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Recombinant Expression Of Human Semenogelin Proteins And Creation Of Novel Antibodies For The Detection Of Human Semen, David Brown 2020 Duquesne University

Recombinant Expression Of Human Semenogelin Proteins And Creation Of Novel Antibodies For The Detection Of Human Semen, David Brown

Graduate Student Research Symposium

The protein component of human semen largely consists of a group of proteins called the semenogelins. After ejaculation, they undergo protein-protein interactions to form the coagulation of seminal fluid for protection of spermatozoa prior to fertilization. Because of their abundance, the semenogelin proteins are an effective marker to detect human semen at crime scenes, even after substantial degradation. The goal of this study is to create an optimized method for producing novel antibodies for the semenogelin proteins that can be used to detect seminal fluid. Segments of the semenogelin 1 gene were amplified, cloned into three mammalian expression vectors, and ...


Staphylococcus Aureus Carriage And Characterization From The Minnesota State Fair, Maddie Mandoza, Amanda Brosnahan Dr, Taylor Mach Dr 2020 Concordia University, St. Paul

Staphylococcus Aureus Carriage And Characterization From The Minnesota State Fair, Maddie Mandoza, Amanda Brosnahan Dr, Taylor Mach Dr

Research and Scholarship Symposium Posters

Staphylococcus aureus is gram-positive cocci in clusters.S. aureus can live in your nose or on your skin without causing harm and is found in 30% of all people. Some strains are antibiotic resistant. Methicillin Resistant Staphylococcus aureus(MRSA) can cause diseases and is resistant to many antibiotics. Some strains of S. aureus can make superantigens that alter our immune response to cause disease. Here, we test 11 swabs obtained from the Minnesota State fair to see if they are positive for Staphylococcus aureus.


Characterization Of Nasal Isolates Of Staphylococcus Aureus From Concordia's Campus, Jeenue Vang 2020 Concordia University St. Paul

Characterization Of Nasal Isolates Of Staphylococcus Aureus From Concordia's Campus, Jeenue Vang

Research and Scholarship Symposium Posters

Research students from the Concordia University, St. Paul Science Department has collected over 1,000 nasal swabs over the past 5 years in an attempt to characterize nasal isolates of Staphylococcus aureus from healthy individuals. S. aureus is a common commensal bacterium found on the skin, in the nares, or in the vaginal tract of approximately 30% of the population. While S. aureus is typically harmless when it is growing in those areas, it can also pose a public health risk as it can act as an opportunistic pathogen to cause a variety of infections, such as toxic shock syndrome ...


Analysis Of Cyclin E In Fibrolamellar Hepatocellular Carcinoma, Hannah Gustafson, Katrina Vang, Tim Vogt, Sara Stickler 2020 Concordia University St. Paul

Analysis Of Cyclin E In Fibrolamellar Hepatocellular Carcinoma, Hannah Gustafson, Katrina Vang, Tim Vogt, Sara Stickler

Research and Scholarship Symposium Posters

Fibrolamellar Hepatocellular Carcinoma (FL-HCC), a rare primary liver cancer, differs from the most common liver cancer, hepatocellular carcinoma, as FL-HCC is not correlated with chronic liver diseases. Mayo Clinic conducted a proteomic screening and found the proline biosynthetic pathway to be dysregulated in FL-HCC patients. In liver cells, free proline has been shown to induce the mTOR pathway, which stimulates cell proliferation through upregulation of full-length Cyclin E (FL-E). In addition, FL-E can be partially cleaved by an enzyme called serine protease neutrophil elastase, creating low molecular weight cyclin E (LMW-E) that has been linked to tumorigenesis. To further investigate ...


Don't You Know That You're Toxic?, Mumina Mohamud 2020 Concordia University, St. Paul

Don't You Know That You're Toxic?, Mumina Mohamud

Research and Scholarship Symposium Posters

The excitatory effects of superantigens in Staphylococcus aureus on the immune system.


Biol 404- The Effects Of Dioxin-Like Polychlorinated Biphenyls (Pcbs) On The Development Of Myeloid Suppressor Cells, Emma Rogers, Ryan Servis, Talbot Thames, Amorette Barber 2020 Longwood University

Biol 404- The Effects Of Dioxin-Like Polychlorinated Biphenyls (Pcbs) On The Development Of Myeloid Suppressor Cells, Emma Rogers, Ryan Servis, Talbot Thames, Amorette Barber

Student Showcase for Research and Creative Inquiry

Polychlorinated biphenyls (PCBs) are a man-made organic compound consisting of two phenyl rings connected by a single bond, with any number of chlorine molecules occupying positions around the rings. They are most commonly used as a dielectric and coolant fluid in electrical generators and transformers. Manufacture has declined drastically since the 1970s in America due to their exertion of estrogen-mimicking effects in the body, although they continue to persist in harmful concentrations in the environment. PCBs are endocrine-disrupting, and through estrogenic or anti-estrogenic effects have been shown to increase breast cancer risk by changing gene expression in several genes common ...


Biol 404- Effects Of Estrogen-Mimicking Compounds, Progesterone And Estriol, On Myeloid-Derived Suppressor Cell Development, Raquel Perez, Tatyana Green, Haley Bresnahan, Matthew Jones, Amorette Barber 2020 Longwood University

Biol 404- Effects Of Estrogen-Mimicking Compounds, Progesterone And Estriol, On Myeloid-Derived Suppressor Cell Development, Raquel Perez, Tatyana Green, Haley Bresnahan, Matthew Jones, Amorette Barber

Student Showcase for Research and Creative Inquiry

Estrogen is primarily known for being a female sex hormone. It has three major subcategories estrone, estradiol, and estriol. They are known to have a role within regulation of the reproductive system and menopause. Progesterone is also a well-known steroid sex hormone that is usually associated with menstruation. These sex hormones are commonly used in oral contraceptive pills. The purpose of this study is to see if progesterone and estriol will have the same effects that estrogen has on MHC II and B7 expression. With the use of flow cytometry, T cell isolation, T cell proliferation, and ELISAs we are ...


Biol 404- Effects Of Phytoestrogens - Lycopene And Trans-Resveratrol - On The Development Of Myeloid-Derived Suppressor Cells (Mdsc), Kayla Cooksey, Adrianna Doggett, Debbie Pitt, Maya Young, Amorette Barber 2020 Longwood University

Biol 404- Effects Of Phytoestrogens - Lycopene And Trans-Resveratrol - On The Development Of Myeloid-Derived Suppressor Cells (Mdsc), Kayla Cooksey, Adrianna Doggett, Debbie Pitt, Maya Young, Amorette Barber

Student Showcase for Research and Creative Inquiry

Trans-Resveratrol and Lycopene are chemical compounds found in the skin of red grapes and tomatoes respectively. This study investigates the effects of these two phytoestrogens on MDSCs.We hypothesized that these phytoestrogens will bind to estrogen receptors and block estrogenic activity, effectively decreasing the production of MDSCs in murine cells.


Biol 404- Dual Nature Of Phytoestrogens As Both Procancer And Anticancer Agents, Marcia Lanasa, Grace Freeman, Carrie Reaver, Natalie Wood, Amorette Barber 2020 Longwood University

Biol 404- Dual Nature Of Phytoestrogens As Both Procancer And Anticancer Agents, Marcia Lanasa, Grace Freeman, Carrie Reaver, Natalie Wood, Amorette Barber

Student Showcase for Research and Creative Inquiry

Phytoestrogens are plant-derived, xenoestrogenic dietary compounds found in various fruits, vegetables, soy products, teas, grains, beans, and more. There are different classes of phytoestrogens, including flavonoids, isoflavonoids, lignans, and coumestans, all of which can affect estrogen-mediated responses in different ways (Bilal et al, 2014). The aim of this project is to investigate the potential duality of phytoestrogens as both estrogen receptor antagonists in cancer cells, but also as potential activators of myeloid-derived suppressor cells. Understanding the complex role phytoestrogens play in cancer progression will prove valuable in the potential development of novel phytoestrogen-base cancer drug therapies.


Biol 404- Can A Soy Diet Mimic The Effects Of Estrogen?, Kelly Tarmon, Jonah Hottinger, Emily Humphries, Cody Gouyer, Amorette Barber 2020 Longwood University

Biol 404- Can A Soy Diet Mimic The Effects Of Estrogen?, Kelly Tarmon, Jonah Hottinger, Emily Humphries, Cody Gouyer, Amorette Barber

Student Showcase for Research and Creative Inquiry

Phytoestrogens are estrogen-mimicking substances that can be found in many of the vegetables, beans, and grains we consume. One of the main phytoestrogens consumed by millions of people can be found in soybeans and tofu and are called isoflavones. We will be examining the first category of isoflavones, the aglycones. The aglycones are made up of daidzein, genistein, and glycitein which are found in soy products. We will determine the function of aglycones using flow cytometry by comparing the effect of these three compounds, estradiol, and the media given. As aglycones are estrogen mimicking compounds, we believe these three phytoestrogens ...


Asd Symptoms In Individuals: A Comparison Of Treatments, Ali Khan 2020 Nova Southeastern University

Asd Symptoms In Individuals: A Comparison Of Treatments, Ali Khan

BIO4960: Practicum in Biology I

Background: Research, as described in the different articles chosen for comparison, indicates that individuals with autism spectrum disorder (ASD) commonly experience difficulties in displaying good memory, proper social communication, and doing physical activities.
Purpose: To determine and compare which treatment type—physical therapy, psychotherapy, or pharmacotherapy—is commonly used and effective for treating what specific symptom of ASD (primarily in children and adolescent diagnosed subjects that are experiencing difficulties).
Methods: 10 peer-reviewed articles published between 2015 and 2020 from different Databases, including CINAHL Complete, MEDLINE (ProQuest), and EMBASE.com, were retrieved.
Results: Thorough examination of the 10 selected studies indicate ...


Dolphinnext: A Distributed Data Processing Platform For High Throughput Genomics, Onur Yukselen, Osman Turkyilmaz, Ahmet R. Ozturk, Manuel Garber, Alper Kucukural 2020 University of Massachusetts Medical School

Dolphinnext: A Distributed Data Processing Platform For High Throughput Genomics, Onur Yukselen, Osman Turkyilmaz, Ahmet R. Ozturk, Manuel Garber, Alper Kucukural

Open Access Articles

BACKGROUND: The emergence of high throughput technologies that produce vast amounts of genomic data, such as next-generation sequencing (NGS) is transforming biological research. The dramatic increase in the volume of data, the variety and continuous change of data processing tools, algorithms and databases make analysis the main bottleneck for scientific discovery. The processing of high throughput datasets typically involves many different computational programs, each of which performs a specific step in a pipeline. Given the wide range of applications and organizational infrastructures, there is a great need for highly parallel, flexible, portable, and reproducible data processing frameworks. Several platforms currently ...


Checklist Of The Freshwater Sponges (Porifera: Spongillida) Of Tennessee, John E. Copeland 2020 Lincoln Memorial University

Checklist Of The Freshwater Sponges (Porifera: Spongillida) Of Tennessee, John E. Copeland

Cumberland Mountain Naturalist

Of the ~8,500 sponge species that are known to exist, approximately 3% inhabit freshwater. Taxonomically, freshwater sponges are divided into 6 families with less than 250 identified species. Of these, 33 species of freshwater sponge can be found in the Nearctic Biogeographical realm with 13 species documented in Tennessee waters. Species of three families, Metanidae, Potamolepidae, and Spongillidae, are known to occur in the United States but only members of Potamolepidae and Spongillidae have been collected from Tennessee waters. This article presents a species checklist with currently known distribution information.


Introgression Zones And Boundary Lines Between Breeding Populations Of Two Subspecies Of Willow Flycatcher, Anna Tipton 2020 Georgia College & State University

Introgression Zones And Boundary Lines Between Breeding Populations Of Two Subspecies Of Willow Flycatcher, Anna Tipton

Georgia College Student Research Events

The Southwestern Willow Flycatcher (Extimus traillii extimus) is an endangered subspecies of the Willow Flycatcher (Extimus traillii) and breeds exclusively in the dwindling riparian habitats in Southwestern US. The northern border between the southwestern subspecies and the subspecies to the north, E. t. adastus, isn’t clear because populations are not continuous along the border and environmental conditions like temperature and elevation differ. Introgression zones are areas where interbreeding between subspecies occurs when there is no physical barrier separating them. Our research objective was to see if subspecies breeding populations were consistent with the boundary lines and if there are ...


Validation Of Antibodies For The Immunolocalization Of Germ Cells In Alligator Gonads., Benjamin Austin 2020 Georgia College

Validation Of Antibodies For The Immunolocalization Of Germ Cells In Alligator Gonads., Benjamin Austin

Georgia College Student Research Events

Previous studies of alligators from pesticide-contaminated lakes have shown decreased fertility in comparison to less polluted reference populations. Our research is focused on elucidating potential mechanisms of decreased reproductive success in alligators exposed to environmental contaminants during critical developmental periods. The localization and identification of germ cells during development can provide critical information in assessing future reproductive capability. Germ cells are the unique precursors of gametes, more commonly referred to as eggs and sperm. Specific cell types can be localized through immunohistochemistry (IHC), which involves the use of labeled antibodies to identify specific molecules present in the cells of interest ...


The Binding Site Between The Adenoviral Protein E4 11k And The Cellular Protein Ddx6, O'Nekia Samuel 2020 Georgia College & State University

The Binding Site Between The Adenoviral Protein E4 11k And The Cellular Protein Ddx6, O'Nekia Samuel

Georgia College Student Research Events

Adenovirus is a nonenveloped virus that consists of an icosahedral capsid that contains double-stranded DNA. Viruses of this type can cause the common cold, conjunctivitis, and diarrhea. An important gene of adenoviruses is an early viral gene called E4 ORF3, which encodes the protein, E4 11k. This gene is responsible for changing the cellular environment, which aids in viral replication and prevents the host cell’s synthesis of proteins. E4 11k binds to Ddx6, a cellular protein located in P-bodies, and disrupts its localization. P-bodies are granules in the cytoplasm that contain mRNAs that have been repressed and proteins that ...


Geographical Disparity Of Suicide, Masiel Perez-Balaguer 2020 University of South Florida St. Petersburg

Geographical Disparity Of Suicide, Masiel Perez-Balaguer

USFSP Student Research Symposium

Suicide has been one of the leading causes of death in the United States for several years (Census, 2017). Multiple studies have looked at the disparity of suicide rates across geographical locations (Wilkinson, 1984; Saunderson,1998; Morrell, 1999). These studies have shown a correlation between rural areas and higher rates of suicide. For this study, data from the Centers for Disease Control and Prevention (CDC) was taken and linked with population data acquired through the Census. This was done for the year 2017 to see any correlation between location and suicide rate could be observed. States were split into six ...


Predicting Seasonal And Spatial Onset Of Chabs In Polymictic Reservoirs, Aaron Krivchenia, Matthew Pierce, Benjamin Carone, Michael Grove, Courtney E. Richmond, Nathan Ruhl 2020 Rowan University

Predicting Seasonal And Spatial Onset Of Chabs In Polymictic Reservoirs, Aaron Krivchenia, Matthew Pierce, Benjamin Carone, Michael Grove, Courtney E. Richmond, Nathan Ruhl

Biology Student Symposium Posters

Cyanobacterial Harmful Algal Blooms (cHABS) are a naturally occurring but increasingly common phenomenon due to anthropogenic activities and climate change. cHABs reduce water quality by forming unsightly surface scums and sometimes producing algal matts on the surface of water bodies, reduce water quality, and in high densities can produce cyanotoxins that can harm humans, pets, and wildlife. Ecological forecasting of cHABs has proved elusive in part because the in-situ fluorometric methods currently employed for detecting cyanobacteria cells are subject to varied interference as water quality and the biotic community changes. In this study we seek to develop an ecological forecasting ...


Assessing The Binding Of Nectin-1 And Cd96 In Human Cells To Investigate How Herpes Simplex Virus Evades The Innate Immune System, Paige T. Richards, Neha Alaparthy, Siranjit Kaur, Claude Krummenacher 2020 Rowan University

Assessing The Binding Of Nectin-1 And Cd96 In Human Cells To Investigate How Herpes Simplex Virus Evades The Innate Immune System, Paige T. Richards, Neha Alaparthy, Siranjit Kaur, Claude Krummenacher

Biology Student Symposium Posters

Nectin-1 is an adhesion protein that also serves as a receptor for herpes simplex virus (HSV) to enter cells. In epithelial tissues nectin-1 proteins naturally bind to other nectin-1 molecules on adjacent cells to organize intercellular junctions. Recently, our lab showed that human nectin-1 also binds to the natural killer (NK) cell receptor CD96 (Holmes et al, PloS One, 2019). CD96 modulates the immune response of NK cells, which are part of the innate immune system of mammals. NK cells play an important role in eliminating virally infected cells and cancer cells. When HSV infection occurs, nectin-1 located at the ...


Zooplankton Biodiversity Patterns Across A Novel Water Storage Complex In The Nj Pinelands, Emily D. Wang, Kathryn Mickle, Courtney E. Richmond, Nathan Ruhl 2020 Rowan University

Zooplankton Biodiversity Patterns Across A Novel Water Storage Complex In The Nj Pinelands, Emily D. Wang, Kathryn Mickle, Courtney E. Richmond, Nathan Ruhl

Biology Student Symposium Posters

The study involves the collection of zooplankton samples from Whitesbog, which is an inactive cranberry bog complex that is used as water storage for cranberry harvest during the fall season. Whitesbog is novel because very little human activity occurs in the surrounding area that could degrade water quality, but the complex itself is not natural. The water found in the upstream parts of the bog is highly acidic, which likely creates a gradient of ecological dystrophy in the zooplankton community. In this study, we investigate patterns of density and biodiversity across the complex and question whether these patterns are driven ...


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