Biomedical Engineering and Bioengineering Commons^™

The Effects Of Compensatory Auditory Stimulation And High-Definition Transcranial Direct Current Stimulation (Hd-Tdcs) On Tinnitus Perception - A Randomized Pilot Study, Simon Henin, Dovid Fein, Eric Smouha, Lucas C. Parra

Publications and Research

Background Tinnitus correlates with elevated hearing thresholds and reduced cochlear compression. We hypothesized that reduced peripheral input leads to elevated neuronal gain resulting in the perception of a phantom sound. Objective The purpose of this pilot study was to test whether compensating for this peripheral deficit could reduce the tinnitus percept acutely using customized auditory stimulation. To further enhance the effects of auditory stimulation, this intervention was paired with high-definition transcranial direct current stimulation (HD-tDCS).

Methods A randomized sham-controlled, single blind study was conducted in a clinical setting on adult participants with chronic tinnitus (n = 14). Compensatory auditory stimulation …

Use Of A Modified Greenscreen Tool To Conduct A Screening-Level Comparative Hazard Assessment Of Conventional Silver And Two Forms Of Nanosilver., Jennifer Sass, Lauren Heine, Nina Hwang

Environmental and Occupational Health Faculty Publications

BACKGROUND: Increased concern for potential health and environmental impacts of chemicals, including nanomaterials, in consumer products is driving demand for greater transparency regarding potential risks. Chemical hazard assessment is a powerful tool to inform product design, development and procurement and has been integrated into alternative assessment frameworks. The extent to which assessment methods originally designed for conventionally-sized materials can be used for nanomaterials, which have size-dependent physical and chemical properties, have not been well established. We contracted with a certified GreenScreen profiler to conduct three GreenScreen hazard assessments, for conventional silver and two forms of nanosilver. The contractor summarized publicly …

Intraocular Pressure Sensing And Control For Glaucoma Research, Simon Antonio Bello

USF Tampa Graduate Theses and Dissertations

Animal models of ocular hypertension are important for glaucoma research but come with experimental costs. Available methods of intraocular pressure (IOP) elevation are not always successful, the amplitude and time course of IOP changes are unpredictable and irreversible, and IOP measurement by tonometry is laborious. This dissertation focuses on the development and implementation of two novel systems for monitoring and controlling IOP without these limitations. The first device consists of a cannula implanted in the anterior chamber of the eye, a pressure sensor that continually measures IOP, and a bidirectional pump driven by control circuitry that can infuse or withdraw …

Corrosion Characteristics Of Magnesium Under Varying Surface Roughness Conditions, Yahya Efe Yayoglu

USF Tampa Graduate Theses and Dissertations

The biggest challenge with magnesium alloy biodegradable implants is the rapid corrosion at the earlier stages of the healing process after implantation. In this research, the impact of surface roughness generated by different means on the corrosion rate of AZ31 magnesium alloy in a simulated biologic environment is investigated. In order to perform accurate experimentation, an in vitro setup is assembled that simulates the human body environment accurately has been prepared using Schinhammer’s in vitro immersion testing setup and Kokubo’s Simulated Body Fluid (SBF). For the immersion test of Mg in SBF, several surface texture groups of Mg have been …

Synthesis, Characterization, And Application Of Monosized Mesoporous Silica Nanoparticle-Supported Lipid Bilayers For Targeted Therapeutic Delivery To Individual Cells, Paul Durfee

Biomedical Engineering ETDs

Mesoporous silica nanoparticle (MSNP) supported-lipid bilayers, termed ‘protocells,’ represent a potentially transformative class of therapeutic and theranostic delivery vehicles. The field of targeted drug delivery poses considerable challenges that cannot be addressed with a single ‘magic bullet’. Consequently, the protocell has been designed as a modular platform composed of interchangeable biocompatible components. The mesoporous silica core can have variable size and shape to direct biodistribution and controlled pore size and surface chemistry to accommodate diverse cargos. The encapsulating supported lipid bilayer can be modified with targeting and trafficking ligands as well as polyethylene glycol (PEG) to effect selective binding, endosomal …

Be Students Attend Bmes Conference | Biological Engineering, Usu College Of Engineering

College of Engineering News

The Biomedical Engineering Society (BMES) is a society of professionals devoted to developing and using engineering and technology to advancing human health and well-being. This year students from the Biological Engineering department at Utah State University attended the annual BMES conference. Here is what one of our students, Ian Wadsworth had to say about the conference.

Biomarker Detection At Risk Forecasting Level Using Metal-Enhanced Fluorescence Combined With Surface Acoustic Wave, Jun Liu

USF Tampa Graduate Theses and Dissertations

In this paper, metal-enhanced fluorescence (MEF) technique is used to lower the detection limit of carcinoembryonic antigen (CEA) which is able to be utilized in forecasting the risk of having certain kinds of cancers, especially colon and rectal cancer. By incubating silver nanocubes (Ag NCs) on the surface of the chips, the detection limit goes down to below 1ng/mL of CEA. Also, when combining MEF with surface acoustic wave (SAW) devices, the incubation time between antigen and antibody will decrease significantly with the fluorescence signal keeping similar or higher level.

Lipid Coated Microbubbles And Low Intensity Pulsed Ultrasound Enhance Chondrogenesis Of Human Mesenchymal Stem Cells In 3d Printed Scaffolds, Mitra Aliabouzar, Lijie Grace Zhang, Kausik Sarkar

Medicine Faculty Publications

Lipid-coated microbubbles are used to enhance ultrasound imaging and drug delivery. Here we apply these microbubbles along with low intensity pulsed ultrasound (LIPUS) for the first time to enhance proliferation and chondrogenic differentiation of human mesenchymal stem cells (hMSCs) in a 3D printed poly-(ethylene glycol)-diacrylate (PEG-DA) hydrogel scaffold. The hMSC proliferation increased up to 40% after 5 days of culture in the presence of 0.5% (v/v) microbubbles and LIPUS in contrast to 18% with LIPUS alone. We systematically varied the acoustic excitation parameters—excitation intensity, frequency and duty cycle—to find 30 mW/cm2, 1.5 MHz and 20% duty cycle to be optimal …

A Real-Time Programmable Pulsatile Flow Pump For In Vitro Cardiovascular Experimentation, Rahul Raj Mechoor, Tyler Schmidt, Ethan Kung

Publications

Benchtop in vitro experiments are valuable tools for investigating the cardiovascular system and testing medical devices. Accurate reproduction of the physiologic flow waveforms at various anatomic locations is an important component of these experimental methods. This study discusses the design, construction, and testing of a low-cost and fully programmable pulsatile flow pump capable of continuously producing unlimited cycles of physiologic waveforms. It consists of a gear pump actuated by an AC servomotor and a feedback algorithm to achieve highly accurate reproduction of flow waveforms for flow rates up to 300 ml/s across a range of loading conditions. The iterative feedback …

Behavior Classification Using Multi-Site Lfp And Ecog Signals, Adam O. Hebb, Hosein M. Golshan, Sara J. Hanrahan, Joshua Nedrud, Mohammad H. Mahoor

Electrical and Computer Engineering: Graduate Student Scholarship

Abstract-Deep Brain Stimulation (DBS) is an effective therapy that alleviates the motor signs of Parkinson’s disease (PD). Existing DBS is open loop, providing a time invariant stimulation pulse train that may generate cognitive, speech, and balance side effects. A closed-loop DBS system that utilizes appropriate physiological control variables may improve therapeutic results, reduce stimulation side effects, and extend battery life of pulse generators. Furthermore, by customizing DBS to a patient’s behavioral goal, side effects of stimulation may arise only when they are non-detrimental to the patient’s current goals. Therefore, classification of human behavior using physiological signals is an …

Effect Of Surgical Fusion On Volitional Weight-Shifting In Individuals With Adolescent Idiopathic Scoliosis, Nikhil T. Kurapati, Joseph Krzak, Adam Graf, Sahar Hassani, Sergey Tarima, Peter F. Sturm, Kim W. Hammerberg, Purnendu Gupta, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

Study Design

Prospective.

Objectives

The goals of this study were to (1) evaluate the differences in weightbearing symmetry between individuals with adolescent idiopathic scoliosis (AIS) and typically developing controls; (2) observe the effect of posterior spinal fusion and instrumentation (PSFI) on volitional weight-shifting at 1 and 2 years postoperatively; and (3) evaluate whether lowest instrumented fusion level (ie, lowest instrumented vertebra [LIV]) in PSFI has an effect on volitional weight-shifting.

Summary of Background Data

Previous studies have conflicting findings with regard to the effect of scoliosis on postural control tasks as well as the effect of surgery. They have also …

Comparing The Tensile And Compressive Young’S Moduli Of Cortical Bone, Deshawn Hoskins, Meir Barak

The Winthrop McNair Research Bulletin

Various methods have been used in the testing of the mechanical properties of cortical bone, specifically the young’s modulus. However, in the case of the material’s Young’s modulus in compression and tension, there is a significant disagreement among the published findings that may be a result of experimental artifacts. This study attempts to solve the scientific question of whether cortical bone is stiffer in compression or tension and if so to understand why that is. Using small samples taken from the distal portion of the neck of a femur belonging to a young white tailed deer, both the Young’s moduli …

A Prototype Bioreactor Incubation System Designed To Improve Cell Response Modeling In Microgravity, Greg Duke, Ryan Longchamps, Azita Amiri

Von Braun Symposium Student Posters

No abstract provided.

Price Controls Through The Back Door: The Parallel Importation Of Pharmaceuticals, A. Bryan Baer

Journal of Intellectual Property Law

No abstract provided.

Comparing Machine Learning And Logistic Regression Methods For Predicting Hypertension Using A Combination Of Gene Expression And Next-Generation Sequencing Data, Elizabeth Held, Joshua Cape, Nathan L. Tintle

Faculty Work Comprehensive List

Machine learning methods continue to show promise in the analysis of data from genetic association studies because of the high number of variables relative to the number of observations. However, few best practices exist for the application of these methods. We extend a recently proposed supervised machine learning approach for predicting disease risk by genotypes to be able to incorporate gene expression data and rare variants. We then apply 2 different versions of the approach (radial and linear support vector machines) to simulated data from Genetic Analysis Workshop 19 and compare performance to logistic regression. Method performance was not radically …

Robust Feedback Control Based On Low Order Models With Uncertainty Estimation For A Class Of Biomedical Problems, Hector Puebla, Miguel A. Gutierrez-Limon, Eliseo Hernandez-Martinez, Alejandra Velasco-Perez

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Surface Engineering Of Titanium Alloy To Stimulate The Bone Regeneration, Yubin Meng, Zhenduo Cui, Zhaoyang Li, Xue Li, Jin Zhao, Xubo Yuan, Xianjin Yang

The 8th International Conference on Physical and Numerical Simulation of Materials Processing

No abstract provided.

Aqueous Processing Of Lignocellulosic Biomass To Advanced Biofuels | Biological Engineering, Usu College Of Engineering

College of Engineering News

An important current focus of research in biology, chemistry, engineering, agriculture, and environmental sciences is the development of clean technologies that utilize cellulosic biomass as a renewable resource to the largest extent possible in a biorefinery setting to produce sustainable liquid transportation fuels and chemicals. Of all sustainable resources, only biomass can be transformed into organic fuels and chemicals that can integrate well into our current transportation infrastructure with the inherent convenience, cost, and efficiency advantages of current fuels. Cellulosic biomass can be converted to fuels and chemicals through aqueous-phase processes involving carbohydrates-derived and lignin-derived reactive intermediates deconstructed from these …

Fluorescent Materials Design At Nanoscale For Biomedical Photonics In Near Infrared Window, Kohei Soga, Masao Kamimura

The 8th International Conference on Physical and Numerical Simulation of Materials Processing

No abstract provided.

Recent Approaches In Designing Bioadhesive Materials Inspired By Mussel Adhesive Protein, Pegah Kord Forooshani, Bruce P. Lee

Department of Biomedical Engineering Publications

Marine mussels secret protein-based adhesives, which enable them to anchor to various surfaces in a saline, intertidal zone. Mussel foot proteins (Mfps) contain a large abundance of a unique, catecholic amino acid, Dopa, in their protein sequences. Catechol offers robust and durable adhe-sion to various substrate surfaces and contributes to the curing of the adhesive plaques. In this article, we review the unique features and the key functionalities of Mfps, catechol chemistry, and strategies for preparing catechol-functionalized poly- mers. Specifically, we reviewed recent findings on the contributions of various features of Mfps on interfacial binding, which include coacervate formation, surface …