been used as a material for tissue engineering due to its prevalence in the extracellular matrix of connective tissues. However, traditional collagen materials utilizing atelocollagen and acid solubilized telocollagen have lacked the mechanical integrity and collagen fibril density found in the in vivo state. Here, we utilize collagen oligomers and confined compression to forcibly remove a portion of the fluid phase component. Materials were created with controlled, substantially increased material properties, including order of magnitude increases in collagen fibril density, elastic modulus, compressive modulus,and resistance to proteolytic degradation. The technique was found to be amenable to cell …
Individual Analysis Of T2*-Weighted Gradient Echo Imaging In Asymptomatic And Symptomatic Athletes,
2015
Purdue University
Individual Analysis Of T2*-Weighted Gradient Echo Imaging In Asymptomatic And Symptomatic Athletes, Xianglun Mao
Open Access Theses
Mild traumatic brain injury (mTBI), is a commonly occurred sports-related injury, especially in contact sports like football and soccer. Hemorrhage will appear as hypointense lesions on T2 *-weighted images, resulting from mTBI. Thus, T 2*-weighted gradient echo pulse sequence can be used to generate magnitude susceptibility-weighted (SW) images, and to further detect negative intensity changes of different regions of interests (ROIs) inside human brains. Our goal was to investigate how the ROI-specific intensity changes in each individual sports athlete over a single competition season and to interrogate whether these changes are correlated with repetitive subconcussive or …
Measurement, Characterization, And Effects Of Head Impacts In Women's Soccer,
2015
Purdue University
Measurement, Characterization, And Effects Of Head Impacts In Women's Soccer, Emily C. Mccuen
Open Access Theses
The potential for long term neurological deficits resulting from repetitive head trauma is a major concern for collision sport athletes. Research conducted on football played has found neurophysiologic changes in the absence of concussion in athletes as early as high school age. Given that female soccer players show the highest rate of concussion for female athletes and a higher rate of concussion than their male counterparts, it is important to characterize the types of impacts female soccer athletes receive and assess female soccer athletes for neurophysiologic changes due to these impacts. This work paired head impact sensors with functional MRI …
A Novel In Vivo Tumor Oxygen Profiling Assay: Combining Functional And Molecular Imaging With Multivariate Mathematical Modeling,
2015
Purdue University
A Novel In Vivo Tumor Oxygen Profiling Assay: Combining Functional And Molecular Imaging With Multivariate Mathematical Modeling, Chung-Wein Lee
Open Access Dissertations
Purpose: The objective of this study is to develop and test a novel high spatio-temporal in vivo assay to quantify tumor oxygenation and hypoxia. The assay implements a biophysical model of oxygen transport to fuse parameters acquired from in vivo functional and molecular imaging modalities. ^ Introduction: Tumor hypoxia plays an important role in carcinogenesis. It triggers pathological angiogenesis to supply more oxygen to the tumor cells and promotes cancer cell metastasis. Preclinical and clinical evidence show that anti-angiogenic treatment is capable of normalizing the tumor vasculature both structurally and functionally. The resulting normalized vasculature provides a more efficient and …
Wireless Tools For Neuromodulation,
2015
Purdue University
Wireless Tools For Neuromodulation, Steven T Lee
Open Access Dissertations
Epilepsy is a spectrum of diseases characterized by recurrent seizures. It is estimated that 50 million individuals worldwide are affected and 30% of cases are medically refractory or drug resistant. Vagus nerve stimulation (VNS) and deep brain stimulation (DBS) are the only FDA approved device based therapies. Neither therapy offers complete seizure freedom in a majority of users. Novel methodologies are needed to better understand mechanisms and chronic nature of epilepsy. Most tools for neuromodulation in rodents are tethered. The few wireless devices use batteries or are inductively powered. The tether restricts movement, limits behavioral tests, and increases the risk …
Freezing-Induced Deformation Of Biomaterials In Cryomedicine,
2015
School of Mechanical Engineering, Purdue University, West Lafayette, IN
Freezing-Induced Deformation Of Biomaterials In Cryomedicine, Altug Ozcelikkale
Open Access Dissertations
Cryomedicine utilizes low temperature treatments of biological proteins, cells and tissues for cryopreservation, materials processing and cryotherapy. Lack of proper understanding of cryodamage that occurs during these applications remains to be the primary bottleneck for development of successful tissue cryopreservation and cryosurgery procedures. An engineering approach based on a view of biological systems as functional biomaterials can help identify, predict and control the primary cryodamage mechanisms by developing an understanding of underlying freezing-induced biophysical processes. In particular, freezing constitutes the main structural/mechanical origin of cryodamage and results in significant deformation of biomaterials at multiple length scales. Understanding of these freezing-induced …
Optimizing The Neural Response To Electrical Stimulation And Exploring New Applications Of Neurostimulation,
2015
Purdue University
Optimizing The Neural Response To Electrical Stimulation And Exploring New Applications Of Neurostimulation, Kurt Yuqin Qing
Open Access Dissertations
Electrical stimulation has been successful in treating patients who suffer from neurologic and neuropsychiatric disorders that are resistant to standard treatments. For deep brain stimulation (DBS), its official approved use has been limited to mainly motor disorders, such as Parkinson's disease and essential tremor. Alcohol use disorder, and addictive disorders in general, is a prevalent condition that is difficult to treat long-term. To determine whether DBS can reduce alcohol drinking in animals, voluntary alcohol consumption of alcohol-preferring rats before, during, and after stimulation of the nucleus accumbens shell were compared. Intake levels in the low stimulus intensity group (n=3, 100&mgr;A …
