Biomechanics and Biotransport Commons^™

Subject-Specific Finite Element Models Of The Human Knee For Transtibial Amputees To Analyze Tibial Cartilage Pressure For Gait, Cycling, And Elliptical Training, Jonathon Stearns

Master's Theses

It is estimated that approximately 10-12% of the adult population suffers from osteoarthritis (OA), with long reaching burdens personally and socioeconomically. OA also causes mild discomfort to severe pain in those suffering from the disease. The incidence rate of OA for individuals with transtibial amputations is much than average in the tibiofemoral joint (TF). It is well understood that abnormal articular cartilage stress, whether that be magnitude or location, increases the risk of developing OA. Finite element (FE) simulations can predict stress in the TF joint, many studies throughout the years have validated the technology used for this purpose. This …

Skier's Edge: Biomechanical Analysis, Benjamin T. Johannes

Master's Theses

ABSTRACT

Skier’s Edge: Biomechanical Analysis

Benjamin T. Johannes

The Skier’s Edge trainer can be used by novice or expert skiers. Testing was performed to analyze if the use of the Skier’s Edge could reduce in shear forces of the valgus moment on the knee joint and anterior cruciate ligament (ACL) due to lesser fatigue of muscle and a higher hamstring to quadricep (H/Q) ratio activity. This leads to a reduction of improper form and an increase in balance. Experiments performed observed the change in muscle activity with the use of the Skier’s Edge over time when compared to other forms …

Electromechanics Modelling Of The Effects Of Myocardial Infarction On Left Ventricular Remodelling, Chin Neng Leong

Student Works (2020-2029)

Myocardial infarction (MI) is one of the diseases with the highest mortality rate. Following MI, myocardium experiences abrupt changes in its loading condition due to the presence of infarct. In response to such changes, myocytes undergo adaptations to maintain homeostasis. However, maladaptation can happen and lead to remodelling, in which the left ventricle (LV) gradually loses its function and eventually turns into heart failure. Nevertheless, the mechanisms underlying LV remodelling are still poorly understood. In this study, a generic LV model was developed, incorporating realistic fibre orientation and excitable contracting myocardium. It was demonstrated that the developed model is capable …

Finite Element Simulation Of Head Impacts In Mixed Martial Arts, Stephen Tiernan, Aidan Meagher, David O'Sullivan Dr, Eoin O'Kelly Dr

Articles

This study determined brain stress and strain in an unhelmeted sport and correlated this with concussive injuries. Thirteen MMA athletes were fitted with the MiG2.0 Stanford instrumented mouthguard. The mouthguard records linear acceleration and angular velocity in 6 degrees of freedom. Angular acceleration was calculated by differentiation. All events were video recorded, time stamped and reported impacts confirmed. 298 impacts above 10g were recorded during sparring sessions and 153 impacts in competitive events. The competitive events resulted in five concussions which were diagnosed by a medical doctor. The impact with the highest angular acceleration from each sparring session and competitive …

Characterization Of Bone Pathology In Sickle Cell Disease And Therapeutic Strategies, Mykel D. Green

Dissertations and Theses

Sickle cell disease (SCD) is a genetic hemoglobinopathy that has grown into a global health concern. While the advances in medical treatment and management of SCD during childhood have drastically improved the overall survival of children, the transition from pediatric to adult services is significantly inadequate in comparison. Life expectancies of patients with SCD in first world countries such as the United States are shortened to averages of 42 and 48 years for men and women, respectively. Despite the increasing number of people living with SCD, remarkably, few detailed studies have described the clinical course and complications of the disease …

Alternative Upper Configurations During Agility-Based Movements: Part 1, Biomechanical Performance, Bradley S. Davidson, Kevin B. Shelburne, Moira Pyrhoda, Rachel Wathen, Nick Nelson, Sean Higinbotham, Jay Dicharry, Daniel Feeney, Kate Harrison

Alternative Upper Configurations During Agility-Based Movements

The objective of this research was to determine if three alternative shoe closures improve biomechanical performance measures compared to a standard lace closure in agility-based movements. NCAA Division 1 and club-level male athletes recruited from lacrosse, soccer, tennis, and rugby performed four court-based movements: Lateral Skater Jump Repeats (LSJ), Countermovement Jump Repeats (CMJ), Triangle Drop Step Drill (TDS), and Anterior-Posterior Drill (AP). Each athlete performed the movements in four shoe upper closures: Standard Closure, Lace Replacement, Y Wrap, and Tri Panel. Movement completion time, Ground contact time, peak eccentric rate of force development (RFD), peak concentric GRF, peak concentric COM …

Alternative Upper Configurations During Agility-Based Movements: Part 2, Joint-Level Biomechanics, Bradley S. Davidson, Kevin B. Shelburne, Moira Pyrhoda, Rachel Wathen, Nick Nelson, Sean Higinbotham, Jay Dicharry, Daniel Feeney, Kate Harrison

Alternative Upper Configurations During Agility-Based Movements

The objective of this research was to determine if three alternative shoe closures improve biomechanical performance measures compared to a standard lace closure in agility-based movements. NCAA Division 1 and club-level male athletes recruited from lacrosse, soccer, tennis, and rugby performed four court-based movements: Lateral Skater Jump Repeats (LSJ), Countermovement Jump Repeats (CMJ), Triangle Drop Step Drill (TDS), and Anterior-Posterior Drill (AP). Each athlete performed the movements in four shoe upper closures: Standard Closure, Lace Replacement, Y Wrap, and Tri Panel. Movement completion time, Ground contact time, peak eccentric rate of force development (RFD), peak concentric GRF, peak concentric COM …

Higher Tensile Forces Across Cellular Junctions And An Intact Nuclear Linc Complex Is Required For Epithelial Function And Stability, Fnu Vani Narayanan

Theses and Dissertations

Recent advances in three-dimensional (3D) cell culture systems have provided key insights into the understanding of biochemical and physiological states of native tissue. A significant progress in the field of mechanobiology involves measuring cellular traction forces in a more native 3D environment. However, the effects of mechanical forces exerted across cellular junctions and the nuclear LINC complex, in an organized 3D system has not been investigated thus far. Epithelial cells spontaneously form acini (also known as cysts or spheroids) with a single, fluid-filled central lumen, when grown in 3D matrices. The size of the lumen is dependent on apical secretion …

Development Of A Torque-Based Device For The Quantification Of Arm Rigidity In Patients With Parkinson’S Disease, Georgina O. Miller

Theses and Dissertations

Parkinsonian rigidity is caused by the inability of the muscles to relax and extend properly, due to reduced dopamine levels and often begins on one side of the body before spreading contralaterally. The current standard for determining joint rigidity in a clinical setting is a test completed by the clinician based on the feel of the relaxed wrist and elbow joints as they are passively flexed and extended and a series of ordinal rating scales, the Movement Disorder Society’s – Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), Hoehn and Yahr Scale (H&Y), and Parkinson’s Disease Questionnaire-39 (PDQ-39). These methods are used …

Knee Joint Loading Following Anterior Cruciate Ligament Reconstruction: Link To Patient Reported Outcomes And A Novel Method To Monitor With Wearable Sensors, Alex Spencer

Theses and Dissertations--Kinesiology and Health Promotion

Recovery from anterior cruciate ligament reconstruction (ACLR) commonly results in undesirable physical and patient-reported outcomes (PROs). Identification of modifiable factors such as knee contact force (KCF) early in rehabilitation that can improve these outcomes is important due to the rapid decrease in function, quality of life, and joint health in this population. Additionally, if noninvasive measurement of KCFs outside of a traditional laboratory were possible, clinicians could optimize patient treatment with personalized care. Therefore, there are two primary aims to this thesis: 1) quantify the link between KCF and PROs which measure pain, ability to perform activities of daily living, …

Atv Dynamics And Pediatric Rider Safety, James T. Auxier Ii

Theses and Dissertations--Biomedical Engineering

It has been observed through numerous academic and governmental agency studies that pediatric all-terrain vehicle ridership carries significant risk of injury and death. While no doubt valuable to safety, the post-hoc approach employed in these studies does little to explain the why and how behind the risk factors. Furthermore, there has been no prolonged, widespread, organized, and concerted effort to reconstruct and catalog the details and causes of the large (20,000+) number of ATV-related injuries that occur each year as has been done for road-based motor vehicle accidents. This dissertation takes the opposite approach from a meta-analysis and instead examines …

Work Related Diurnal Changes In Trunk Mechanical Behavior, Maeve Mcdonald

Theses and Dissertations--Biomedical Engineering

The objectives of this study were to analyze effects of day-long exposure to LBP risk factors on lumbo-pelvic coordination (LPC) in nursing occupations and to verify if physical activity level affects diurnal work-related changes in LPC. Thirty-three nurses were recruited into three groups based on workplace physical demands and each completed two data collection sessions, one before and one after their 8-12 hour work shift. Participants completed several stationary trunk forward-bending/backward-return exercises at self-selected “fast” and “slow” rotational speeds, and while holding a 15 lbs. load. Kinematic data collected during these exercises were then used to characterize the timing and …

Diffuse Damage Repair Mechanism In Bone, Leila Mehraban Alvandi

Dissertations and Theses

Bone microdamage is a result of fatigue, creep or ‘wear and tear’ caused by physiological activities and largely contributes to bone fragility. Bone, unlike engineered materials, has the ability to repair the microscopic cracking or microdamage through targeted, osteoclast-mediated bone remodeling. This capability is crucial for preservation of its structural integrity and quality; failure of the skeleton to effectively repair microdamage leads to accumulation of damage, which is one of the main contributors to bone fragility. Linear microcracks (50-100 µm) and diffuse damage (Dif.Dx) (sub-micron) are the two types of microdamage. Recent studies show that Dif.Dx repairs without bone remodeling, …

The Effects And Analysis Of Implant Type And Surgical Approach In Total Hip Arthroplasty Dislocation Resistance, Brittany Marshall

Electronic Theses and Dissertations

Total hip arthroplasty (THA) is one of the most successful orthopaedic surgeries performed, in which the hip joint is reconstructed to decrease pain and to improve the functionality to the joint. Although these surgeries are very successful, there still remain areas for improvement, such as failures due to instability and dislocation of the implanted joint. The purpose of this thesis is to investigate the effect of surgical entrance approach on dislocation, the effect of implant type, and the effect of capsule repair and closure. The need to quantify the resistance to dislocation is important in understanding the effect that each …

Adaptive Bike Pedals, Norman Hansen, Robert Csaky

Williams Honors College, Honors Research Projects

The Adaptive Bike Pedals project is set out to create a new attachment for tricycle pedals that improves on a previous model. The need for these attachments is common in rehabilitation and physical therapy centers to help patients keep their feet on pedals when they are not able to. They can also be used in homes of families that have children with disabilities, diseases, or disorders that inhibit them from keeping their feet on the pedals. There are attachments on the market already, but the problem with those models is that they are costly and made for specific pedals. The …

The Tera Multi Terrain Mobility Aid Chassis, Colton Kemp, Daniel Nicoll, Ibrahim Suleiman, Mohammad Alyami

Williams Honors College, Honors Research Projects

The natural environment poses a significant number of obstacles and dynamic settings that makes mobility difficult for those with physical and mobility impairments. To approach this problem, a suspension was designed using inspiration from the early Mars rovers developed by NASA for traversing the varied Martian landscape. The course of the project followed the direction of a start-up through problem identification, early design generation and review, and final design production. The project outcome, through client request and proven market research, aimed to produce a multi-terrain wheelchair. The final product is a kinematic body with mobile front “legs” and a rotational …

Transcatheter Mitral Valve Replacement: Structural And Hemodynamic Analysis, Saba Ravaghi

Electronic Theses and Dissertations

Transcatheter mitral valve replacement (TMVR) is being developed to become a substitute therapy for surgery in prohibitive or high surgical risk patients to treat severe mitral regurgitation. A limited number of TMVR systems are under clinical evaluation. However, transcatheter mitral valve (TMV) long-term durability and hemodynamic performance is not known. TMV durability and hemodynamics must match with that of surgical bioprostheses for potential commercialization of TMVR. Experimental and computational approaches were used to find the leaflets’ three-dimensional anisotropic mechanical properties in a transcatheter Edwards SAPIEN 3 valve and a surgical Carpentier-Edwards PERIMOUNT Magna mitral valve and finite element (FE) simulations …

Upper Extremity Mobility Device, Timothy J. Grassi, Jacob R. Miller

Williams Honors College, Honors Research Projects

The goal of this project was to evaluate a clinical problem, explore possible solutions, and produce a functioning prototype that would conform to all the established guidelines and requirements. The project focused on developing an upper extremity mobility device for a singular client with limited muscle activity in his arms due to childhood polio. Our design process was governed by an adapted form of the FDA Design Control Process, 21 CFR 820.30 [1]. The outcome of this project was a functioning prototype that utilized the concept of a motorized pulley system remote controlled using a key fob. This research project …

Prosthetic Foot/Ankle Inversion & Eversion Enhancement, Jason Wiebrecht, Maddison Grimes

Williams Honors College, Honors Research Projects

Modify a prosthetic foot/ankle, that currently has power at the ankle joint, for dorsiflexion/flexion so that it supplies power across a simulated subtalar joint, making the joint capable of inversion/eversion.

All-Wheel-Ukraine, Sofiya Rakovska, Hannah Mcculloch, Andrey Garasimchuk, Ahmad Alsaihati

Williams Honors College, Honors Research Projects

We are working with a non-profit organization in Ukraine that provides wheelchairs/strollers to families of disables children who cannot afford them. Their current preferred solution is a baby stroller. The organization asked us to create a wheelchair that is cost efficient, light and collapsible to be used for children ages up to thirteen years old. We will be creating an alpha prototype wheelchair by modifying a basic wheelchair that we purchased. This modifications include adding a headrest that is adjustable and provides a sufficient support for children within the age group given to us and diverse levels of disabilities. We …