Biomedical Engineering and Bioengineering Commons^™

Biom 4730 / Mech 4365: Biomaterials, Joel D. Bumgardner

Biomedical Engineering Syllabi Archive

Course Description: Synthetic materials and their interaction with the physiological environment; methods to design and study materials that are compatible with natural tissue.

Biom 4110(Honors)/6110: The Science Of Medicine (Syllabus), Bradford D. Pendley

Biomedical Engineering Syllabi Archive

Course Description: Integration of fundamental principles from physics, chemistry, biology and mathematics, and applications of these principles to solve problems in medicine.

Board 341: Mobile Learning In Stem: A Case Study In An Undergraduate Engineering Course, Krishna Pakala, Maeve Bakic, Diana Bairaktarova, Devshikha Bose

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Student-centered educational system is needed for better educational outcomes. Technology enabled pedagogy has helped immensely during the pandemic times when rapid transition to remote learning was essential. This poster reports findings on year one of a two-year research study to utilize mobile technologies and a technology-enhanced curriculum to improve student engagement and learning in STEM undergraduate courses. This poster describes a quasi-experimental mixed methods study on implementing mobile devices (iPad and Pencil) and a technology-enhanced curriculum in an undergraduate thermal-fluids engineering course, a foundational engineering class.

The technology-enabled curriculum was fully integrated in the thermal-fluids course to deliver content and …

Embok 5.0 - Industry 4.0/5.0 Manifest And Latent Dimensions Mapping To The Asem Embok, T. Steven Cotter

Engineering Management & Systems Engineering Faculty Publications

Industry 3.0 automation emerged replacing human labor with high volume processes and robotics. Industry 4.0, cyber-physical systems, and Industry 5.0, mass customization and cognitive systems, are in the early stages of emergence. Research into the impact of Industry 4.0 and 5.0 is focused at the strategic or organizational levels or on the technological challenges. Research into the impact of Industry 4.0 and 5.0 on engineering management has been limited to their impact on project management. This leaves open the question of the directions in which ASEM should evolve the Engineering Management Body of Knowledge (EMBOK) under the emergence of Industry …

Identifying A Novel Ferrocene Derivative As A K-Ras Inhibitor, Kristen Marie Rehl

Browse all Theses and Dissertations

Ras proteins are small GTPases that regulate cell proliferation, differentiation and survival at the plasma membrane (PM). There are three Ras isoforms ubiquitously expressed in mammalian cells: H-, N- and K-Ras. Constitutively active Ras mutations are found in ~19% of all human cancers, with ~75% of those being in K-Ras. There are K-Ras inhibitors in clinic but they only target the oncogenic K-RasG12C mutant, which only makes up a small sub-set of K-Ras-driven cancers. Thus, there still exists a need for a pan anti-K-Ras drug. Ferrocene derivatives are a class of compounds that have been shown to inhibit the growth …

Evaluation Of The Impact Of The Covid-19 Pandemic On The Teaching Of Otolaryngology And Cervico-Facial Surgery, I. Tahiri, H. Bensouda, O. Haddani, O. El Houari, S. Anajar, L. Taali, A. Hajjij, M. Essaadi, M. Jahidi, F. Benariba, M. Zalagh, F. Guessous, S. Chaouir

Health Sciences

Background: During the Covid-19 pandemic, distance learning is increasingly present in the field of education, particularly in the health sciences. This type of teaching has emerged as the appropriate solution to the problem of knowledge transfer. The objective of this study is to evaluate the impact of distance learning of the ENT (ear, nose and throat) and CFS (cervico-facial surgery) module on students and the impact of the pandemic on their quality of life. Methods: We conducted a survey on students' feelings about distance learning courses, the impact of the pandemic on their lifestyle and the consequences of the protective …

Student Evaluation Of Pre-Clinical Teaching On A Dental Simulator, Manal Elhijazi, Hafsa Elmrini, Ihsane Benyahya

Health Sciences

Context: Student evaluation of teaching (SET) is a pedagogical tool which is part of a quality control process of teaching. Material and methods: An anonymous and voluntary e-questionnaire was sent to all 3rd year students of the Faculty of Dentistry in university Mohamed VI of sciences and health at the end of the academic year 2021-2022 in order to evaluate the progress of practical pre-clinical learning by dental simulator in conservative dentistry. The aim was to evaluate the teaching tools, the organization of the lessons, the content of the program as well as their overall perceptions of this practical pre-clinical …

Pharmacy Students' Perception And Satisfaction With Chemistry Education: A Crosssectional Study, Fayssal Jhilal, Lamia Slimani, Lamia Zaari Lambarki, Ali Jafri, Samy Iskandar, Mariam El Jemli, Najib Alidrissi, Samir Ahid

Health Sciences

Chemistry is an important part of the curriculum for pharmacy students, as there are many disciplines within chemistry that are actually involved in the design and development of drugs, namely; general chemistry, synthetic organic chemistry, analytical chemistry, biochemistry, pharmaceutical chemistry (or therapeutic chemistry), pharmacognosy and materials chemistry for the design of dosage forms. The learning of chemistry by pharmacy students is generally influenced by their perception of theoretical courses, tutorials or practical work. In order to evaluate this perception, we conducted a cross-sectional study based on an anonymous electronic questionnaire distributed to students of all the Moroccan Faculty of Pharmacy …

Instrumental Fracture In Endodontics: A Short Review, Fatima Zohra Rouggani, Ayoub Belkamel

Health Sciences

Oneofthemostfrequentaccidentsthattakeplaceduringstandardendodontictreatment is instrument fracture. The fractured instrument such as a metallic obstruction inthe root canal system, hinders cleaning and shaping operations, and affects the effectivenessofendodontictherapy.Themanagementofinstrumentfracture,factorsthataffe ctinstrumentfracture,andprecautionsforinstrumentfracturearethethreeheadingsusedtoel aborateonthistopicin thisreview.

Psychological Burden Of Second Line Healthcare Workers In Morocco During Covid-19 Outbreak: A Cross-Sectional Study, Ismail Hanine, Khadija Benallel, Roukaya Benjelloun, Mohamed Kadiri

Health Sciences

Background: Second-line healthcare workers have played a crucial role during the covid-19 pandemic, providing essential support to frontline workers and ensuring the smooth functioning of healthcare systems. Aim: Our subjects were not the focus of many research studies. Our aim was to explore the relationship between the outbreak and the experience of the second line of defense and if they endured the psychological burden of the pandemic as much as those on the frontline, despite not being in direct contact with infected or suspected cases in the first wave. Methods: In this study, we focused our attention on those not …

Biom 3110: Medical Physiology (Syllabus), Bradford D. Pendley

Biomedical Engineering Syllabi Archive

Course Description: Basic principles of human physiology and how these are applied in medicine and biomedical engineering problem and devices; physiological principles using appropriate mathematical and engineering models to construct an understanding of how the body works as an integrated system.

An Experimental Study On The Mechanical Properties And Chemical Composition Of Lcd 3d Printed Specimens, Sebastian Gomez

College of Graduate Studies: Theses & Dissertations

Additive manufacturing technologies have been enhanced throughout the years yet have surprised the manufacturing industry due to their high-end surface finish and dimensional accuracy. Different experiments have been done to identify a specific phenomenon known in the vat-polymerization field. Distortion and dimensional inaccuracy tend to affect the overall properties of the process, either physical or chemical. This approach allows the understanding of how the physical properties have been affected and how to study the chemical properties to avoid this type of phenomenon. The chemical reaction between polymer and UV light has been studied and experimented with to the point that …

Design And Fabrication Of A Force-Displacement Control Mechanism For Bone-Surgical Tool Testing, Kenneth Nwagu

College of Graduate Studies: Theses & Dissertations

This project focuses on the design and fabrication of an experimental setup for orthopedic-tool testing, tailored for a surgical instrumentation company. The multifaceted project encompasses a literature review, conceptual design, prototyping, and rigorous testing, resulting in a versatile control system capable of assessing various orthopedic tools, including bone drills, saws, burrs, and power handpieces.

Orthopedic surgical procedures (which include cutting and/or drilling into bone) often need to be performed on bones for faster recovery. The drilling and cutting process can cause an increase in temperature at the cutting site which can cause bone necrosis. The tools also need to be …

Reactive Oxygen Species (Ros)-Responsive Size-Reducible Nanoassemblies For Deeper Atherosclerotic Plaque Penetration And Enhanced Macrophage-Targeted Drug Delivery, Jianhua He, Wenli Zhang, Xiaoju Zhou, Fengfei Xu, Jiahui Zou, Qiqi Zhang, Yi Zhao, Hongliang He, Hu Yang, Jianping Liu

Chemical and Biochemical Engineering Faculty Research & Creative Works

Nanoparticle-Based therapeutics represent potential strategies for treating atherosclerosis; however, the complex plaque microenvironment poses a barrier for nanoparticles to target the dysfunctional cells. Here, we report reactive oxygen species (ROS)-responsive and size-reducible nano assemblies, formed by multivalent host-guest interactions between β-cyclodextrins (β-CD)-anchored discoidal recombinant high-density lipoprotein (NP3ST) and hyaluronic acid-ferrocene (HA-Fc) conjugates. the HA-Fc/NP3ST nano assemblies have extended blood circulation time, specifically accumulate in atherosclerotic plaque mediated by the HA receptors CD44 highly expressed in injured endothelium, rapidly disassemble in response to excess ROS in the intimal and release smaller NP3ST, allowing for further plaque penetration, macrophage-targeted cholesterol efflux and …

Nanomaterial Payload Delivery To Central Nervous System Glia For Neural Protection And Repair, Jayant Saksena, Adelle E. Hamilton, Ryan J. Gilbert, Jonathan M. Zuidema

Chemical and Biochemical Engineering Faculty Research & Creative Works

Central nervous system (CNS) glia, including astrocytes, microglia, and oligodendrocytes, play prominent roles in traumatic injury and degenerative disorders. Due to their importance, active pharmaceutical ingredients (APIs) are being developed to modulate CNS glia in order to improve outcomes in traumatic injury and disease. While many of these APIs show promise in vitro, the majority of APIs that are systemically delivered show little penetration through the blood–brain barrier (BBB) or blood-spinal cord barrier (BSCB) and into the CNS, rendering them ineffective. Novel nanomaterials are being developed to deliver APIs into the CNS to modulate glial responses and improve outcomes in …

Synthesis And Processing Of Pcl And Irdye Nanoparticles For Application In Drug Release Mechanism, Michael Adeniyi

College of Graduate Studies: Theses & Dissertations

The objective of this study is to produce core-shell nanoparticles utilizing PCL and IRDye and investigate the nanoparticle release mechanism. Biodegradable polymer, Polycaprolactone (PCL), was electrosprayed separately with two types of IRDye, NHS and Dextran Texas red. The solution of PCL was formed by mixing PCL in a solution of 9.47ml Acetic Acid, 9.47ml Formic Acid, and 1.05ml Trifluoroethanol, following a ratio of 9:9:1. The two solutions of IRDye were prepared by mixing 2mg of the IRdye with 20ml of DMF at a rate of 0.1mg/ml.

The NHS IRDye was electrosprayed coaxially with PCL and the Dextran Texas red dye …

On The Chronological Understanding Of The Homogeneous Dielectric Barrier Discharge, Xinpei Lu, Zhi Fang, Dong Dai, Tao Shao, Feng Liu, Cheng Zhang, Dawei Liu, Lanlan Nie, Chunqi Jiang

Bioelectrics Publications

Dielectric barrier discharges (DBD) are widely utilised non-equilibrium atmospheric pressure plasmas with a diverse range of applications, such as material processing, surface treatment, light sources, pollution control, and medicine. Over the course of several decades, extensive research has been dedicated to the generation of homogeneous DBD (H-DBD), focussing on understanding the transition from H-DBD to filamentary DBD and exploring strategies to create and sustain H-DBD. This paper first discusses the influence of various parameters on DBD, including gas flow, dielectric material, surface conductivity, and mesh electrode. Secondly, a chronological literature review is presented, highlighting the development of H-DBD and the …

Extracellular Vesticles In Acute Respiratory Distress Syndrome: Understanding Protective And Harmful Signaling For The Development Of New Therapeutics, Matthew Bavuso, Noel Miller, Joshua M. Sill, Anca Dobrian, Ruben M. L. Colunga Biancatelli

Bioelectrics Publications

Acute respiratory distress syndrome (ARDS) is a severe respiratory condition characterized by increased lung permeability, hyper-inflammatory state, and fluid leak into the alveolar spaces. ARDS is a heterogeneous disease, with multiple direct and indirect causes that result in a mortality of up to 40%. Due to the ongoing Covid-19 pandemic, its incidence has increased up to ten-fold. Extracellular vesicles (EVs) are small liposome-like particles that mediate intercellular communication and play a major role in ARDS pathophysiology. Indeed, they participate in endothelial barrier dysfunction and permeability, neutrophil, and macrophage activation, and also in the development of a hypercoagulable state. A more …

Interactions Of Carboxylated Nanodiamonds With Mouse Macrophages Cell Line And Primary Cells, Maisoun Bani-Hani, Stephen J. Beebe, Michael W. Stacey, Christopher Osgood

Bioelectrics Publications

Nanodiamonds (ND) have attracted significant interest for their use in several biomedical applications. These applications can be very useful if the safety and compatibility of ND are proven. We assessed the effects of ND (100 nm, Carboxylated) on primary macrophages and a macrophage-like cell line and found that these particles are not toxic to these cells at lower concentrations but may interfere with cell functions and differentiation. Internalization of ND by these cells in a time- and dose-dependent manner was mostly via phagocytosis and clathrin-dependent endocytosis and localized to the cytoplasm but not into the nucleus. No significant induction of …

Evaluation Of Cold Atmospheric Plasma For The Decontamination Of Flexible Endoscopes, R. C. Hervé, Michael G. Kong, Sudhir Bhatt, Hai-Lan Chen, E. E. Comoy, J-P. Deslys, T. J. Secker, C. W. Keevil

Bioelectrics Publications

Background: Despite adherence to standard protocols, residues including live microorganisms may remain on the various surfaces of reprocessed flexible endoscopes. Prions are infectious proteins notoriously difficult to eliminate.

Aim: We tested the potential of cold atmospheric plasma (CAP) for the decontamination of flexible endoscope various surfaces, measuring total proteins and prion-residual infectivity as an indicator of efficacy.

Methods: New PTFE endoscope channels and metal test surfaces spiked with test soil or prion-infected tissues were treated using different CAP-generating prototypes. Surfaces were then examined for the presence of residues using very sensitive fluorescence epi-microscopy. Prion residual infectivity was determined using the …