Using Eeg-Validated Music Emotion Recognition Techniques To Classify Multi-Genre Popular Music For Therapeutic Purposes,
2018
NUS High School of Mathematics and Science
Using Eeg-Validated Music Emotion Recognition Techniques To Classify Multi-Genre Popular Music For Therapeutic Purposes, Dejoy Shastikk Kumaran
The International Student Science Fair 2018
Music is observed to possess significant beneficial effects to human mental health, especially for patients undergoing therapy and older adults. Prior research focusing on machine recognition of the emotion music induces by classifying low-level music features has utilized subjective annotation to label data for classification. We validate this approach by using an electroencephalography-based approach to cross-check the predictions of music emotion made with the predictions from low-level music feature data as well as collected subjective annotation data. Collecting 8-channel EEG data from 10 participants listening to segments of 40 songs from 5 different genres, we obtain a subject-independent classification accuracy …
Design And Testing Of A Passive Prosthetic Ankle Foot Optimized To Mimic An Able-Bodied Gait,
2018
University of South Florida
Design And Testing Of A Passive Prosthetic Ankle Foot Optimized To Mimic An Able-Bodied Gait, Millicent Schlafly
USF Tampa Graduate Theses and Dissertations
Currently there are nearly 2 million people living with limb loss in the United States [1]. Many of these individuals are either transtibial (below knee) or transfemoral (above knee) amputees and require an ankle-foot prosthesis for basic mobility. While there are an abundance of options available for individuals who require an ankle-foot prosthesis, these options fail to mimic an intact ankle when it comes to key evaluation criteria such as range of motion, push-off force, and roll over shape. The roll over shape is created by plotting the center of pressure during a step in a shank-based coordinate system. To …
Correcting For Targeted And Control Agent Signal Differences In Paired-Agent Molecular Imaging Of Cancer Cell-Surface Receptors,
2018
Illinois Institute of Technology
Correcting For Targeted And Control Agent Signal Differences In Paired-Agent Molecular Imaging Of Cancer Cell-Surface Receptors, Negar Sadeghipour, Scott C. Davis, Kenneth M. Tichauer
Dartmouth Scholarship
Paired-agent kinetic modeling protocols provide one means of estimating cancer cell-surface receptors with in vivo molecular imaging. The protocols employ the coadministration of a control imaging agent with one or more targeted imaging agent to account for the nonspecific uptake and retention of the targeted agent. These methods require the targeted and control agent data be converted to equivalent units of concentration, typically requiring specialized equipment and calibration, and/or complex algorithms that raise the barrier to adoption. This work evaluates a kinetic model capable of correcting for targeted and control agent signal differences. This approach was compared with an existing …
A Novel Multiscale Mathematical Model For Building Bone Substitute Materials For Children,
2018
University of Tlemcen
A Novel Multiscale Mathematical Model For Building Bone Substitute Materials For Children, Abdennasser Chekroun, Laurent Pujo-Menjouet, Jean-Philippe Berteau
Publications and Research
Bone is an engineering marvel that achieves a unique combination of stiffness and toughness exceeding that of synthesized materials. In orthopedics, we are currently challenged for the child population that needs a less stiff but a tougher bone substitute than adults. Recent evidence suggests that the relationship between inter-molecular connections that involve the two main bone building blocks, TropoCollagen molecules (TC) and carbonated Hydroxyapatite (cAp), and bone macroscopic mechanical properties, stiffness and toughness, are key to building bone substitute materials for children. The goal of our study is to establish how inter-molecular connections that occur during bone mineralization are related …
Distribution And Localization Of Novel Iodine Nanoparticles In The Human Glioma 1242 Growing In The Brains Of Mice,
2018
University of Connecticut
Distribution And Localization Of Novel Iodine Nanoparticles In The Human Glioma 1242 Growing In The Brains Of Mice, Benjamin Billings
Honors Scholar Theses
Observing and designing the in vivo distribution and localization of therapeutic nanoparticles is an essential aspect of developing and understanding novel nanoparticle- based medical treatments. This study investigates novel PEGylated Iodine-based nanoparticles (INPs), an alternate composition to the more widely researched gold nanoparticles (AuNPs), which may help avoid adverse effects associated with AuNPs, such as potential toxicity and skin discoloration, when used in similar applications. Determining the localization of the novel INPs within murine brains containing human glioma U-1242MG cells is critical in assisting the development of radiation dose enhancement therapy for this aggressive cancer. Radiation dose enhancement utilizes the …
Effects Of 8-Week Sensory Electrical Stimulation Combined With Motor Training On Eeg-Emg Coherence And Motor Function In Individuals With Stroke,
2018
National Yang-Ming University
Effects Of 8-Week Sensory Electrical Stimulation Combined With Motor Training On Eeg-Emg Coherence And Motor Function In Individuals With Stroke, Li-Ling Hope Pan, Wen-Wen Yang, Mei-Wun Tsai, Shun-Hwa Wei, Felipe Fregni, Vincent Chiun-Fan Chen, Li-Wei Chou
Engineering Science Faculty Publications
The peripheral sensory system is critical to regulating motor plasticity and motor recovery. Peripheral electrical stimulation (ES) can generate constant and adequate sensory input to influence the excitability of the motor cortex. The aim of this proof of concept study was to assess whether ES prior to each hand function training session for eight weeks can better improve neuromuscular control and hand function in chronic stroke individuals and change electroencephalography-electromyography (EEG-EMG) coherence, as compared to the control (sham ES). We recruited twelve subjects and randomly assigned them into ES and control groups. Both groups received 20-minute hand function training twice …
Effects Of 8-Week Sensory Electrical Stimulation Combined With Motor Training On Eeg-Emg Coherence And Motor Function In Individuals With Stroke,
2018
National Yang-Ming University
Effects Of 8-Week Sensory Electrical Stimulation Combined With Motor Training On Eeg-Emg Coherence And Motor Function In Individuals With Stroke, Li-Ling Hope Pan, Wen-Wen Yang, Chung-Lan Kao, Mei-Wun Tsai, Shun-Hwa Wei, Felipe Fregni, Vincent Chiun-Fan Chen, Li-Wei Chou
Engineering Science Faculty Publications
The peripheral sensory system is critical to regulating motor plasticity and motor recovery. Peripheral electrical stimulation (ES) can generate constant and adequate sensory input to influence the excitability of the motor cortex. The aim of this proof of concept study was to assess whether ES prior to each hand function training session for eight weeks can better improve neuromuscular control and hand function in chronic stroke individuals and change electroencephalography-electromyography (EEG-EMG) coherence, as compared to the control (sham ES). We recruited twelve subjects and randomly assigned them into ES and control groups. Both groups received 20-minute hand function training twice …
Metabolic Patterning On A Chip: Towards In Vitro Liver Zonation Of Primary Rat And Human Hepatocytes,
2018
George Fox University
Metabolic Patterning On A Chip: Towards In Vitro Liver Zonation Of Primary Rat And Human Hepatocytes, Young Bok (Abraham) Kang, Jinsu Eo, Safak Mert, Martin L. Yarmush, O. Berk Usta
Faculty Publications - Biomedical, Mechanical, and Civil Engineering
An important number of healthy and diseased tissues shows spatial variations in their metabolic capacities across the tissue. The liver is a prime example of such heterogeneity where the gradual changes in various metabolic activities across the liver sinusoid is termed as “zonation” of the liver. Here, we introduce the Metabolic Patterning on a Chip (MPOC) platform capable of dynamically creating metabolic patterns across the length of a microchamber of liver tissue via actively enforced gradients of various metabolic modulators such as hormones and inducers. Using this platform, we were able to create continuous liver tissues of both rat and …
Metabolic Patterning On A Chip: Towards In Vitro Liver Zonation Of Primary Rat And Human Hepatocytes,
2018
George Fox University
Metabolic Patterning On A Chip: Towards In Vitro Liver Zonation Of Primary Rat And Human Hepatocytes, Young Bok Abraham Kang, Jinsu Eo, Safak Mert, Martin L. Yarmush, O. Berk Usta
Faculty Publications - Biomedical, Mechanical, and Civil Engineering
An important number of healthy and diseased tissues shows spatial variations in their metabolic capacities across the tissue. The liver is a prime example of such heterogeneity where the gradual changes in various metabolic activities across the liver sinusoid is termed as “zonation” of the liver. Here, we introduce the Metabolic Patterning on a Chip (MPOC) platform capable of dynamically creating metabolic patterns across the length of a microchamber of liver tissue via actively enforced gradients of various metabolic modulators such as hormones and inducers. Using this platform, we were able to create continuous liver tissues of both rat and …
Wearable Assistive Technologies For Autism: Opportunities And Challenges,
2018
University of St Andrews
Wearable Assistive Technologies For Autism: Opportunities And Challenges, Emma Mansouri Benssassi, Juan-Carlos Gomez, Louanne E. Boyd, Gillian R. Hayes, Juan Ye
Engineering Faculty Articles and Research
Autism is a lifelong developmental condition that affects how people perceive the world and interact with others. Challenges with typical social engagement, common in the autism experience, can have a significant negative impact on the quality of life of individuals and families living with autism. Recent advances in sensing, intelligent, and interactive technologies can enable new forms of assistive and augmentative technologies to support social interactions. However, researchers have not yet demonstrated effectiveness of these technologies in long-term real-world use. This article presents an overview of the social and sensory challenges of autism, which offer great opportunities and challenges for …
Production Of Living Nanoparticles For Blood Cancer Therapy,
2018
Santa Clara University
Production Of Living Nanoparticles For Blood Cancer Therapy, Michael Pierotti, Matthew Piro, Peter Mitchell
Bioengineering Senior Theses
Current cancer therapies leave much to be desired because they are very harmful to the patient and cause a significant decrease in quality of life. Chimeric Antigen Receptors (CAR) are a promising novel approach for treating specific types of leukemia due to their binding affinity for proteins expressed solely on leukemia B cells. This approach increases specificity of how cells receive treatment, thus allowing for the destruction of cancerous cells while leaving the healthy cells unharmed. In this experiment, we show that production of CAR expressing exosomes (liposome like vesicles produced naturally by human cells) is possible through cell transfection. …
The Effect Of Nd On Mechanical Properties And Corrosion Performance Of Biodegradable Mg-5%Zn Alloy,
2018
Ben-Gurion University of the Negev
The Effect Of Nd On Mechanical Properties And Corrosion Performance Of Biodegradable Mg-5%Zn Alloy, Lilach Elkaiam, Orly Hakimi, Jeremy Goldman, Eli Aghion
Michigan Tech Publications, Part 1
Mg based implants are limited by their poor strength, ductility, and corrosion performance in physiological environments, drawbacks further compounded by their premature loss of mechanical integrity and evolution of harmful hydrogen gas. Neodymium additions to magnesium have been shown to improve mechanical properties through precipitation and solid solution hardening. Therefore, the present study incorporated Nd additions (up to 3%) into a promising Mg-5%Zn-0.13%Y-0.35%Zr alloy to improve mechanical properties and corrosion resistance. The microstructure evaluation of a series of alloys was performed using optical microscopy, scanning electron microscopy (SEM), and X-ray diffraction analysis. The mechanical properties were examined in terms of …
Medical Perspective Articles To Stimulate The Field For Needs-Finding,
2018
Dartmouth College
Medical Perspective Articles To Stimulate The Field For Needs-Finding, Brian W. Pogue
Dartmouth Scholarship
This editorial by the journal's Editor in Chief, Brian Pogue, explains the need for a new type of paper.
New Algorithms For Compressed Sensing Of Mri: Wtwts, Dwts, Wdwts,
2018
Kennesaw State University
New Algorithms For Compressed Sensing Of Mri: Wtwts, Dwts, Wdwts, Srivarna Settisara Janney
Master of Science in Computer Science Theses
Magnetic resonance imaging (MRI) is one of the most accurate imaging techniques that can be used to detect several diseases, where other imaging methodologies fail. MRI data takes a longer time to capture. This is a pain taking process for the patients to remain still while the data is being captured. This is also hard for the doctor as well because if the images are not captured correctly then it will lead to wrong diagnoses of illness that might put the patients lives in danger. Since long scanning time is one of most serious drawback of the MRI modality, reducing …
Influence Of Silica Nanoparticle Density And Flow Conditions On Sedimentation, Cell Uptake, And Cytotoxicity,
2018
Missouri University of Science and Technology
Influence Of Silica Nanoparticle Density And Flow Conditions On Sedimentation, Cell Uptake, And Cytotoxicity, Mostafa Yazdimamaghani, Zachary B. Barber, Seyyed Pouya Hadipour Moghaddam, Hamidreza Ghandehari
Chemical and Biochemical Engineering Faculty Research & Creative Works
Careful evaluation of the toxicological response of engineered nanomaterials (ENMs) as a function of physicochemical properties can aid in the design of safe platforms for biomedical applications including drug delivery. Typically, in vitro ENM cytotoxicity assessments are performed under conventional static cell culture conditions. However, such conditions do not take into account the sedimentation rate of ENMs. Herein, we synthesized four types of similar size silica nanoparticles (SNPs) with modified surface roughness, charge, and density and characterized their cytotoxicity under static and dynamic conditions. Influence of particle density on sedimentation and diffusion velocities were studied by comparing solid dense silica …
Regulation Of Cellular Patterning Through The Extracellular Matrix,
2018
Virginia Commonwealth University
Regulation Of Cellular Patterning Through The Extracellular Matrix, Lewis Scott, Lauren Griggs, Vani Narayanan, Daniel Conway Phd, Seth H. Weinberg Phd, Christopher Lemmon Phd
Biology and Medicine Through Mathematics Conference
No abstract provided.
Influence Of Macromolecular Crowding And Confinement On Enzyme Activity And Structure Under Native And Denaturing Conditions,
2018
Santa Clara University
Influence Of Macromolecular Crowding And Confinement On Enzyme Activity And Structure Under Native And Denaturing Conditions, Steven Long, Jeffrey Kunkel, Prashanth Asuri
Bioengineering
It is now well appreciated that both crowding and confinement influence enzyme structure and function due to excluded volume effects; however, the relative efficacies of these environments on protein fates remain unclear due to a lack of direct comparison studies. In this study, we explore the use of the biopolymer alginate to develop an in vitro platform to investigate the effects of both crowding and confinement on the behavior of two model enzymes - horseradish peroxidase and β-galactosidase. Alginate, in its solution phase, can be used as a crowding agent and, in its gel phase by crosslinking using divalent cations, …
Fixing Vertebral Compression Fractures With Medtronic,
2018
California Polytechnic State University, San Luis Obispo
Fixing Vertebral Compression Fractures With Medtronic, Kelly Fitzgerald, Trevor Bingham, Alex Denbaugh, Jordan Tang, Jon Stearns
Industrial and Manufacturing Engineering
No abstract provided.
Lysosomal Delivery Of Bioactive Proteins To Living Human Cells Via Engineered Exosomes,
2018
Santa Clara University
Lysosomal Delivery Of Bioactive Proteins To Living Human Cells Via Engineered Exosomes, Daniel Levy
Bioengineering Master's Theses
Exosomes are naturally secreted nanovesicles derived from mammalian cells that are used for intercellular communication in vivo. As a result, they can potentially be used for intracellular delivery of therapeutics for disease treatment. We have developed an exosome pseudotyping approach using vesicular stomatitis virus glycoprotein (VSVG) to produce protein chimeras that optimize production of modified exosomes containing protein therapeutics and facilitate effective delivery to their target cells. To the VSVG transmembrane scaffold, we have fused both fluorescent and luminescent reporters for exosome tracking/visualization and quantification of activity respectively. Through our design, we have shown the biogenesis of VSVG modified exosomes …
Engineering Nanoscale Exosomes For Lysosomal Delivery Of Bioactive Enzymes,
2018
Santa Clara University
Engineering Nanoscale Exosomes For Lysosomal Delivery Of Bioactive Enzymes, Mai Anh Do
Bioengineering Master's Theses
There are at least 50 lysosomal storage diseases that are caused by accumulation of a substrate due to a defective enzyme. Although some treatment options are available, low efficacy, high cost, and immunogenicity are main challenges of current treatments. To overcome those limitations, we use cell-derived nanoparticles to deliver biologically active cargos into lysosomes. Naturally produced exosomes can deliver proteins without triggering an immune response. Additionally, exosome have an intrinsic ability to cross blood brain barrier benefiting patients at a late disease stage that affects the brain. After fusing either Gaussia luciferase (gLuc) or puromycin resistant protein (puro) onto a …
