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Articles 1 - 30 of 36586
Full-Text Articles in Biology
Transcription Factor Expression Landscape In Drosophila Embryonic Cell Lines, Robert A. Drewell, Daniel Klonaros, Jacqueline Dresch
Transcription Factor Expression Landscape In Drosophila Embryonic Cell Lines, Robert A. Drewell, Daniel Klonaros, Jacqueline Dresch
Biology
Background: Transcription factor (TF) proteins are a key component of the gene regulatory networks that control cellular fates and function. TFs bind DNA regulatory elements in a sequence-specific manner and modulate target gene expression through combinatorial interactions with each other, cofactors, and chromatin-modifying proteins. Large-scale studies over the last two decades have helped shed light on the complex network of TFs that regulate development in Drosophila melanogaster. Results: Here, we present a detailed characterization of expression of all known and predicted Drosophila TFs in two well-established embryonic cell lines, Kc167 and S2 cells. Using deep coverage RNA sequencing approaches we …
Effects Of Roadways On Seasonal Movement Strategies And Mate Location Success In An Imperiled Pit Viper (Crotalus Horridus), Elizabeth J. Noble
Effects Of Roadways On Seasonal Movement Strategies And Mate Location Success In An Imperiled Pit Viper (Crotalus Horridus), Elizabeth J. Noble
Graduate Research Showcase
A detailed understanding of animal movement behavior is fundamental to effective conservation and management. Within populations, a diversity of movement strategies can be displayed in search of critical resources, and these strategies are influenced by multiple interacting factors related to individuals and the environment. Mating partners are one critical resource that often serves as a prominent selective force shaping movement during mating seasons. For many large-bodied snakes, such as pit vipers (Viperidae: Crotalinae), male mate- searching movements are the primary determinant of mate location success. During this time, males incur significant risks associated with elevated movement. In an increasingly human- …
Oil Identification Of Harp Seal And Other Select Marine Mammals, Meghan Pinedo, Deborah A. Duffield, Dalin N. D’Alessandro, Erin R. Price, Edgard O. Espinoza
Oil Identification Of Harp Seal And Other Select Marine Mammals, Meghan Pinedo, Deborah A. Duffield, Dalin N. D’Alessandro, Erin R. Price, Edgard O. Espinoza
Biology Faculty Publications and Presentations
Because of the rich omega-3 fatty acids content, harp seal (Pagophilus groenlandicus) oil is a popular supplement that is packaged as pills in Canada and sold for medicinal purposes, although this practice is banned in the United States. Due to US regulations, it is important to be able to distinguish between fish oil and seal oil, but the taxonomic determination of oils provenance has been a difficult problem to solve. In this study, Direct Analysis in Real Time time-of-flight mass spectrometry (DART TOFMS) was used to analyze the chemotypes of blubber samples collected from seven species of …
Utilizing Biomimicry To Design Sustainable Architecture, Virginia Hammond
Utilizing Biomimicry To Design Sustainable Architecture, Virginia Hammond
Architecture Undergraduate Honors Theses
Nature has an integral relationship with architecture and serves as a sustainable role model and inspiration for designers. The process of biomimicry in architecture has the potential to produce more sustainable design solutions and foster a connection between humans and nature. Existing biomimetic design projects have varying strengths and weaknesses as examples of the process. Utilizing guidelines and references from key leaders in biomimetic design consultancy (Biomimicry 3.8), selected case studies are assessed for their ability to demonstrate the benefits of this design strategy. Using these evaluations, the case studies are diagrammed and critiqued to determine how new projects could …
Investigating Large Repeats In The Arabidopsis Thaliana Mitochondrial Genome Using Mitotalens, Megan Gusso
Investigating Large Repeats In The Arabidopsis Thaliana Mitochondrial Genome Using Mitotalens, Megan Gusso
Honors Theses
This lab project explores the complexity of the mitochondrial genome by investigating large genomic repeats and their effect on flowering plants’ reproduction and viability. Mitochondria are the site of cellular respiration to create energy and contain their own DNA. This is counterintuitive because the byproducts of cellular respiration impose a threat of mutation for the stored DNA. The mitochondrial genome differs in size between animals and plants. Plant mitochondrial DNA is larger due to the presence of large, noncoding repeated sequences, and a large amount of DNA of unknown function. These sequences undergo high levels of recombination and rearrangement. The …
Spatial Ecology Of Mule Deer Migrations From Grand Teton National Park And The Teton Range, Justin K. Schwabedissen
Spatial Ecology Of Mule Deer Migrations From Grand Teton National Park And The Teton Range, Justin K. Schwabedissen
All Graduate Theses and Dissertations, Fall 2023 to Present
The Greater Yellowstone Ecosystem hosts several of the longest, fully intact ungulate migrations remaining in the continental United States. However, expanding development and an increasing human footprint continue to truncate migratory routes. While the endpoints are often a seasonal range on protected lands, these migration corridors frequently cross other jurisdictional boundaries, including large tracts of private or multiple-use lands, with varying levels of protection. Thus, it is critical resource managers understand the dynamics of migratory movements to define population-level corridors and prioritize appropriate conservation strategies. Mule deer in Wyoming have been documented traveling long distances between summer and winter ranges; …
Mate Guarding Against Strong Men Displaying Affiliative And Aggressive Humor, Jacob Pauley
Mate Guarding Against Strong Men Displaying Affiliative And Aggressive Humor, Jacob Pauley
Biological Sciences Undergraduate Honors Theses
Mate retention behaviors serve to discourage partner defection from a current pairbond. Such behaviors are oftentimes more prevalent toward intrasexual rivals exhibiting physical and behavioral cues implicating that rival as an optimal mate. Among these features in men are their upper body strength, a feature diagnostic of heritable fitness, and men's ability to produce humor, a cue to their social competence. This study considered the intersection of these desirable features in shaping men's mate retention behavior toward an intrasexual rival. After learning of a hypothetical interloper exhibiting high or low upper body strength while similarly using humor in an affiliative …
Towards Understanding The Function Of An Ets-Like Gene In Nematostella Vectensis: Generation Of A Knockout Mutant Line And A Transgenic Reporter Line, Emily Bullock
Biological Sciences Undergraduate Honors Theses
Due to their unique phylogenic position as sister to Bilateria, Cnidaria are often credited with the utility of allowing for reconstruction of ancestral biology based on characteristics shared with bilaterians and other animals. This factor makes investigation into the nervous systems of cnidarians critical in understanding early neural evolution. Wamides, a class of neuropeptides, have been shown to play a regulatory role in life cycle transitions across many different species. The cnidarian specific Wamide neuropeptide, GLWamide, has previously been identified to play an accelerator role in the metamorphic timing of a specific species of sea anemone, Nematostella vectensis. However, …
Targeting Tgf-Β During Epithelial-To-Mesenchymal Progression As An Effective Therapy Against Colorectal Cancer, Joyce Fan
Undergraduate Research
Colorectal cancer is one of the most common cancers worldwide. Understanding the mechanisms of colorectal cancer progression is crucial for the development of effective therapeutics. Epithelial-to-mesenchymal transition is a hallmark feature of cancer and is defined as the loss of epithelial cell features, such as apical-basal polarity and high expression of cell adhesion molecules, and the development of mesenchymal features, such as lack of polarity and increased cell mobility. Epithelial-to-mesenchymal is essential for cell migration, proliferation, and tumor growth. Both the TGF-β and SMAD pathway are associated with colorectal cancer progression. TGF-β is crucial to the cellular mechanism of cell …
Estimating Changing Marshland Habitat And Conservation Potential For Diamondback Terrapins In New Jersey Under Climate Change And Development Pressures, Jacqueline Ganter
Estimating Changing Marshland Habitat And Conservation Potential For Diamondback Terrapins In New Jersey Under Climate Change And Development Pressures, Jacqueline Ganter
STEM Student Research Symposium Posters
The diamondback terrapin, a brackish water turtle native to the eastern US, is listed as a species of ‘special concern’ in the state of New Jersey, due to decreasing habitat from development and changing climatic conditions. Diamondback terrapins reside in saline marshes and wetlands and nest in sandy substrate, primarily beaches and dunes, in June and July. The state of New Jersey is vulnerable to both sea level rise, leaving diamondback terrapin habitats and nesting areas at risk of inundation under future climate scenarios, and, as the most densely populated state, subject to continual development pressures on potentially conservable land. …
Monotypic: Evolution And Adaptations Of The World's Most Distinctive Species, Emerson Harman, Amanda Almon
Monotypic: Evolution And Adaptations Of The World's Most Distinctive Species, Emerson Harman, Amanda Almon
STEM Student Research Symposium Posters
"Monotypic: Evolution and Adaptations of the World’s Most Distinctive Species" is a BFA and Honors Capstone exhibition focused on introducing the public to the unique qualities of plants and animals that are the sole extant representative of their taxonomic family or higher classification. The exhibition is centered around the use of illustrative infographics to effectively deliver scientific information in an engaging manner to a wide audience. "Monotypic" explores the individual evolutionary adaptations that make each of these lineages so distinct from any of their living relatives while also touching on the interactions with their environments, relationships with other species, and …
One-Pot Synthesis Green Zinc Oxide Nanoparticles Immobilized On Activated Carbon Derived From Pineapple Peel For Adsorption Of Pb(Ii), Vienna Saraswaty, Evyka Setya Aji, Ardi Ardiansyah, Ayu Hanifah, Nathania Puspitasari, Shella Permatasari Santoso, Sandy Budi Hartono, Chandra Risdian, Elsy Rahimi Chaldun, Henry Setiyanto
One-Pot Synthesis Green Zinc Oxide Nanoparticles Immobilized On Activated Carbon Derived From Pineapple Peel For Adsorption Of Pb(Ii), Vienna Saraswaty, Evyka Setya Aji, Ardi Ardiansyah, Ayu Hanifah, Nathania Puspitasari, Shella Permatasari Santoso, Sandy Budi Hartono, Chandra Risdian, Elsy Rahimi Chaldun, Henry Setiyanto
Karbala International Journal of Modern Science
The current study introduces a one-pot technique for synthesizing an environmentally benign and cheap composite adsorbent, namely ZnO-PPAC, for the adsorption of Pb(II). The designated adsorbent was prepared by incorporating green synthesized zinc oxide (ZnO) nanoparticles on activated carbon-derived from pineapple peel. The prepared adsorbents were characterized using XRD, SEM, EDS, FTIR, and BET techniques. The XRD pattern verifies that the ZnO was successfully synthesized and immobilized onto the PPAC in a one pot synthesis system. The surface areas of ZnOPPAC and PPAC adsorbents were 13.62 m2/g and 961.96 m2/g, respectively. The FTIR evaluation of the ZnO-PPAC adsorbent revealed several …
Evolution Of The Human Eye: As Compared To Other Vertebrates, Madison Queener
Evolution Of The Human Eye: As Compared To Other Vertebrates, Madison Queener
Honors Projects
There are three different types of eyes, the simple eye, the compound eye, and the camera eye (Cambridge Dictionary) (Myer-Rochow, 2014) (UCL, 2020). The retina of the eye has evolved and adapted to fit the lifestyles of the respective organisms. Because of this part of the eye, organisms are able to see different colors and use light to define the world using photoreceptors. Photoreceptors are rod cells, which are light sensitive and process light, and cone cells, which perceive the different color wavelengths, that pass visual information to the brain (Kazilek, 2010). About 5% of the photoreceptors in the retinas …
Alleviating Environmental Stresses In Native Arkansas Plants By Arbuscular Mycorrhizal Fungi Inoculation, Rebecca C. Morse
Alleviating Environmental Stresses In Native Arkansas Plants By Arbuscular Mycorrhizal Fungi Inoculation, Rebecca C. Morse
ATU Research Symposium
The rapid human-driven changes in the environment during the Anthropocene have placed extreme stress on many native plants and animals. Beneficial interactions with microorganisms may be crucial for ameliorating these stressors and facilitating the ecosystem services host organisms provide. The role of an important mutualistic association with arbuscular mycorrhizal fungi (AMF) in the competitive ability and successful adaptation of Arkansas native species by enhancing nutrient uptake has not been previously considered. Analysis of field root and soil samples from the native species in their native range as well as a controlled green-house experiment will be conducted to determine the level …
Bat Survey Of Winona, Hailey B. Christensen, Morgan L. Winter
Bat Survey Of Winona, Hailey B. Christensen, Morgan L. Winter
Research & Creative Achievement Day
Two bat detectors were placed at Garvin Heights and West Lake Winona to test bat activity in Winona, Minnesota. It was hypothesized that there would be a higher activity of bats at West Lake Winona than there would be at Garvin Heights. It was also hypothesized that high moonlight illumination would impact bat activity in a negative way. After data analyses were performed, it was found that bats were more active at West Lake Winona than at Garvin Heights. Based on the data analyses for moon light illumination and bat activity, there is no pattern common to all species, but …
Post Rehabilitation Analysis Of Stream Habitat And Brown Trout In Cedar Valley Creek, Ashlynn D. Leonard, Emma C. Ehlers
Post Rehabilitation Analysis Of Stream Habitat And Brown Trout In Cedar Valley Creek, Ashlynn D. Leonard, Emma C. Ehlers
Research & Creative Achievement Day
A section of Cedar Valley Creek went through a rehabilitation process that was intended to improve the trout habitat as well as to reinforce banks, deepen the stream, and narrow the channel. We took brown trout (Salmo trutta) counts and did habitat analyses at five locations (each 50 m long), in the restored stream section of Cedar Valley Creek during fall 2023 to compare to pre-rehabilitation data collected in 2022. A backpack electrofisher and nets were used to collect brown trout via a single-pass removal sampling process. All trout were measured for total length (mm) before being released back into …
Changes In Animal Vocalizations In Response To A Total Solar Eclipse, Colton W. Morris
Changes In Animal Vocalizations In Response To A Total Solar Eclipse, Colton W. Morris
ATU Research Symposium
My proposed research project will study the changes in animal vocalizations in response to the total solar eclipse that will take place in Russellville, Arkansas, on April 8, 2024. I will use audio recordings before, during, and after the eclipse to quantify changes in animal vocalizations. Most recordings will be in the range of normal hearing, and will primarily detect birds, frogs, and insects. Additionally, I will deploy one ultrasonic recorder capable of detecting bats. From these recordings I will be able to quantify overall and species-specific call rates. Audio recordings will be paired with continuous measurements of light intensity …
Molecular Methods Used To Identify A New Species Of Dictyocaulus (Family Dictyocaulidae) In White-Tailed Deer, Garit T. Wollan, Elisa M. Quevedo
Molecular Methods Used To Identify A New Species Of Dictyocaulus (Family Dictyocaulidae) In White-Tailed Deer, Garit T. Wollan, Elisa M. Quevedo
Research & Creative Achievement Day
Lungworms (Dictyocaulus) are a type of parasitic nematode found in the lungs of vertebrates and can cause life threatening diseases to their host(s). Dictyocaulus is a type of lungworm found in cattle (Bos taurus), deer (Cervidae), goat (Capra aegagrus hircus), sheep (Ovis aries), and horses (Equus caballus). The purpose of this study was to use DNA analysis to distinguish between different species of Dictyocaulus among cattle, white-tailed deer (Odocoileus virginianus), and red deer (Cervus elaphus). Adult lungworms were collected from the lungs of cattle from research farms in Missouri, Wisconsin, and Mississippi, from the lungs of red deer from a …
Carbon Sequestration And Its Role In Mitigating Climate Change, Mallory Woodward
Carbon Sequestration And Its Role In Mitigating Climate Change, Mallory Woodward
ATU Research Symposium
Carbon sequestration is when carbon dioxide is stored in ecosystems like grasslands forests, soils and oceans. Wetlands are one of the many important ecosystems that sequester carbon and act as a carbon sink. The U.S. Energy Information Administration estimates that in 2019 33,621.5 million metric tons of carbon were released into the atmosphere globally, due to human emissions. Anthropogenic carbon emissions have rapidly increased over the past 150 years. Since 1982, The global rate of warming is more than three times as fast, currently rising 0.36 degrees Fahrenheit each decade, and the rate will continue to increase. How do wetlands …
Characterization Of Bacteria And Fungi In Hotel Bathroom Products, Madie Clarke, Regan L. Feit, Rebecca A. Nachreiner
Characterization Of Bacteria And Fungi In Hotel Bathroom Products, Madie Clarke, Regan L. Feit, Rebecca A. Nachreiner
Research & Creative Achievement Day
Refilling hotel products and storing open products in bathrooms are excellent conditions for bacterial growth. Bacteria accumulate in frequently touched surfaces and thrive in warm, moist, nutrient-rich environments. Bathrooms are also the perfect breeding ground for microbes to flourish. Not all bacteria are bad for our health, but it would be beneficial to know what microorganisms can be found in cosmetic or cream products that are used on a daily basis. This is especially important when bacteria or fungi are known pathogens. This study evaluated and classified bacteria and fungi in shampoos and body lotions using Trypticase Soy Agar (TSA) …
Microbiological Study Of Used Cosmetic Products, Macy S. Priest, Rachel L. Przybilla
Microbiological Study Of Used Cosmetic Products, Macy S. Priest, Rachel L. Przybilla
Research & Creative Achievement Day
The bacterial and fungal load in commercial creams and cosmetic products -was examined. This research aimed to identify pathogenic microbes, their toxin production, and their potential impact on product integrity. Our tests showed bacterial growth in the beauty products Cetaphil Facial Cleanser, CereVe moisturizing lotion, and Maybelline facial powder. Several microbes were characterized: a gram-positive bacteria identified as Bacillus cereus as well as an unknown gram-negative bacteria. In addition, the fungus Fusarium was observed. These microbes might be commonly observed in beauty products, but theoretically many different species of bacteria could grow in this type of environment.
Morphology Of Trematodes In Gadwall Ducks (Mareca Strepera) Found In The Mississippi Valley: Parasitology Class Project, Annika N. Lensch, Ethan B. Gjervik, Mckenna A. Baker, Elizabeth K. Haumont, Mivang Xiong
Morphology Of Trematodes In Gadwall Ducks (Mareca Strepera) Found In The Mississippi Valley: Parasitology Class Project, Annika N. Lensch, Ethan B. Gjervik, Mckenna A. Baker, Elizabeth K. Haumont, Mivang Xiong
Research & Creative Achievement Day
Gadwall ducks (Mareca strepera) are commonly found in lakes, ponds, and marshes west of the Mississippi River in summer months. A Gadwall duck is considered a dabbler duck which feeds on aquatic plants floating on the water's surface occasionally feeding on insects, crustaceans (crayfish, crabs), and small fish. Trematodes are a commonly found parasite in the gastrointestinal tract of many species of ducks. The ducks used in this study were legally collected and donated by hunters from Buffalo City, Wisconsin along the Mississippi River. This study will focus on identifying trematodes found within Gadwall ducks such as Echinostoma, Zygocotyle, and …
Genetic Association In Entylia Carinata Using Random Forest Classification, Caden J. Harper
Genetic Association In Entylia Carinata Using Random Forest Classification, Caden J. Harper
Research & Creative Achievement Day
The goal of this research was to identify locations in the genome of the Entylia carinata, known as the treehopper, that are associated with anomalous behavior exhibited by the species. Treehoppers are phytophagous insects and are shown to feed, reproduce, and rear their young on specific aster species. Observation has shown that the insects will disregard potential mates in close proximity in favor of those that originate from the same plant species as themselves. This behavior suggests genetic separation in the species based on plant nativity and warrants genetic analysis. Machine learning offers an effective genetic association technique due to …
Detection Of Lyme's Disease Caused By Borrelia Burgdorferi In Ixodes Scapularis Using A Pcr Multiplex And Real-Time Pcr, Emily T. Dittman, Bethany G. Basile
Detection Of Lyme's Disease Caused By Borrelia Burgdorferi In Ixodes Scapularis Using A Pcr Multiplex And Real-Time Pcr, Emily T. Dittman, Bethany G. Basile
Research & Creative Achievement Day
Ixodes scapularis (deer ticks) are a vector for the bacterium Borrelia burgdorferi that is known to cause Lyme's Disease in animals and humans (Homo sapiens). In the past few years, there has been an increase in the prevalence of Lyme's Disease cases throughout the midwestern United States indicating that many ticks have been infected with B. burgdorferi. Using I. scapularis DNA samples collected from white-tailed deer (Odocoileus virginianus) in the spring of 2006 from Buffalo County, WI and Winona County, MN, both traditional and real-time PCR methods were used to test for the presence of the B. burgdorferi organism in …
Exploring The Longitudinal Effects: Non-Traditional Pedagogies And Practical Learning On Biology Education And Medical Understanding, Thomas Ziebro
Exploring The Longitudinal Effects: Non-Traditional Pedagogies And Practical Learning On Biology Education And Medical Understanding, Thomas Ziebro
Honors Projects
Medical disinformation is becoming a rampant problem in the United States, and the Covid-19 pandemic highlighted it. There have been attempts to fight the problem at the source through fact verification. These attempts have been unsuccessful. This paper investigates the efficacy of non-traditional pedagogies and the correlation between them and an individual perceived and practical ability to understand their primary care provider. The purpose of this research was to establish whether non-traditional pedagogies at the secondary and post-secondary level are more effective than traditional lecture-based instruction. The research was conducted through an anonymous cross-sectional survey which included questions about educational …
Denial Of Pregnancy Or Cryptic Pregnancy, Nadia N. Shuriah, Elaine Mcfarland, Bethany Spenn, Kaisha Butz Mcmanus
Denial Of Pregnancy Or Cryptic Pregnancy, Nadia N. Shuriah, Elaine Mcfarland, Bethany Spenn, Kaisha Butz Mcmanus
BIO4960: Practicum in Biology I
Denial of pregnancy, or cryptic pregnancy, presents a complex situation where individuals are unaware of their pregnancy until the late stages of labor. This study delves into the multifaceted nature of concealed and denied pregnancies, exploring their prevalence, factors contributing to them, and their implications for both individuals and healthcare systems. By reviewing relevant literature and case studies, we aim to illuminate the difficulties healthcare providers face in identifying and managing cases of denial of pregnancy. Additionally, we stress the significance of proactive screening and comprehensive care to ensure the well-being of mothers and infants. This research endeavors to deepen …
Annotation Of Hypothetical Genes In Lactococcus Lactis Ssp. Il403, Jennifer A. Tangires
Annotation Of Hypothetical Genes In Lactococcus Lactis Ssp. Il403, Jennifer A. Tangires
Student Scholar Showcase
The human gastrointestinal tract (GIT) harnesses various microbial organisms involved in almost all processes of physiological homeostasis, among these are lactic acid bacteria (LAB). These bacteria, almost all of which belong to the order Lactobacillales, are able to produce lactic acid, and play an important role in food preservation because they produce bacteriocins. Bacteriocins are antimicrobial proteins that are used to fight off related bacteria in their environment that are competing for the same resources. This study focuses on a specific LAB strain, Lactococcus lactis ssp. IL1403 where 21.9% of its predicted genes have not yet been assigned a function. …
Exploring Racial And Ethnic Disparities In Alzheimer's Disease And Related Dementias: Prevalence, Healthcare Utilization, And Costs, Michael E. Myers Ii
Exploring Racial And Ethnic Disparities In Alzheimer's Disease And Related Dementias: Prevalence, Healthcare Utilization, And Costs, Michael E. Myers Ii
Doctoral Dissertations and Projects
Objective: This study aims to investigate the disparities in prevalence rates, healthcare utilization patterns, and healthcare costs associated with Alzheimer’s Disease and Related Dementias (ADRD) among various racial and ethnic groups over time. Methods: Utilizing data from the medical expenditure panel survey over a five-year period, this study employs factorial logistic regression to analyze ADRD prevalence rates and multivariate analysis of variance to examine healthcare utilization and costs. The analysis focuses on weighted populations to account for the representation of racial and ethnic groups, ensuring the generalizability of the findings. Results: The study identifies statistically significant disparities in ADRD prevalence, …
Ammonium Chemotaxis In Chlamydomonas Reinhardtii, Gabela Nelson
Ammonium Chemotaxis In Chlamydomonas Reinhardtii, Gabela Nelson
LSU Doctoral Dissertations
Analysis of ammonium chemotaxis in Chlamydomonas reinhardtii is largely hindered, compared to that of phototaxis, despite equal importance on flagellated microalgal physiology. A major contribution of this shortfall is the lack of proper assay method. We developed a simple Petri dish assay method in which light is homogenously exposed while patterns of the cellular migration are tracked with a function of time. Using the method, new findings were revealed. First, this research presented that a strain lacking the eyespot organelle required for light gradient-sensing exhibits similar chemotactic behavior compared to a wild-type strain, suggesting Chlamydomonas sense an ammonium gradient not …
Unravelling The Genetic Basis Of Schizophrenia, Clara Casey, John F. Fullard, Roy D. Sleator
Unravelling The Genetic Basis Of Schizophrenia, Clara Casey, John F. Fullard, Roy D. Sleator
Department of Biological Sciences Publications
Neuronal development is a highly regulated mechanism that is central to organismal function in animals. In humans, disruptions to this process can lead to a range of neurodevelopmental phenotypes, including Schizophrenia (SCZ). SCZ has a significant genetic component, whereby an individual with an SCZ affected family member is eight times more likely to develop the disease than someone with no family history of SCZ. By examining a combination of genomic, transcriptomic and epigenomic datasets, large-scale ‘omics’ studies aim to delineate the relationship between genetic variation and abnormal cellular activity in the SCZ brain. Herein, we provide a brief overview of …